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Items: 37

1.

The Magnitude of IFN-γ Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1.

Petermann F, Pękowska A, Johnson CA, Jankovic D, Shih HY, Jiang K, Hudson WH, Brooks SR, Sun HW, Villarino AV, Yao C, Singleton K, Akondy RS, Kanno Y, Sher A, Casellas R, Ahmed R, O'Shea JJ.

Mol Cell. 2019 Sep 19;75(6):1229-1242.e5. doi: 10.1016/j.molcel.2019.06.025. Epub 2019 Jul 31.

PMID:
31377117
2.

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair.

Linehan JL, Harrison OJ, Han SJ, Byrd AL, Vujkovic-Cvijin I, Villarino AV, Sen SK, Shaik J, Smelkinson M, Tamoutounour S, Collins N, Bouladoux N, Dzutsev A, Rosshart SP, Arbuckle JH, Wang CR, Kristie TM, Rehermann B, Trinchieri G, Brenchley JM, O'Shea JJ, Belkaid Y.

Cell. 2018 Feb 8;172(4):784-796.e18. doi: 10.1016/j.cell.2017.12.033. Epub 2018 Jan 18.

3.

IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.

Le Saout C, Luckey MA, Villarino AV, Smith M, Hasley RB, Myers TG, Imamichi H, Park JH, O'Shea JJ, Lane HC, Catalfamo M.

JCI Insight. 2017 Nov 16;2(22). pii: 96228. doi: 10.1172/jci.insight.96228. eCollection 2017 Nov 16.

4.

STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells.

Majri SS, Fritz JM, Villarino AV, Zheng L, Kanellopoulou C, Chaigne-Delalande B, Grönholm J, Niemela JE, Afzali B, Biancalana M, Pittaluga S, Sun A, Cohen JL, Holland SM, O'Shea JJ, Uzel G, Lenardo MJ.

J Immunol. 2018 Jan 1;200(1):110-118. doi: 10.4049/jimmunol.1701133. Epub 2017 Nov 29.

5.

Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells.

Villarino AV, Sciumè G, Davis FP, Iwata S, Zitti B, Robinson GW, Hennighausen L, Kanno Y, O'Shea JJ.

J Exp Med. 2017 Oct 2;214(10):2999-3014. doi: 10.1084/jem.20150907. Epub 2017 Sep 15.

6.

IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes.

Poholek AC, Jankovic D, Villarino AV, Petermann F, Hettinga A, Shouval DS, Snapper SB, Kaech SM, Brooks SR, Vahedi G, Sher A, Kanno Y, O'Shea JJ.

Sci Immunol. 2016 Oct;1(5). pii: eaaf8612. Epub 2016 Nov 11.

7.

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

Afzali B, Grönholm J, Vandrovcova J, O'Brien C, Sun HW, Vanderleyden I, Davis FP, Khoder A, Zhang Y, Hegazy AN, Villarino AV, Palmer IW, Kaufman J, Watts NR, Kazemian M, Kamenyeva O, Keith J, Sayed A, Kasperaviciute D, Mueller M, Hughes JD, Fuss IJ, Sadiyah MF, Montgomery-Recht K, McElwee J, Restifo NP, Strober W, Linterman MA, Wingfield PT, Uhlig HH, Roychoudhuri R, Aitman TJ, Kelleher P, Lenardo MJ, O'Shea JJ, Cooper N, Laurence ADJ.

Nat Immunol. 2017 Jul;18(7):813-823. doi: 10.1038/ni.3753. Epub 2017 May 22.

8.

Mechanisms and consequences of Jak-STAT signaling in the immune system.

Villarino AV, Kanno Y, O'Shea JJ.

Nat Immunol. 2017 Mar 22;18(4):374-384. doi: 10.1038/ni.3691. Review.

PMID:
28323260
9.

IL-27 shakes up the establishment of ectopic lymphoid structures.

Villarino AV, O'Shea JJ, Hunter CA.

J Exp Med. 2015 Oct 19;212(11):1757. doi: 10.1084/jem.21211insight4. No abstract available.

10.

An autoregulatory enhancer controls mammary-specific STAT5 functions.

Metser G, Shin HY, Wang C, Yoo KH, Oh S, Villarino AV, O'Shea JJ, Kang K, Hennighausen L.

Nucleic Acids Res. 2016 Feb 18;44(3):1052-63. doi: 10.1093/nar/gkv999. Epub 2015 Oct 7.

11.

Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.

Hirahara K, Onodera A, Villarino AV, Bonelli M, Sciumè G, Laurence A, Sun HW, Brooks SR, Vahedi G, Shih HY, Gutierrez-Cruz G, Iwata S, Suzuki R, Mikami Y, Okamoto Y, Nakayama T, Holland SM, Hunter CA, Kanno Y, O'Shea JJ.

Immunity. 2015 May 19;42(5):877-89. doi: 10.1016/j.immuni.2015.04.014.

12.

IL-1 watches the watchmen.

Villarino AV, Laurence A.

Nat Immunol. 2015 Mar;16(3):226-7. doi: 10.1038/ni.3105. No abstract available.

PMID:
25689436
13.

The JAK-STAT pathway: impact on human disease and therapeutic intervention.

O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A.

Annu Rev Med. 2015;66:311-28. doi: 10.1146/annurev-med-051113-024537. Review.

14.

Mechanisms of Jak/STAT signaling in immunity and disease.

Villarino AV, Kanno Y, Ferdinand JR, O'Shea JJ.

J Immunol. 2015 Jan 1;194(1):21-7. doi: 10.4049/jimmunol.1401867. Review.

15.

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.

Canna SW, de Jesus AA, Gouni S, Brooks SR, Marrero B, Liu Y, DiMattia MA, Zaal KJ, Sanchez GA, Kim H, Chapelle D, Plass N, Huang Y, Villarino AV, Biancotto A, Fleisher TA, Duncan JA, O'Shea JJ, Benseler S, Grom A, Deng Z, Laxer RM, Goldbach-Mansky R.

Nat Genet. 2014 Oct;46(10):1140-6. doi: 10.1038/ng.3089. Epub 2014 Sep 14.

16.

Transcriptional and epigenetic networks of helper T and innate lymphoid cells.

Shih HY, Sciumè G, Poholek AC, Vahedi G, Hirahara K, Villarino AV, Bonelli M, Bosselut R, Kanno Y, Muljo SA, O'Shea JJ.

Immunol Rev. 2014 Sep;261(1):23-49. doi: 10.1111/imr.12208. Review.

17.

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.

Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun HW, Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, O'Shea JJ.

Blood. 2014 May 8;123(19):2978-87. doi: 10.1182/blood-2013-09-523167. Epub 2014 Mar 14.

18.

Posttranscriptional control of T cell effector function by aerobic glycolysis.

Chang CH, Curtis JD, Maggi LB Jr, Faubert B, Villarino AV, O'Sullivan D, Huang SC, van der Windt GJ, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL.

Cell. 2013 Jun 6;153(6):1239-51. doi: 10.1016/j.cell.2013.05.016.

19.

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.

Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM.

J Exp Med. 2013 Feb 11;210(2):417-32. doi: 10.1084/jem.20111717. Epub 2013 Feb 4.

20.

Distinct requirements for T-bet in gut innate lymphoid cells.

Sciumé G, Hirahara K, Takahashi H, Laurence A, Villarino AV, Singleton KL, Spencer SP, Wilhelm C, Poholek AC, Vahedi G, Kanno Y, Belkaid Y, O'Shea JJ.

J Exp Med. 2012 Dec 17;209(13):2331-8. doi: 10.1084/jem.20122097. Epub 2012 Dec 3.

21.

IL-13-producing Th1 and Th17 cells characterize adaptive responses to both self and foreign antigens.

Gallo E, Katzman S, Villarino AV.

Eur J Immunol. 2012 Sep;42(9):2322-8. doi: 10.1002/eji.201142227. Epub 2012 Jul 27.

22.

Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells.

Villarino AV, Katzman SD, Gallo E, Miller O, Jiang S, McManus MT, Abbas AK.

Immunity. 2011 Jan 28;34(1):50-60. doi: 10.1016/j.immuni.2010.12.014. Epub 2011 Jan 13.

23.

STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms.

Villarino AV, Gallo E, Abbas AK.

J Immunol. 2010 Dec 1;185(11):6461-71. doi: 10.4049/jimmunol.1001343. Epub 2010 Oct 25.

24.

Duration of antigen receptor signaling determines T-cell tolerance or activation.

Katzman SD, O'Gorman WE, Villarino AV, Gallo E, Friedman RS, Krummel MF, Nolan GP, Abbas AK.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18085-90. doi: 10.1073/pnas.1010560107. Epub 2010 Oct 4.

25.

Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells.

Caretto D, Katzman SD, Villarino AV, Gallo E, Abbas AK.

J Immunol. 2010 Jan 1;184(1):30-4. doi: 10.4049/jimmunol.0903412. Epub 2009 Nov 30.

26.

IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD.

Villarino AV, Artis D, Bezbradica JS, Miller O, Saris CJ, Joyce S, Hunter CA.

Int Immunol. 2008 Jun;20(6):739-52. doi: 10.1093/intimm/dxn032. Epub 2008 Mar 28.

PMID:
18375937
27.

Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.

Villarino AV, Tato CM, Stumhofer JS, Yao Z, Cui YK, Hennighausen L, O'Shea JJ, Hunter CA.

J Exp Med. 2007 Jan 22;204(1):65-71. Epub 2007 Jan 16.

28.

Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease.

Lohr J, Knoechel B, Wang JJ, Villarino AV, Abbas AK.

J Exp Med. 2006 Dec 25;203(13):2785-91. Epub 2006 Nov 27.

29.

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.

Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, Johnson LM, Villarino AV, Huang Q, Yoshimura A, Sehy D, Saris CJ, O'Shea JJ, Hennighausen L, Ernst M, Hunter CA.

Nat Immunol. 2006 Sep;7(9):937-45. Epub 2006 Aug 13.

PMID:
16906166
30.

IL-27 limits IL-2 production during Th1 differentiation.

Villarino AV, Stumhofer JS, Saris CJ, Kastelein RA, de Sauvage FJ, Hunter CA.

J Immunol. 2006 Jan 1;176(1):237-47.

31.

Positive and negative regulation of the IL-27 receptor during lymphoid cell activation.

Villarino AV, Larkin J 3rd, Saris CJ, Caton AJ, Lucas S, Wong T, de Sauvage FJ, Hunter CA.

J Immunol. 2005 Jun 15;174(12):7684-91.

32.

TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development.

Sun J, Walsh M, Villarino AV, Cervi L, Hunter CA, Choi Y, Pearce EJ.

J Immunol. 2005 Jan 15;174(2):742-51.

33.

Biology of recently discovered cytokines: discerning the pro- and anti-inflammatory properties of interleukin-27.

Villarino AV, Hunter CA.

Arthritis Res Ther. 2004;6(5):225-33. Epub 2004 Aug 16. Review.

34.

Understanding the pro- and anti-inflammatory properties of IL-27.

Villarino AV, Huang E, Hunter CA.

J Immunol. 2004 Jul 15;173(2):715-20. Review.

35.

Cell cycle controlling the silencing and functioning of mammalian activators.

Mullen AC, Hutchins AS, Villarino AV, Lee HW, High FA, Cereb N, Yang SY, Hua X, Reiner SL.

Curr Biol. 2001 Oct 30;11(21):1695-9.

36.

Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restricts clonal expansion of helper T cells.

Doyle AM, Mullen AC, Villarino AV, Hutchins AS, High FA, Lee HW, Thompson CB, Reiner SL.

J Exp Med. 2001 Oct 1;194(7):893-902.

37.

Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.

Mullen AC, High FA, Hutchins AS, Lee HW, Villarino AV, Livingston DM, Kung AL, Cereb N, Yao TP, Yang SY, Reiner SL.

Science. 2001 Jun 8;292(5523):1907-10.

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