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Items: 1 to 50 of 74

1.

Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells.

Papillion A, Powell MD, Chisolm DA, Bachus H, Fuller MJ, Weinmann AS, Villarino A, O'Shea JJ, León B, Oestreich KJ, Ballesteros-Tato A.

Sci Immunol. 2019 Sep 13;4(39). pii: eaaw7636. doi: 10.1126/sciimmunol.aaw7636.

PMID:
31519812
2.

The Magnitude of IFN-γ Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1.

Petermann F, Pękowska A, Johnson CA, Jankovic D, Shih HY, Jiang K, Hudson WH, Brooks SR, Sun HW, Villarino AV, Yao C, Singleton K, Akondy RS, Kanno Y, Sher A, Casellas R, Ahmed R, O'Shea JJ.

Mol Cell. 2019 Sep 19;75(6):1229-1242.e5. doi: 10.1016/j.molcel.2019.06.025. Epub 2019 Jul 31.

PMID:
31377117
3.

Consensus document on exclusion diets in irritable bowel syndrome (IBS).

Casellas F, Burgos R, Marcos A, Santos J, Ciriza-de-Los-Ríos C, García-Manzanares Á, Polanco I, Puy-Portillo M, Villarino A, Lema-Marqués B, Vázquez-Alférez MªDC.

Nutr Hosp. 2018 Dec 3;35(6):1450-1466. doi: 10.20960/nh.2357.

4.

Consensus document on exclusion diets in irritable bowel syndrome (IBS).

Casellas F, Burgos R, Marcos A, Santos J, Ciriza de Los Ríos C, García Manzanares Á, Polanco I, Puy Portillo M, Villarino A, Lema Marqués B, Vázquez Alférez MDC.

Rev Esp Enferm Dig. 2018 Dec;110(12):806-824. doi: 10.17235/reed.2018.5941/2018.

5.

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair.

Linehan JL, Harrison OJ, Han SJ, Byrd AL, Vujkovic-Cvijin I, Villarino AV, Sen SK, Shaik J, Smelkinson M, Tamoutounour S, Collins N, Bouladoux N, Dzutsev A, Rosshart SP, Arbuckle JH, Wang CR, Kristie TM, Rehermann B, Trinchieri G, Brenchley JM, O'Shea JJ, Belkaid Y.

Cell. 2018 Feb 8;172(4):784-796.e18. doi: 10.1016/j.cell.2017.12.033. Epub 2018 Jan 18.

6.

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases.

Schwartz DM, Kanno Y, Villarino A, Ward M, Gadina M, O'Shea JJ.

Nat Rev Drug Discov. 2017 Dec 28;17(1):78. doi: 10.1038/nrd.2017.267.

7.

IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.

Le Saout C, Luckey MA, Villarino AV, Smith M, Hasley RB, Myers TG, Imamichi H, Park JH, O'Shea JJ, Lane HC, Catalfamo M.

JCI Insight. 2017 Nov 16;2(22). pii: 96228. doi: 10.1172/jci.insight.96228. eCollection 2017 Nov 16.

8.

STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells.

Majri SS, Fritz JM, Villarino AV, Zheng L, Kanellopoulou C, Chaigne-Delalande B, Grönholm J, Niemela JE, Afzali B, Biancalana M, Pittaluga S, Sun A, Cohen JL, Holland SM, O'Shea JJ, Uzel G, Lenardo MJ.

J Immunol. 2018 Jan 1;200(1):110-118. doi: 10.4049/jimmunol.1701133. Epub 2017 Nov 29.

9.

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases.

Schwartz DM, Kanno Y, Villarino A, Ward M, Gadina M, O'Shea JJ.

Nat Rev Drug Discov. 2017 Dec;16(12):843-862. doi: 10.1038/nrd.2017.201. Epub 2017 Nov 6. Review. Erratum in: Nat Rev Drug Discov. 2017 Dec 28;17 (1):78.

PMID:
29104284
10.

Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.

Mowel WK, McCright SJ, Kotzin JJ, Collet MA, Uyar A, Chen X, DeLaney A, Spencer SP, Virtue AT, Yang E, Villarino A, Kurachi M, Dunagin MC, Pritchard GH, Stein J, Hughes C, Fonseca-Pereira D, Veiga-Fernandes H, Raj A, Kambayashi T, Brodsky IE, O'Shea JJ, Wherry EJ, Goff LA, Rinn JL, Williams A, Flavell RA, Henao-Mejia J.

Immunity. 2017 Sep 19;47(3):435-449.e8. doi: 10.1016/j.immuni.2017.08.012.

11.

Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells.

Villarino AV, Sciumè G, Davis FP, Iwata S, Zitti B, Robinson GW, Hennighausen L, Kanno Y, O'Shea JJ.

J Exp Med. 2017 Oct 2;214(10):2999-3014. doi: 10.1084/jem.20150907. Epub 2017 Sep 15.

12.

OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity.

Segovia D, Haouz A, Porley D, Olivero N, Martínez M, Mariadassou M, Berois M, André-Leroux G, Villarino A.

J Mol Biol. 2017 Sep 1;429(18):2816-2824. doi: 10.1016/j.jmb.2017.07.017. Epub 2017 Jul 25.

PMID:
28754374
13.

Russian sturgeon cultured in a subtropical climate shows weaken innate defences and a chronic stress response.

Castellano M, Silva-Álvarez V, Fernández-López E, Mauris V, Conijeski D, Villarino A, Ferreira AM.

Fish Shellfish Immunol. 2017 Sep;68:443-451. doi: 10.1016/j.fsi.2017.07.048. Epub 2017 Jul 22.

PMID:
28743624
14.

IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes.

Poholek AC, Jankovic D, Villarino AV, Petermann F, Hettinga A, Shouval DS, Snapper SB, Kaech SM, Brooks SR, Vahedi G, Sher A, Kanno Y, O'Shea JJ.

Sci Immunol. 2016 Oct;1(5). pii: eaaf8612. Epub 2016 Nov 11.

15.

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

Afzali B, Grönholm J, Vandrovcova J, O'Brien C, Sun HW, Vanderleyden I, Davis FP, Khoder A, Zhang Y, Hegazy AN, Villarino AV, Palmer IW, Kaufman J, Watts NR, Kazemian M, Kamenyeva O, Keith J, Sayed A, Kasperaviciute D, Mueller M, Hughes JD, Fuss IJ, Sadiyah MF, Montgomery-Recht K, McElwee J, Restifo NP, Strober W, Linterman MA, Wingfield PT, Uhlig HH, Roychoudhuri R, Aitman TJ, Kelleher P, Lenardo MJ, O'Shea JJ, Cooper N, Laurence ADJ.

Nat Immunol. 2017 Jul;18(7):813-823. doi: 10.1038/ni.3753. Epub 2017 May 22.

16.

Extraordinary effects of unnatural pairings.

Villarino A, O'Shea JJ.

Elife. 2017 May 12;6. pii: e27198. doi: 10.7554/eLife.27198.

17.

Mechanisms and consequences of Jak-STAT signaling in the immune system.

Villarino AV, Kanno Y, O'Shea JJ.

Nat Immunol. 2017 Mar 22;18(4):374-384. doi: 10.1038/ni.3691. Review.

PMID:
28323260
18.

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

Villarino A, Laurence A, Robinson GW, Bonelli M, Dema B, Afzali B, Shih HY, Sun HW, Brooks SR, Hennighausen L, Kanno Y, O'Shea JJ.

Elife. 2016 Mar 21;5. pii: e08384. doi: 10.7554/eLife.08384.

19.

IL-27 shakes up the establishment of ectopic lymphoid structures.

Villarino AV, O'Shea JJ, Hunter CA.

J Exp Med. 2015 Oct 19;212(11):1757. doi: 10.1084/jem.21211insight4. No abstract available.

20.

An autoregulatory enhancer controls mammary-specific STAT5 functions.

Metser G, Shin HY, Wang C, Yoo KH, Oh S, Villarino AV, O'Shea JJ, Kang K, Hennighausen L.

Nucleic Acids Res. 2016 Feb 18;44(3):1052-63. doi: 10.1093/nar/gkv999. Epub 2015 Oct 7.

21.

Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.

Hirahara K, Onodera A, Villarino AV, Bonelli M, Sciumè G, Laurence A, Sun HW, Brooks SR, Vahedi G, Shih HY, Gutierrez-Cruz G, Iwata S, Suzuki R, Mikami Y, Okamoto Y, Nakayama T, Holland SM, Hunter CA, Kanno Y, O'Shea JJ.

Immunity. 2015 May 19;42(5):877-89. doi: 10.1016/j.immuni.2015.04.014.

22.

New potential eukaryotic substrates of the mycobacterial protein tyrosine phosphatase PtpA: hints of a bacterial modulation of macrophage bioenergetics state.

Margenat M, Labandera AM, Gil M, Carrion F, Purificação M, Razzera G, Portela MM, Obal G, Terenzi H, Pritsch O, Durán R, Ferreira AM, Villarino A.

Sci Rep. 2015 Mar 6;5:8819. doi: 10.1038/srep08819.

23.

IL-1 watches the watchmen.

Villarino AV, Laurence A.

Nat Immunol. 2015 Mar;16(3):226-7. doi: 10.1038/ni.3105. No abstract available.

PMID:
25689436
24.

The JAK-STAT pathway: impact on human disease and therapeutic intervention.

O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A.

Annu Rev Med. 2015;66:311-28. doi: 10.1146/annurev-med-051113-024537. Review.

25.

Mechanisms of Jak/STAT signaling in immunity and disease.

Villarino AV, Kanno Y, Ferdinand JR, O'Shea JJ.

J Immunol. 2015 Jan 1;194(1):21-7. doi: 10.4049/jimmunol.1401867. Review.

26.

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.

Canna SW, de Jesus AA, Gouni S, Brooks SR, Marrero B, Liu Y, DiMattia MA, Zaal KJ, Sanchez GA, Kim H, Chapelle D, Plass N, Huang Y, Villarino AV, Biancotto A, Fleisher TA, Duncan JA, O'Shea JJ, Benseler S, Grom A, Deng Z, Laxer RM, Goldbach-Mansky R.

Nat Genet. 2014 Oct;46(10):1140-6. doi: 10.1038/ng.3089. Epub 2014 Sep 14.

27.

Transcriptional and epigenetic networks of helper T and innate lymphoid cells.

Shih HY, Sciumè G, Poholek AC, Vahedi G, Hirahara K, Villarino AV, Bonelli M, Bosselut R, Kanno Y, Muljo SA, O'Shea JJ.

Immunol Rev. 2014 Sep;261(1):23-49. doi: 10.1111/imr.12208. Review.

28.

Body mass index through self-reported data and body image perception in Spanish adults attending dietary consultation.

Acevedo P, López-Ejeda N, Alférez-García I, Martínez-Álvarez JR, Villarino A, Cabañas MD, Marrodán MD.

Nutrition. 2014 Jun;30(6):679-84. doi: 10.1016/j.nut.2013.11.006. Epub 2013 Nov 20.

PMID:
24800667
29.

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.

Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun HW, Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, O'Shea JJ.

Blood. 2014 May 8;123(19):2978-87. doi: 10.1182/blood-2013-09-523167. Epub 2014 Mar 14.

30.

[Utility of self-reported anthropometric data for evaluation of obesity in the Spanish population; study EPINUT-ARKOPHARMA].

Marrodán MD, Martínez-Álvarez JR, Villarino A, Alférez-García I, González-Montero de Espinosa M, López-Ejeda N, Sánchez-Álvarez M, Cabañas MD.

Nutr Hosp. 2013 May-Jun;28(3):676-82. doi: 10.3305/nh.2013.28.3.6197. Spanish.

31.

Posttranscriptional control of T cell effector function by aerobic glycolysis.

Chang CH, Curtis JD, Maggi LB Jr, Faubert B, Villarino AV, O'Sullivan D, Huang SC, van der Windt GJ, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL.

Cell. 2013 Jun 6;153(6):1239-51. doi: 10.1016/j.cell.2013.05.016.

32.

Predicting percentage body fat through waist-to-height ratio (WtHR) in Spanish schoolchildren.

Marrodán M, Alvarez JM, de Espinosa MG, Carmenate M, López-Ejeda N, Cabañas M, Pacheco J, Mesa M, Romero-Collazos J, Prado C, Villarino A.

Public Health Nutr. 2014 Apr;17(4):870-6. doi: 10.1017/S1368980013000888. Epub 2013 Mar 28.

PMID:
23537776
33.

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.

Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM.

J Exp Med. 2013 Feb 11;210(2):417-32. doi: 10.1084/jem.20111717. Epub 2013 Feb 4.

34.

Distinct requirements for T-bet in gut innate lymphoid cells.

Sciumé G, Hirahara K, Takahashi H, Laurence A, Villarino AV, Singleton KL, Spencer SP, Wilhelm C, Poholek AC, Vahedi G, Kanno Y, Belkaid Y, O'Shea JJ.

J Exp Med. 2012 Dec 17;209(13):2331-8. doi: 10.1084/jem.20122097. Epub 2012 Dec 3.

35.

IL-13-producing Th1 and Th17 cells characterize adaptive responses to both self and foreign antigens.

Gallo E, Katzman S, Villarino AV.

Eur J Immunol. 2012 Sep;42(9):2322-8. doi: 10.1002/eji.201142227. Epub 2012 Jul 27.

36.

Modulation of lysozyme activity by lead administered by different routes. In vitro study and analysis in blood, kidney, and lung.

Olmo R, Teijón C, Muñiz E, Beneit JV, Villarino AL, Blanco MD.

Biol Trace Elem Res. 2012 Dec;149(3):405-11. doi: 10.1007/s12011-012-9446-1. Epub 2012 May 15.

PMID:
22581110
37.

Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells.

Villarino AV, Katzman SD, Gallo E, Miller O, Jiang S, McManus MT, Abbas AK.

Immunity. 2011 Jan 28;34(1):50-60. doi: 10.1016/j.immuni.2010.12.014. Epub 2011 Jan 13.

38.

STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms.

Villarino AV, Gallo E, Abbas AK.

J Immunol. 2010 Dec 1;185(11):6461-71. doi: 10.4049/jimmunol.1001343. Epub 2010 Oct 25.

39.

Duration of antigen receptor signaling determines T-cell tolerance or activation.

Katzman SD, O'Gorman WE, Villarino AV, Gallo E, Friedman RS, Krummel MF, Nolan GP, Abbas AK.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18085-90. doi: 10.1073/pnas.1010560107. Epub 2010 Oct 4.

40.

Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth.

Mascarello A, Chiaradia LD, Vernal J, Villarino A, Guido RV, Perizzolo P, Poirier V, Wong D, Martins PG, Nunes RJ, Yunes RA, Andricopulo AD, Av-Gay Y, Terenzi H.

Bioorg Med Chem. 2010 Jun 1;18(11):3783-9. doi: 10.1016/j.bmc.2010.04.051. Epub 2010 Apr 21.

PMID:
20462762
41.

Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells.

Caretto D, Katzman SD, Villarino AV, Gallo E, Abbas AK.

J Immunol. 2010 Jan 1;184(1):30-4. doi: 10.4049/jimmunol.0903412. Epub 2009 Nov 30.

42.

Study of response of thymic and submaxillary lymph node lymphocytes to administration of lead by different routes.

Teijón C, Blanco MD, Romero CS, Beneit JV, Villarino AL, Guerrero S, Olmo R.

Biol Trace Elem Res. 2010 Jun;135(1-3):74-85. doi: 10.1007/s12011-009-8495-6. Epub 2009 Sep 15.

PMID:
19756406
43.

[Comparison of dietary reference intakes (DRI) between different countries of the European Union, The United States and the World Health Organization].

Cuervo M, Corbalán M, Baladía E, Cabrerizo L, Formiguera X, Iglesias C, Lorenzo H, Polanco I, Quiles J, Romero de Avila MD, Russolillo G, Villarino A, Alfredo Martínez J.

Nutr Hosp. 2009 Jul-Aug;24(4):384-414. Spanish.

PMID:
19721919
44.

The FHA-containing protein GarA acts as a phosphorylation-dependent molecular switch in mycobacterial signaling.

England P, Wehenkel A, Martins S, Hoos S, André-Leroux G, Villarino A, Alzari PM.

FEBS Lett. 2009 Jan 22;583(2):301-7. doi: 10.1016/j.febslet.2008.12.036. Epub 2008 Dec 27.

45.

Covalent immobilization of tobacco-etch-virus NIa protease: a useful tool for cleavage of the histidine tag of recombinant proteins.

Puhl AC, Giacomini C, Irazoqui G, Batista-Viera F, Villarino A, Terenzi H.

Biotechnol Appl Biochem. 2009 May 29;53(Pt 3):165-74. doi: 10.1042/BA20080063.

PMID:
18937642
46.

Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.

Chiaradia LD, Mascarello A, Purificação M, Vernal J, Cordeiro MN, Zenteno ME, Villarino A, Nunes RJ, Yunes RA, Terenzi H.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6227-30. doi: 10.1016/j.bmcl.2008.09.105. Epub 2008 Oct 5.

PMID:
18930396
47.

IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD.

Villarino AV, Artis D, Bezbradica JS, Miller O, Saris CJ, Joyce S, Hunter CA.

Int Immunol. 2008 Jun;20(6):739-52. doi: 10.1093/intimm/dxn032. Epub 2008 Mar 28.

PMID:
18375937
48.

Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases.

Wehenkel A, Bellinzoni M, Schaeffer F, Villarino A, Alzari PM.

J Mol Biol. 2007 Dec 7;374(4):890-8. Epub 2007 Oct 2.

PMID:
17961594
49.

Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential.

Wehenkel A, Bellinzoni M, Graña M, Duran R, Villarino A, Fernandez P, Andre-Leroux G, England P, Takiff H, Cerveñansky C, Cole ST, Alzari PM.

Biochim Biophys Acta. 2008 Jan;1784(1):193-202. Epub 2007 Aug 14. Review.

PMID:
17869195
50.

An event-related potentials study of identity positive and negative priming.

Hinojosa JA, Villarino A, Pozo MA, Rosa Elosúa M, Merino JM, Moreno E, Luna D.

Int J Psychophysiol. 2007 Oct;66(1):48-55. Epub 2007 Jun 7.

PMID:
17610972

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