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Items: 18

1.

Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease.

Southwell AL, Kordasiewicz HB, Langbehn D, Skotte NH, Parsons MP, Villanueva EB, Caron NS, Østergaard ME, Anderson LM, Xie Y, Cengio LD, Findlay-Black H, Doty CN, Fitsimmons B, Swayze EE, Seth PP, Raymond LA, Frank Bennett C, Hayden MR.

Sci Transl Med. 2018 Oct 3;10(461). pii: eaar3959. doi: 10.1126/scitranslmed.aar3959.

PMID:
30282695
2.

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo.

Ehrnhoefer DE, Southwell AL, Sivasubramanian M, Qiu X, Villanueva EB, Xie Y, Waltl S, Anderson L, Fazeli A, Casal L, Felczak B, Tsang M, Hayden MR.

Hum Mol Genet. 2018 Jan 15;27(2):239-253. doi: 10.1093/hmg/ddx394.

3.

A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles.

Southwell AL, Skotte NH, Villanueva EB, Østergaard ME, Gu X, Kordasiewicz HB, Kay C, Cheung D, Xie Y, Waltl S, Dal Cengio L, Findlay-Black H, Doty CN, Petoukhov E, Iworima D, Slama R, Ooi J, Pouladi MA, Yang XW, Swayze EE, Seth PP, Hayden MR.

Hum Mol Genet. 2017 Mar 15;26(6):1115-1132. doi: 10.1093/hmg/ddx021.

PMID:
28104789
4.

The contribution of the sympathetic nervous system to the immunopathology of experimental pulmonary tuberculosis.

Barrios-Payán J, Revuelta A, Mata-Espinosa D, Marquina-Castillo B, Villanueva EB, Gutiérrez ME, Pérez-Sánchez G, Pavón L, Hernandez-Pando R.

J Neuroimmunol. 2016 Sep 15;298:98-105. doi: 10.1016/j.jneuroim.2016.07.012. Epub 2016 Jul 15.

PMID:
27609282
5.

An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes.

Southwell AL, Smith-Dijak A, Kay C, Sepers M, Villanueva EB, Parsons MP, Xie Y, Anderson L, Felczak B, Waltl S, Ko S, Cheung D, Dal Cengio L, Slama R, Petoukhov E, Raymond LA, Hayden MR.

Hum Mol Genet. 2016 Sep 1;25(17):3654-3675. doi: 10.1093/hmg/ddw212. Epub 2016 Jul 4.

6.

Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression.

Southwell AL, Smith SE, Davis TR, Caron NS, Villanueva EB, Xie Y, Collins JA, Ye ML, Sturrock A, Leavitt BR, Schrum AG, Hayden MR.

Sci Rep. 2015 Jul 15;5:12166. doi: 10.1038/srep12166.

7.

Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease.

Southwell AL, Franciosi S, Villanueva EB, Xie Y, Winter LA, Veeraraghavan J, Jonason A, Felczak B, Zhang W, Kovalik V, Waltl S, Hall G, Pouladi MA, Smith ES, Bowers WJ, Zauderer M, Hayden MR.

Neurobiol Dis. 2015 Apr;76:46-56. doi: 10.1016/j.nbd.2015.01.002. Epub 2015 Feb 3.

8.

Induction and treatment of anergy in murine leprosy.

Juarez-Ortega M, Hernandez VG, Arce-Paredes P, Villanueva EB, Aguilar-Santelises M, Rojas-Espinosa O.

Int J Exp Pathol. 2015 Feb;96(1):31-41. doi: 10.1111/iep.12108. Epub 2014 Dec 21.

9.

In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides.

Southwell AL, Skotte NH, Kordasiewicz HB, Østergaard ME, Watt AT, Carroll JB, Doty CN, Villanueva EB, Petoukhov E, Vaid K, Xie Y, Freier SM, Swayze EE, Seth PP, Bennett CF, Hayden MR.

Mol Ther. 2014 Dec;22(12):2093-106. doi: 10.1038/mt.2014.153. Epub 2014 Aug 7.

10.

Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia.

Little JP, Simtchouk S, Schindler SM, Villanueva EB, Gill NE, Walker DG, Wolthers KR, Klegeris A.

Mol Cell Neurosci. 2014 May;60:88-96. doi: 10.1016/j.mcn.2014.04.003. Epub 2014 Apr 23.

PMID:
24769106
11.

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS.

Østergaard ME, Southwell AL, Kordasiewicz H, Watt AT, Skotte NH, Doty CN, Vaid K, Villanueva EB, Swayze EE, Bennett CF, Hayden MR, Seth PP.

Nucleic Acids Res. 2013 Nov;41(21):9634-50. doi: 10.1093/nar/gkt725. Epub 2013 Aug 19.

12.

A fully humanized transgenic mouse model of Huntington disease.

Southwell AL, Warby SC, Carroll JB, Doty CN, Skotte NH, Zhang W, Villanueva EB, Kovalik V, Xie Y, Pouladi MA, Collins JA, Yang XW, Franciosi S, Hayden MR.

Hum Mol Genet. 2013 Jan 1;22(1):18-34. doi: 10.1093/hmg/dds397. Epub 2012 Sep 21.

13.

Secreted phospholipase A(2) group IIA is a neurotoxin released by stimulated human glial cells.

Villanueva EB, Little JP, Lambeau G, Klegeris A.

Mol Cell Neurosci. 2012 Apr;49(4):430-8. doi: 10.1016/j.mcn.2012.02.006. Epub 2012 Mar 3.

PMID:
22406427
14.

Therapeutic potential of cannabinoids in the treatment of neuroinflammation associated with Parkinson's disease.

Little JP, Villanueva EB, Klegeris A.

Mini Rev Med Chem. 2011 Jun;11(7):582-90. Review.

PMID:
21699489
15.

Cultured adult porcine astrocytes and microglia express functional interferon-γ receptors and exhibit toxicity towards SH-SY5Y cells.

Ionescu VA, Villanueva EB, Hashioka S, Bahniwal M, Klegeris A.

Brain Res Bull. 2011 Feb 28;84(3):244-51. doi: 10.1016/j.brainresbull.2010.12.011. Epub 2010 Dec 24.

PMID:
21185917
16.

Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain: human cell culture studies.

Bahniwal M, Villanueva EB, Klegeris A.

J Neuroimmunol. 2011 Apr;233(1-2):65-72. doi: 10.1016/j.jneuroim.2010.11.016. Epub 2010 Dec 24.

PMID:
21185608
17.

Synthesis and biological evaluation of novel pyrazole compounds.

Youssef AM, Neeland EG, Villanueva EB, White MS, El-Ashmawy IM, Patrick B, Klegeris A, Abd-El-Aziz AS.

Bioorg Med Chem. 2010 Aug 1;18(15):5685-96. doi: 10.1016/j.bmc.2010.06.018. Epub 2010 Jun 12.

PMID:
20609589
18.

Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents.

Youssef AM, White MS, Villanueva EB, El-Ashmawy IM, Klegeris A.

Bioorg Med Chem. 2010 Mar 1;18(5):2019-28. doi: 10.1016/j.bmc.2010.01.021. Epub 2010 Jan 15.

PMID:
20138770

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