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Items: 1 to 50 of 133

1.

Regulation of biofilm aging and dispersal in Bacillus subtilis by the alternative sigma factor SigB.

Bartolini M, Cogliati S, Vileta D, Bauman C, Rateni L, Leñini C, Argañaraz F, Francisco M, Villalba JM, Steil L, Völker U, Grau R.

J Bacteriol. 2018 Nov 5. pii: JB.00473-18. doi: 10.1128/JB.00473-18. [Epub ahead of print]

PMID:
30396900
2.

The impact of aging, calorie restriction and dietary fat on mitochondrial ultrastructure, dynamics and autophagy markers in mouse skeletal muscle.

Gutiérrez-Casado E, Khraiwesh H, López-Domínguez JA, Montero-Guisado J, López-Lluch G, Navas P, de Cabo R, Ramsey JJ, González-Reyes JA, Villalba JM.

J Gerontol A Biol Sci Med Sci. 2018 Jul 13. doi: 10.1093/gerona/gly161. [Epub ahead of print]

PMID:
30010806
3.

Regulation of the oxidative balance with coenzyme Q10 sensitizes human glioblastoma cells to radiation and temozolomide.

Frontiñán-Rubio J, Santiago-Mora RM, Nieva-Velasco CM, Ferrín G, Martínez-González A, Gómez MV, Moreno M, Ariza J, Lozano E, Arjona-Gutiérrez J, Gil-Agudo A, De la Mata M, Pesic M, Peinado JR, Villalba JM, Pérez-Romasanta L, Pérez-García VM, Alcaín FJ, Durán-Prado M.

Radiother Oncol. 2018 Aug;128(2):236-244. doi: 10.1016/j.radonc.2018.04.033. Epub 2018 May 18.

PMID:
29784452
4.

Overexpression of CYB5R3 and NQO1, two NAD+ -producing enzymes, mimics aspects of caloric restriction.

Diaz-Ruiz A, Lanasa M, Garcia J, Mora H, Fan F, Martin-Montalvo A, Di Francesco A, Calvo-Rubio M, Salvador-Pascual A, Aon MA, Fishbein KW, Pearson KJ, Villalba JM, Navas P, Bernier M, de Cabo R.

Aging Cell. 2018 Apr 28:e12767. doi: 10.1111/acel.12767. [Epub ahead of print]

5.

Coenzyme Q10: From bench to clinic in aging diseases, a translational review.

Gutierrez-Mariscal FM, Yubero-Serrano EM, Villalba JM, Lopez-Miranda J.

Crit Rev Food Sci Nutr. 2018 Feb 16:1-18. doi: 10.1080/10408398.2018.1442316. [Epub ahead of print]

PMID:
29451807
6.

Protein tyrosine phosphatase 1B deficiency in podocytes mitigates hyperglycemia-induced renal injury.

Ito Y, Hsu MF, Bettaieb A, Koike S, Mello A, Calvo-Rubio M, Villalba JM, Haj FG.

Metabolism. 2017 Nov;76:56-69. doi: 10.1016/j.metabol.2017.07.009. Epub 2017 Aug 8.

7.

Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia.

Bettaieb A, Koike S, Hsu MF, Ito Y, Chahed S, Bachaalany S, Gruzdev A, Calvo-Rubio M, Lee KSS, Inceoglu B, Imig JD, Villalba JM, Zeldin DC, Hammock BD, Haj FG.

Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt A):2758-2765. doi: 10.1016/j.bbagen.2017.07.021. Epub 2017 Jul 27.

8.

Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial.

Pérez-Sánchez C, Aguirre MÁ, Ruiz-Limón P, Ábalos-Aguilera MC, Jiménez-Gómez Y, Arias-de la Rosa I, Rodriguez-Ariza A, Fernández-Del Río L, González-Reyes JA, Segui P, Collantes-Estévez E, Barbarroja N, Velasco F, Sciascia S, Cecchi I, Cuadrado MJ, Villalba JM, López-Pedrera C.

Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1923-1932. doi: 10.1161/ATVBAHA.117.309225. Epub 2017 Jul 6.

PMID:
28684614
9.

Conserved and species-specific molecular denominators in mammalian skeletal muscle aging.

Mercken EM, Capri M, Carboneau BA, Conte M, Heidler J, Santoro A, Martin-Montalvo A, Gonzalez-Freire M, Khraiwesh H, González-Reyes JA, Moaddel R, Zhang Y, Becker KG, Villalba JM, Mattison JA, Wittig I, Franceschi C, de Cabo R.

NPJ Aging Mech Dis. 2017 May 5;3:8. doi: 10.1038/s41514-017-0009-8. eCollection 2017.

10.

Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor.

Fernández-Del-Río L, Nag A, Gutiérrez Casado E, Ariza J, Awad AM, Joseph AI, Kwon O, Verdin E, de Cabo R, Schneider C, Torres JZ, Burón MI, Clarke CF, Villalba JM.

Free Radic Biol Med. 2017 Sep;110:176-187. doi: 10.1016/j.freeradbiomed.2017.06.006. Epub 2017 Jun 9.

11.

Diagnostic potential of NETosis-derived products for disease activity, atherosclerosis and therapeutic effectiveness in Rheumatoid Arthritis patients.

Pérez-Sánchez C, Ruiz-Limón P, Aguirre MA, Jiménez-Gómez Y, Arias-de la Rosa I, Ábalos-Aguilera MC, Rodriguez-Ariza A, Castro-Villegas MC, Ortega-Castro R, Segui P, Martinez C, Gonzalez-Conejero R, Rodríguez-López S, Gonzalez-Reyes JA, Villalba JM, Collantes-Estévez E, Escudero A, Barbarroja N, López-Pedrera C.

J Autoimmun. 2017 Aug;82:31-40. doi: 10.1016/j.jaut.2017.04.007. Epub 2017 Apr 29.

PMID:
28465139
12.

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R.

Cell Metab. 2016 Jun 14;23(6):1093-1112. doi: 10.1016/j.cmet.2016.05.027.

13.

Cytochrome b5 reductase and the control of lipid metabolism and healthspan.

Martin-Montalvo A, Sun Y, Diaz-Ruiz A, Ali A, Gutierrez V, Palacios HH, Curtis J, Siendones E, Ariza J, Abulwerdi GA, Sun X, Wang AX, Pearson KJ, Fishbein KW, Spencer RG, Wang M, Han X, Scheibye-Knudsen M, Baur JA, Shertzer HG, Navas P, Villalba JM, Zou S, Bernier M, de Cabo R.

NPJ Aging Mech Dis. 2016 May 12;2:16006. doi: 10.1038/npjamd.2016.6. eCollection 2016.

14.

Mitochondrial permeabilization without caspase activation mediates the increase of basal apoptosis in cells lacking Nrf2.

Ariza J, González-Reyes JA, Jódar L, Díaz-Ruiz A, de Cabo R, Villalba JM.

Free Radic Biol Med. 2016 Jun;95:82-95. doi: 10.1016/j.freeradbiomed.2016.03.015. Epub 2016 Mar 22.

15.

Omega-3 fatty acids partially revert the metabolic gene expression profile induced by long-term calorie restriction.

López-Domínguez JA, Cánovas Á, Medrano JF, Islas-Trejo A, Kim K, Taylor SL, Villalba JM, López-Lluch G, Navas P, Ramsey JJ.

Exp Gerontol. 2016 May;77:29-37. doi: 10.1016/j.exger.2016.02.002. Epub 2016 Feb 11.

PMID:
26875793
16.

Dietary fat composition influences glomerular and proximal convoluted tubule cell structure and autophagic processes in kidneys from calorie-restricted mice.

Calvo-Rubio M, Burón MI, López-Lluch G, Navas P, de Cabo R, Ramsey JJ, Villalba JM, González-Reyes JA.

Aging Cell. 2016 Jun;15(3):477-87. doi: 10.1111/acel.12451. Epub 2016 Feb 8.

17.

Olive Oil and the Hallmarks of Aging.

Fernández del Río L, Gutiérrez-Casado E, Varela-López A, Villalba JM.

Molecules. 2016 Jan 29;21(2):163. doi: 10.3390/molecules21020163. Review.

18.

Mediterranean Diet Supplemented With Coenzyme Q10 Modulates the Postprandial Metabolism of Advanced Glycation End Products in Elderly Men and Women.

Lopez-Moreno J, Quintana-Navarro GM, Delgado-Lista J, Garcia-Rios A, Alcala-Diaz JF, Gomez-Delgado F, Camargo A, Perez-Martinez P, Tinahones FJ, Striker GE, Perez-Jimenez F, Villalba JM, Lopez-Miranda J, Yubero-Serrano EM.

J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):340-346. doi: 10.1093/gerona/glw214.

PMID:
28329789
19.

The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice.

Villalba JM, López-Domínguez JA, Chen Y, Khraiwesh H, González-Reyes JA, Del Río LF, Gutiérrez-Casado E, Del Río M, Calvo-Rubio M, Ariza J, de Cabo R, López-Lluch G, Navas P, Hagopian K, Burón MI, Ramsey JJ.

Biogerontology. 2015 Oct;16(5):655-70. doi: 10.1007/s10522-015-9572-1. Epub 2015 Apr 10. Review.

20.

The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice.

López-Domínguez JA, Ramsey JJ, Tran D, Imai DM, Koehne A, Laing ST, Griffey SM, Kim K, Taylor SL, Hagopian K, Villalba JM, López-Lluch G, Navas P, McDonald RB.

J Gerontol A Biol Sci Med Sci. 2015 Oct;70(10):1181-8. doi: 10.1093/gerona/glu177. Epub 2014 Oct 13.

21.

Coenzyme Q10 protects human endothelial cells from β-amyloid uptake and oxidative stress-induced injury.

Durán-Prado M, Frontiñán J, Santiago-Mora R, Peinado JR, Parrado-Fernández C, Gómez-Almagro MV, Moreno M, López-Domínguez JA, Villalba JM, Alcaín FJ.

PLoS One. 2014 Oct 1;9(10):e109223. doi: 10.1371/journal.pone.0109223. eCollection 2014.

22.

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.

Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R.

Aging Cell. 2014 Oct;13(5):787-96. doi: 10.1111/acel.12220. Epub 2014 Jun 16.

23.

Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats.

Khraiwesh H, López-Domínguez JA, Fernández del Río L, Gutierrez-Casado E, López-Lluch G, Navas P, de Cabo R, Ramsey JJ, Burón MI, Villalba JM, González-Reyes JA.

Exp Gerontol. 2014 Aug;56:77-88. doi: 10.1016/j.exger.2014.03.023. Epub 2014 Apr 4.

24.

Dietary fat and aging modulate apoptotic signaling in liver of calorie-restricted mice.

López-Domínguez JA, Khraiwesh H, González-Reyes JA, López-Lluch G, Navas P, Ramsey JJ, de Cabo R, Burón MI, Villalba JM.

J Gerontol A Biol Sci Med Sci. 2015 Apr;70(4):399-409. doi: 10.1093/gerona/glu045. Epub 2014 Apr 1.

25.

Atherosclerosis and cardiovascular disease in systemic lupus erythematosus: effects of in vivo statin treatment.

Ruiz-Limon P, Barbarroja N, Perez-Sanchez C, Aguirre MA, Bertolaccini ML, Khamashta MA, Rodriguez-Ariza A, Almadén Y, Segui P, Khraiwesh H, Gonzalez-Reyes JA, Villalba JM, Collantes-Estevez E, Cuadrado MJ, Lopez-Pedrera C.

Ann Rheum Dis. 2015 Jul;74(7):1450-8. doi: 10.1136/annrheumdis-2013-204351. Epub 2014 Mar 21.

PMID:
24658835
26.

Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2.

Siendones E, SantaCruz-Calvo S, Martín-Montalvo A, Cascajo MV, Ariza J, López-Lluch G, Villalba JM, Acquaviva-Bourdain C, Roze E, Bernier M, de Cabo R, Navas P.

Antioxid Redox Signal. 2014 Oct 20;21(12):1708-25. doi: 10.1089/ars.2013.5479. Epub 2014 Feb 28.

27.

The influence of dietary lipid composition on skeletal muscle mitochondria from mice following eight months of calorie restriction.

Chen Y, Hagopian K, Bibus D, Villalba JM, López-Lluch G, Navas P, Kim K, Ramsey JJ.

Physiol Res. 2014;63(1):57-71. Epub 2013 Nov 1.

28.

Alterations of ultrastructural and fission/fusion markers in hepatocyte mitochondria from mice following calorie restriction with different dietary fats.

Khraiwesh H, López-Domínguez JA, López-Lluch G, Navas P, de Cabo R, Ramsey JJ, Villalba JM, González-Reyes JA.

J Gerontol A Biol Sci Med Sci. 2013 Sep;68(9):1023-34. doi: 10.1093/gerona/glt006. Epub 2013 Feb 12.

29.

Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorie-restricted mice.

López-Domínguez JA, Khraiwesh H, González-Reyes JA, López-Lluch G, Navas P, Ramsey JJ, de Cabo R, Burón MI, Villalba JM.

Age (Dordr). 2013 Dec;35(6):2027-44. doi: 10.1007/s11357-012-9492-9. Epub 2012 Nov 20.

30.

The influence of dietary lipid composition on liver mitochondria from mice following 1 month of calorie restriction.

Chen Y, Hagopian K, Bibus D, Villalba JM, López-Lluch G, Navas P, Kim K, McDonald RB, Ramsey JJ.

Biosci Rep. 2012 Dec 13;33(1):83-95. doi: 10.1042/BSR20120060.

31.

Sirtuin activators and inhibitors.

Villalba JM, Alcaín FJ.

Biofactors. 2012 Sep-Oct;38(5):349-59. doi: 10.1002/biof.1032. Epub 2012 Jun 25. Review.

32.

Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q(10) treatment.

Perez-Sanchez C, Ruiz-Limon P, Aguirre MA, Bertolaccini ML, Khamashta MA, Rodriguez-Ariza A, Segui P, Collantes-Estevez E, Barbarroja N, Khraiwesh H, Gonzalez-Reyes JA, Villalba JM, Velasco F, Cuadrado MJ, Lopez-Pedrera C.

Blood. 2012 Jun 14;119(24):5859-70. doi: 10.1182/blood-2011-12-400986. Epub 2012 Apr 23.

33.

The influence of dietary lipid composition on skeletal muscle mitochondria from mice following 1 month of calorie restriction.

Chen Y, Hagopian K, McDonald RB, Bibus D, López-Lluch G, Villalba JM, Navas P, Ramsey JJ.

J Gerontol A Biol Sci Med Sci. 2012 Nov;67(11):1121-31. doi: 10.1093/gerona/gls113. Epub 2012 Apr 13.

34.

A patent review of sirtuin activators: an update.

Villalba JM, de Cabo R, Alcain FJ.

Expert Opin Ther Pat. 2012 Apr;22(4):355-67. doi: 10.1517/13543776.2012.669374. Epub 2012 Mar 9. Review.

PMID:
22475539
35.

Postprandial antioxidant gene expression is modified by Mediterranean diet supplemented with coenzyme Q(10) in elderly men and women.

Yubero-Serrano EM, Gonzalez-Guardia L, Rangel-Zuñiga O, Delgado-Casado N, Delgado-Lista J, Perez-Martinez P, Garcia-Rios A, Caballero J, Marin C, Gutierrez-Mariscal FM, Tinahones FJ, Villalba JM, Tunez I, Perez-Jimenez F, Lopez-Miranda J.

Age (Dordr). 2013 Feb;35(1):159-70. doi: 10.1007/s11357-011-9331-4. Epub 2011 Nov 6.

36.

Mediterranean diet supplemented with coenzyme Q10 modifies the expression of proinflammatory and endoplasmic reticulum stress-related genes in elderly men and women.

Yubero-Serrano EM, Gonzalez-Guardia L, Rangel-Zuñiga O, Delgado-Lista J, Gutierrez-Mariscal FM, Perez-Martinez P, Delgado-Casado N, Cruz-Teno C, Tinahones FJ, Villalba JM, Perez-Jimenez F, Lopez-Miranda J.

J Gerontol A Biol Sci Med Sci. 2012 Jan;67(1):3-10. doi: 10.1093/gerona/glr167. Epub 2011 Oct 20.

PMID:
22016358
37.

Dietary oil modifies the plasma proteome during aging in the rat.

Santos-González M, López-Miranda J, Pérez-Jiménez F, Navas P, Villalba JM.

Age (Dordr). 2012 Apr;34(2):341-58. doi: 10.1007/s11357-011-9239-z. Epub 2011 Apr 7.

38.

Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues.

Parrado-Fernández C, López-Lluch G, Rodríguez-Bies E, Santa-Cruz S, Navas P, Ramsey JJ, Villalba JM.

Free Radic Biol Med. 2011 Jun 15;50(12):1728-36. doi: 10.1016/j.freeradbiomed.2011.03.024. Epub 2011 Mar 27.

39.

Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q10 in elderly men and women.

Yubero-Serrano EM, Delgado-Casado N, Delgado-Lista J, Perez-Martinez P, Tasset-Cuevas I, Santos-Gonzalez M, Caballero J, Garcia-Rios A, Marin C, Gutierrez-Mariscal FM, Fuentes F, Villalba JM, Tunez I, Perez-Jimenez F, Lopez-Miranda J.

Age (Dordr). 2011 Dec;33(4):579-90. doi: 10.1007/s11357-010-9199-8. Epub 2010 Dec 18.

40.

NRF2, cancer and calorie restriction.

Martín-Montalvo A, Villalba JM, Navas P, de Cabo R.

Oncogene. 2011 Feb 3;30(5):505-20. doi: 10.1038/onc.2010.492. Epub 2010 Nov 8. Review.

41.

Genetic deletion of Nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts.

Jódar L, Mercken EM, Ariza J, Younts C, González-Reyes JA, Alcaín FJ, Burón I, de Cabo R, Villalba JM.

J Gerontol A Biol Sci Med Sci. 2011 Mar;66(3):247-56. doi: 10.1093/gerona/glq181. Epub 2010 Oct 25.

42.

Computerized evaluation of mean residence times in multicompartmental linear system and pharmacokinetics.

Villalba JM, Barbero AJ, Diaz-Sierra R, Arribas E, Garcia-Meseguer MJ, Garcia-Sevilla F, Garcia-Moreno M, De Labra JA, Varon R.

J Comput Chem. 2011 Apr 15;32(5):915-31. doi: 10.1002/jcc.21677. Epub 2010 Oct 19.

PMID:
20960438
43.

Student peer evaluation using a remote response system.

Nájera A, Villalba JM, Arribas E.

Med Educ. 2010 Nov;44(11):1146. doi: 10.1111/j.1365-2923.2010.03837.x. No abstract available.

PMID:
20946511
44.

Complex I-associated hydrogen peroxide production is decreased and electron transport chain enzyme activities are altered in n-3 enriched fat-1 mice.

Hagopian K, Weber KL, Hwee DT, Van Eenennaam AL, López-Lluch G, Villalba JM, Burón I, Navas P, German JB, Watkins SM, Chen Y, Wei A, McDonald RB, Ramsey JJ.

PLoS One. 2010 Sep 13;5(9):e12696. doi: 10.1371/journal.pone.0012696.

45.

ES936 stimulates DNA synthesis in HeLa cells independently on NAD(P)H:quinone oxidoreductase 1 inhibition, through a mechanism involving p38 MAPK.

González-Aragón D, Alcaín FJ, Ariza J, Jódar L, Barbarroja N, López-Pedrera C, Villalba JM.

Chem Biol Interact. 2010 Jul 30;186(2):174-83. doi: 10.1016/j.cbi.2010.04.022. Epub 2010 Apr 28.

PMID:
20433816
46.

Therapeutic use of coenzyme Q10 and coenzyme Q10-related compounds and formulations.

Villalba JM, Parrado C, Santos-Gonzalez M, Alcain FJ.

Expert Opin Investig Drugs. 2010 Apr;19(4):535-54. doi: 10.1517/13543781003727495. Review.

PMID:
20367194
47.

N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes.

González R, Ferrín G, Hidalgo AB, Ranchal I, López-Cillero P, Santos-Gónzalez M, López-Lluch G, Briceño J, Gómez MA, Poyato A, Villalba JM, Navas P, de la Mata M, Muntané J.

Chem Biol Interact. 2009 Sep 14;181(1):95-106. doi: 10.1016/j.cbi.2009.06.003. Epub 2009 Jun 11.

PMID:
19523936
48.

Sirtuin activators.

Alcaín FJ, Villalba JM.

Expert Opin Ther Pat. 2009 Apr;19(4):403-14. doi: 10.1517/13543770902762893. Review.

PMID:
19441923
49.

Sirtuin inhibitors.

Alcaín FJ, Villalba JM.

Expert Opin Ther Pat. 2009 Mar;19(3):283-94. doi: 10.1517/13543770902755111. Review.

PMID:
19441904
50.

NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast.

Jiménez-Hidalgo M, Santos-Ocaña C, Padilla S, Villalba JM, López-Lluch G, Martín-Montalvo A, Minor RK, Sinclair DA, de Cabo R, Navas P.

Aging Cell. 2009 Apr;8(2):140-51. doi: 10.1111/j.1474-9726.2009.00461.x. Epub 2009 Feb 23.

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