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Items: 1 to 50 of 110

1.

Author Correction: Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells.

Knox T, Sahakian E, Banik D, Hadley M, Palmer E, Noonepalle S, Kim J, Powers J, Gracia-Hernandez M, Oliveira V, Cheng F, Chen J, Barinka C, Pinilla-Ibarz J, Lee NH, Kozikowski A, Villagra A.

Sci Rep. 2019 Oct 10;9(1):14824. doi: 10.1038/s41598-019-51403-6.

2.

Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.

Shen S, Hadley M, Ustinova K, Pavlicek J, Knox T, Noonepalle S, Tavares MT, Zimprich CA, Zhang G, Robers MB, Bařinka C, Kozikowski AP, Villagra A.

J Med Chem. 2019 Sep 26;62(18):8557-8577. doi: 10.1021/acs.jmedchem.9b00946. Epub 2019 Sep 4.

PMID:
31414801
3.

Changes in Body Composition and Physical Fitness in Adolescents with Down Syndrome: The UP&DOWN Longitudinal Study.

Suarez-Villadat B, Veiga OL, Villagra A, Izquierdo-Gomez R; UP&DOWN Study Group.

Child Obes. 2019 Sep;15(6):397-405. doi: 10.1089/chi.2018.0198. Epub 2019 Jun 6.

PMID:
31170003
4.

Functional Analysis of HDACs in Tumorigenesis.

Hadley M, Noonepalle S, Banik D, Villagra A.

Methods Mol Biol. 2019;1983:279-307. doi: 10.1007/978-1-4939-9434-2_17.

PMID:
31087305
5.

Immunoepigenetics Combination Therapies: An Overview of the Role of HDACs in Cancer Immunotherapy.

Banik D, Moufarrij S, Villagra A.

Int J Mol Sci. 2019 May 7;20(9). pii: E2241. doi: 10.3390/ijms20092241. Review.

6.

Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells.

Knox T, Sahakian E, Banik D, Hadley M, Palmer E, Noonepalle S, Kim J, Powers J, Gracia-Hernandez M, Oliveira V, Cheng F, Chen J, Barinka C, Pinilla-Ibarz J, Lee NH, Kozikowski A, Villagra A.

Sci Rep. 2019 Apr 16;9(1):6136. doi: 10.1038/s41598-019-42237-3. Erratum in: Sci Rep. 2019 Oct 10;9(1):14824.

7.

Epigenetic therapy for ovarian cancer: promise and progress.

Moufarrij S, Dandapani M, Arthofer E, Gomez S, Srivastava A, Lopez-Acevedo M, Villagra A, Chiappinelli KB.

Clin Epigenetics. 2019 Jan 15;11(1):7. doi: 10.1186/s13148-018-0602-0. Review.

8.

Silencing of HDAC6 as a therapeutic target in chronic lymphocytic leukemia.

Maharaj K, Powers JJ, Achille A, Deng S, Fonseca R, Pabon-Saldana M, Quayle SN, Jones SS, Villagra A, Sotomayor EM, Sahakian E, Pinilla-Ibarz J.

Blood Adv. 2018 Nov 13;2(21):3012-3024. doi: 10.1182/bloodadvances.2018020065.

9.

A systematic review of non-productivity-related animal-based indicators of heat stress resilience in dairy cattle.

Galán E, Llonch P, Villagrá A, Levit H, Pinto S, Del Prado A.

PLoS One. 2018 Nov 1;13(11):e0206520. doi: 10.1371/journal.pone.0206520. eCollection 2018.

10.

Diet quality index as a predictor of treatment efficacy in overweight and obese adolescents: The EVASYON study.

De Miguel-Etayo P, Moreno LA, Santabárbara J, Martín-Matillas M, Azcona-San Julian MC, Marti Del Moral A, Campoy C, Marcos A, Garagorri JM; EVASYON Study Group.

Clin Nutr. 2019 Apr;38(2):782-790. doi: 10.1016/j.clnu.2018.02.032. Epub 2018 Mar 29.

PMID:
29730135
11.

Phase I trial of histone deacetylase inhibitor panobinostat in addition to glucocorticoids for primary therapy of acute graft-versus-host disease.

Perez L, Fernandez H, Horna P, Riches M, Locke F, Field T, Powers J, Sahakian E, Villagra A, Mishra A, Betts B, Kharfan-Dabaja M, Beato F, Ochoa-Bayona L, Pidala J, Anasetti C.

Bone Marrow Transplant. 2018 Nov;53(11):1434-1444. doi: 10.1038/s41409-018-0163-z. Epub 2018 Apr 18.

PMID:
29670210
12.

In-frame Variants in FLNA Proximal Rod 1 Domain Associate With a Predominant Cardiac Valvular Phenotype.

Fernández L, Tenorio J, Polo-Vaquero C, Vallespín E, Palomares-Bralo M, García-Miñaúr S, Santos-Simarro F, Arias P, Carnicer H, Giannivelli S, Medina J, Pérez-Piaya R, Solís J, Rodríguez M, Villagrá A, Rodríguez L, Nevado J, Martínez-Glez V, Heath KE, Lapunzina P.

Rev Esp Cardiol (Engl Ed). 2018 Jul;71(7):545-552. doi: 10.1016/j.rec.2017.10.013. Epub 2017 Nov 14. English, Spanish.

PMID:
29146485
13.

Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models.

Tavares MT, Shen S, Knox T, Hadley M, Kutil Z, Bařinka C, Villagra A, Kozikowski AP.

ACS Med Chem Lett. 2017 Sep 5;8(10):1031-1036. doi: 10.1021/acsmedchemlett.7b00223. eCollection 2017 Oct 12.

14.
15.

Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology.

Sahakian E, Chen J, Powers JJ, Chen X, Maharaj K, Deng SL, Achille AN, Lienlaf M, Wang HW, Cheng F, Sodré AL, Distler A, Xing L, Perez-Villarroel P, Wei S, Villagra A, Seto E, Sotomayor EM, Horna P, Pinilla-Ibarz J.

J Leukoc Biol. 2017 Aug;102(2):475-486. doi: 10.1189/jlb.1A0415-176RRR. Epub 2017 May 26.

16.

T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model.

Woods DM, Woan KV, Cheng F, Sodré AL, Wang D, Wu Y, Wang Z, Chen J, Powers J, Pinilla-Ibarz J, Yu Y, Zhang Y, Wu X, Zheng X, Weber J, Hancock WW, Seto E, Villagra A, Yu XZ, Sotomayor EM.

Blood. 2017 Jul 13;130(2):146-155. doi: 10.1182/blood-2016-08-731505. Epub 2017 May 26.

17.

Changes in objectively measured physical activity in adolescents with Down syndrome: the UP&DOWN longitudinal study.

Izquierdo-Gomez R, Martinez-Gómez D, Esteban-Cornejo I, Hallal PC, García-Cervantes L, Villagra A, Veiga OL; UP&DOWN study group.

J Intellect Disabil Res. 2017 Apr;61(4):363-372. doi: 10.1111/jir.12354. Epub 2017 Jan 16.

PMID:
28090738
18.

Erratum to: Functional Analysis of Histone Deacetylase 11 (HDAC11).

Chen J, Sahakian E, Powers J, Lienlaf M, Perez-Villarroel P, Knox T, Villagra A.

Methods Mol Biol. 2016;1436:E1. No abstract available.

PMID:
27535557
19.

A Methodology for the Hybridization Based in Active Components: The Case of cGA and Scatter Search.

Villagra A, Alba E, Leguizamón G.

Comput Intell Neurosci. 2016;2016:8289237. doi: 10.1155/2016/8289237. Epub 2016 Jun 14.

20.

Preparation and Biochemical Analysis of Classical Histone Deacetylases.

Villagra A, Sahakian E, Seto E.

Methods Enzymol. 2016;573:161-81. doi: 10.1016/bs.mie.2016.04.005. Epub 2016 May 31. Review.

21.

Functional Analysis of Histone Deacetylase 11 (HDAC11).

Chen J, Sahakian E, Powers J, Lienlaf M, Perez-Villarroel P, Knox T, Villagra A.

Methods Mol Biol. 2016;1436:147-65. doi: 10.1007/978-1-4939-3667-0_11.

PMID:
27246214
22.

Expression and Function of Histone Deacetylase 10 (HDAC10) in B Cell Malignancies.

Powers J, Lienlaf M, Perez-Villarroel P, Deng S, Knox T, Villagra A, Sahakian E.

Methods Mol Biol. 2016;1436:129-45. doi: 10.1007/978-1-4939-3667-0_10.

PMID:
27246213
23.

Antimicrobial resistance of Escherichia coli isolated in newly-hatched chickens and effect of amoxicillin treatment during their growth.

Jiménez-Belenguer A, Doménech E, Villagrá A, Fenollar A, Ferrús MA.

Avian Pathol. 2016 Aug;45(4):501-7. doi: 10.1080/03079457.2016.1168515.

24.

Essential role of HDAC6 in the regulation of PD-L1 in melanoma.

M L, P PV, T K, M P, E S, J P, K V W, C L, F C, S D, M SKS, M M, A K, J PI, A S, E S, J W, E M S, A V.

Mol Oncol. 2016 May;10(5):735-750. doi: 10.1016/j.molonc.2015.12.012. Epub 2016 Jan 6.

25.

BODY COMPOSITION CHANGES DURING A MULTIDISCIPLINARY TREATMENT PROGRAMME IN OVERWEIGHT ADOLESCENTS: EVASYON STUDY.

De Miguel-Etayo P, Moreno LA, Santabárbara J, Bueno G, Martín-Matillas M, Zapatera B, Azcona-San Julián C, Marti A, Campoy C, Marcos A, Garagorri JM; nombre del Grupo de Estudio EVASYON.

Nutr Hosp. 2015 Dec 1;32(6):2525-34. doi: 10.3305/nh.2015.32.6.9663.

26.

Behavioral predictors of attrition in adolescents participating in a multidisciplinary obesity treatment program: EVASYON study.

De Miguel-Etayo P, Muro C, Santabárbara J, López-Antón R, Morandé G, Martín-Matillas M, Azcona-San Julián MC, Martí A, Campoy C, Marcos A, Moreno LA, Garagorri JM; EVASYON Study Group.

Int J Obes (Lond). 2016 Jan;40(1):84-7. doi: 10.1038/ijo.2015.183. Epub 2015 Sep 18.

PMID:
26381348
27.

HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade.

Woods DM, Sodré AL, Villagra A, Sarnaik A, Sotomayor EM, Weber J.

Cancer Immunol Res. 2015 Dec;3(12):1375-85. doi: 10.1158/2326-6066.CIR-15-0077-T. Epub 2015 Aug 21.

28.

Correlates of objectively measured physical activity in adolescents with Down syndrome: the UP & DOWN study.

Izquierdo-Gomez R, Veiga ÓL, Sanz A, Fernhall B, Díaz-Cueto M, Villagra A; UP&DOWN Study Group.

Nutr Hosp. 2015 Jun 1;31(6):2606-17. doi: 10.3305/nh.2015.31.6.8694.

29.

Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation.

Woan KV, Lienlaf M, Perez-Villaroel P, Lee C, Cheng F, Knox T, Woods DM, Barrios K, Powers J, Sahakian E, Wang HW, Canales J, Marante D, Smalley KSM, Bergman J, Seto E, Kozikowski A, Pinilla-Ibarz J, Sarnaik A, Celis E, Weber J, Sotomayor EM, Villagra A.

Mol Oncol. 2015 Aug;9(7):1447-1457. doi: 10.1016/j.molonc.2015.04.002. Epub 2015 Apr 24.

30.

Asynchronies during mechanical ventilation are associated with mortality.

Blanch L, Villagra A, Sales B, Montanya J, Lucangelo U, Luján M, García-Esquirol O, Chacón E, Estruga A, Oliva JC, Hernández-Abadia A, Albaiceta GM, Fernández-Mondejar E, Fernández R, Lopez-Aguilar J, Villar J, Murias G, Kacmarek RM.

Intensive Care Med. 2015 Apr;41(4):633-41. doi: 10.1007/s00134-015-3692-6. Epub 2015 Feb 19.

PMID:
25693449
31.

Correlates of sedentary behaviour in youths with Down syndrome: the UP&DOWN study.

Izquierdo-Gomez R, Veiga ÓL, Villagra A, Diaz-Cueto M; UP&DOWN Study Group.

J Sports Sci. 2015;33(14):1504-14. doi: 10.1080/02640414.2014.994660. Epub 2015 Jan 6.

PMID:
25562179
32.

Ligand-independent EPHA2 signaling drives the adoption of a targeted therapy-mediated metastatic melanoma phenotype.

Paraiso KH, Das Thakur M, Fang B, Koomen JM, Fedorenko IV, John JK, Tsao H, Flaherty KT, Sondak VK, Messina JL, Pasquale EB, Villagra A, Rao UN, Kirkwood JM, Meier F, Sloot S, Gibney GT, Stuart D, Tawbi H, Smalley KS.

Cancer Discov. 2015 Mar;5(3):264-73. doi: 10.1158/2159-8290.CD-14-0293. Epub 2014 Dec 26.

33.

Associations of physical activity with fatness and fitness in adolescents with Down syndrome: The UP&DOWN study.

Izquierdo-Gomez R, Martínez-Gómez D, Villagra A, Fernhall B, Veiga OL; on behalf of the UP&DOWN study group.

Res Dev Disabil. 2015 Jan;36C:428-436. doi: 10.1016/j.ridd.2014.10.022. Epub 2014 Nov 8.

PMID:
25462503
34.

c-Abl stabilizes HDAC2 levels by tyrosine phosphorylation repressing neuronal gene expression in Alzheimer's disease.

Gonzalez-Zuñiga M, Contreras PS, Estrada LD, Chamorro D, Villagra A, Zanlungo S, Seto E, Alvarez AR.

Mol Cell. 2014 Oct 2;56(1):163-73. doi: 10.1016/j.molcel.2014.08.013. Epub 2014 Sep 11.

35.

[Active nutrition policy in the implementation of the hospital nutritional support; results of an observational study].

Rodriguez Bugueiro J, Lacquaniti N, Merkel MC, Villagra A.

Nutr Hosp. 2014 Aug 1;30(2):447-52. doi: 10.3305/nh.2014.30.2.7243. Spanish.

36.

Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function.

Sahakian E, Powers JJ, Chen J, Deng SL, Cheng F, Distler A, Woods DM, Rock-Klotz J, Sodre AL, Youn JI, Woan KV, Villagra A, Gabrilovich D, Sotomayor EM, Pinilla-Ibarz J.

Mol Immunol. 2015 Feb;63(2):579-85. doi: 10.1016/j.molimm.2014.08.002. Epub 2014 Aug 23.

37.

A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs.

Cheng F, Lienlaf M, Wang HW, Perez-Villarroel P, Lee C, Woan K, Rock-Klotz J, Sahakian E, Woods D, Pinilla-Ibarz J, Kalin J, Tao J, Hancock W, Kozikowski A, Seto E, Villagra A, Sotomayor EM.

J Immunol. 2014 Sep 15;193(6):2850-62. doi: 10.4049/jimmunol.1302778. Epub 2014 Aug 8.

38.

Anthropometric indices to assess body-fat changes during a multidisciplinary obesity treatment in adolescents: EVASYON Study.

De Miguel-Etayo P, Moreno LA, Santabárbara J, Martín-Matillas M, Piqueras MJ, Rocha-Silva D, Marti Del Moral A, Campoy C, Marcos A, Garagorri JM; EVASYON Study Group.

Clin Nutr. 2015 Jun;34(3):523-8. doi: 10.1016/j.clnu.2014.06.004. Epub 2014 Jun 17.

PMID:
24993080
39.

Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells.

Cheng F, Lienlaf M, Perez-Villarroel P, Wang HW, Lee C, Woan K, Woods D, Knox T, Bergman J, Pinilla-Ibarz J, Kozikowski A, Seto E, Sotomayor EM, Villagra A.

Mol Immunol. 2014 Jul;60(1):44-53. doi: 10.1016/j.molimm.2014.02.019. Epub 2014 Apr 18.

40.

Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers.

Kizuka Y, Kitazume S, Okahara K, Villagra A, Sotomayor EM, Taniguchi N.

J Biol Chem. 2014 Apr 18;289(16):11253-61. doi: 10.1074/jbc.M114.554311. Epub 2014 Mar 10.

41.

Telomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the EVASYON study.

García-Calzón S, Moleres A, Marcos A, Campoy C, Moreno LA, Azcona-Sanjulián MC, Martínez-González MA, Martínez JA, Zalba G, Marti A; EVASYON Study Group.

PLoS One. 2014 Feb 24;9(2):e89828. doi: 10.1371/journal.pone.0089828. eCollection 2014.

42.

Objective assessment of sedentary time and physical activity throughout the week in adolescents with Down syndrome. The UP&DOWN study.

Izquierdo-Gomez R, Martínez-Gómez D, Acha A, Veiga OL, Villagra A, Diaz-Cueto M; UP&DOWN study group.

Res Dev Disabil. 2014 Feb;35(2):482-9. doi: 10.1016/j.ridd.2013.11.026. Epub 2013 Dec 25.

PMID:
24374601
43.

[Adherence to oral nutrition supplements in hospitalized patients with clinical pathology-surgical].

Villagra A, Merkel MC, Rodriguez Bugueiro J, Lacquaniti N, Remoli R.

Nutr Hosp. 2014 Sep 12;31(3):1376-80. doi: 10.3305/nh.2015.31.3.8044. Spanish.

44.

The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity.

Woods DM, Woan K, Cheng F, Wang H, Perez-Villarroel P, Lee C, Lienlaf M, Atadja P, Seto E, Weber J, Sotomayor EM, Villagra A.

Melanoma Res. 2013 Oct;23(5):341-8. doi: 10.1097/CMR.0b013e328364c0ed.

45.

Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study.

Moleres A, Campión J, Milagro FI, Marcos A, Campoy C, Garagorri JM, Gómez-Martínez S, Martínez JA, Azcona-Sanjulián MC, Martí A; EVASYON Study Group.

FASEB J. 2013 Jun;27(6):2504-12. doi: 10.1096/fj.12-215566. Epub 2013 Mar 8.

46.

Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer.

Youn JI, Kumar V, Collazo M, Nefedova Y, Condamine T, Cheng P, Villagra A, Antonia S, McCaffrey JC, Fishman M, Sarnaik A, Horna P, Sotomayor E, Gabrilovich DI.

Nat Immunol. 2013 Mar;14(3):211-20. doi: 10.1038/ni.2526. Epub 2013 Jan 27.

47.

Thenar oxygen saturation during weaning from mechanical ventilation: an observational study.

Gruartmoner G, Mesquida J, Masip J, Martínez ML, Villagra A, Baigorri F, Pinsky MR, Artigas A.

Eur Respir J. 2014 Jan;43(1):213-20. doi: 10.1183/09031936.00126312. Epub 2013 Jan 11.

48.

Development of a pododermatitis score in breeding does using clustering methods.

Olivas I, Torres AG, Villagrá A.

Animal. 2013 Jun;7(6):1011-6. doi: 10.1017/S1751731112002509. Epub 2013 Jan 9.

PMID:
23298607
49.

Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients.

Fernandez R, Gili G, Villagra A, Lopez-Aguilar J, Artigas A.

Intensive Care Med. 2013 Apr;39(4):711-6. doi: 10.1007/s00134-012-2801-z. Epub 2013 Jan 8.

PMID:
23296630
50.

Patient-ventilator dyssynchrony during assisted invasive mechanical ventilation.

Murias G, Villagra A, Blanch L.

Minerva Anestesiol. 2013 Apr;79(4):434-44. Epub 2012 Dec 20. Review.

PMID:
23254162

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