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Items: 1 to 50 of 104

1.

Epigenetic therapy for ovarian cancer: promise and progress.

Moufarrij S, Dandapani M, Arthofer E, Gomez S, Srivastava A, Lopez-Acevedo M, Villagra A, Chiappinelli KB.

Clin Epigenetics. 2019 Jan 15;11(1):7. doi: 10.1186/s13148-018-0602-0. Review.

2.

Silencing of HDAC6 as a therapeutic target in chronic lymphocytic leukemia.

Maharaj K, Powers JJ, Achille A, Deng S, Fonseca R, Pabon-Saldana M, Quayle SN, Jones SS, Villagra A, Sotomayor EM, Sahakian E, Pinilla-Ibarz J.

Blood Adv. 2018 Nov 13;2(21):3012-3024. doi: 10.1182/bloodadvances.2018020065.

3.

A systematic review of non-productivity-related animal-based indicators of heat stress resilience in dairy cattle.

Galán E, Llonch P, Villagrá A, Levit H, Pinto S, Del Prado A.

PLoS One. 2018 Nov 1;13(11):e0206520. doi: 10.1371/journal.pone.0206520. eCollection 2018.

4.

Diet quality index as a predictor of treatment efficacy in overweight and obese adolescents: The EVASYON study.

De Miguel-Etayo P, Moreno LA, Santabárbara J, Martín-Matillas M, Azcona-San Julian MC, Marti Del Moral A, Campoy C, Marcos A, Garagorri JM; EVASYON Study Group.

Clin Nutr. 2018 Mar 29. pii: S0261-5614(18)30111-0. doi: 10.1016/j.clnu.2018.02.032. [Epub ahead of print]

PMID:
29730135
5.

Phase I trial of histone deacetylase inhibitor panobinostat in addition to glucocorticoids for primary therapy of acute graft-versus-host disease.

Perez L, Fernandez H, Horna P, Riches M, Locke F, Field T, Powers J, Sahakian E, Villagra A, Mishra A, Betts B, Kharfan-Dabaja M, Beato F, Ochoa-Bayona L, Pidala J, Anasetti C.

Bone Marrow Transplant. 2018 Nov;53(11):1434-1444. doi: 10.1038/s41409-018-0163-z. Epub 2018 Apr 18.

PMID:
29670210
6.

In-frame Variants in FLNA Proximal Rod 1 Domain Associate With a Predominant Cardiac Valvular Phenotype.

Fernández L, Tenorio J, Polo-Vaquero C, Vallespín E, Palomares-Bralo M, García-Miñaúr S, Santos-Simarro F, Arias P, Carnicer H, Giannivelli S, Medina J, Pérez-Piaya R, Solís J, Rodríguez M, Villagrá A, Rodríguez L, Nevado J, Martínez-Glez V, Heath KE, Lapunzina P.

Rev Esp Cardiol (Engl Ed). 2018 Jul;71(7):545-552. doi: 10.1016/j.rec.2017.10.013. Epub 2017 Nov 14. English, Spanish.

PMID:
29146485
7.

Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models.

Tavares MT, Shen S, Knox T, Hadley M, Kutil Z, Bařinka C, Villagra A, Kozikowski AP.

ACS Med Chem Lett. 2017 Sep 5;8(10):1031-1036. doi: 10.1021/acsmedchemlett.7b00223. eCollection 2017 Oct 12.

8.
9.

Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology.

Sahakian E, Chen J, Powers JJ, Chen X, Maharaj K, Deng SL, Achille AN, Lienlaf M, Wang HW, Cheng F, Sodré AL, Distler A, Xing L, Perez-Villarroel P, Wei S, Villagra A, Seto E, Sotomayor EM, Horna P, Pinilla-Ibarz J.

J Leukoc Biol. 2017 Aug;102(2):475-486. doi: 10.1189/jlb.1A0415-176RRR. Epub 2017 May 26.

PMID:
28550123
10.

T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model.

Woods DM, Woan KV, Cheng F, Sodré AL, Wang D, Wu Y, Wang Z, Chen J, Powers J, Pinilla-Ibarz J, Yu Y, Zhang Y, Wu X, Zheng X, Weber J, Hancock WW, Seto E, Villagra A, Yu XZ, Sotomayor EM.

Blood. 2017 Jul 13;130(2):146-155. doi: 10.1182/blood-2016-08-731505. Epub 2017 May 26.

11.

Changes in objectively measured physical activity in adolescents with Down syndrome: the UP&DOWN longitudinal study.

Izquierdo-Gomez R, Martinez-Gómez D, Esteban-Cornejo I, Hallal PC, García-Cervantes L, Villagra A, Veiga OL; UP&DOWN study group.

J Intellect Disabil Res. 2017 Apr;61(4):363-372. doi: 10.1111/jir.12354. Epub 2017 Jan 16.

PMID:
28090738
12.

Erratum to: Functional Analysis of Histone Deacetylase 11 (HDAC11).

Chen J, Sahakian E, Powers J, Lienlaf M, Perez-Villarroel P, Knox T, Villagra A.

Methods Mol Biol. 2016;1436:E1. No abstract available.

PMID:
27535557
13.

A Methodology for the Hybridization Based in Active Components: The Case of cGA and Scatter Search.

Villagra A, Alba E, Leguizamón G.

Comput Intell Neurosci. 2016;2016:8289237. doi: 10.1155/2016/8289237. Epub 2016 Jun 14.

14.

Preparation and Biochemical Analysis of Classical Histone Deacetylases.

Villagra A, Sahakian E, Seto E.

Methods Enzymol. 2016;573:161-81. doi: 10.1016/bs.mie.2016.04.005. Epub 2016 May 31. Review.

15.

Functional Analysis of Histone Deacetylase 11 (HDAC11).

Chen J, Sahakian E, Powers J, Lienlaf M, Perez-Villarroel P, Knox T, Villagra A.

Methods Mol Biol. 2016;1436:147-65. doi: 10.1007/978-1-4939-3667-0_11.

PMID:
27246214
16.

Expression and Function of Histone Deacetylase 10 (HDAC10) in B Cell Malignancies.

Powers J, Lienlaf M, Perez-Villarroel P, Deng S, Knox T, Villagra A, Sahakian E.

Methods Mol Biol. 2016;1436:129-45. doi: 10.1007/978-1-4939-3667-0_10.

PMID:
27246213
17.

Antimicrobial resistance of Escherichia coli isolated in newly-hatched chickens and effect of amoxicillin treatment during their growth.

Jiménez-Belenguer A, Doménech E, Villagrá A, Fenollar A, Ferrús MA.

Avian Pathol. 2016 Aug;45(4):501-7. doi: 10.1080/03079457.2016.1168515.

18.

Essential role of HDAC6 in the regulation of PD-L1 in melanoma.

M L, P PV, T K, M P, E S, J P, K V W, C L, F C, S D, M SKS, M M, A K, J PI, A S, E S, J W, E M S, A V.

Mol Oncol. 2016 May;10(5):735-750. doi: 10.1016/j.molonc.2015.12.012. Epub 2016 Jan 6.

19.

BODY COMPOSITION CHANGES DURING A MULTIDISCIPLINARY TREATMENT PROGRAMME IN OVERWEIGHT ADOLESCENTS: EVASYON STUDY.

De Miguel-Etayo P, Moreno LA, Santabárbara J, Bueno G, Martín-Matillas M, Zapatera B, Azcona-San Julián C, Marti A, Campoy C, Marcos A, Garagorri JM; nombre del Grupo de Estudio EVASYON.

Nutr Hosp. 2015 Dec 1;32(6):2525-34. doi: 10.3305/nh.2015.32.6.9663.

20.

Behavioral predictors of attrition in adolescents participating in a multidisciplinary obesity treatment program: EVASYON study.

De Miguel-Etayo P, Muro C, Santabárbara J, López-Antón R, Morandé G, Martín-Matillas M, Azcona-San Julián MC, Martí A, Campoy C, Marcos A, Moreno LA, Garagorri JM; EVASYON Study Group.

Int J Obes (Lond). 2016 Jan;40(1):84-7. doi: 10.1038/ijo.2015.183. Epub 2015 Sep 18.

PMID:
26381348
21.

HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade.

Woods DM, Sodré AL, Villagra A, Sarnaik A, Sotomayor EM, Weber J.

Cancer Immunol Res. 2015 Dec;3(12):1375-85. doi: 10.1158/2326-6066.CIR-15-0077-T. Epub 2015 Aug 21.

22.

Correlates of objectively measured physical activity in adolescents with Down syndrome: the UP & DOWN study.

Izquierdo-Gomez R, Veiga ÓL, Sanz A, Fernhall B, Díaz-Cueto M, Villagra A; UP&DOWN Study Group.

Nutr Hosp. 2015 Jun 1;31(6):2606-17. doi: 10.3305/nh.2015.31.6.8694.

23.

Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation.

Woan KV, Lienlaf M, Perez-Villaroel P, Lee C, Cheng F, Knox T, Woods DM, Barrios K, Powers J, Sahakian E, Wang HW, Canales J, Marante D, Smalley KSM, Bergman J, Seto E, Kozikowski A, Pinilla-Ibarz J, Sarnaik A, Celis E, Weber J, Sotomayor EM, Villagra A.

Mol Oncol. 2015 Aug;9(7):1447-1457. doi: 10.1016/j.molonc.2015.04.002. Epub 2015 Apr 24.

24.

Asynchronies during mechanical ventilation are associated with mortality.

Blanch L, Villagra A, Sales B, Montanya J, Lucangelo U, Luján M, García-Esquirol O, Chacón E, Estruga A, Oliva JC, Hernández-Abadia A, Albaiceta GM, Fernández-Mondejar E, Fernández R, Lopez-Aguilar J, Villar J, Murias G, Kacmarek RM.

Intensive Care Med. 2015 Apr;41(4):633-41. doi: 10.1007/s00134-015-3692-6. Epub 2015 Feb 19.

PMID:
25693449
25.

Correlates of sedentary behaviour in youths with Down syndrome: the UP&DOWN study.

Izquierdo-Gomez R, Veiga ÓL, Villagra A, Diaz-Cueto M; UP&DOWN Study Group.

J Sports Sci. 2015;33(14):1504-14. doi: 10.1080/02640414.2014.994660. Epub 2015 Jan 6.

PMID:
25562179
26.

Ligand-independent EPHA2 signaling drives the adoption of a targeted therapy-mediated metastatic melanoma phenotype.

Paraiso KH, Das Thakur M, Fang B, Koomen JM, Fedorenko IV, John JK, Tsao H, Flaherty KT, Sondak VK, Messina JL, Pasquale EB, Villagra A, Rao UN, Kirkwood JM, Meier F, Sloot S, Gibney GT, Stuart D, Tawbi H, Smalley KS.

Cancer Discov. 2015 Mar;5(3):264-73. doi: 10.1158/2159-8290.CD-14-0293. Epub 2014 Dec 26.

27.

Associations of physical activity with fatness and fitness in adolescents with Down syndrome: The UP&DOWN study.

Izquierdo-Gomez R, Martínez-Gómez D, Villagra A, Fernhall B, Veiga OL; on behalf of the UP&DOWN study group.

Res Dev Disabil. 2015 Jan;36C:428-436. doi: 10.1016/j.ridd.2014.10.022. Epub 2014 Nov 8.

PMID:
25462503
28.

c-Abl stabilizes HDAC2 levels by tyrosine phosphorylation repressing neuronal gene expression in Alzheimer's disease.

Gonzalez-Zuñiga M, Contreras PS, Estrada LD, Chamorro D, Villagra A, Zanlungo S, Seto E, Alvarez AR.

Mol Cell. 2014 Oct 2;56(1):163-73. doi: 10.1016/j.molcel.2014.08.013. Epub 2014 Sep 11.

29.

[Active nutrition policy in the implementation of the hospital nutritional support; results of an observational study].

Rodriguez Bugueiro J, Lacquaniti N, Merkel MC, Villagra A.

Nutr Hosp. 2014 Aug 1;30(2):447-52. doi: 10.3305/nh.2014.30.2.7243. Spanish.

30.

Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function.

Sahakian E, Powers JJ, Chen J, Deng SL, Cheng F, Distler A, Woods DM, Rock-Klotz J, Sodre AL, Youn JI, Woan KV, Villagra A, Gabrilovich D, Sotomayor EM, Pinilla-Ibarz J.

Mol Immunol. 2015 Feb;63(2):579-85. doi: 10.1016/j.molimm.2014.08.002. Epub 2014 Aug 23.

31.

A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs.

Cheng F, Lienlaf M, Wang HW, Perez-Villarroel P, Lee C, Woan K, Rock-Klotz J, Sahakian E, Woods D, Pinilla-Ibarz J, Kalin J, Tao J, Hancock W, Kozikowski A, Seto E, Villagra A, Sotomayor EM.

J Immunol. 2014 Sep 15;193(6):2850-62. doi: 10.4049/jimmunol.1302778. Epub 2014 Aug 8.

32.

Anthropometric indices to assess body-fat changes during a multidisciplinary obesity treatment in adolescents: EVASYON Study.

De Miguel-Etayo P, Moreno LA, Santabárbara J, Martín-Matillas M, Piqueras MJ, Rocha-Silva D, Marti Del Moral A, Campoy C, Marcos A, Garagorri JM; EVASYON Study Group.

Clin Nutr. 2015 Jun;34(3):523-8. doi: 10.1016/j.clnu.2014.06.004. Epub 2014 Jun 17.

PMID:
24993080
33.

Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells.

Cheng F, Lienlaf M, Perez-Villarroel P, Wang HW, Lee C, Woan K, Woods D, Knox T, Bergman J, Pinilla-Ibarz J, Kozikowski A, Seto E, Sotomayor EM, Villagra A.

Mol Immunol. 2014 Jul;60(1):44-53. doi: 10.1016/j.molimm.2014.02.019. Epub 2014 Apr 18.

34.

Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers.

Kizuka Y, Kitazume S, Okahara K, Villagra A, Sotomayor EM, Taniguchi N.

J Biol Chem. 2014 Apr 18;289(16):11253-61. doi: 10.1074/jbc.M114.554311. Epub 2014 Mar 10.

35.

Telomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the EVASYON study.

García-Calzón S, Moleres A, Marcos A, Campoy C, Moreno LA, Azcona-Sanjulián MC, Martínez-González MA, Martínez JA, Zalba G, Marti A; EVASYON Study Group.

PLoS One. 2014 Feb 24;9(2):e89828. doi: 10.1371/journal.pone.0089828. eCollection 2014.

36.

Objective assessment of sedentary time and physical activity throughout the week in adolescents with Down syndrome. The UP&DOWN study.

Izquierdo-Gomez R, Martínez-Gómez D, Acha A, Veiga OL, Villagra A, Diaz-Cueto M; UP&DOWN study group.

Res Dev Disabil. 2014 Feb;35(2):482-9. doi: 10.1016/j.ridd.2013.11.026. Epub 2013 Dec 25.

PMID:
24374601
37.

[Adherence to oral nutrition supplements in hospitalized patients with clinical pathology-surgical].

Villagra A, Merkel MC, Rodriguez Bugueiro J, Lacquaniti N, Remoli R.

Nutr Hosp. 2014 Sep 12;31(3):1376-80. doi: 10.3305/nh.2015.31.3.8044. Spanish.

38.

The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity.

Woods DM, Woan K, Cheng F, Wang H, Perez-Villarroel P, Lee C, Lienlaf M, Atadja P, Seto E, Weber J, Sotomayor EM, Villagra A.

Melanoma Res. 2013 Oct;23(5):341-8. doi: 10.1097/CMR.0b013e328364c0ed.

39.

Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study.

Moleres A, Campión J, Milagro FI, Marcos A, Campoy C, Garagorri JM, Gómez-Martínez S, Martínez JA, Azcona-Sanjulián MC, Martí A; EVASYON Study Group.

FASEB J. 2013 Jun;27(6):2504-12. doi: 10.1096/fj.12-215566. Epub 2013 Mar 8.

40.

Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer.

Youn JI, Kumar V, Collazo M, Nefedova Y, Condamine T, Cheng P, Villagra A, Antonia S, McCaffrey JC, Fishman M, Sarnaik A, Horna P, Sotomayor E, Gabrilovich DI.

Nat Immunol. 2013 Mar;14(3):211-20. doi: 10.1038/ni.2526. Epub 2013 Jan 27.

41.

Thenar oxygen saturation during weaning from mechanical ventilation: an observational study.

Gruartmoner G, Mesquida J, Masip J, Martínez ML, Villagra A, Baigorri F, Pinsky MR, Artigas A.

Eur Respir J. 2014 Jan;43(1):213-20. doi: 10.1183/09031936.00126312. Epub 2013 Jan 11.

42.

Development of a pododermatitis score in breeding does using clustering methods.

Olivas I, Torres AG, Villagrá A.

Animal. 2013 Jun;7(6):1011-6. doi: 10.1017/S1751731112002509. Epub 2013 Jan 9.

PMID:
23298607
43.

Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients.

Fernandez R, Gili G, Villagra A, Lopez-Aguilar J, Artigas A.

Intensive Care Med. 2013 Apr;39(4):711-6. doi: 10.1007/s00134-012-2801-z. Epub 2013 Jan 8.

PMID:
23296630
44.

Patient-ventilator dyssynchrony during assisted invasive mechanical ventilation.

Murias G, Villagra A, Blanch L.

Minerva Anestesiol. 2013 Apr;79(4):434-44. Epub 2012 Dec 20. Review.

PMID:
23254162
45.

Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.

Bergman JA, Woan K, Perez-Villarroel P, Villagra A, Sotomayor EM, Kozikowski AP.

J Med Chem. 2012 Nov 26;55(22):9891-9. doi: 10.1021/jm301098e. Epub 2012 Oct 23.

46.

Nurses' detection of ineffective inspiratory efforts during mechanical ventilation.

Chacón E, Estruga A, Murias G, Sales B, Montanya J, Lucangelo U, Garcia-Esquirol O, Villagrá A, Villar J, Kacmarek RM, Burgueño MJ, Blanch L, Jam R.

Am J Crit Care. 2012 Jul;21(4):e89-93. doi: 10.4037/ajcc2012108.

47.

Stat3 inhibition augments the immunogenicity of B-cell lymphoma cells, leading to effective antitumor immunity.

Cheng F, Wang H, Horna P, Wang Z, Shah B, Sahakian E, Woan KV, Villagra A, Pinilla-Ibarz J, Sebti S, Smith M, Tao J, Sotomayor EM.

Cancer Res. 2012 Sep 1;72(17):4440-8. doi: 10.1158/0008-5472.CAN-11-3619. Epub 2012 Jun 22.

48.

Validation of the Better Care® system to detect ineffective efforts during expiration in mechanically ventilated patients: a pilot study.

Blanch L, Sales B, Montanya J, Lucangelo U, Garcia-Esquirol O, Villagra A, Chacon E, Estruga A, Borelli M, Burgueño MJ, Oliva JC, Fernandez R, Villar J, Kacmarek R, Murias G.

Intensive Care Med. 2012 May;38(5):772-80. doi: 10.1007/s00134-012-2493-4. Erratum in: Intensive Care Med. 2013 Feb;39(2):341.

PMID:
22297667
49.

Modulation of antigen-presenting cells by HDAC inhibitors: implications in autoimmunity and cancer.

Woan KV, Sahakian E, Sotomayor EM, Seto E, Villagra A.

Immunol Cell Biol. 2012 Jan;90(1):55-65. doi: 10.1038/icb.2011.96. Epub 2011 Nov 22. Review.

50.

Sleep duration and emerging cardiometabolic risk markers in adolescents. The AFINOS study.

Martinez-Gomez D, Eisenmann JC, Gomez-Martinez S, Hill EE, Zapatera B, Veiga OL, Marcos A; AFINOS Study Group.

Sleep Med. 2011 Dec;12(10):997-1002. doi: 10.1016/j.sleep.2011.05.009. Epub 2011 Oct 28.

PMID:
22036601

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