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Items: 1 to 50 of 273

1.

Efficacy and safety of once-weekly semaglutide versus daily canagliflozin as add-on to metformin in patients with type 2 diabetes (SUSTAIN 8): a double-blind, phase 3b, randomised controlled trial.

Lingvay I, Catarig AM, Frias JP, Kumar H, Lausvig NL, le Roux CW, Thielke D, Viljoen A, McCrimmon RJ.

Lancet Diabetes Endocrinol. 2019 Sep 17. pii: S2213-8587(19)30311-0. doi: 10.1016/S2213-8587(19)30311-0. [Epub ahead of print]

PMID:
31540867
2.

Fusaric acid instigates the invasion of banana by Fusarium oxysporum f. sp. cubense TR4.

Liu S, Li J, Zhang Y, Liu N, Viljoen A, Mostert D, Zuo C, Hu C, Bi F, Gao H, Sheng O, Deng G, Yang Q, Dong T, Dou T, Yi G, Ma LJ, Li C.

New Phytol. 2019 Sep 12. doi: 10.1111/nph.16193. [Epub ahead of print]

PMID:
31513293
3.

IDegLira improves patient-reported outcomes while using a simple regimen with fewer injections and dose adjustments compared with basal-bolus therapy.

Miller E, Doshi A, Grøn R, Jódar E, Őrsy P, Ranthe MF, Sugimoto D, Tentolouris N, Viljoen A, Billings LK.

Diabetes Obes Metab. 2019 Aug 6. doi: 10.1111/dom.13851. [Epub ahead of print]

PMID:
31385425
4.

The TetR-family transcription factor MAB_2299c regulates the expression of two distinct MmpS-MmpL efflux pumps involved in cross-resistance to clofazimine and bedaquiline in Mycobacterium abscessus.

Gutiérrez AV, Richard M, Roquet-Banères F, Viljoen A, Kremer L.

Antimicrob Agents Chemother. 2019 Jul 22. pii: AAC.01000-19. doi: 10.1128/AAC.01000-19. [Epub ahead of print]

PMID:
31332077
5.

1H-benzo[d]imidazole derivatives affect MmpL3 in Mycobacterium tuberculosis.

Korycka-Machała M, Viljoen A, Pawełczyk J, Borówka P, Dziadek B, Gobis K, Brzostek A, Kawka M, Blaise M, Strapagiel D, Kremer L, Dziadek J.

Antimicrob Agents Chemother. 2019 Jul 22. pii: AAC.00441-19. doi: 10.1128/AAC.00441-19. [Epub ahead of print]

PMID:
31332069
6.

Correction to: SGLT2 Inhibitors: Cardiovascular Benefits Beyond HbA1c-Translating Evidence into Practice.

Ali A, Bain S, Hicks D, Newland Jones P, Patel DC, Evans M, Fernando K, James J, Milne N, Viljoen A, Wilding J; As part of The Improving Diabetes Steering Committee.

Diabetes Ther. 2019 Jul 18. doi: 10.1007/s13300-019-0670-y. [Epub ahead of print]

PMID:
31321747
7.

Mesembrine: The archetypal psycho-active Sceletium alkaloid.

Makolo F, Viljoen A, Veale CGL.

Phytochemistry. 2019 Oct;166:112061. doi: 10.1016/j.phytochem.2019.112061. Epub 2019 Jul 9. Review.

PMID:
31299396
8.

SGLT2 Inhibitors: Cardiovascular Benefits Beyond HbA1c-Translating Evidence into Practice.

Ali A, Bain S, Hicks D, Newland Jones P, Patel DC, Evans M, Fernando K, James J, Milne N, Viljoen A, Wilding J; As part of The Improving Diabetes Steering Committee.

Diabetes Ther. 2019 Jul 9. doi: 10.1007/s13300-019-0657-8. [Epub ahead of print] Review. Erratum in: Diabetes Ther. 2019 Jul 18;:.

PMID:
31290126
9.

Anthraquinone-Based Specialized Metabolites from Rhizomes of Bulbine natalensis.

Bae JY, Ali Z, Wang YH, Chittiboyina AG, Zaki AA, Viljoen AM, Khan IA.

J Nat Prod. 2019 Jul 26;82(7):1893-1901. doi: 10.1021/acs.jnatprod.9b00187. Epub 2019 Jul 9.

PMID:
31287681
10.

Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria.

Santucci P, Johansen MD, Point V, Poncin I, Viljoen A, Cavalier JF, Kremer L, Canaan S.

Sci Rep. 2019 Jun 17;9(1):8667. doi: 10.1038/s41598-019-45164-5.

11.

Verapamil Improves the Activity of Bedaquiline against Mycobacterium abscessus In Vitro and in Macrophages.

Viljoen A, Raynaud C, Johansen MD, Roquet-Banères F, Herrmann JL, Daher W, Kremer L.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00705-19. doi: 10.1128/AAC.00705-19. Print 2019 Sep.

PMID:
31209005
12.

Lsr2 Is an Important Determinant of Intracellular Growth and Virulence in Mycobacterium abscessus.

Le Moigne V, Bernut A, Cortès M, Viljoen A, Dupont C, Pawlik A, Gaillard JL, Misguich F, Crémazy F, Kremer L, Herrmann JL.

Front Microbiol. 2019 Apr 30;10:905. doi: 10.3389/fmicb.2019.00905. eCollection 2019.

13.

A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model.

Calitz C, Hamman JH, Fey SJ, Viljoen AM, Gouws C, Wrzesinski K.

J Ethnopharmacol. 2019 Jul 15;239:111897. doi: 10.1016/j.jep.2019.111897. Epub 2019 Apr 19.

PMID:
31009705
14.

The new buzz: Investigating the antimicrobial interactions between bioactive compounds found in South African propolis.

Kharsany K, Viljoen A, Leonard C, van Vuuren S.

J Ethnopharmacol. 2019 Jun 28;238:111867. doi: 10.1016/j.jep.2019.111867. Epub 2019 Apr 9.

PMID:
30978456
15.

Safety Assessment of Phytochemicals Derived from the Globalized South African Rooibos Tea ( Aspalathus linearis) through Interaction with CYP, PXR, and P-gp.

Fantoukh OI, Dale OR, Parveen A, Hawwal MF, Ali Z, Manda VK, Khan SI, Chittiboyina AG, Viljoen A, Khan IA.

J Agric Food Chem. 2019 May 1;67(17):4967-4975. doi: 10.1021/acs.jafc.9b00846. Epub 2019 Apr 18.

PMID:
30955332
16.

Exploring Common Culinary Herbs and Spices as Potential Anti-Quorum Sensing Agents.

Cosa S, Chaudhary SK, Chen W, Combrinck S, Viljoen A.

Nutrients. 2019 Mar 29;11(4). pii: E739. doi: 10.3390/nu11040739.

17.
18.

The Influence of Carrier Oils on the Antimicrobial Activity and Cytotoxicity of Essential Oils.

Orchard A, Kamatou G, Viljoen AM, Patel N, Mawela P, van Vuuren SF.

Evid Based Complement Alternat Med. 2019 Jan 14;2019:6981305. doi: 10.1155/2019/6981305. eCollection 2019.

19.

Genetic Diversity of Fusarium oxysporum f. sp. cubense in East and Central Africa.

Karangwa P, Mostert D, Ndayihanzamaso P, Dubois T, Niere B, Zum Felde A, Schouten A, Blomme G, Beed F, Viljoen A.

Plant Dis. 2018 Mar;102(3):552-560. doi: 10.1094/PDIS-02-17-0282-RE. Epub 2018 Jan 9.

PMID:
30673475
20.

Wound Pathogens: Investigating Antimicrobial Activity of Commercial Essential Oil Combinations against Reference Strains.

Orchard A, Viljoen A, van Vuuren S.

Chem Biodivers. 2018 Dec;15(12):e1800405. doi: 10.1002/cbdv.201800405. Epub 2018 Dec 17.

PMID:
30362637
21.

Evaluation of the long-term cost-effectiveness of once-weekly semaglutide versus dulaglutide for treatment of type 2 diabetes mellitus in the UK.

Viljoen A, Hoxer CS, Johansen P, Malkin S, Hunt B, Bain SC.

Diabetes Obes Metab. 2019 Mar;21(3):611-621. doi: 10.1111/dom.13564. Epub 2018 Nov 28.

22.

Mutations in the MAB_2299c TetR Regulator Confer Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus.

Richard M, Gutiérrez AV, Viljoen A, Rodriguez-Rincon D, Roquet-Baneres F, Blaise M, Everall I, Parkhill J, Floto RA, Kremer L.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01316-18. doi: 10.1128/AAC.01316-18. Print 2019 Jan.

23.

MmpL8MAB controls Mycobacterium abscessus virulence and production of a previously unknown glycolipid family.

Dubois V, Viljoen A, Laencina L, Le Moigne V, Bernut A, Dubar F, Blaise M, Gaillard JL, Guérardel Y, Kremer L, Herrmann JL, Girard-Misguich F.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10147-E10156. doi: 10.1073/pnas.1812984115. Epub 2018 Oct 9.

24.

Intra-operative cortical motor mapping using subdural grid electrodes in children undergoing epilepsy surgery evaluation and comparison with the conventional extra-operative motor mapping.

Jain P, Whitney R, Strantzas S, McCoy B, Ochi A, Otsubo H, Snead OC 3rd, Weiss S, Donner E, Pang E, Sharma R, Viljoen A, Keller A, Drake JM, Rutka JT, Go C.

Clin Neurophysiol. 2018 Dec;129(12):2642-2649. doi: 10.1016/j.clinph.2018.07.022. Epub 2018 Aug 12.

PMID:
30150028
25.

SGLT2 Inhibitors in Type 2 Diabetes Management: Key Evidence and Implications for Clinical Practice.

Wilding J, Fernando K, Milne N, Evans M, Ali A, Bain S, Hicks D, James J, Newland-Jones P, Patel D, Viljoen A.

Diabetes Ther. 2018 Oct;9(5):1757-1773. doi: 10.1007/s13300-018-0471-8. Epub 2018 Jul 23. Review.

26.

Delineating the Physiological Roles of the PE and Catalytic Domains of LipY in Lipid Consumption in Mycobacterium-Infected Foamy Macrophages.

Santucci P, Diomandé S, Poncin I, Alibaud L, Viljoen A, Kremer L, de Chastellier C, Canaan S.

Infect Immun. 2018 Aug 22;86(9). pii: e00394-18. doi: 10.1128/IAI.00394-18. Print 2018 Sep.

27.

Glycopeptidolipids, a Double-Edged Sword of the Mycobacterium abscessus Complex.

Gutiérrez AV, Viljoen A, Ghigo E, Herrmann JL, Kremer L.

Front Microbiol. 2018 Jun 5;9:1145. doi: 10.3389/fmicb.2018.01145. eCollection 2018. Review.

28.

Toxicity and anti-prolific properties of Xysmalobium undulatum water extract during short-term exposure to two-dimensional and three-dimensional spheroid cell cultures.

Calitz C, Hamman JH, Viljoen AM, Fey SJ, Wrzesinski K, Gouws C.

Toxicol Mech Methods. 2018 Nov;28(9):641-652. doi: 10.1080/15376516.2018.1485805. Epub 2018 Sep 26.

PMID:
29873580
29.

Pharmacological treatment options for severe hypertriglyceridemia and familial chylomicronemia syndrome.

Chaudhry R, Viljoen A, Wierzbicki AS.

Expert Rev Clin Pharmacol. 2018 Jun;11(6):589-598. doi: 10.1080/17512433.2018.1480368. Epub 2018 Jun 11. Review.

PMID:
29842811
30.

Renal stones.

Viljoen A, Chaudhry R, Bycroft J.

Ann Clin Biochem. 2019 Jan;56(1):15-27. doi: 10.1177/0004563218781672. Epub 2018 Jun 13.

PMID:
29792045
31.

1H-NMR and UPLC-MS metabolomics: Functional tools for exploring chemotypic variation in Sceletium tortuosum from two provinces in South Africa.

Zhao J, Khan IA, Combrinck S, Sandasi M, Chen W, Viljoen AM.

Phytochemistry. 2018 Aug;152:191-203. doi: 10.1016/j.phytochem.2018.03.013. Epub 2018 May 21.

PMID:
29783186
32.

Novel Natural Products for Healthy Ageing from the Mediterranean Diet and Food Plants of Other Global Sources-The MediHealth Project.

Waltenberger B, Halabalaki M, Schwaiger S, Adamopoulos N, Allouche N, Fiebich BL, Hermans N, Jansen-Dürr P, Kesternich V, Pieters L, Schönbichler S, Skaltsounis AL, Tran H, Trougakos IP, Viljoen A, Wolfender JL, Wolfrum C, Xynos N, Stuppner H.

Molecules. 2018 May 6;23(5). pii: E1097. doi: 10.3390/molecules23051097.

33.

Structural rearrangements occurring upon cofactor binding in the Mycobacterium smegmatis β-ketoacyl-acyl carrier protein reductase MabA.

Küssau T, Flipo M, Van Wyk N, Viljoen A, Olieric V, Kremer L, Blaise M.

Acta Crystallogr D Struct Biol. 2018 May 1;74(Pt 5):383-393. doi: 10.1107/S2059798318002917. Epub 2018 Apr 24.

PMID:
29717709
34.

Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus.

Richard M, Gutiérrez AV, Viljoen AJ, Ghigo E, Blaise M, Kremer L.

Front Microbiol. 2018 Apr 5;9:649. doi: 10.3389/fmicb.2018.00649. eCollection 2018.

35.

The In Vitro and In Vivo Effects of Hypoxis hemerocallidea on Indinavir Pharmacokinetics: Modulation of Efflux.

Havenga K, Abay E, Wiesner L, Viljoen A, Steyn D, Hamman J.

Planta Med. 2018 Aug;84(12-13):895-901. doi: 10.1055/a-0607-2743. Epub 2018 Apr 19.

PMID:
29672818
36.

Identification, Isolation and Determination of Biomarkers for Quality Control of Bush Tea (Athrixia phyllicoides).

Lerotholi LJ, Chaudhary SK, Chen W, Veale CGL, Combrinck S, Viljoen AM.

Planta Med. 2018 Aug;84(12-13):902-912. doi: 10.1055/a-0594-9527. Epub 2018 Apr 13.

PMID:
29653455
37.

A Simple and Rapid Gene Disruption Strategy in Mycobacterium abscessus: On the Design and Application of Glycopeptidolipid Mutants.

Viljoen A, Gutiérrez AV, Dupont C, Ghigo E, Kremer L.

Front Cell Infect Microbiol. 2018 Mar 14;8:69. doi: 10.3389/fcimb.2018.00069. eCollection 2018.

38.

Antimicrobial Essential Oil Combinations to Combat Foot Odour.

Orchard A, Viljoen A, van Vuuren S.

Planta Med. 2018 Jul;84(9-10):662-673. doi: 10.1055/a-0592-8022. Epub 2018 Mar 26.

PMID:
29579744
39.

The in vitro antimicrobial evaluation of commercially essential oils and their combinations against acne.

Orchard A, van Vuuren SF, Viljoen AM, Kamatou G.

Int J Cosmet Sci. 2018 Mar 24. doi: 10.1111/ics.12456. [Epub ahead of print]

PMID:
29574906
40.

An update on trials of novel lipid-lowering drugs.

Wierzbicki AS, Reynolds TM, Viljoen A.

Curr Opin Cardiol. 2018 Jul;33(4):416-422. doi: 10.1097/HCO.0000000000000518. Review.

PMID:
29561321
41.

Potential Herb-Drug Pharmacokinetic Interactions between African Wild Olive Leaf Extract and Selected Antihypertensive Drugs.

Mmopele K, Combrinck S, Hamman J, Willers C, Chen W, Viljoen A.

Planta Med. 2018 Aug;84(12-13):886-894. doi: 10.1055/a-0583-0543. Epub 2018 Mar 19.

PMID:
29554707
42.

Alkylated/aminated nitroimidazoles and nitroimidazole-7-chloroquinoline conjugates: Synthesis and anti-mycobacterial evaluation.

Shalini, Viljoen A, Kremer L, Kumar V.

Bioorg Med Chem Lett. 2018 May 1;28(8):1309-1312. doi: 10.1016/j.bmcl.2018.03.021. Epub 2018 Mar 8.

PMID:
29551480
43.

Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial.

Pratley RE, Aroda VR, Lingvay I, Lüdemann J, Andreassen C, Navarria A, Viljoen A; SUSTAIN 7 investigators.

Lancet Diabetes Endocrinol. 2018 Apr;6(4):275-286. doi: 10.1016/S2213-8587(18)30024-X. Epub 2018 Feb 1.

PMID:
29397376
44.

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus.

Laencina L, Dubois V, Le Moigne V, Viljoen A, Majlessi L, Pritchard J, Bernut A, Piel L, Roux AL, Gaillard JL, Lombard B, Loew D, Rubin EJ, Brosch R, Kremer L, Herrmann JL, Girard-Misguich F.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E1002-E1011. doi: 10.1073/pnas.1713195115. Epub 2018 Jan 17.

45.

Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo.

Viljoen A, Richard M, Nguyen PC, Fourquet P, Camoin L, Paudal RR, Gnawali GR, Spilling CD, Cavalier JF, Canaan S, Blaise M, Kremer L.

J Biol Chem. 2018 Feb 23;293(8):2755-2769. doi: 10.1074/jbc.RA117.000760. Epub 2018 Jan 4.

46.

Hyperspectral Imaging and Support Vector Machine: A Powerful Combination to Differentiate Black Cohosh (Actaea racemosa) from Other Cohosh Species.

Tankeu S, Vermaak I, Chen W, Sandasi M, Kamatou G, Viljoen A.

Planta Med. 2018 Apr;84(6-07):407-419. doi: 10.1055/s-0043-119887. Epub 2017 Oct 6.

PMID:
28985643
47.

Controlling Extra- and Intramacrophagic Mycobacterium abscessus by Targeting Mycolic Acid Transport.

Viljoen A, Herrmann JL, Onajole OK, Stec J, Kozikowski AP, Kremer L.

Front Cell Infect Microbiol. 2017 Sep 1;7:388. doi: 10.3389/fcimb.2017.00388. eCollection 2017.

48.

Azide-alkyne cycloaddition en route to 4-aminoquinoline-ferrocenylchalcone conjugates: synthesis and anti-TB evaluation.

Singh A, Viljoen A, Kremer L, Kumar V.

Future Med Chem. 2017 Oct;9(15):1701-1708. doi: 10.4155/fmc-2017-0098. Epub 2017 Sep 4.

PMID:
28869400
49.

Bedaquiline Inhibits the ATP Synthase in Mycobacterium abscessus and Is Effective in Infected Zebrafish.

Dupont C, Viljoen A, Thomas S, Roquet-Banères F, Herrmann JL, Pethe K, Kremer L.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01225-17. doi: 10.1128/AAC.01225-17. Print 2017 Nov.

50.

The distribution and host range of the banana Fusarium wilt fungus, Fusarium oxysporum f. sp. cubense, in Asia.

Mostert D, Molina AB, Daniells J, Fourie G, Hermanto C, Chao CP, Fabregar E, Sinohin VG, Masdek N, Thangavelu R, Li C, Yi G, Mostert L, Viljoen A.

PLoS One. 2017 Jul 18;12(7):e0181630. doi: 10.1371/journal.pone.0181630. eCollection 2017.

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