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Items: 13

1.

Quantification of Hepatic Organic Anion Transport Proteins OAT2 and OAT7 in Human Liver Tissue and Primary Hepatocytes.

Vildhede A, Kimoto E, Rodrigues AD, Varma MVS.

Mol Pharm. 2018 Jun 25. doi: 10.1021/acs.molpharmaceut.8b00320. [Epub ahead of print]

PMID:
29906129
2.

Comparison of Proteomic Quantification Approaches for Hepatic Drug Transporters: Multiplexed Global Quantitation Correlates with Targeted Proteomic Quantitation.

Vildhede A, Nguyen C, Erickson BK, Kunz RC, Jones R, Kimoto E, Bourbonais F, Rodrigues AD, Varma MVS.

Drug Metab Dispos. 2018 May;46(5):692-696. doi: 10.1124/dmd.117.079285. Epub 2018 Feb 8.

PMID:
29439128
3.

Organic Anion Transporter 2 Mediates Hepatic Uptake of Tolbutamide, a CYP2C9 Probe Drug.

Bi YA, Mathialagan S, Tylaska L, Fu M, Keefer J, Vildhede A, Costales C, Rodrigues AD, Varma MVS.

J Pharmacol Exp Ther. 2018 Mar;364(3):390-398. doi: 10.1124/jpet.117.245951. Epub 2018 Jan 11.

PMID:
29326367
4.

In vitro studies with two human organic anion transporters: OAT2 and OAT7.

Mathialagan S, Costales C, Tylaska L, Kimoto E, Vildhede A, Johnson J, Johnson N, Sarashina T, Hashizume K, Isringhausen CD, Vermeer LMM, Wolff AR, Rodrigues AD.

Xenobiotica. 2017 Oct 13:1-13. doi: 10.1080/00498254.2017.1384595. [Epub ahead of print]

PMID:
28945155
5.

Transporter-Mediated Disposition, Clinical Pharmacokinetics and Cholestatic Potential of Glyburide and Its Primary Active Metabolites.

Li R, Bi YA, Vildhede A, Scialis RJ, Mathialagan S, Yang X, Marroquin LD, Lin J, Varma MVS.

Drug Metab Dispos. 2017 Jul;45(7):737-747. doi: 10.1124/dmd.116.074815. Epub 2017 Apr 24.

6.

Global Proteome Changes in Liver Tissue 6 Weeks after FOLFOX Treatment of Colorectal Cancer Liver Metastases.

Urdzik J, Vildhede A, Wiśniewski JR, Duraj F, Haglund U, Artursson P, Norén A.

Proteomes. 2016 Oct 14;4(4). pii: E30. doi: 10.3390/proteomes4040030.

7.

Erratum to: Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS.

AAPS J. 2017 May;19(3):882. doi: 10.1208/s12248-017-0061-0. No abstract available.

PMID:
28233243
8.

Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS.

AAPS J. 2017 May;19(3):787-796. doi: 10.1208/s12248-017-0051-2. Epub 2017 Feb 10. Erratum in: AAPS J. 2017 May;19(3):882.

PMID:
28188574
9.

Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach.

Vildhede A, Mateus A, Khan EK, Lai Y, Karlgren M, Artursson P, Kjellsson MC.

Drug Metab Dispos. 2016 Apr;44(4):505-16. doi: 10.1124/dmd.115.066746. Epub 2016 Feb 3.

10.

In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes.

Wiśniewski JR, Vildhede A, Norén A, Artursson P.

J Proteomics. 2016 Mar 16;136:234-47. doi: 10.1016/j.jprot.2016.01.016. Epub 2016 Jan 26.

11.

Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure.

Vildhede A, Wiśniewski JR, Norén A, Karlgren M, Artursson P.

J Proteome Res. 2015 Aug 7;14(8):3305-14. doi: 10.1021/acs.jproteome.5b00334. Epub 2015 Jul 20.

12.

Hepatic uptake of atorvastatin: influence of variability in transporter expression on uptake clearance and drug-drug interactions.

Vildhede A, Karlgren M, Svedberg EK, Wisniewski JR, Lai Y, Norén A, Artursson P.

Drug Metab Dispos. 2014 Jul;42(7):1210-8. doi: 10.1124/dmd.113.056309. Epub 2014 May 5. Erratum in: Drug Metab Dispos. 2015 May;43(5):786-7.

13.

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Karlgren M, Vildhede A, Norinder U, Wisniewski JR, Kimoto E, Lai Y, Haglund U, Artursson P.

J Med Chem. 2012 May 24;55(10):4740-63. doi: 10.1021/jm300212s. Epub 2012 May 15.

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