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Items: 1 to 50 of 58

1.

Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3).

Breuker C, Moreau A, Lakhal L, Tamasi V, Parmentier Y, Meyer U, Maurel P, Lumbroso S, Vilarem MJ, Pascussi JM.

Endocrinology. 2010 Apr;151(4):1653-61. doi: 10.1210/en.2009-1435. Epub 2010 Feb 25.

PMID:
20185760
2.

Identification of proteomic changes during human liver development by 2D-DIGE and mass spectrometry.

Brizard JP, Ramos J, Robert A, Lafitte D, Bigi N, Sarda P, Laoudj-Chenivesse D, Navarro F, Blanc P, Assenat E, Maurel P, Pascussi JM, Vilarem MJ.

J Hepatol. 2009 Jul;51(1):114-26. doi: 10.1016/j.jhep.2009.02.029. Epub 2009 Apr 17.

PMID:
19443070
3.

A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte.

Moreau A, Téruel C, Beylot M, Albalea V, Tamasi V, Umbdenstock T, Parmentier Y, Sa-Cunha A, Suc B, Fabre JM, Navarro F, Ramos J, Meyer U, Maurel P, Vilarem MJ, Pascussi JM.

Hepatology. 2009 Jun;49(6):2068-79. doi: 10.1002/hep.22907.

PMID:
19437491
4.

[[Inflammation and drug metabolism: NF-kappB and the CAR and PXR xeno-receptors].

Pascussi JM, Vilarem MJ.

Med Sci (Paris). 2008 Mar;24(3):301-5. doi: 10.1051/medsci/2008243301. Review. French.

5.

Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response.

Moreau A, Vilarem MJ, Maurel P, Pascussi JM.

Mol Pharm. 2008 Jan-Feb;5(1):35-41. Epub 2007 Dec 27. Review.

PMID:
18159929
6.

Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter.

Onica T, Nichols K, Larin M, Ng L, Maslen A, Dvorak Z, Pascussi JM, Vilarem MJ, Maurel P, Kirby GM.

Mol Pharmacol. 2008 Feb;73(2):451-60. Epub 2007 Oct 31.

PMID:
17978169
7.

Cytoprotective properties of alpha-tocopherol are related to gene regulation in cultured D-galactosamine-treated human hepatocytes.

González R, Collado JA, Nell S, Briceño J, Tamayo MJ, Fraga E, Bernardos A, López-Cillero P, Pascussi JM, Rufián S, Vilarem MJ, De la Mata M, Brigelius-Flohe R, Maurel P, Muntané J.

Free Radic Biol Med. 2007 Nov 15;43(10):1439-52. Epub 2007 Aug 3.

PMID:
17936189
8.

The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.

Pascussi JM, Gerbal-Chaloin S, Duret C, Daujat-Chavanieu M, Vilarem MJ, Maurel P.

Annu Rev Pharmacol Toxicol. 2008;48:1-32. Review.

PMID:
17608617
9.

Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression.

Moreau A, Maurel P, Vilarem MJ, Pascussi JM.

Biochem Biophys Res Commun. 2007 Aug 17;360(1):76-82. Epub 2007 Jun 13.

PMID:
17585873
10.

Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4alpha isoforms.

Pascussi JM, Robert A, Moreau A, Ramos J, Bioulac-Sage P, Navarro F, Blanc P, Assenat E, Maurel P, Vilarem MJ.

Hepatology. 2007 May;45(5):1146-53.

PMID:
17464991
11.
12.

Expression and transcriptional activities of nuclear receptors involved in regulation of drug-metabolizing enzymes are not altered by colchicine: focus on PXR, CAR, and GR in primary human hepatocytes.

Dvorák Z, Maurel P, Vilarem MJ, Ulrichová J, Modrianský M.

Cell Biol Toxicol. 2007 Mar;23(2):63-73. Epub 2006 Sep 10. Erratum in: Cell Biol Toxicol. 2007 Mar;23(2):141.

PMID:
16964586
13.

Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.

Duret C, Daujat-Chavanieu M, Pascussi JM, Pichard-Garcia L, Balaguer P, Fabre JM, Vilarem MJ, Maurel P, Gerbal-Chaloin S.

Mol Pharmacol. 2006 Jul;70(1):329-39. Epub 2006 Apr 11.

PMID:
16608920
14.

Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer?

Assenat E, Gerbal-chaloin S, Maurel P, Vilarem MJ, Pascussi JM.

Eur J Cancer. 2006 Apr;42(6):785-92. Epub 2006 Feb 28. Review.

PMID:
16510279
15.

[Drug-induced osteomalacia : possible role of PXR, a receptor involved in detoxification].

Pascussi JM, Vilarem MJ.

Med Sci (Paris). 2005 Jun-Jul;21(6-7):582-3. French. No abstract available.

16.

Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences.

Pascussi JM, Gerbal-Chaloin S, Drocourt L, Assénat E, Larrey D, Pichard-Garcia L, Vilarem MJ, Maurel P.

Xenobiotica. 2004 Jul;34(7):633-64. Review.

PMID:
15672753
17.

Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia.

Pascussi JM, Robert A, Nguyen M, Walrant-Debray O, Garabedian M, Martin P, Pineau T, Saric J, Navarro F, Maurel P, Vilarem MJ.

J Clin Invest. 2005 Jan;115(1):177-86.

18.

Disruption of microtubules leads to glucocorticoid receptor degradation in HeLa cell line.

Dvorák Z, Modrianský M, Ulrichová J, Maurel P, Vilarem MJ, Pascussi JM.

Cell Signal. 2005 Feb;17(2):187-96.

PMID:
15494210
19.

Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance.

Assenat E, Gerbal-Chaloin S, Larrey D, Saric J, Fabre JM, Maurel P, Vilarem MJ, Pascussi JM.

Hepatology. 2004 Oct;40(4):951-60.

PMID:
15382119
20.

Pathophysiological factors affecting CAR gene expression.

Pascussi JM, Dvorák Z, Gerbal-Chaloin S, Assenat E, Maurel P, Vilarem MJ.

Drug Metab Rev. 2003 Nov;35(4):255-68. Review.

PMID:
14705859
21.

Lipid-mediated gene transfer into normal adult human hepatocytes in primary culture.

Ourlin JC, Vilarem MJ, Daujat M, Harricane MC, Maurel P.

Methods Mol Biol. 1998;107:371-80. No abstract available.

PMID:
14577246
22.

Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation.

Dvorak Z, Modriansky M, Pichard-Garcia L, Balaguer P, Vilarem MJ, Ulrichová J, Maurel P, Pascussi JM.

Mol Pharmacol. 2003 Jul;64(1):160-9.

PMID:
12815172
23.

The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.

Ourlin JC, Lasserre F, Pineau T, Fabre JM, Sa-Cunha A, Maurel P, Vilarem MJ, Pascussi JM.

Mol Endocrinol. 2003 Sep;17(9):1693-703. Epub 2003 Jun 12.

PMID:
12805410
24.

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ.

Biochim Biophys Acta. 2003 Feb 17;1619(3):243-53. Review.

PMID:
12573484
25.

Two CCAAT/enhancer binding protein sites in the cytochrome P4503A1 locus. Potential role in the glucocorticoid response.

Rodrigues E, Vilarem MJ, Ribeiro V, Maurel P, Lechner MC.

Eur J Biochem. 2003 Feb;270(3):556-64.

26.
27.

Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.

Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ.

J Biol Chem. 2002 Jul 12;277(28):25125-32. Epub 2002 May 3.

28.

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

Pascussi JM, Drocourt L, Gerbal-Chaloin S, Fabre JM, Maurel P, Vilarem MJ.

Eur J Biochem. 2001 Dec;268(24):6346-58.

29.

Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor.

Gerbal-Chaloin S, Daujat M, Pascussi JM, Pichard-Garcia L, Vilarem MJ, Maurel P.

J Biol Chem. 2002 Jan 4;277(1):209-17. Epub 2001 Oct 25.

30.

Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes.

Drocourt L, Pascussi JM, Assenat E, Fabre JM, Maurel P, Vilarem MJ.

Drug Metab Dispos. 2001 Oct;29(10):1325-31.

PMID:
11560876
31.

Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation.

Pascussi JM, Gerbal-Chaloin S, Fabre JM, Maurel P, Vilarem MJ.

Mol Pharmacol. 2000 Dec;58(6):1441-50.

PMID:
11093784
32.

Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes.

Pascussi JM, Gerbal-Chaloin S, Pichard-Garcia L, Daujat M, Fabre JM, Maurel P, Vilarem MJ.

Biochem Biophys Res Commun. 2000 Aug 11;274(3):707-13.

PMID:
10924340
33.
34.

Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene.

Pascussi JM, Jounaidi Y, Drocourt L, Domergue J, Balabaud C, Maurel P, Vilarem MJ.

Biochem Biophys Res Commun. 1999 Jul 5;260(2):377-81.

PMID:
10403778
35.

The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor.

Calleja C, Pascussi JM, Mani JC, Maurel P, Vilarem MJ.

Nat Med. 1998 Jan;4(1):92-6.

PMID:
9427613
36.

Lipid-mediated transfection of normal adult human hepatocytes in primary culture.

Ourlin JC, Vilarem MJ, Daujat M, Harricane MC, Domergue J, Joyeux H, Baulieux J, Maurel P.

Anal Biochem. 1997 Apr 5;247(1):34-44.

PMID:
9126368
37.

Role of the liver-enriched transcription factors C/EBP alpha and DBP in the expression of human CYP3A4 and CYP3A7.

Ourlin JC, Jounaïdi Y, Maurel P, Vilarem MJ.

J Hepatol. 1997;26 Suppl 2:54-62.

PMID:
9204410
38.

Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7.

Jounaïdi Y, Guzelian PS, Maurel P, Vilarem MJ.

Biochem Biophys Res Commun. 1994 Dec 30;205(3):1741-7.

PMID:
7811260
39.
40.

Functional characterization of the promoter of pp63, a gene encoding a natural inhibitor of the insulin receptor tyrosine kinase.

Falquerho L, Paquereau L, Vilarem MJ, Galas S, Patey G, Le Cam A.

Nucleic Acids Res. 1992 Apr 25;20(8):1983-90.

41.

Analysis of proteins binding to the proximal promoter region of two rat serine protease inhibitor genes.

Rossi V, Rouayrenc JF, Paquereau L, Vilarem MJ, Le Cam A.

Nucleic Acids Res. 1992 Mar 11;20(5):1061-8.

42.

Lineage-specific patterns of p21ras proteins in immortalized cell lines derived from mouse teratocarcinoma.

Vilarem MJ, Kellermann O, Gras MP, Larsen C, Buc-Caron MH.

Res Virol. 1990 Jan-Feb;141(1):45-55.

PMID:
2183321
43.
44.

[Lack of expression of the protein p53 gene in a human T-cell leukemia line].

Soudon J, Vilarem MJ, Caron de Fromentel C, Gras MP, Larsen CJ.

C R Acad Sci III. 1988;306(2):35-8. French.

PMID:
3126985
45.

[Study, at the gene level, of the activation of topoisomerase II by antitumor agents].

Vilarem MJ, Riou JF, Riou G, Larsen CJ.

Pathol Biol (Paris). 1987 Nov;35(9):1263-9. French.

PMID:
2827094
46.
47.
48.

The in vitro involvement of topoisomerase II in the activity of aza-ellipticine analogues is not correlated with drug activity on isolated nuclei.

Vilarem MJ, Riou JF, Multon E, Gras MP, Larsen CJ.

Biochem Pharmacol. 1986 Jul 1;35(13):2087-95.

PMID:
3015146
49.

In vivo stimulation by antitumor drugs of the topoisomerase II induced cleavage sites in c-myc protooncogene.

Riou JF, Multon E, Vilarem MJ, Larsen CJ, Riou G.

Biochem Biophys Res Commun. 1986 May 29;137(1):154-60.

PMID:
3013177

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