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Items: 1 to 50 of 147

1.

Immune Activation in Mismatch Repair Deficient Carcinogenesis: More Than Just Mutational Rate.

Willis JA, Reyes-Uribe L, Chang K, Lipkin SM, Vilar E.

Clin Cancer Res. 2019 Aug 5. pii: clincanres.0856.2019. doi: 10.1158/1078-0432.CCR-18-0856. [Epub ahead of print]

PMID:
31383734
2.

Fibrosing Alopecia in a Pattern Distribution (FAPD) in 16 African-Descent and Hispanic Female Patients: A Challenging Diagnosis.

Teixeira MS, Gavazzoni Dias MFR, Trüeb RM, Rochael MC, Vilar EAG.

Skin Appendage Disord. 2019 Jun;5(4):211-215. doi: 10.1159/000496837. Epub 2019 Feb 25.

PMID:
31367598
3.

Mismatch Repair-Proficient Colorectal Cancer: Finding the Right TiME to Respond.

Willis JA, Overman MJ, Vilar E.

Clin Cancer Res. 2019 Jul 1. doi: 10.1158/1078-0432.CCR-19-1447. [Epub ahead of print]

PMID:
31263028
4.

Energy balance related lifestyle factors and risk of endometrial and colorectal cancer among individuals with lynch syndrome: a systematic review.

Coletta AM, Peterson SK, Gatus LA, Krause KJ, Schembre SM, Gilchrist SC, Pande M, Vilar E, You YN, Rodriguez-Bigas MA, Strong LL, Lynch PM, Lu KH, Basen-Engquist K.

Fam Cancer. 2019 Jun 24. doi: 10.1007/s10689-019-00135-7. [Epub ahead of print] Review.

PMID:
31236808
5.

Functional characterization of CNOT3 variants identified in familial adenomatous polyposis adenomas.

Delacruz RGC, Sandoval IT, Chang K, Miller BN, Reyes-Uribe L, Borras E, Lynch PM, Taggart MW, Hawk ET, Vilar E, Jones DA.

Oncotarget. 2019 Jun 11;10(39):3939-3951. doi: 10.18632/oncotarget.27003. eCollection 2019 Jun 11.

6.

Development and Validation of Hepamet Fibrosis Scoring System A Simple, Noninvasive Test to Identify Patients With Nonalcoholic Fatty Liver Disease With Advanced Fibrosis.

Ampuero J, Pais R, Aller R, Gallego-Durán R, Crespo J, García-Monzón C, Boursier J, Vilar E, Petta S, Ming-Hua Z, Escudero D, Calleja JL, Aspichueta P, Diago M, Rosales JM, Caballería J, Gómez-Camarero J, Lo Iacono O, Benlloch S, Albillos A, Turnes J, Banales JM, Ratziu V, Romero-Gómez M; HEPAmet Registry.

Clin Gastroenterol Hepatol. 2019 Jun 11. pii: S1542-3565(19)30602-0. doi: 10.1016/j.cgh.2019.05.051. [Epub ahead of print]

PMID:
31195161
7.

Outcomes of disease-specific next-generation sequencing gene panel testing in adolescents and young adults with colorectal cancer.

Mork ME, Rodriguez A, Bannon SA, Lynch PM, Rodriguez-Bigas MA, Thirumurthi S, You YN, Vilar E.

Cancer Genet. 2019 Jun;235-236:77-83. doi: 10.1016/j.cancergen.2019.04.064. Epub 2019 Apr 26.

PMID:
31101557
8.
9.

Acute haemodynamic changes during haemodialysis do not exacerbate gut hyperpermeability.

Wong J, Lenaerts K, Meesters DM, Olde Damink SWM, van Eijk HMH, Vilar E, Farrington K.

Biosci Rep. 2019 Apr 12;39(4). pii: BSR20181704. doi: 10.1042/BSR20181704. Print 2019 Apr 30.

10.

Lichenoid folliculitis of the scalp in four patients with ichthyosiform skin disorders and cicatricial alopecia.

Gavazzoni Dias MFR, Dutra H, Trüeb R, Vilar E, Rochael M, Quattrino A, Cury A.

J Cutan Pathol. 2019 Jun;46(6):431-435. doi: 10.1111/cup.13439. Epub 2019 Apr 3.

PMID:
30734338
11.

Detection of Pathogenic Germline Variants Among Patients With Advanced Colorectal Cancer Undergoing Tumor Genomic Profiling for Precision Medicine.

You YN, Borras E, Chang K, Price BA, Mork M, Chang GJ, Rodriguez-Bigas MA, Bednarski BK, Meric-Bernstam F, Vilar E.

Dis Colon Rectum. 2019 Apr;62(4):429-437. doi: 10.1097/DCR.0000000000001322.

PMID:
30730459
12.

Real-Time Interrogation of Aspirin Reactivity, Biochemistry, and Biodistribution by Hyperpolarized Magnetic Resonance Spectroscopy.

Zacharias NM, Ornelas A, Lee J, Hu J, Davis JS, Uddin N, Pudakalakatti S, Menter DG, Karam JA, Wood CG, Hawk ET, Kopetz S, Vilar E, Bhattacharya PK, Millward SW.

Angew Chem Int Ed Engl. 2019 Mar 22;58(13):4179-4183. doi: 10.1002/anie.201812759. Epub 2019 Feb 20.

13.

Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition.

Rajendran P, Johnson G, Li L, Chen YS, Dashwood M, Nguyen N, Ulusan A, Ertem F, Zhang M, Li J, Sun D, Huang Y, Wang S, Leung HC, Lieberman D, Beaver L, Ho E, Bedford M, Chang K, Vilar E, Dashwood R.

Cancer Res. 2019 Mar 1;79(5):918-927. doi: 10.1158/0008-5472.CAN-18-2003. Epub 2019 Jan 14.

PMID:
30643017
14.

Genetic predisposition to colorectal cancer: syndromes, genes, classification of genetic variants and implications for precision medicine.

Valle L, Vilar E, Tavtigian SV, Stoffel EM.

J Pathol. 2019 Apr;247(5):574-588. doi: 10.1002/path.5229. Epub 2019 Feb 20. Review.

PMID:
30584801
15.

AACR White Paper: Shaping the Future of Cancer Prevention - A Roadmap for Advancing Science and Public Health.

Lippman SM, Abate-Shen C, Colbert Maresso KL, Colditz GA, Dannenberg AJ, Davidson NE, Disis ML, DuBois RN, Szabo E, Giuliano AR, Hait WN, Lee JJ, Kensler TW, Kramer BS, Limburg P, Maitra A, Martinez ME, Rebbeck TR, Schmitz KH, Vilar E, Hawk ET.

Cancer Prev Res (Phila). 2018 Dec;11(12):735-778. doi: 10.1158/1940-6207.CAPR-18-0421.

PMID:
30530635
16.

Anti-EGFR-resistant clones decay exponentially after progression: implications for anti-EGFR re-challenge.

Parseghian CM, Loree JM, Morris VK, Liu X, Clifton KK, Napolitano S, Henry JT, Pereira AA, Vilar E, Johnson B, Kee B, Raghav K, Dasari A, Wu J, Garg N, Raymond VM, Banks KC, Talasaz AA, Lanman RB, Strickler JH, Hong DS, Corcoran RB, Overman MJ, Kopetz S.

Ann Oncol. 2019 Feb 1;30(2):243-249. doi: 10.1093/annonc/mdy509.

PMID:
30462160
17.

Colorectal premalignancy is associated with consensus molecular subtypes 1 and 2.

Chang K, Willis JA, Reumers J, Taggart MW, San Lucas FA, Thirumurthi S, Kanth P, Delker DA, Hagedorn CH, Lynch PM, Ellis LM, Hawk ET, Scheet PA, Kopetz S, Arts J, Guinney J, Dienstmann R, Vilar E.

Ann Oncol. 2018 Oct 1;29(10):2061-2067. doi: 10.1093/annonc/mdy337.

PMID:
30412224
18.

Hyperpigmented Upper Eyelid: A Clue to the Diagnosis of Facial Lichen Planus Pigmentosus in a Patient with Frontal Fibrosing Alopecia.

Gavazzoni Dias MFR, Rezende HD, Lofeu Cury A, Trüeb RM, Vilar E.

Skin Appendage Disord. 2018 Oct;4(4):335-338. doi: 10.1159/000487338. Epub 2018 Apr 4.

19.

Initiating haemodialysis twice-weekly as part of an incremental programme may protect residual kidney function.

Kaja Kamal RM, Farrington K, Busby AD, Wellsted D, Chandna H, Mawer LJ, Sridharan S, Vilar E.

Nephrol Dial Transplant. 2019 Jun 1;34(6):1017-1025. doi: 10.1093/ndt/gfy321.

PMID:
30357360
20.

High Prevalence of Hereditary Cancer Syndromes and Outcomes in Adults with Early-Onset Pancreatic Cancer.

Bannon SA, Montiel MF, Goldstein JB, Dong W, Mork ME, Borras E, Hasanov M, Varadhachary GR, Maitra A, Katz MH, Feng L, Futreal A, Fogelman DR, Vilar E, McAllister F.

Cancer Prev Res (Phila). 2018 Nov;11(11):679-686. doi: 10.1158/1940-6207.CAPR-18-0014. Epub 2018 Oct 1.

PMID:
30274973
21.

Coxiella and Bartonella spp. in bats (Chiroptera) captured in the Brazilian Atlantic Forest biome.

Ferreira MS, Guterres A, Rozental T, Novaes RLM, Vilar EM, Oliveira RC, Fernandes J, Forneas D, Junior AA, Brandão ML, Cordeiro JLP, Del Valle Alvarez MR, Althoff SL, Moratelli R, Cordeiro-Estrela P, Silva RCD, Lemos ERS.

BMC Vet Res. 2018 Sep 10;14(1):279. doi: 10.1186/s12917-018-1603-0.

22.

Indexing dialysis dose for gender, body size and physical activity: Impact on survival.

Sridharan S, Vilar E, Davenport A, Ashman N, Almond M, Banerjee A, Roberts J, Farrington K.

PLoS One. 2018 Sep 7;13(9):e0203075. doi: 10.1371/journal.pone.0203075. eCollection 2018.

23.

Phase II study of nab-paclitaxel in refractory small bowel adenocarcinoma and CpG island methylator phenotype (CIMP)-high colorectal cancer.

Overman MJ, Adam L, Raghav K, Wang J, Kee B, Fogelman D, Eng C, Vilar E, Shroff R, Dasari A, Wolff R, Morris J, Karunasena E, Pisanic TR, Azad N, Kopetz S.

Ann Oncol. 2019 Mar 1;30(3):495. doi: 10.1093/annonc/mdy221. No abstract available.

24.

Body Composition, Dietary, and Gustatory Function Assessment in People With Alzheimer's Disease.

Martín ISM, Barato VP, Oliva SL, Rodríguez M, Yurrita LC, Cabañas MJC, Rojo SS, de la Calle L, Díaz EÁ, Santos YQ, Pascual PE, Nieto MV, Vilar EG.

Am J Alzheimers Dis Other Demen. 2018 Dec;33(8):508-515. doi: 10.1177/1533317518782173. Epub 2018 Jun 19.

PMID:
29916258
25.

Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome.

Chang K, Taggart MW, Reyes-Uribe L, Borras E, Riquelme E, Barnett RM, Leoni G, San Lucas FA, Catanese MT, Mori F, Diodoro MG, You YN, Hawk ET, Roszik J, Scheet P, Kopetz S, Nicosia A, Scarselli E, Lynch PM, McAllister F, Vilar E.

JAMA Oncol. 2018 Aug 1;4(8):1085-1092. doi: 10.1001/jamaoncol.2018.1482.

26.

Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.

Crespo M, Vilar E, Tsai SY, Chang K, Amin S, Srinivasan T, Zhang T, Pipalia NH, Chen HJ, Witherspoon M, Gordillo M, Xiang JZ, Maxfield FR, Lipkin S, Evans T, Chen S.

Nat Med. 2018 Apr 10;24(4):526. doi: 10.1038/nm0418-526a.

PMID:
29634683
27.

Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells.

Zhang Y, Zoltan M, Riquelme E, Xu H, Sahin I, Castro-Pando S, Montiel MF, Chang K, Jiang Z, Ling J, Gupta S, Horne W, Pruski M, Wang H, Sun SC, Lozano G, Chiao P, Maitra A, Leach SD, Kolls JK, Vilar E, Wang TC, Bailey JM, McAllister F.

Gastroenterology. 2018 Jul;155(1):210-223.e3. doi: 10.1053/j.gastro.2018.03.041. Epub 2018 Mar 29.

28.

Pharmacogenomics: time to rethink its role in precision medicine.

Willis JA, Vilar E.

Ann Oncol. 2018 Feb 1;29(2):293-295. doi: 10.1093/annonc/mdx780. No abstract available.

29.

Nevus lipomatosus cutaneous superficialis.

Lima CDS, Issa MCA, Souza MB, Góes HFO, Santos TBPD, Vilar EAG.

An Bras Dermatol. 2017 Sep-Oct;92(5):711-713. doi: 10.1590/abd1806-4841.20175217.

30.

Phase II study of nab-paclitaxel in refractory small bowel adenocarcinoma and CpG island methylator phenotype (CIMP)-high colorectal cancer.

Overman MJ, Adam L, Raghav K, Wang J, Kee B, Fogelman D, Eng C, Vilar E, Shroff R, Dasari A, Wolff R, Morris J, Karunasena E, Pisanic R 2nd, Azad N, Kopetz S.

Ann Oncol. 2018 Jan 1;29(1):139-144. doi: 10.1093/annonc/mdx688. Erratum in: Ann Oncol. 2019 Mar 1;30(3):495.

31.

Targeted Therapy for Cancer-Associated Fibroblasts: Are We There Yet?

Barnett RM, Vilar E.

J Natl Cancer Inst. 2018 Jan 1;110(1). doi: 10.1093/jnci/djx131. No abstract available.

PMID:
28922783
32.

Clinical utility of circulating cell-free DNA in advanced colorectal cancer.

Pereira AAL, Morelli MP, Overman M, Kee B, Fogelman D, Vilar E, Shureiqi I, Raghav K, Eng C, Manuel S, Crosby S, Wolff RA, Banks K, Lanman R, Talasaz A, Kopetz S, Morris V.

PLoS One. 2017 Aug 29;12(8):e0183949. doi: 10.1371/journal.pone.0183949. eCollection 2017.

33.

In Silico Systems Biology Analysis of Variants of Uncertain Significance in Lynch Syndrome Supports the Prioritization of Functional Molecular Validation.

Borras E, Chang K, Pande M, Cuddy A, Bosch JL, Bannon SA, Mork ME, Rodriguez-Bigas MA, Taggart MW, Lynch PM, You YN, Vilar E.

Cancer Prev Res (Phila). 2017 Oct;10(10):580-587. doi: 10.1158/1940-6207.CAPR-17-0058. Epub 2017 Aug 1.

34.

Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention.

Ornelas A, Zacharias-Millward N, Menter DG, Davis JS, Lichtenberger L, Hawke D, Hawk E, Vilar E, Bhattacharya P, Millward S.

Cancer Metastasis Rev. 2017 Jun;36(2):289-303. doi: 10.1007/s10555-017-9675-z. Review.

35.

Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis.

Gausachs M, Borras E, Chang K, Gonzalez S, Azuara D, Delgado Amador A, Lopez-Doriga A, San Lucas FA, Sanjuan X, Paules MJ, Taggart MW, Davies GE, Ehli EA, Fowler J, Moreno V, Pineda M, You YN, Lynch PM, Lazaro C, Navin NE, Scheet PA, Hawk ET, Capella G, Vilar E.

Clin Cancer Res. 2017 Oct 1;23(19):5936-5947. doi: 10.1158/1078-0432.CCR-17-0821. Epub 2017 Jun 23.

36.

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.

Crespo M, Vilar E, Tsai SY, Chang K, Amin S, Srinivasan T, Zhang T, Pipalia NH, Chen HJ, Witherspoon M, Gordillo M, Xiang JZ, Maxfield FR, Lipkin S, Evans T, Chen S.

Nat Med. 2017 Jul;23(7):878-884. doi: 10.1038/nm.4355. Epub 2017 Jun 19. Erratum in: Nat Med. 2018 Apr 10;24(4):526.

37.

Refining prognosis in early-stage colorectal cancer: one or multiple genes at a time?

Willis JA, Vilar E.

Ann Oncol. 2017 Aug 1;28(8):1686-1688. doi: 10.1093/annonc/mdx272. No abstract available.

PMID:
28549076
38.

Single-cell DNA sequencing reveals a late-dissemination model in metastatic colorectal cancer.

Leung ML, Davis A, Gao R, Casasent A, Wang Y, Sei E, Vilar E, Maru D, Kopetz S, Navin NE.

Genome Res. 2017 Aug;27(8):1287-1299. doi: 10.1101/gr.209973.116. Epub 2017 May 25.

39.

Sweet's syndrome associated with Crohn's disease.

Lima CDS, Pinto RDB, Góes HFO, Salles SAN, Vilar EAG, Lima CDS.

An Bras Dermatol. 2017 Mar-Apr;92(2):263-265. doi: 10.1590/abd1806-4841.20175298.

40.

Can Microsatellite Status of Colorectal Cancer Be Reliably Assessed after Neoadjuvant Therapy?

Goldstein JB, Wu W, Borras E, Masand G, Cuddy A, Mork ME, Bannon SA, Lynch PM, Rodriguez-Bigas M, Taggart MW, Wu J, Scheet P, Kopetz S, You YN, Vilar E.

Clin Cancer Res. 2017 Sep 1;23(17):5246-5254. doi: 10.1158/1078-0432.CCR-16-2994. Epub 2017 May 18.

41.

SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of β-catenin.

Lo YH, Noah TK, Chen MS, Zou W, Borras E, Vilar E, Shroyer NF.

Gastroenterology. 2017 Jul;153(1):205-218.e8. doi: 10.1053/j.gastro.2017.03.048. Epub 2017 Apr 5.

PMID:
28390865
42.

Precancer Atlas to Drive Precision Prevention Trials.

Spira A, Yurgelun MB, Alexandrov L, Rao A, Bejar R, Polyak K, Giannakis M, Shilatifard A, Finn OJ, Dhodapkar M, Kay NE, Braggio E, Vilar E, Mazzilli SA, Rebbeck TR, Garber JE, Velculescu VE, Disis ML, Wallace DC, Lippman SM.

Cancer Res. 2017 Apr 1;77(7):1510-1541. doi: 10.1158/0008-5472.CAN-16-2346.

43.

Pruritic folliculitis of pregnancy.

Delorenze LM, Branco LG, Cerqueira LF, Vasques WB, Salles SA, Vilar EG.

An Bras Dermatol. 2016 Sep-Oct;91(5 suppl 1):66-68. doi: 10.1590/abd1806-4841.20164735.

44.

Oncogenic Kras drives invasion and maintains metastases in colorectal cancer.

Boutin AT, Liao WT, Wang M, Hwang SS, Karpinets TV, Cheung H, Chu GC, Jiang S, Hu J, Chang K, Vilar E, Song X, Zhang J, Kopetz S, Futreal A, Wang YA, Kwong LN, DePinho RA.

Genes Dev. 2017 Feb 15;31(4):370-382. doi: 10.1101/gad.293449.116. Epub 2017 Mar 13.

45.

Association of SMAD4 mutation with patient demographics, tumor characteristics, and clinical outcomes in colorectal cancer.

Mehrvarz Sarshekeh A, Advani S, Overman MJ, Manyam G, Kee BK, Fogelman DR, Dasari A, Raghav K, Vilar E, Manuel S, Shureiqi I, Wolff RA, Patel KP, Luthra R, Shaw K, Eng C, Maru DM, Routbort MJ, Meric-Bernstam F, Kopetz S.

PLoS One. 2017 Mar 7;12(3):e0173345. doi: 10.1371/journal.pone.0173345. eCollection 2017. Erratum in: PLoS One. 2017 May 17;12 (5):e0178275.

46.

The Effect of Intra-Dialytic Exercise on Inflammation and Blood Endotoxin Levels.

Wong J, Davis P, Patidar A, Zhang Y, Vilar E, Finkelman M, Farrington K.

Blood Purif. 2017;44(1):51-59. doi: 10.1159/000455059. Epub 2017 Feb 28.

PMID:
28241125
47.

Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome.

Maletzki C, Huehns M, Bauer I, Ripperger T, Mork MM, Vilar E, Klöcking S, Zettl H, Prall F, Linnebacher M.

Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.

PMID:
28218421
48.

Identification of MSH2 inversion of exons 1-7 in clinical evaluation of families with suspected Lynch syndrome.

Mork ME, Rodriguez A, Taggart MW, Rodriguez-Bigas MA, Lynch PM, Bannon SA, You YN, Vilar E.

Fam Cancer. 2017 Jul;16(3):357-361. doi: 10.1007/s10689-016-9960-y.

49.

Universal Genetic Testing for Younger Patients With Colorectal Cancer.

Vilar E, Stoffel EM.

JAMA Oncol. 2017 Apr 1;3(4):448-449. doi: 10.1001/jamaoncol.2016.5193. No abstract available.

PMID:
27978567
50.

Is Endotoxemia in Stable Hemodialysis Patients an Artefact? Limitations of the Limulus Amebocyte Lysate Assay and Role of (1→3)-β-D Glucan.

Wong J, Zhang Y, Patidar A, Vilar E, Finkelman M, Farrington K.

PLoS One. 2016 Oct 20;11(10):e0164978. doi: 10.1371/journal.pone.0164978. eCollection 2016.

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