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Items: 21

1.

Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans.

Cruces-Sande M, Vila-Bedmar R, Arcones AC, González-Rodríguez Á, Rada P, Gutiérrez-de-Juan V, Vargas-Castrillón J, Iruzubieta P, Sánchez-González C, Formentini L, Crespo J, García-Monzón C, Martínez-Chantar ML, Valverde ÁM, Mayor F Jr, Murga C.

Biochim Biophys Acta Mol Basis Dis. 2018 Dec;1864(12):3655-3667. doi: 10.1016/j.bbadis.2018.09.027. Epub 2018 Sep 24.

PMID:
30261289
2.

G protein-coupled receptor kinase 2 (GRK2) as an integrative signalling node in the regulation of cardiovascular function and metabolic homeostasis.

Mayor F Jr, Cruces-Sande M, Arcones AC, Vila-Bedmar R, Briones AM, Salaices M, Murga C.

Cell Signal. 2018 Jan;41:25-32. doi: 10.1016/j.cellsig.2017.04.002. Epub 2017 Apr 4. Review.

PMID:
28389415
3.

Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels.

Lucas E, Vila-Bedmar R, Arcones AC, Cruces-Sande M, Cachofeiro V, Mayor F Jr, Murga C.

Cardiovasc Diabetol. 2016 Nov 10;15(1):155.

4.

Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: a brown adipose tissue-derived endocrine factor with a potential role in fetal growth.

Martinez-Perez B, Ejarque M, Gutierrez C, Nuñez-Roa C, Roche K, Vila-Bedmar R, Ballesteros M, Redondo-Angulo I, Planavila A, Villarroya F, Vendrell J, Fernández-Veledo S, Megía A.

Transl Res. 2016 Dec;178:1-12. doi: 10.1016/j.trsl.2016.06.012. Epub 2016 Jul 9.

PMID:
27469268
5.

Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2.

Lucas E, Cruces-Sande M, Briones AM, Salaices M, Mayor F Jr, Murga C, Vila-Bedmar R.

Arch Physiol Biochem. 2015;121(5):163-77. doi: 10.3109/13813455.2015.1107589. Epub 2015 Dec 7. Review.

6.

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.

Vila-Bedmar R, Cruces-Sande M, Lucas E, Willemen HL, Heijnen CJ, Kavelaars A, Mayor F Jr, Murga C.

Sci Signal. 2015 Jul 21;8(386):ra73. doi: 10.1126/scisignal.aaa4374.

7.

Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns.

Lucas E, Jurado-Pueyo M, Fortuño MA, Fernández-Veledo S, Vila-Bedmar R, Jiménez-Borreguero LJ, Lazcano JJ, Gao E, Gómez-Ambrosi J, Frühbeck G, Koch WJ, Díez J, Mayor F Jr, Murga C.

Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2448-56. doi: 10.1016/j.bbadis.2014.09.004. Epub 2014 Sep 18.

8.

Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2.

Garcia-Guerra L, Vila-Bedmar R, Carrasco-Rando M, Cruces-Sande M, Martín M, Ruiz-Gómez A, Ruiz-Gómez M, Lorenzo M, Fernández-Veledo S, Mayor F Jr, Murga C, Nieto-Vázquez I.

J Mol Cell Biol. 2014 Aug;6(4):299-311. doi: 10.1093/jmcb/mju025. Epub 2014 Jun 13.

9.

Increased nitric oxide bioavailability in adult GRK2 hemizygous mice protects against angiotensin II-induced hypertension.

Avendaño MS, Lucas E, Jurado-Pueyo M, Martínez-Revelles S, Vila-Bedmar R, Mayor F Jr, Salaices M, Briones AM, Murga C.

Hypertension. 2014 Feb;63(2):369-75. doi: 10.1161/HYPERTENSIONAHA.113.01991. Epub 2013 Nov 4.

10.

Role of energy- and nutrient-sensing kinases AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in adipocyte differentiation.

Fernández-Veledo S, Vázquez-Carballo A, Vila-Bedmar R, Ceperuelo-Mallafré V, Vendrell J.

IUBMB Life. 2013 Jul;65(7):572-83. doi: 10.1002/iub.1170. Epub 2013 May 14. Review.

11.

Concerted expression of the thermogenic and bioenergetic mitochondrial protein machinery in brown adipose tissue.

Guillen C, Bartolome A, Vila-Bedmar R, García-Aguilar A, Gomez-Hernandez A, Benito M.

J Cell Biochem. 2013 Oct;114(10):2306-13. doi: 10.1002/jcb.24577.

PMID:
23606415
12.

Roles of GRK2 in cell signaling beyond GPCR desensitization: GRK2-HDAC6 interaction modulates cell spreading and motility.

Penela P, Lafarga V, Tapia O, Rivas V, Nogués L, Lucas E, Vila-Bedmar R, Murga C, Mayor F Jr.

Sci Signal. 2012 May 15;5(224):pt3. doi: 10.1126/scisignal.2003098.

PMID:
22589388
13.

GRK2 contribution to the regulation of energy expenditure and brown fat function.

Vila-Bedmar R, Garcia-Guerra L, Nieto-Vazquez I, Mayor F Jr, Lorenzo M, Murga C, Fernández-Veledo S.

FASEB J. 2012 Aug;26(8):3503-14. doi: 10.1096/fj.11-202267. Epub 2012 Apr 19.

PMID:
22516294
14.

G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance.

Mayor F Jr, Lucas E, Jurado-Pueyo M, Garcia-Guerra L, Nieto-Vazquez I, Vila-Bedmar R, Fernández-Veledo S, Murga C.

Arch Physiol Biochem. 2011 Jul;117(3):125-30. doi: 10.3109/13813455.2011.584693. Epub 2011 May 26. Review.

PMID:
21615207
15.

A new era for brown adipose tissue: New insights into brown adipocyte function and differentiation.

Vila-Bedmar R, Fernández-Veledo S.

Arch Physiol Biochem. 2011 Jul;117(3):195-208. doi: 10.3109/13813455.2011.560951. Epub 2011 Mar 23. Review.

PMID:
21428723
16.

G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity.

Garcia-Guerra L, Nieto-Vazquez I, Vila-Bedmar R, Jurado-Pueyo M, Zalba G, Díez J, Murga C, Fernández-Veledo S, Mayor F Jr, Lorenzo M.

Diabetes. 2010 Oct;59(10):2407-17. doi: 10.2337/db10-0771. Epub 2010 Jul 13.

17.

Adenosine 5'-monophosphate-activated protein kinase-mammalian target of rapamycin cross talk regulates brown adipocyte differentiation.

Vila-Bedmar R, Lorenzo M, Fernández-Veledo S.

Endocrinology. 2010 Mar;151(3):980-92. doi: 10.1210/en.2009-0810. Epub 2010 Feb 4.

PMID:
20133456
18.

Molecular mechanisms involved in obesity-associated insulin resistance: therapeutical approach.

Fernández-Veledo S, Nieto-Vazquez I, Vila-Bedmar R, Garcia-Guerra L, Alonso-Chamorro M, Lorenzo M.

Arch Physiol Biochem. 2009 Oct;115(4):227-39. doi: 10.1080/13813450903164330. Review.

PMID:
19673658
19.

c-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-alpha induces insulin resistance in human visceral but not subcutaneous adipocytes: reversal by liver X receptor agonists.

Fernández-Veledo S, Vila-Bedmar R, Nieto-Vazquez I, Lorenzo M.

J Clin Endocrinol Metab. 2009 Sep;94(9):3583-93. doi: 10.1210/jc.2009-0558. Epub 2009 Jun 30.

PMID:
19567513
20.

Insulin resistance associated to obesity: the link TNF-alpha.

Nieto-Vazquez I, Fernández-Veledo S, Krämer DK, Vila-Bedmar R, Garcia-Guerra L, Lorenzo M.

Arch Physiol Biochem. 2008 Jul;114(3):183-94. doi: 10.1080/13813450802181047 . Review. Erratum in: Arch Physiol Biochem. 2009 May;115(2):117.

PMID:
18629684
21.

Insulin resistance induced by tumor necrosis factor-alpha in myocytes and brown adipocytes.

Lorenzo M, Fernández-Veledo S, Vila-Bedmar R, Garcia-Guerra L, De Alvaro C, Nieto-Vazquez I.

J Anim Sci. 2008 Apr;86(14 Suppl):E94-104. Epub 2007 Oct 16. Review.

PMID:
17940160

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