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New Insights into Bioactive Compounds of Traditional Chinese Medicines for Insulin Resistance Based on Signaling Pathways.

He J, Wang H, Vijg J.

Chem Biodivers. 2019 Sep;16(9):e1900176. doi: 10.1002/cbdv.201900176. Epub 2019 Sep 17. Review.


A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses.

Andriani GA, Maggi E, Piqué D, Zimmerman SE, Lee M, Quispe-Tintaya W, Maslov A, Campisi J, Vijg J, Mar JC, Montagna C.

Sci Rep. 2019 Jul 19;9(1):10508. doi: 10.1038/s41598-019-46606-w.


SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.

Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V.

Cell. 2019 Apr 18;177(3):622-638.e22. doi: 10.1016/j.cell.2019.03.043.


Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan.

Zhang L, Dong X, Lee M, Maslov AY, Wang T, Vijg J.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9014-9019. doi: 10.1073/pnas.1902510116. Epub 2019 Apr 16.


Bleomycin-induced genome structural variations in normal, non-tumor cells.

Quispe-Tintaya W, Lee M, Dong X, Weiser DA, Vijg J, Maslov AY.

Sci Rep. 2018 Nov 8;8(1):16523. doi: 10.1038/s41598-018-34580-8.


Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging.

Zhang L, Vijg J.

Annu Rev Genet. 2018 Nov 23;52:397-419. doi: 10.1146/annurev-genet-120417-031501. Epub 2018 Sep 13. Review.


Nuclear Genomic Instability and Aging.

Niedernhofer LJ, Gurkar AU, Wang Y, Vijg J, Hoeijmakers JHJ, Robbins PD.

Annu Rev Biochem. 2018 Jun 20;87:295-322. doi: 10.1146/annurev-biochem-062917-012239. Review.


Mechanisms of cancer resistance in long-lived mammals.

Seluanov A, Gladyshev VN, Vijg J, Gorbunova V.

Nat Rev Cancer. 2018 Jul;18(7):433-441. doi: 10.1038/s41568-018-0004-9. Review.


Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities.

Hébert JM, Vijg J.

Trends Neurosci. 2018 May;41(5):267-279. doi: 10.1016/j.tins.2018.02.008. Epub 2018 Mar 13. Review.


Global, integrated analysis of methylomes and transcriptomes from laser capture microdissected bronchial and alveolar cells in human lung.

Dong X, Shi M, Lee M, Toro R, Gravina S, Han W, Yasuda S, Wang T, Zhang Z, Vijg J, Suh Y, Spivack SD.

Epigenetics. 2018;13(3):264-274. doi: 10.1080/15592294.2018.1441650. Epub 2018 May 10.


Development of a Method to Implement Whole-Genome Bisulfite Sequencing of cfDNA from Cancer Patients and a Mouse Tumor Model.

Maggi EC, Gravina S, Cheng H, Piperdi B, Yuan Z, Dong X, Libutti SK, Vijg J, Montagna C.

Front Genet. 2018 Jan 23;9:6. doi: 10.3389/fgene.2018.00006. eCollection 2018.


Development and validation of a targeted next generation DNA sequencing panel outperforming whole exome sequencing for the identification of clinically relevant genetic variants.

Miller EM, Patterson NE, Zechmeister JM, Bejerano-Sagie M, Delio M, Patel K, Ravi N, Quispe-Tintaya W, Maslov A, Simmons N, Castaldi M, Vijg J, Karabakhtsian RG, Greally JM, Kuo DYS, Montagna C.

Oncotarget. 2017 Oct 26;8(60):102033-102045. doi: 10.18632/oncotarget.22116. eCollection 2017 Nov 24.


"Best-Guess" MRAD Provides Robust Evidence for a Limit to Human Lifespan: Reply to de Grey (Rejuvenation Res. 2017;20:261-262).

Milholland B, Dong X, Vijg J.

Rejuvenation Res. 2017 Oct;20(5):437-440. doi: 10.1089/rej.2017.2008.


The Future of Human Longevity: Time for a Reality Check.

Le Bourg E, Vijg J.

Gerontology. 2017;63(6):527-528. doi: 10.1159/000478891. Epub 2017 Aug 22.


A high-fidelity method for genomic sequencing of single somatic cells reveals a very high mutational burden.

Vijg J, Dong X, Zhang L.

Exp Biol Med (Maywood). 2017 Jul;242(13):1318-1324. doi: 10.1177/1535370217717696. Review.


Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence.

Wiley CD, Flynn JM, Morrissey C, Lebofsky R, Shuga J, Dong X, Unger MA, Vijg J, Melov S, Campisi J.

Aging Cell. 2017 Oct;16(5):1043-1050. doi: 10.1111/acel.12632. Epub 2017 Jul 11.


Dong et al. reply.

Dong X, Milholland B, Vijg J.

Nature. 2017 Jun 28;546(7660):E9-E10. doi: 10.1038/nature22787. No abstract available.


Dong et al. reply.

Dong X, Milholland B, Vijg J.

Nature. 2017 Jun 28;546(7660):E12. doi: 10.1038/nature22789. No abstract available.


Dong et al. reply.

Dong X, Milholland B, Vijg J.

Nature. 2017 Jun 28;546(7660):E7. doi: 10.1038/nature22785. No abstract available.


Dong et al. reply.

Dong X, Milholland B, Vijg J.

Nature. 2017 Jun 28;546(7660):E14-E15. doi: 10.1038/nature22791. No abstract available.


Dong et al. reply.

Dong X, Milholland B, Vijg J.

Nature. 2017 Jun 28;546(7660):E21. doi: 10.1038/nature22793. No abstract available.


Genome-wide, Single-Cell DNA Methylomics Reveals Increased Non-CpG Methylation during Human Oocyte Maturation.

Yu B, Dong X, Gravina S, Kartal Ö, Schimmel T, Cohen J, Tortoriello D, Zody R, Hawkins RD, Vijg J.

Stem Cell Reports. 2017 Jul 11;9(1):397-407. doi: 10.1016/j.stemcr.2017.05.026. Epub 2017 Jun 22.


Genome instability: a conserved mechanism of ageing?

Vijg J, Dong X, Milholland B, Zhang L.

Essays Biochem. 2017 Jul 11;61(3):305-315. doi: 10.1042/EBC20160082. Print 2017 Jul 15. Review.


Aging and the Inevitable Limit to Human Life Span.

Vijg J, Le Bourg E.

Gerontology. 2017;63(5):432-434. doi: 10.1159/000477210. Epub 2017 May 17.


Differences between germline and somatic mutation rates in humans and mice.

Milholland B, Dong X, Zhang L, Hao X, Suh Y, Vijg J.

Nat Commun. 2017 May 9;8:15183. doi: 10.1038/ncomms15183.


Accurate identification of single-nucleotide variants in whole-genome-amplified single cells.

Dong X, Zhang L, Milholland B, Lee M, Maslov AY, Wang T, Vijg J.

Nat Methods. 2017 May;14(5):491-493. doi: 10.1038/nmeth.4227. Epub 2017 Mar 20.


Mutation and catastrophe in the aging genome.

Milholland B, Suh Y, Vijg J.

Exp Gerontol. 2017 Aug;94:34-40. doi: 10.1016/j.exger.2017.02.073. Epub 2017 Mar 2. Review.


In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development.

Ozerov IV, Lezhnina KV, Izumchenko E, Artemov AV, Medintsev S, Vanhaelen Q, Aliper A, Vijg J, Osipov AN, Labat I, West MD, Buzdin A, Cantor CR, Nikolsky Y, Borisov N, Irincheeva I, Khokhlovich E, Sidransky D, Camargo ML, Zhavoronkov A.

Nat Commun. 2016 Nov 16;7:13427. doi: 10.1038/ncomms13427.


Whole Chromosome Instability induces senescence and promotes SASP.

Andriani GA, Almeida VP, Faggioli F, Mauro M, Tsai WL, Santambrogio L, Maslov A, Gadina M, Campisi J, Vijg J, Montagna C.

Sci Rep. 2016 Oct 12;6:35218. doi: 10.1038/srep35218.


Evidence for a limit to human lifespan.

Dong X, Milholland B, Vijg J.

Nature. 2016 Oct 13;538(7624):257-259. doi: 10.1038/nature19793. Epub 2016 Oct 5.


Do DNA Double-Strand Breaks Drive Aging?

White RR, Vijg J.

Mol Cell. 2016 Sep 1;63(5):729-38. doi: 10.1016/j.molcel.2016.08.004. Review.


Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice.

Vermeij WP, Dollé ME, Reiling E, Jaarsma D, Payan-Gomez C, Bombardieri CR, Wu H, Roks AJ, Botter SM, van der Eerden BC, Youssef SA, Kuiper RV, Nagarajah B, van Oostrom CT, Brandt RM, Barnhoorn S, Imholz S, Pennings JL, de Bruin A, Gyenis Á, Pothof J, Vijg J, van Steeg H, Hoeijmakers JH.

Nature. 2016 Sep 15;537(7620):427-431. doi: 10.1038/nature19329. Epub 2016 Aug 24.


Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome.

Gravina S, Dong X, Yu B, Vijg J.

Genome Biol. 2016 Jul 5;17(1):150. doi: 10.1186/s13059-016-1011-3.


Quantitative detection of low-abundance somatic structural variants in normal cells by high-throughput sequencing.

Quispe-Tintaya W, Gorbacheva T, Lee M, Makhortov S, Popov VN, Vijg J, Maslov AY.

Nat Methods. 2016 Jul;13(7):584-6. doi: 10.1038/nmeth.3893. Epub 2016 Jun 6.


Deep biomarkers of human aging: Application of deep neural networks to biomarker development.

Putin E, Mamoshina P, Aliper A, Korzinkin M, Moskalev A, Kolosov A, Ostrovskiy A, Cantor C, Vijg J, Zhavoronkov A.

Aging (Albany NY). 2016 May;8(5):1021-33. doi: 10.18632/aging.100968.


Systems-level analysis of human aging genes shed new light on mechanisms of aging.

Zhang Q, Nogales-Cadenas R, Lin JR, Zhang W, Cai Y, Vijg J, Zhang ZD.

Hum Mol Genet. 2016 Jul 15;25(14):2934-2947. Epub 2016 May 14.


Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan.

Patrick A, Seluanov M, Hwang C, Tam J, Khan T, Morgenstern A, Wiener L, Vazquez JM, Zafar H, Wen R, Muratkalyeva M, Doerig K, Zagorulya M, Cole L, Catalano S, Lobo Ladd AA, Coppi AA, Coşkun Y, Tian X, Ablaeva J, Nevo E, Gladyshev VN, Zhang ZD, Vijg J, Seluanov A, Gorbunova V.

Aging (Albany NY). 2016 May;8(5):841-7. doi: 10.18632/aging.100958.


Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain.

Andriani GA, Vijg J, Montagna C.

Mech Ageing Dev. 2017 Jan;161(Pt A):19-36. doi: 10.1016/j.mad.2016.03.007. Epub 2016 Mar 21. Review.


The dark side of circulating nucleic acids.

Gravina S, Sedivy JM, Vijg J.

Aging Cell. 2016 Jun;15(3):398-9. doi: 10.1111/acel.12454. Epub 2016 Feb 22. Review.


DNA repair in species with extreme lifespan differences.

MacRae SL, Croken MM, Calder RB, Aliper A, Milholland B, White RR, Zhavoronkov A, Gladyshev VN, Seluanov A, Gorbunova V, Zhang ZD, Vijg J.

Aging (Albany NY). 2015 Dec;7(12):1171-84.


Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice.

Andriani GA, Faggioli F, Baker D, Dollé ME, Sellers RS, Hébert JM, Van Steeg H, Hoeijmakers J, Vijg J, Montagna C.

Hum Mol Genet. 2016 Feb 15;25(4):755-65. doi: 10.1093/hmg/ddv612. Epub 2015 Dec 17.


Comprehensive transcriptional landscape of aging mouse liver.

White RR, Milholland B, MacRae SL, Lin M, Zheng D, Vijg J.

BMC Genomics. 2015 Nov 5;16:899. doi: 10.1186/s12864-015-2061-8.


The Essence of Aging.

Vijg J, Kennedy BK.

Gerontology. 2016;62(4):381-5. doi: 10.1159/000439348. Epub 2015 Sep 22. Review.


Age-related somatic mutations in the cancer genome.

Milholland B, Auton A, Suh Y, Vijg J.

Oncotarget. 2015 Sep 22;6(28):24627-35. doi: 10.18632/oncotarget.5685.


Development of a Targeted Multi-Disorder High-Throughput Sequencing Assay for the Effective Identification of Disease-Causing Variants.

Delio M, Patel K, Maslov A, Marion RW, McDonald TV, Cadoff EM, Golden A, Greally JM, Vijg J, Morrow B, Montagna C.

PLoS One. 2015 Jul 27;10(7):e0133742. doi: 10.1371/journal.pone.0133742. eCollection 2015.


Genetic evidence for common pathways in human age-related diseases.

Johnson SC, Dong X, Vijg J, Suh Y.

Aging Cell. 2015 Oct;14(5):809-17. doi: 10.1111/acel.12362. Epub 2015 Jun 15.


High-throughput sequencing in mutation detection: A new generation of genotoxicity tests?

Maslov AY, Quispe-Tintaya W, Gorbacheva T, White RR, Vijg J.

Mutat Res. 2015 Jun;776:136-43. doi: 10.1016/j.mrfmmm.2015.03.014. Epub 2015 Apr 20. Review.


Interventions to Slow Aging in Humans: Are We Ready?

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.

Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. Review.


Single-cell, locus-specific bisulfite sequencing (SLBS) for direct detection of epimutations in DNA methylation patterns.

Gravina S, Ganapathi S, Vijg J.

Nucleic Acids Res. 2015 Aug 18;43(14):e93. doi: 10.1093/nar/gkv366. Epub 2015 Apr 19.


Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing.

White RR, Milholland B, de Bruin A, Curran S, Laberge RM, van Steeg H, Campisi J, Maslov AY, Vijg J.

Nat Commun. 2015 Apr 10;6:6790. doi: 10.1038/ncomms7790.

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