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Cryo-EM of retinoschisin branched networks suggests an intercellular adhesive scaffold in the retina.

Heymann JB, Vijayasarathy C, Huang RK, Dearborn AD, Sieving PA, Steven AC.

J Cell Biol. 2019 Jan 10. pii: jcb.201806148. doi: 10.1083/jcb.201806148. [Epub ahead of print]


Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery.

Cukras C, Wiley HE, Jeffrey BG, Sen HN, Turriff A, Zeng Y, Vijayasarathy C, Marangoni D, Ziccardi L, Kjellstrom S, Park TK, Hiriyanna S, Wright JF, Colosi P, Wu Z, Bush RA, Wei LL, Sieving PA.

Mol Ther. 2018 Sep 5;26(9):2282-2294. doi: 10.1016/j.ymthe.2018.05.025. Epub 2018 Jul 7.


Rearing Light Intensity Affects Inner Retinal Pathology in a Mouse Model of X-Linked Retinoschisis but Does Not Alter Gene Therapy Outcome.

Marangoni D, Yong Z, Kjellström S, Vijayasarathy C, A Sieving P, Bush RA.

Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1656-1664. doi: 10.1167/iovs.16-21016.


Ocular and systemic safety of a recombinant AAV8 vector for X-linked retinoschisis gene therapy: GLP studies in rabbits and Rs1-KO mice.

Marangoni D, Bush RA, Zeng Y, Wei LL, Ziccardi L, Vijayasarathy C, Bartoe JT, Palyada K, Santos M, Hiriyanna S, Wu Z, Colosi P, Sieving PA.

Mol Ther Methods Clin Dev. 2016 Mar 16;5:16011. doi: 10.1038/mtm.2016.11. eCollection 2016.


Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography.

Zeng Y, Petralia RS, Vijayasarathy C, Wu Z, Hiriyanna S, Song H, Wang YX, Sieving PA, Bush RA.

Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT277-87. doi: 10.1167/iovs.15-18920.


NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice.

Song H, Vijayasarathy C, Zeng Y, Marangoni D, Bush RA, Wu Z, Sieving PA.

Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2864-75. doi: 10.1167/iovs.15-18974.


Paired octamer rings of retinoschisin suggest a junctional model for cell-cell adhesion in the retina.

Tolun G, Vijayasarathy C, Huang R, Zeng Y, Li Y, Steven AC, Sieving PA, Heymann JB.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5287-92. doi: 10.1073/pnas.1519048113. Epub 2016 Apr 25.


Preclinical Dose-Escalation Study of Intravitreal AAV-RS1 Gene Therapy in a Mouse Model of X-linked Retinoschisis: Dose-Dependent Expression and Improved Retinal Structure and Function.

Bush RA, Zeng Y, Colosi P, Kjellstrom S, Hiriyanna S, Vijayasarathy C, Santos M, Li J, Wu Z, Sieving PA.

Hum Gene Ther. 2016 May;27(5):376-89. doi: 10.1089/hum.2015.142.


Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3-/- Mouse Model of Achromatopsia.

Marangoni D, Vijayasarathy C, Bush RA, Wei LL, Wen R, Sieving PA.

Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6810-22. doi: 10.1167/iovs.15-16866.


Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer.

Ou J, Vijayasarathy C, Ziccardi L, Chen S, Zeng Y, Marangoni D, Pope JG, Bush RA, Wu Z, Li W, Sieving PA.

J Clin Invest. 2015 Jul 1;125(7):2891-903. doi: 10.1172/JCI81380. Epub 2015 Jun 22.


Resveratrol attenuates CXCL11 expression induced by proinflammatory cytokines in retinal pigment epithelial cells.

Kutty RK, Samuel W, Abay R, Cherukuri A, Nagineni CN, Duncan T, Jaworski C, Vijayasarathy C, Redmond TM.

Cytokine. 2015 Aug;74(2):335-8. doi: 10.1016/j.cyto.2015.03.016. Epub 2015 Apr 15.


Preclinical safety evaluation of a recombinant AAV8 vector for X-linked retinoschisis after intravitreal administration in rabbits.

Marangoni D, Wu Z, Wiley HE, Zeiss CJ, Vijayasarathy C, Zeng Y, Hiriyanna S, Bush RA, Wei LL, Colosi P, Sieving PA.

Hum Gene Ther Clin Dev. 2014 Dec;25(4):202-11. doi: 10.1089/humc.2014.067.


Photoreceptor pathology in the X-linked retinoschisis (XLRS) mouse results in delayed rod maturation and impaired light driven transducin translocation.

Ziccardi L, Vijayasarathy C, Bush RA, Sieving PA.

Adv Exp Med Biol. 2014;801:559-66. doi: 10.1007/978-1-4614-3209-8_71.


Transgenic expression of constitutively active RAC1 disrupts mouse rod morphogenesis.

Song H, Bush RA, Vijayasarathy C, Fariss RN, Kjellstrom S, Sieving PA.

Invest Ophthalmol Vis Sci. 2014 Apr 25;55(4):2659-68. doi: 10.1167/iovs.13-13649.


Alteration of vitreal retinoschisin level in human primary retinal detachment.

Kjellström S, Ghosh F, Vijayasarathy C, Andréasson S.

JAMA Ophthalmol. 2014 Mar;132(3):353-4. doi: 10.1001/jamaophthalmol.2013.6306. No abstract available.


Fenretinide induces ubiquitin-dependent proteasomal degradation of stearoyl-CoA desaturase in human retinal pigment epithelial cells.

Samuel W, Kutty RK, Duncan T, Vijayasarathy C, Kuo BC, Chapa KM, Redmond TM.

J Cell Physiol. 2014 Aug;229(8):1028-38. doi: 10.1002/jcp.24527.


Differential regulation of microRNA-146a and microRNA-146b-5p in human retinal pigment epithelial cells by interleukin-1β, tumor necrosis factor-α, and interferon-γ.

Kutty RK, Nagineni CN, Samuel W, Vijayasarathy C, Jaworski C, Duncan T, Cameron JE, Flemington EK, Hooks JJ, Redmond TM.

Mol Vis. 2013 Apr 3;19:737-50. Print 2013.


Biology of retinoschisin.

Vijayasarathy C, Ziccardi L, Sieving PA.

Adv Exp Med Biol. 2012;723:513-8. doi: 10.1007/978-1-4614-0631-0_64. Review. No abstract available.


Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway.

Kutty RK, Nagineni CN, Samuel W, Vijayasarathy C, Hooks JJ, Redmond TM.

Biochem Biophys Res Commun. 2010 Nov 12;402(2):390-5. doi: 10.1016/j.bbrc.2010.10.042. Epub 2010 Oct 13.


Molecular mechanisms leading to null-protein product from retinoschisin (RS1) signal-sequence mutants in X-linked retinoschisis (XLRS) disease.

Vijayasarathy C, Sui R, Zeng Y, Yang G, Xu F, Caruso RC, Lewis RA, Ziccardi L, Sieving PA.

Hum Mutat. 2010 Nov;31(11):1251-60. doi: 10.1002/humu.21350.


Retinoschisin (RS1) interacts with negatively charged lipid bilayers in the presence of Ca2+: an atomic force microscopy study.

Kotova S, Vijayasarathy C, Dimitriadis EK, Ikonomou L, Jaffe H, Sieving PA.

Biochemistry. 2010 Aug 24;49(33):7023-32. doi: 10.1021/bi1007029.


Probing potassium channel function in vivo by intracellular delivery of antibodies in a rat model of retinal neurodegeneration.

Raz-Prag D, Grimes WN, Fariss RN, Vijayasarathy C, Campos MM, Bush RA, Diamond JS, Sieving PA.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12710-5. doi: 10.1073/pnas.0913472107. Epub 2010 Jun 28.


Long-term 12 year follow-up of X-linked congenital retinoschisis.

Kjellström S, Vijayasarathy C, Ponjavic V, Sieving PA, Andréasson S.

Ophthalmic Genet. 2010 Sep;31(3):114-25. doi: 10.3109/13816810.2010.482555.


Papillorenal syndrome-causing missense mutations in PAX2/Pax2 result in hypomorphic alleles in mouse and human.

Alur RP, Vijayasarathy C, Brown JD, Mehtani M, Onojafe IF, Sergeev YV, Boobalan E, Jones M, Tang K, Liu H, Xia CH, Gong X, Brooks BP.

PLoS Genet. 2010 Mar 5;6(3):e1000870. doi: 10.1371/journal.pgen.1000870.


Null retinoschisin-protein expression from an RS1 c354del1-ins18 mutation causing progressive and severe XLRS in a cross-sectional family study.

Vijayasarathy C, Ziccardi L, Zeng Y, Smaoui N, Caruso RC, Sieving PA.

Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5375-83. doi: 10.1167/iovs.09-3839. Epub 2009 May 27.


Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function.

Haruta M, Bush RA, Kjellstrom S, Vijayasarathy C, Zeng Y, Le YZ, Sieving PA.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9397-402. doi: 10.1073/pnas.0808940106. Epub 2009 May 21.


Synaptic pathology in retinoschisis knockout (Rs1-/y) mouse retina and modification by rAAV-Rs1 gene delivery.

Takada Y, Vijayasarathy C, Zeng Y, Kjellstrom S, Bush RA, Sieving PA.

Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3677-86. doi: 10.1167/iovs.07-1071.


Mitogen-activated protein kinase pathway mediates N-(4-hydroxyphenyl)retinamide-induced neuronal differentiation in the ARPE-19 human retinal pigment epithelial cell line.

Samuel W, Kutty RK, Sekhar S, Vijayasarathy C, Wiggert B, Redmond TM.

J Neurochem. 2008 Jul;106(2):591-602. doi: 10.1111/j.1471-4159.2008.05409.x. Epub 2008 Apr 10.


Organization and molecular interactions of retinoschisin in photoreceptors.

Vijayasarathy C, Takada Y, Zeng Y, Bush RA, Sieving PA.

Adv Exp Med Biol. 2008;613:291-7. doi: 10.1007/978-0-387-74904-4_34. Review. No abstract available.


Retinoschisin is a peripheral membrane protein with affinity for anionic phospholipids and affected by divalent cations.

Vijayasarathy C, Takada Y, Zeng Y, Bush RA, Sieving PA.

Invest Ophthalmol Vis Sci. 2007 Mar;48(3):991-1000.


Identification and characterization of two mature isoforms of retinoschisin in murine retina.

Vijayasarathy C, Gawinowicz MA, Zeng Y, Takada Y, Bush RA, Sieving PA.

Biochem Biophys Res Commun. 2006 Oct 13;349(1):99-105. Epub 2006 Aug 10.


Immunofluorescence analysis of the expression of Norpeg (Rai14) in retinal Müller and ganglion cells.

Kutty RK, Samuel W, Chen S, Vijayasarathy C, Dun Y, Mysona B, Wiggert B, Smith SB.

Neurosci Lett. 2006 Sep 1;404(3):294-8. Epub 2006 Jun 27.


Cell density-dependent nuclear/cytoplasmic localization of NORPEG (RAI14) protein.

Kutty RK, Chen S, Samuel W, Vijayasarathy C, Duncan T, Tsai JY, Fariss RN, Carper D, Jaworski C, Wiggert B.

Biochem Biophys Res Commun. 2006 Jul 14;345(4):1333-41. Epub 2006 May 16.


Stargardt-like macular dystrophy protein ELOVL4 exerts a dominant negative effect by recruiting wild-type protein into aggresomes.

Vasireddy V, Vijayasarathy C, Huang J, Wang XF, Jablonski MM, Petty HR, Sieving PA, Ayyagari R.

Mol Vis. 2005 Aug 30;11:665-76.


Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragm.

Nguyen T, Rubinstein NA, Vijayasarathy C, Rome LC, Kaiser LR, Shrager JB, Levine S.

J Appl Physiol (1985). 2005 Jun;98(6):2004-10. Epub 2005 Feb 17.


Differences in activity of cytochrome C oxidase in brain between sleep and wakefulness.

Nikonova EV, Vijayasarathy C, Zhang L, Cater JR, Galante RJ, Ward SE, Avadhani NG, Pack AI.

Sleep. 2005 Jan;28(1):21-7.


Evidence for a dual pathway of activation in CD43-stimulated Th2 cells: differential requirement for the Lck tyrosine kinase.

Fernandez-Cabezudo MJ, Vijayasarathy C, Pflugh DL, Bothwell AL, al-Ramadi BK.

Int Immunol. 2004 Aug;16(8):1215-23. Epub 2004 Jul 5.


Competitive and noncompetitive inhibition of myocardial cytochrome C oxidase in sepsis.

Levy RJ, Vijayasarathy C, Raj NR, Avadhani NG, Deutschman CS.

Shock. 2004 Feb;21(2):110-4.


Metoclopramide protection of cholinesterase from paraoxon inhibition.

Petroianu GA, Hasan MY, Kosanovic M, Vijayasarathy C, Saleh AM.

Vet Hum Toxicol. 2003 Oct;45(5):251-3.


Paraoxon induces apoptosis in EL4 cells via activation of mitochondrial pathways.

Saleh AM, Vijayasarathy C, Masoud L, Kumar L, Shahin A, Kambal A.

Toxicol Appl Pharmacol. 2003 Jul 1;190(1):47-57.


Influence of paraoxon (POX) and parathion (PAT) on apoptosis: a possible mechanism for toxicity in low-dose exposure.

Saleh AM, Vijayasarathy C, Fernandez-Cabezudo M, Taleb M, Petroianu G.

J Appl Toxicol. 2003 Jan-Feb;23(1):23-9.


Effect of malathion on apoptosis of murine L929 fibroblasts: a possible mechanism for toxicity in low dose exposure.

Masoud L, Vijayasarathy C, Fernandez-Cabezudo M, Petroianu G, Saleh AM.

Toxicology. 2003 Mar 14;185(1-2):89-102.


Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells.

Amuthan G, Biswas G, Ananadatheerthavarada HK, Vijayasarathy C, Shephard HM, Avadhani NG.

Oncogene. 2002 Nov 7;21(51):7839-49.


Dilated cardiomyopathy in juvenile Portuguese Water Dogs.

Sleeper MM, Henthorn PS, Vijayasarathy C, Dambach DM, Bowers T, Tijskens P, Armstrong CF, Lankford EB.

J Vet Intern Med. 2002 Jan-Feb;16(1):52-62.


Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion.

Amuthan G, Biswas G, Zhang SY, Klein-Szanto A, Vijayasarathy C, Avadhani NG.

EMBO J. 2001 Apr 17;20(8):1910-20.

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