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Items: 38


Are Platelets the Primary Target of Aspirin's Remarkable Anticancer Activity?

Lichtenberger LM, Vijayan KV.

Cancer Res. 2019 Aug 1;79(15):3820-3823. doi: 10.1158/0008-5472.CAN-19-0762. Epub 2019 Jul 12.


In vitro phosphorylation of von Willebrand factor by FAM20c enhances its ability to support platelet adhesion.

Da Q, Han H, Valladolid C, Fernández M, Khatlani T, Pradhan S, Nolasco J, Matsunami RK, Engler DA, Cruz MA, Vijayan KV.

J Thromb Haemost. 2019 Jun;17(6):866-877. doi: 10.1111/jth.14426. Epub 2019 Apr 5.


Myosin IIa signal von Willebrand factor release.

Vijayan KV.

Blood. 2018 Feb 8;131(6):592-593. doi: 10.1182/blood-2017-12-821579. No abstract available.


The heterotrimeric G protein Gβ1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets.

Pradhan S, Khatlani T, Nairn AC, Vijayan KV.

J Biol Chem. 2017 Aug 11;292(32):13133-13142. doi: 10.1074/jbc.M117.796656. Epub 2017 Jun 14.


Dasatinib inhibits actin fiber reorganization and promotes endothelial cell permeability through RhoA-ROCK pathway.

Dasgupta SK, Le A, Vijayan KV, Thiagarajan P.

Cancer Med. 2017 Apr;6(4):809-818. doi: 10.1002/cam4.1019. Epub 2017 Mar 18.


PAI1: a novel PP1-interacting protein that mediates human plasma's anti-apoptotic effect in endothelial cells.

Yao H, He G, Chen C, Yan S, Lu L, Song L, Vijayan KV, Li Q, Xiong L, Miao X, Deng X.

J Cell Mol Med. 2017 Sep;21(9):2068-2076. doi: 10.1111/jcmm.13127. Epub 2017 Mar 11.


Disruption of protein complexes containing protein phosphatase 2B and Munc18c reduces the secretion of von Willebrand factor from endothelial cells.

Da Q, Shaw T, Pradhan S, Roche PA, Cruz MA, Vijayan KV.

J Thromb Haemost. 2017 May;15(5):1032-1039. doi: 10.1111/jth.13671. Epub 2017 Apr 13.


Unlocking Aspirin's Chemopreventive Activity: Role of Irreversibly Inhibiting Platelet Cyclooxygenase-1.

Lichtenberger LM, Fang D, Bick RJ, Poindexter BJ, Phan T, Bergeron AL, Pradhan S, Dial EJ, Vijayan KV.

Cancer Prev Res (Phila). 2017 Feb;10(2):142-152. doi: 10.1158/1940-6207.CAPR-16-0241. Epub 2016 Dec 20.


A Novel Interaction of the Catalytic Subunit of Protein Phosphatase 2A with the Adaptor Protein CIN85 Suppresses Phosphatase Activity and Facilitates Platelet Outside-in αIIbβ3 Integrin Signaling.

Khatlani T, Pradhan S, Da Q, Shaw T, Buchman VL, Cruz MA, Vijayan KV.

J Biol Chem. 2016 Aug 12;291(33):17360-8. doi: 10.1074/jbc.M115.704296. Epub 2016 Jun 22.


Electron cryotomography reveals ultrastructure alterations in platelets from patients with ovarian cancer.

Wang R, Stone RL, Kaelber JT, Rochat RH, Nick AM, Vijayan KV, Afshar-Kharghan V, Schmid MF, Dong JF, Sood AK, Chiu W.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14266-71. doi: 10.1073/pnas.1518628112. Epub 2015 Nov 2.


Platelets and Their Interactions with Other Immune Cells.

Lam FW, Vijayan KV, Rumbaut RE.

Compr Physiol. 2015 Jul 1;5(3):1265-80. doi: 10.1002/cphy.c140074. Review.


DGKE disruption ditches complement and drives p38 signaling.

Vijayan KV.

Blood. 2015 Feb 5;125(6):898-9. doi: 10.1182/blood-2014-12-617589. No abstract available.


The β isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in αII b β3 integrin signaling.

Khatlani T, Pradhan S, Da Q, Gushiken FC, Bergeron AL, Langlois KW, Molkentin JD, Rumbaut RE, Vijayan KV.

J Thromb Haemost. 2014 Dec;12(12):2089-101. doi: 10.1111/jth.12761. Epub 2014 Nov 15.


Association between cell-derived microparticles and adverse events in patients with nonpulsatile left ventricular assist devices.

Nascimbene A, Hernandez R, George JK, Parker A, Bergeron AL, Pradhan S, Vijayan KV, Civitello A, Simpson L, Nawrot M, Lee VV, Mallidi HR, Delgado RM, Dong JF, Frazier OH.

J Heart Lung Transplant. 2014 May;33(5):470-7. doi: 10.1016/j.healun.2014.01.004. Epub 2014 Jan 19.


Platelet adhesion involves a novel interaction between vimentin and von Willebrand factor under high shear stress.

Da Q, Behymer M, Correa JI, Vijayan KV, Cruz MA.

Blood. 2014 Apr 24;123(17):2715-21. doi: 10.1182/blood-2013-10-530428. Epub 2014 Mar 18.


Lipid rafts contribute to agonist-induced serine/threonine phosphatase activation and platelet aggregation.

Pradhan S, Vijayan KV.

J Thromb Haemost. 2013 Aug;11(8):1612-5. doi: 10.1111/jth.12329. No abstract available.


Signal transducer and activator of transcription 3 (STAT3) regulates collagen-induced platelet aggregation independently of its transcription factor activity.

Zhou Z, Gushiken FC, Bolgiano D, Salsbery BJ, Aghakasiri N, Jing N, Wu X, Vijayan KV, Rumbaut RE, Adachi R, Lopez JA, Dong JF.

Circulation. 2013 Jan 29;127(4):476-485. doi: 10.1161/CIRCULATIONAHA.112.132126. Epub 2012 Dec 24.


Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions.

Alrehani N, Pradhan S, Khatlani T, Kailasam L, Vijayan KV.

Thromb Haemost. 2013 Jan;109(1):118-26. doi: 10.1160/TH12-04-0237. Epub 2012 Nov 29.


Differential dephosphorylation of the protein kinase C-zeta (PKCζ) in an integrin αIIbβ3-dependent manner in platelets.

Mayanglambam A, Bhavanasi D, Vijayan KV, Kunapuli SP.

Biochem Pharmacol. 2011 Sep 1;82(5):505-13. doi: 10.1016/j.bcp.2011.05.022. Epub 2011 May 27.


Decline in platelet microparticles contributes to reduced hemostatic potential of stored plasma.

Matijevic N, Wang YW, Kostousov V, Wade CE, Vijayan KV, Holcomb JB.

Thromb Res. 2011 Jul;128(1):35-41. doi: 10.1016/j.thromres.2011.02.011. Epub 2011 Mar 21.


Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin αIIbβ3 to fibrinogen.

Pradhan S, Alrehani N, Patel V, Khatlani T, Vijayan KV.

J Biol Chem. 2010 Sep 17;285(38):29059-68. doi: 10.1074/jbc.M109.085167. Epub 2010 Jul 8.


Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress.

Auton M, Sowa KE, Smith SM, Sedlák E, Vijayan KV, Cruz MA.

J Biol Chem. 2010 Jul 23;285(30):22831-9. doi: 10.1074/jbc.M110.103358. Epub 2010 May 24.


The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function.

Gushiken FC, Hyojeong H, Pradhan S, Langlois KW, Alrehani N, Cruz MA, Rumbaut RE, Vijayan KV.

PLoS One. 2009 Dec 15;4(12):e8304. doi: 10.1371/journal.pone.0008304.


Protein phosphatase 2B inhibition promotes the secretion of von Willebrand factor from endothelial cells.

Nolasco LH, Gushiken FC, Turner NA, Khatlani TS, Pradhan S, Dong JF, Moake JL, Vijayan KV.

J Thromb Haemost. 2009 Jun;7(6):1009-18. doi: 10.1111/j.1538-7836.2009.03355.x. Epub 2009 Mar 27.


Mechanism of activation and functional role of protein kinase Ceta in human platelets.

Bynagari YS, Nagy B Jr, Tuluc F, Bhavaraju K, Kim S, Vijayan KV, Kunapuli SP.

J Biol Chem. 2009 May 15;284(20):13413-21. doi: 10.1074/jbc.M808970200. Epub 2009 Mar 13.


Glutathione regulates integrin alpha(IIb)beta(3)-mediated cell adhesion under flow conditions.

Ball C, Vijayan KV, Nguyen T, Anthony K, Bray PF, Essex DW, Dong JF.

Thromb Haemost. 2008 Nov;100(5):857-63.


Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling.

Gushiken FC, Patel V, Liu Y, Pradhan S, Bergeron AL, Peng Y, Vijayan KV.

J Biol Chem. 2008 May 9;283(19):12862-9. doi: 10.1074/jbc.M708804200. Epub 2008 Mar 11.


Fibrinogen and prothrombin binding is enhanced to the Pro33 isoform of purified integrin alphaIIbbeta3.

Vijayan KV, Liu Y, Souza S, Thiagarajan P, Bray PF.

J Thromb Haemost. 2006 Apr;4(4):905-6. No abstract available.


The Pro33 isoform of integrin beta3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases.

Vijayan KV, Liu Y, Sun W, Ito M, Bray PF.

J Biol Chem. 2005 Jun 10;280(23):21756-62. Epub 2005 Apr 11.


Protein phosphatase 1 associates with the integrin alphaIIb subunit and regulates signaling.

Vijayan KV, Liu Y, Li TT, Bray PF.

J Biol Chem. 2004 Aug 6;279(32):33039-42. Epub 2004 Jun 17.


Shear stress augments the enhanced adhesive phenotype of cells expressing the Pro33 isoform of integrin beta3.

Vijayan KV, Huang TC, Liu Y, Bernardo A, Dong JF, Goldschmidt-Clermont PJ, Alevriadou BR, Bray PF.

FEBS Lett. 2003 Apr 10;540(1-3):41-6.


PlA polymorphism of integrin beta 3 differentially modulates cellular migration on extracellular matrix proteins.

Sajid M, Vijayan KV, Souza S, Bray PF.

Arterioscler Thromb Vasc Biol. 2002 Dec 1;22(12):1984-9.


Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3.

Vijayan KV, Liu Y, Dong JF, Bray PF.

J Biol Chem. 2003 Feb 7;278(6):3860-7. Epub 2002 Nov 29.


Human platelets contain a glycosylated estrogen receptor beta.

Nealen ML, Vijayan KV, Bolton E, Bray PF.

Circ Res. 2001 Mar 2;88(4):438-42.


Human megakaryocytes and platelets contain the estrogen receptor beta and androgen receptor (AR): testosterone regulates AR expression.

Khetawat G, Faraday N, Nealen ML, Vijayan KV, Bolton E, Noga SJ, Bray PF.

Blood. 2000 Apr 1;95(7):2289-96.


The Pl(A2) polymorphism of integrin beta(3) enhances outside-in signaling and adhesive functions.

Vijayan KV, Goldschmidt-Clermont PJ, Roos C, Bray PF.

J Clin Invest. 2000 Mar;105(6):793-802.

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