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Items: 50

1.

MicroRNA-155 is essential for the optimal proliferation and survival of plasmablast B cells.

Arbore G, Henley T, Biggins L, Andrews S, Vigorito E, Turner M, Leyland R.

Life Sci Alliance. 2019 May 16;2(3). pii: e201800244. doi: 10.26508/lsa.201800244. Print 2019 Jun.

2.

Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.

Vigorito E, Kuchenbaecker KB, Beesley J, Adlard J, Agnarsson BA, Andrulis IL, Arun BK, Barjhoux L, Belotti M, Benitez J, Berger A, Bojesen A, Bonanni B, Brewer C, Caldes T, Caligo MA, Campbell I, Chan SB, Claes KB, Cohn DE, Cook J, Daly MB, Damiola F, Davidson R, Pauw Ad, Delnatte C, Diez O, Domchek SM, Dumont M, Durda K, Dworniczak B, Easton DF, Eccles D, Edwinsdotter Ardnor C, Eeles R, Ejlertsen B, Ellis S, Evans DG, Feliubadalo L, Fostira F, Foulkes WD, Friedman E, Frost D, Gaddam P, Ganz PA, Garber J, Garcia-Barberan V, Gauthier-Villars M, Gehrig A, Gerdes AM, Giraud S, Godwin AK, Goldgar DE, Hake CR, Hansen TV, Healey S, Hodgson S, Hogervorst FB, Houdayer C, Hulick PJ, Imyanitov EN, Isaacs C, Izatt L, Izquierdo A, Jacobs L, Jakubowska A, Janavicius R, Jaworska-Bieniek K, Jensen UB, John EM, Vijai J, Karlan BY, Kast K, Investigators K, Khan S, Kwong A, Laitman Y, Lester J, Lesueur F, Liljegren A, Lubinski J, Mai PL, Manoukian S, Mazoyer S, Meindl A, Mensenkamp AR, Montagna M, Nathanson KL, Neuhausen SL, Nevanlinna H, Niederacher D, Olah E, Olopade OI, Ong KR, Osorio A, Park SK, Paulsson-Karlsson Y, Pedersen IS, Peissel B, Peterlongo P, Pfeiler G, Phelan CM, Piedmonte M, Poppe B, Pujana MA, Radice P, Rennert G, Rodriguez GC, Rookus MA, Ross EA, Schmutzler RK, Simard J, Singer CF, Slavin TP, Soucy P, Southey M, Steinemann D, Stoppa-Lyonnet D, Sukiennicki G, Sutter C, Szabo CI, Tea MK, Teixeira MR, Teo SH, Terry MB, Thomassen M, Tibiletti MG, Tihomirova L, Tognazzo S, van Rensburg EJ, Varesco L, Varon-Mateeva R, Vratimos A, Weitzel JN, McGuffog L, Kirk J, Toland AE, Hamann U, Lindor N, Ramus SJ, Greene MH, Couch FJ, Offit K, Pharoah PD, Chenevix-Trench G, Antoniou AC.

PLoS One. 2016 Jul 27;11(7):e0158801. doi: 10.1371/journal.pone.0158801. eCollection 2016.

3.

MicroRNA-155 controls affinity-based selection by protecting c-MYC+ B cells from apoptosis.

Nakagawa R, Leyland R, Meyer-Hermann M, Lu D, Turner M, Arbore G, Phan TG, Brink R, Vigorito E.

J Clin Invest. 2016 Jan;126(1):377-88. doi: 10.1172/JCI82914. Epub 2015 Dec 14.

4.

Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1.

Curtis AM, Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, Vigorito E, FitzGerald GA, O'Neill LA.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7231-6. doi: 10.1073/pnas.1501327112. Epub 2015 May 20.

5.

The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation.

Lu D, Nakagawa R, Lazzaro S, Staudacher P, Abreu-Goodger C, Henley T, Boiani S, Leyland R, Galloway A, Andrews S, Butcher G, Nutt SL, Turner M, Vigorito E.

J Exp Med. 2014 Oct 20;211(11):2183-98. doi: 10.1084/jem.20140338. Epub 2014 Oct 6.

6.

Noncoding RNA and its associated proteins as regulatory elements of the immune system.

Turner M, Galloway A, Vigorito E.

Nat Immunol. 2014 Jun;15(6):484-91. doi: 10.1038/ni.2887. Review.

PMID:
24840979
7.

miRNA-155 controls mast cell activation by regulating the PI3Kγ pathway and anaphylaxis in a mouse model.

Biethahn K, Orinska Z, Vigorito E, Goyeneche-Patino DA, Mirghomizadeh F, Föger N, Bulfone-Paus S.

Allergy. 2014 Jun;69(6):752-62. doi: 10.1111/all.12407. Epub 2014 Apr 15.

PMID:
24734904
8.

MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.

Mok Y, Schwierzeck V, Thomas DC, Vigorito E, Rayner TF, Jarvis LB, Prosser HM, Bradley A, Withers DR, Mårtensson IL, Corcoran LM, Blenkiron C, Miska EA, Lyons PA, Smith KGC.

J Immunol. 2013 Sep 15;191(6):3037-3048. doi: 10.4049/jimmunol.1301289. Epub 2013 Aug 19.

9.

Macrophage microRNA-155 promotes cardiac hypertrophy and failure.

Heymans S, Corsten MF, Verhesen W, Carai P, van Leeuwen RE, Custers K, Peters T, Hazebroek M, Stöger L, Wijnands E, Janssen BJ, Creemers EE, Pinto YM, Grimm D, Schürmann N, Vigorito E, Thum T, Stassen F, Yin X, Mayr M, de Windt LJ, Lutgens E, Wouters K, de Winther MP, Zacchigna S, Giacca M, van Bilsen M, Papageorgiou AP, Schroen B.

Circulation. 2013 Sep 24;128(13):1420-32. doi: 10.1161/CIRCULATIONAHA.112.001357. Epub 2013 Aug 16.

PMID:
23956210
10.

miR-155: an ancient regulator of the immune system.

Vigorito E, Kohlhaas S, Lu D, Leyland R.

Immunol Rev. 2013 May;253(1):146-57. doi: 10.1111/imr.12057. Review.

PMID:
23550644
11.

Enhanced susceptibility to Citrobacter rodentium infection in microRNA-155-deficient mice.

Clare S, John V, Walker AW, Hill JL, Abreu-Goodger C, Hale C, Goulding D, Lawley TD, Mastroeni P, Frankel G, Enright AJ, Vigorito E, Dougan G.

Infect Immun. 2013 Mar;81(3):723-32. doi: 10.1128/IAI.00969-12. Epub 2012 Dec 21.

12.

Epstein-Barr nuclear antigen 1 induces expression of the cellular microRNA hsa-miR-127 and impairing B-cell differentiation in EBV-infected memory B cells. New insights into the pathogenesis of Burkitt lymphoma.

Onnis A, Navari M, Antonicelli G, Morettini F, Mannucci S, De Falco G, Vigorito E, Leoncini L.

Blood Cancer J. 2012 Aug 31;2:e84. doi: 10.1038/bcj.2012.29.

13.

MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs.

Lu D, Davis MP, Abreu-Goodger C, Wang W, Campos LS, Siede J, Vigorito E, Skarnes WC, Dunham I, Enright AJ, Liu P.

PLoS One. 2012;7(8):e40938. doi: 10.1371/journal.pone.0040938. Epub 2012 Aug 17.

14.

Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs.

Torres AG, Fabani MM, Vigorito E, Williams D, Al-Obaidi N, Wojciechowski F, Hudson RH, Seitz O, Gait MJ.

Nucleic Acids Res. 2012 Mar;40(5):2152-67. doi: 10.1093/nar/gkr885. Epub 2011 Nov 8.

15.

MicroRNA fate upon targeting with anti-miRNA oligonucleotides as revealed by an improved Northern-blot-based method for miRNA detection.

Torres AG, Fabani MM, Vigorito E, Gait MJ.

RNA. 2011 May;17(5):933-43. doi: 10.1261/rna.2533811. Epub 2011 Mar 25.

16.

Efficient inhibition of miR-155 function in vivo by peptide nucleic acids.

Fabani MM, Abreu-Goodger C, Williams D, Lyons PA, Torres AG, Smith KG, Enright AJ, Gait MJ, Vigorito E.

Nucleic Acids Res. 2010 Jul;38(13):4466-75. doi: 10.1093/nar/gkq160. Epub 2010 Mar 11.

17.

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.

Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ.

Nat Immunol. 2010 Mar;11(3):265-72. doi: 10.1038/ni.1843. Epub 2010 Feb 7.

18.

Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation.

Bhavsar PJ, Vigorito E, Turner M, Ridley AJ.

Exp Cell Res. 2009 Nov 15;315(19):3345-58. doi: 10.1016/j.yexcr.2009.08.010. Epub 2009 Aug 26.

PMID:
19715691
19.

Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells.

Kohlhaas S, Garden OA, Scudamore C, Turner M, Okkenhaug K, Vigorito E.

J Immunol. 2009 Mar 1;182(5):2578-82. doi: 10.4049/jimmunol.0803162.

20.

Regulation of B- and T-cell differentiation by a single microRNA.

Turner M, Vigorito E.

Biochem Soc Trans. 2008 Jun;36(Pt 3):531-3. doi: 10.1042/BST0360531.

PMID:
18481999
21.

Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.

Arana E, Vehlow A, Harwood NE, Vigorito E, Henderson R, Turner M, Tybulewicz VL, Batista FD.

Immunity. 2008 Jan;28(1):88-99. doi: 10.1016/j.immuni.2007.12.003.

22.

The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells.

Janas ML, Hodson D, Stamataki Z, Hill S, Welch K, Gambardella L, Trotman LC, Pandolfi PP, Vigorito E, Turner M.

J Immunol. 2008 Jan 15;180(2):739-46.

23.

microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells.

Vigorito E, Perks KL, Abreu-Goodger C, Bunting S, Xiang Z, Kohlhaas S, Das PP, Miska EA, Rodriguez A, Bradley A, Smith KG, Rada C, Enright AJ, Toellner KM, Maclennan IC, Turner M.

Immunity. 2007 Dec;27(6):847-59. Epub 2007 Dec 6.

24.

Requirement of bic/microRNA-155 for normal immune function.

Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, Vetrie D, Okkenhaug K, Enright AJ, Dougan G, Turner M, Bradley A.

Science. 2007 Apr 27;316(5824):608-11.

25.

Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.

Pearce AC, McCarty OJ, Calaminus SD, Vigorito E, Turner M, Watson SP.

Biochem J. 2007 Feb 1;401(3):753-61.

26.

Differential requirements of PI3K subunits for BCR or BCR/CD19-induced ERK activation.

Vigorito E, Turner M.

Adv Exp Med Biol. 2006;584:43-52. No abstract available.

PMID:
16802598
27.

RhoG regulates the neutrophil NADPH oxidase.

Condliffe AM, Webb LM, Ferguson GJ, Davidson K, Turner M, Vigorito E, Manifava M, Chilvers ER, Stephens LR, Hawkins PT.

J Immunol. 2006 May 1;176(9):5314-20.

28.

Synergistic activation of PKD by the B cell antigen receptor and CD19 requires PI3K, Vav1 and PLCgamma.

Vigorito E, Kovesdi D, Turner M.

Cell Signal. 2006 Sep;18(9):1455-60. Epub 2005 Dec 27.

PMID:
16380231
29.

Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization.

Wells CM, Bhavsar PJ, Evans IR, Vigorito E, Turner M, Tybulewicz V, Ridley AJ.

Exp Cell Res. 2005 Nov 1;310(2):303-10. Epub 2005 Aug 31.

PMID:
16137676
30.
31.

Phosphatidylinositol 3-kinase is required for the transcriptional activation of cyclin D2 in BCR activated primary mouse B lymphocytes.

Glassford J, Vigorito E, Soeiro I, Madureira PA, Zoumpoulidou G, Brosens JJ, Turner M, Lam EW.

Eur J Immunol. 2005 Sep;35(9):2748-61.

32.

Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets.

Senis YA, Atkinson BT, Pearce AC, Wonerow P, Auger JM, Okkenhaug K, Pearce W, Vigorito E, Vanhaesebroeck B, Turner M, Watson SP.

Platelets. 2005 May-Jun;16(3-4):191-202.

33.

Vav proteins regulate peripheral B-cell survival.

Vigorito E, Gambardella L, Colucci F, McAdam S, Turner M.

Blood. 2005 Oct 1;106(7):2391-8. Epub 2005 Jun 7.

34.

Vav proteins are required for B-lymphocyte responses to LPS.

Hebeis B, Vigorito E, Kovesdi D, Turner M.

Blood. 2005 Jul 15;106(2):635-40. Epub 2005 Apr 5.

35.

The p110delta subunit of phosphoinositide 3-kinase is required for the lipopolysaccharide response of mouse B cells.

Hebeis BJ, Vigorito E, Turner M.

Biochem Soc Trans. 2004 Nov;32(Pt 5):789-91. Review.

PMID:
15494016
36.

BCR activation of PI3K is Vav-independent in murine B cells.

Vigorito E, Clayton E, Turner M.

Biochem Soc Trans. 2004 Nov;32(Pt 5):781-4.

PMID:
15494014
37.

Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.

Pearce AC, Senis YA, Billadeau DD, Turner M, Watson SP, Vigorito E.

J Biol Chem. 2004 Dec 24;279(52):53955-62. Epub 2004 Sep 27.

38.

Vav-dependent and vav-independent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus.

Vigorito E, Bardi G, Glassford J, Lam EW, Clayton E, Turner M.

J Immunol. 2004 Sep 1;173(5):3209-14.

39.

PLCgamma2 regulates Bcl-2 levels and is required for survival rather than differentiation of marginal zone and follicular B cells.

Bell SE, Vigorito E, McAdam S, Reynolds HM, Caraux A, Colucci F, Turner M.

Eur J Immunol. 2004 Aug;34(8):2237-47.

40.

Immunological function in mice lacking the Rac-related GTPase RhoG.

Vigorito E, Bell S, Hebeis BJ, Reynolds H, McAdam S, Emson PC, McKenzie A, Turner M.

Mol Cell Biol. 2004 Jan;24(2):719-29.

41.

Regulation of Vav localization in membrane rafts by adaptor molecules Grb2 and BLNK.

Johmura S, Oh-hora M, Inabe K, Nishikawa Y, Hayashi K, Vigorito E, Kitamura D, Turner M, Shingu K, Hikida M, Kurosaki T.

Immunity. 2003 Jun;18(6):777-87.

42.

RhoG regulates gene expression and the actin cytoskeleton in lymphocytes.

Vigorito E, Billadeu DD, Savoy D, McAdam S, Doody G, Fort P, Turner M.

Oncogene. 2003 Jan 23;22(3):330-42.

PMID:
12545154
43.

Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C.

Pearce AC, Wilde JI, Doody GM, Best D, Inoue O, Vigorito E, Tybulewicz VL, Turner M, Watson SP.

Blood. 2002 Nov 15;100(10):3561-9.

44.

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation.

Clayton E, Bardi G, Bell SE, Chantry D, Downes CP, Gray A, Humphries LA, Rawlings D, Reynolds H, Vigorito E, Turner M.

J Exp Med. 2002 Sep 16;196(6):753-63.

45.

True anti-anionic phospholipid immunoglobulin M antibodies can exert lupus anticoagulant activity.

Gallart T, Benito C, Reverter JC, Bosch F, Blay M, Tàssies D, Vigorito E, Cervera R, Font J, Gomis R, Campo E, Vives J.

Br J Haematol. 2002 Mar;116(4):875-86.

PMID:
11886395
46.

Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation.

Doody GM, Bell SE, Vigorito E, Clayton E, McAdam S, Tooze R, Fernandez C, Lee IJ, Turner M.

Nat Immunol. 2001 Jun;2(6):542-7.

PMID:
11376342
47.

Association of the cell cycle regulatory proteins p45(SKP2) and CksHs1. Functional effect on CDK2 complex formation and kinase activity.

Mongay L, Plaza S, Vigorito E, Serra-Pagès C, Vives J.

J Biol Chem. 2001 Jul 6;276(27):25030-6. Epub 2001 May 10.

48.

Contributions of p53 and PMA to gamma-irradiation induced apoptosis in Jurkat cells.

Vigorito E, Plaza S, Mir L, Mongay L, Viñas O, Serra-Pagès C, Vives J.

Hematol Cell Ther. 1999 Aug;41(4):153-61.

PMID:
10543370
49.

Relevance of individual CD5 extracellular domains on antibody recognition, glycosylation and co-mitogenic signalling.

Calvo J, Padilla O, Places L, Vigorito E, Vilà JM, Vilella R, Milà J, Vives J, Bowen MA, Lozano F.

Tissue Antigens. 1999 Jul;54(1):16-26.

PMID:
10458319
50.

[125I]IgM (KAU) human monoclonal cold agglutinin: labelling and studies on its biological activity.

Vigorito E, Robles A, Balter H, Nappa A, Goñi F.

Appl Radiat Isot. 1995 Oct;46(10):975-9.

PMID:
7496374

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