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Items: 18

1.

Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model.

Vignaroli G, Iovenitti G, Zamperini C, Coniglio F, Calandro P, Molinari A, Fallacara AL, Sartucci A, Calgani A, Colecchia D, Mancini A, Festuccia C, Dreassi E, Valoti M, Musumeci F, Chiariello M, Angelucci A, Botta M, Schenone S.

J Med Chem. 2017 Jul 27;60(14):6305-6320. doi: 10.1021/acs.jmedchem.7b00637. Epub 2017 Jul 18.

PMID:
28650650
2.

Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells.

Calgani A, Vignaroli G, Zamperini C, Coniglio F, Festuccia C, Di Cesare E, Gravina GL, Mattei C, Vitale F, Schenone S, Botta M, Angelucci A.

Mol Cancer Ther. 2016 Jul;15(7):1535-44. doi: 10.1158/1535-7163.MCT-15-1011. Epub 2016 May 11.

3.

Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery.

Vignaroli G, Calandro P, Zamperini C, Coniglio F, Iovenitti G, Tavanti M, Colecchia D, Dreassi E, Valoti M, Schenone S, Chiariello M, Botta M.

Sci Rep. 2016 Feb 22;6:21509. doi: 10.1038/srep21509.

4.

Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions.

Valensin D, Cau Y, Calandro P, Vignaroli G, Dello Iacono L, Chiariello M, Mori M, Botta M.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):894-898. doi: 10.1016/j.bmcl.2015.12.066. Epub 2015 Dec 21.

PMID:
26774582
5.

Hit Recycling: Discovery of a Potent Carbonic Anhydrase Inhibitor by in Silico Target Fishing.

Mori M, Cau Y, Vignaroli G, Laurenzana I, Caivano A, Vullo D, Supuran CT, Botta M.

ACS Chem Biol. 2015 Sep 18;10(9):1964-9. doi: 10.1021/acschembio.5b00337. Epub 2015 Jul 1.

PMID:
26121309
6.

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors.

Tintori C, La Sala G, Vignaroli G, Botta L, Fallacara AL, Falchi F, Radi M, Zamperini C, Dreassi E, Dello Iacono L, Orioli D, Biamonti G, Garbelli M, Lossani A, Gasparrini F, Tuccinardi T, Laurenzana I, Angelucci A, Maga G, Schenone S, Brullo C, Musumeci F, Desogus A, Crespan E, Botta M.

J Med Chem. 2015 Jun 11;58(11):4590-609. doi: 10.1021/acs.jmedchem.5b00140. Epub 2015 May 20.

PMID:
25923950
7.

Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors.

Vignaroli G, Zamperini C, Dreassi E, Radi M, Angelucci A, Sanità P, Crespan E, Kissova M, Maga G, Schenone S, Musumeci F, Botta M.

ACS Med Chem Lett. 2013 May 20;4(7):622-6. doi: 10.1021/ml4000782. eCollection 2013 Jul 11.

8.

CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction.

Zamperini C, Dreassi E, Vignaroli G, Radi M, Dragoni S, Schenone S, Musumeci F, Valoti M, Antiochia R, Botta M.

Drug Metab Pharmacokinet. 2014;29(6):433-40. doi: 10.2133/dmpk.DMPK-13-RG-094. Epub 2014 May 20.

9.

Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693.

Mori M, Vignaroli G, Cau Y, Dinić J, Hill R, Rossi M, Colecchia D, Pešić M, Link W, Chiariello M, Ottmann C, Botta M.

ChemMedChem. 2014 May;9(5):973-83. doi: 10.1002/cmdc.201400044. Epub 2014 Apr 8.

PMID:
24715717
10.

Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: toward novel allosteric inhibitors of T315I-mutated Abl.

Vignaroli G, Mencarelli M, Sementa D, Crespan E, Kissova M, Maga G, Schenone S, Radi M, Botta M.

ACS Comb Sci. 2014 Apr 14;16(4):168-75. doi: 10.1021/co500004e. Epub 2014 Mar 18.

PMID:
24597676
11.

Small molecules modulation of 14-3-3 protein-protein interactions.

Mori M, Vignaroli G, Botta M.

Drug Discov Today Technol. 2013 Dec;10(4):e541-7. doi: 10.1016/j.ddtec.2012.10.001. Review.

PMID:
24451646
12.

Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands.

Ohnmacht SA, Ciancimino C, Vignaroli G, Gunaratnam M, Neidle S.

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5351-5. doi: 10.1016/j.bmcl.2013.07.057. Epub 2013 Aug 1.

PMID:
23972440
13.

Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant.

Radi M, Tintori C, Musumeci F, Brullo C, Zamperini C, Dreassi E, Fallacara AL, Vignaroli G, Crespan E, Zanoli S, Laurenzana I, Filippi I, Maga G, Schenone S, Angelucci A, Botta M.

J Med Chem. 2013 Jul 11;56(13):5382-94. doi: 10.1021/jm400233w. Epub 2013 Jun 20.

PMID:
23746084
14.

Pharmacokinetic evaluation of almotriptan for the treatment of migraines.

Negro A, Lionetto L, D'Alonzo L, Casolla B, Marsibilio F, Vignaroli G, Simmaco M, Martelletti P.

Expert Opin Drug Metab Toxicol. 2013 May;9(5):637-44. doi: 10.1517/17425255.2013.783012. Epub 2013 Apr 9.

PMID:
23570251
15.

The assessment of particulate matter emitted from stone-crushing industry by correlating rock textures with particles generated after comminution and dispersed in air environment.

Belardi G, Vignaroli G, Plescia P, Passeri L.

Environ Sci Pollut Res Int. 2013 Jul;20(7):4711-28. doi: 10.1007/s11356-012-1434-7. Epub 2013 Jan 5.

PMID:
23292201
16.

Deciphering the task of N-acetyl aspartate in migraine.

Lionetto L, Capi M, Vignaroli G, Negro A, Martelletti P.

Expert Rev Neurother. 2012 Sep;12(9):1057-9. doi: 10.1586/ern.12.97.

PMID:
23039385
17.

Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3σ case.

Corradi V, Mancini M, Santucci MA, Carlomagno T, Sanfelice D, Mori M, Vignaroli G, Falchi F, Manetti F, Radi M, Botta M.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6867-71. doi: 10.1016/j.bmcl.2011.09.011. Epub 2011 Sep 10.

PMID:
21962576
18.

A versatile and practical synthesis toward the development of novel HIV-1 integrase inhibitors.

Rinaldi M, Tintori C, Franchi L, Vignaroli G, Innitzer A, Massa S, Esté JA, Gonzalo E, Christ F, Debyser Z, Botta M.

ChemMedChem. 2011 Feb 7;6(2):343-52. doi: 10.1002/cmdc.201000510. Epub 2011 Jan 18.

PMID:
21246739

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