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Items: 1 to 50 of 181

1.

Polyclonal Campylobacter fetus infections among unrelated patients, Montevideo, Uruguay, 2013-2018.

Costa D, Betancor L, Gadea P, Cabezas L, Caiata L, Palacio R, Seija V, Galiana A, Vieytes M, Cristophersen I, Calleros L, Iraola G.

Clin Infect Dis. 2019 Jul 15. pii: ciz657. doi: 10.1093/cid/ciz657. [Epub ahead of print]

PMID:
31309972
2.

Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin.

Abal P, Louzao MC, Vilariño N, Vieytes MR, Botana LM.

Toxins (Basel). 2019 May 29;11(6). pii: E305. doi: 10.3390/toxins11060305.

3.

Detoxification agents based on magnetic nanostructured particles as a novel strategy for mycotoxin mitigation in food.

González-Jartín JM, de Castro Alves L, Alfonso A, Piñeiro Y, Vilar SY, Gomez MG, Osorio ZV, Sainz MJ, Vieytes MR, Rivas J, Botana LM.

Food Chem. 2019 Oct 1;294:60-66. doi: 10.1016/j.foodchem.2019.05.013. Epub 2019 May 3.

PMID:
31126505
4.

A QuEChERS based extraction procedure coupled to UPLC-MS/MS detection for mycotoxins analysis in beer.

González-Jartín JM, Alfonso A, Rodríguez I, Sainz MJ, Vieytes MR, Botana LM.

Food Chem. 2019 Mar 1;275:703-710. doi: 10.1016/j.foodchem.2018.09.162. Epub 2018 Sep 27.

PMID:
30724252
5.

First report of Fusarium foetens as a mycotoxin producer.

González-Jartín JM, Alfonso A, Sainz MJ, Vieytes MR, Aguín O, Ferreiroa V, Botana LM.

Mycotoxin Res. 2019 May;35(2):177-186. doi: 10.1007/s12550-019-00341-3. Epub 2019 Jan 31.

PMID:
30706436
6.

Toxic Action Reevaluation of Okadaic Acid, Dinophysistoxin-1 and Dinophysistoxin-2: Toxicity Equivalency Factors Based on the Oral Toxicity Study.

Abal P, Louzao MC, Suzuki T, Watanabe R, Vilariño N, Carrera C, Botana AM, Vieytes MR, Botana LM.

Cell Physiol Biochem. 2018;49(2):743-757. doi: 10.1159/000493039. Epub 2018 Sep 3.

7.

Human Poisoning from Marine Toxins: Unknowns for Optimal Consumer Protection.

Vilariño N, Louzao MC, Abal P, Cagide E, Carrera C, Vieytes MR, Botana LM.

Toxins (Basel). 2018 Aug 9;10(8). pii: E324. doi: 10.3390/toxins10080324. Review.

8.

A single run UPLC-MS/MS method for detection of all EU-regulated marine toxins.

Rodríguez I, Alfonso A, González-Jartín JM, Vieytes MR, Botana LM.

Talanta. 2018 Nov 1;189:622-628. doi: 10.1016/j.talanta.2018.07.050. Epub 2018 Jul 18.

PMID:
30086968
9.

Transcriptomic Analysis of Ciguatoxin-Induced Changes in Gene Expression in Primary Cultures of Mice Cortical Neurons.

Rubiolo JA, Vale C, Boente-Juncal A, Hirama M, Yamashita S, Camiña M, Vieytes MR, Botana LM.

Toxins (Basel). 2018 May 10;10(5). pii: E192. doi: 10.3390/toxins10050192.

10.

In Vitro Effects of Chronic Spirolide Treatment on Human Neuronal Stem Cell Differentiation and Cholinergic System Development.

Boente-Juncal A, Méndez AG, Vale C, Vieytes MR, Botana LM.

ACS Chem Neurosci. 2018 Jun 20;9(6):1441-1452. doi: 10.1021/acschemneuro.8b00036. Epub 2018 Mar 14.

PMID:
29518322
11.

The impact of depuration on mussel hepatopancreas bacteriome composition and predicted metagenome.

Rubiolo JA, Lozano-Leon A, Rodriguez-Souto R, Fol Rodríguez N, Vieytes MR, Botana LM.

Antonie Van Leeuwenhoek. 2018 Jul;111(7):1117-1129. doi: 10.1007/s10482-018-1015-y. Epub 2018 Jan 17.

PMID:
29340947
12.

Detection of new emerging type-A trichothecenes by untargeted mass spectrometry.

González-Jartín JM, Alfonso A, Sainz MJ, Vieytes MR, Botana LM.

Talanta. 2018 Feb 1;178:37-42. doi: 10.1016/j.talanta.2017.09.009. Epub 2017 Sep 6.

PMID:
29136836
13.

Absorption and Effect of Azaspiracid-1 Over the Human Intestinal Barrier.

Abal P, Louzao MC, Fraga M, Vilariño N, Ferreiro S, Vieytes MR, Botana LM.

Cell Physiol Biochem. 2017;43(1):136-146. doi: 10.1159/000480331. Epub 2017 Aug 28.

14.

UPLC-MS-IT-TOF Identification of Circumdatins Produced by Aspergillus ochraceus.

González-Jartı N JM, Alfonso A, Sainz MJ, Vieytes MR, Botana LM.

J Agric Food Chem. 2017 Jun 14;65(23):4843-4852. doi: 10.1021/acs.jafc.7b01845. Epub 2017 Jun 5.

PMID:
28535676
15.

The Marine Guanidine Alkaloid Crambescidin 816 Induces Calcium Influx and Cytotoxicity in Primary Cultures of Cortical Neurons through Glutamate Receptors.

Mendez AG, Juncal AB, Silva SBL, Thomas OP, Martín Vázquez V, Alfonso A, Vieytes MR, Vale C, Botana LM.

ACS Chem Neurosci. 2017 Jul 19;8(7):1609-1617. doi: 10.1021/acschemneuro.7b00096. Epub 2017 Apr 24.

PMID:
28375602
16.

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL).

Abal P, Louzao MC, Antelo A, Alvarez M, Cagide E, Vilariño N, Vieytes MR, Botana LM.

Toxins (Basel). 2017 Feb 24;9(3). pii: E75. doi: 10.3390/toxins9030075.

17.

Characterization of the dinophysistoxin-2 acute oral toxicity in mice to define the Toxicity Equivalency Factor.

Abal P, Louzao MC, Cifuentes JM, Vilariño N, Rodriguez I, Alfonso A, Vieytes MR, Botana LM.

Food Chem Toxicol. 2017 Apr;102:166-175. doi: 10.1016/j.fct.2017.02.023. Epub 2017 Feb 20.

PMID:
28223118
18.

How Safe Is Safe for Marine Toxins Monitoring?

Botana LM, Alfonso A, Rodríguez I, Botana AM, Louzao Mdel C, Vieytes MR.

Toxins (Basel). 2016 Jul 6;8(7). pii: E208. doi: 10.3390/toxins8070208.

19.

Cytotoxicity of goniodomin A and B in non contractile cells.

Espiña B, Cagide E, Louzao MC, Vilariño N, Vieytes MR, Takeda Y, Sasaki M, Botana LM.

Toxicol Lett. 2016 May 27;250-251:10-20. doi: 10.1016/j.toxlet.2016.04.001. Epub 2016 Apr 2.

PMID:
27050798
20.

Yessotoxin, a Promising Therapeutic Tool.

Alfonso A, Vieytes MR, Botana LM.

Mar Drugs. 2016 Jan 28;14(2). pii: E30. doi: 10.3390/md14020030. Review.

21.

Study of Adsorption and Flocculation Properties of Natural Clays to Remove Prorocentrum lima.

Louzao MC, Abal P, Fernández DA, Vieytes MR, Legido JL, Gómez CP, Pais J, Botana LM.

Toxins (Basel). 2015 Sep 29;7(10):3977-88. doi: 10.3390/toxins7103977.

22.

Crambescin C1 Exerts a Cytoprotective Effect on HepG2 Cells through Metallothionein Induction.

Roel M, Rubiolo JA, Ternon E, Thomas OP, Vieytes MR, Botana LM.

Mar Drugs. 2015 Jul 27;13(8):4633-53. doi: 10.3390/md13084633.

23.

Different toxic effects of YTX in tumor K-562 and lymphoblastoid cell lines.

Fernández-Araujo A, Sánchez JA, Alfonso A, Vieytes MR, Botana LM.

Front Pharmacol. 2015 Jun 17;6:124. doi: 10.3389/fphar.2015.00124. eCollection 2015.

24.

Diarrhetic effect of okadaic acid could be related with its neuronal action: Changes in neuropeptide Y.

Louzao MC, Fernández DA, Abal P, Fraga M, Vilariño N, Vieytes MR, Botana LM.

Toxicol Lett. 2015 Sep 2;237(2):151-60. doi: 10.1016/j.toxlet.2015.06.004. Epub 2015 Jun 15.

PMID:
26086426
25.

Yessotoxin activates cell death pathways independent of Protein Kinase C in K-562 human leukemic cell line.

Fernández-Araujo A, Alfonso A, Vieytes MR, Botana LM.

Toxicol In Vitro. 2015 Oct;29(7):1545-54. doi: 10.1016/j.tiv.2015.05.013. Epub 2015 May 27.

PMID:
26025416
26.

Chronic ciguatoxin treatment induces synaptic scaling through voltage gated sodium channels in cortical neurons.

Martín V, Vale C, Rubiolo JA, Roel M, Hirama M, Yamashita S, Vieytes MR, Botana LM.

Chem Res Toxicol. 2015 Jun 15;28(6):1109-19. doi: 10.1021/tx500506q. Epub 2015 May 19.

PMID:
25945544
27.

Synthetic ciguatoxin CTX 3C induces a rapid imbalance in neuronal excitability.

Martín V, Vale C, Hirama M, Yamashita S, Rubiolo JA, Vieytes MR, Botana LM.

Chem Res Toxicol. 2015 Jun 15;28(6):1095-108. doi: 10.1021/tx500503d. Epub 2015 May 19.

PMID:
25945403
28.

Key role of phosphodiesterase 4A (PDE4A) in autophagy triggered by yessotoxin.

Fernández-Araujo A, Alfonso A, Vieytes MR, Botana LM.

Toxicology. 2015 Mar 2;329:60-72. doi: 10.1016/j.tox.2015.01.004. Epub 2015 Jan 7.

29.

Evaluation of toxicity equivalent factors of paralytic shellfish poisoning toxins in seven human sodium channels types by an automated high throughput electrophysiology system.

Alonso E, Alfonso A, Vieytes MR, Botana LM.

Arch Toxicol. 2016 Feb;90(2):479-88. doi: 10.1007/s00204-014-1444-y. Epub 2015 Jan 9.

PMID:
25572188
30.

Hapalindoles from the cyanobacterium fischerella: potential sodium channel modulators.

Cagide E, Becher PG, Louzao MC, Espiña B, Vieytes MR, Jüttner F, Botana LM.

Chem Res Toxicol. 2014 Oct 20;27(10):1696-706. doi: 10.1021/tx500188a. Epub 2014 Oct 6.

PMID:
25285689
31.

Evaluation of the intestinal permeability and cytotoxic effects of cylindrospermopsin.

Fernández DA, Louzao MC, Vilariño N, Fraga M, Espiña B, Vieytes MR, Botana LM.

Toxicon. 2014 Dec;91:23-34. doi: 10.1016/j.toxicon.2014.08.072. Epub 2014 Aug 30.

PMID:
25181460
32.

Differential effects of ciguatoxin and maitotoxin in primary cultures of cortical neurons.

Martin V, Vale C, Antelo A, Hirama M, Yamashita S, Vieytes MR, Botana LM.

Chem Res Toxicol. 2014 Aug 18;27(8):1387-400. doi: 10.1021/tx5000969. Epub 2014 Jul 15.

PMID:
24999537
33.

Yessotoxin induces ER-stress followed by autophagic cell death in glioma cells mediated by mTOR and BNIP3.

Rubiolo JA, López-Alonso H, Martínez P, Millán A, Cagide E, Vieytes MR, Vega FV, Botana LM.

Cell Signal. 2014 Feb;26(2):419-32.

PMID:
24511615
34.

Detection of anatoxin-a and three analogs in Anabaena spp. cultures: new fluorescence polarization assay and toxin profile by LC-MS/MS.

Sanchez JA, Otero P, Alfonso A, Ramos V, Vasconcelos V, Aráoz R, Molgó J, Vieytes MR, Botana LM.

Toxins (Basel). 2014 Jan 24;6(2):402-15. doi: 10.3390/toxins6020402.

35.

Experimental basis for the high oral toxicity of dinophysistoxin 1: a comparative study of DSP.

Fernández DA, Louzao MC, Fraga M, Vilariño N, Vieytes MR, Botana LM.

Toxins (Basel). 2014 Jan 3;6(1):211-28. doi: 10.3390/toxins6010211.

36.

Surface plasmon resonance biosensor method for palytoxin detection based on Na+,K+-ATPase affinity.

Alfonso A, Pazos MJ, Fernández-Araujo A, Tobio A, Alfonso C, Vieytes MR, Botana LM.

Toxins (Basel). 2013 Dec 27;6(1):96-107. doi: 10.3390/toxins6010096.

37.

Mechanism of cytotoxic action of crambescidin-816 on human liver-derived tumour cells.

Rubiolo JA, López-Alonso H, Roel M, Vieytes MR, Thomas O, Ternon E, Vega FV, Botana LM.

Br J Pharmacol. 2014 Apr;171(7):1655-67. doi: 10.1111/bph.12552.

38.

Oral toxicity of okadaic acid in mice: study of lethality, organ damage, distribution and effects on detoxifying gene expression.

Vieira AC, Rubiolo JA, López-Alonso H, Cifuentes JM, Alfonso A, Bermúdez R, Otero P, Vieytes MR, Vega FV, Botana LM.

Toxins (Basel). 2013 Nov 8;5(11):2093-108. doi: 10.3390/toxins5112093.

39.

Crambescidin-816 acts as a fungicidal with more potency than crambescidin-800 and -830, inducing cell cycle arrest, increased cell size and apoptosis in Saccharomyces cerevisiae.

Rubiolo JA, Ternon E, López-Alonso H, Thomas OP, Vega FV, Vieytes MR, Botana LM.

Mar Drugs. 2013 Nov 8;11(11):4419-34. doi: 10.3390/md11114419.

40.

The kinetic, mechanistic and cytomorphological effects of palytoxin in human intestinal cells (Caco-2) explain its lower-than-parenteral oral toxicity.

Fernández DA, Louzao MC, Vilariño N, Espiña B, Fraga M, Vieytes MR, Román A, Poli M, Botana LM.

FEBS J. 2013 Aug;280(16):3906-19. doi: 10.1111/febs.12390. Epub 2013 Jul 5.

41.

Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology.

Alonso E, Vale C, Vieytes MR, Botana LM.

ACS Chem Neurosci. 2013 Jul 17;4(7):1062-70. doi: 10.1021/cn400018y. Epub 2013 Apr 8.

42.

Protein synthesis inhibition and oxidative stress induced by cylindrospermopsin elicit apoptosis in primary rat hepatocytes.

López-Alonso H, Rubiolo JA, Vega F, Vieytes MR, Botana LM.

Chem Res Toxicol. 2013 Feb 18;26(2):203-12. doi: 10.1021/tx3003438. Epub 2013 Jan 15.

PMID:
23270326
43.

Differential effects of crambescins and crambescidin 816 in voltage-gated sodium, potassium and calcium channels in neurons.

Martín V, Vale C, Bondu S, Thomas OP, Vieytes MR, Botana LM.

Chem Res Toxicol. 2013 Jan 18;26(1):169-78. doi: 10.1021/tx3004483. Epub 2013 Jan 9.

PMID:
23270282
44.

Bioengineered protein phosphatase 2A: update on need.

Rubiolo JA, López-Alonso H, Alfonso A, Vega FV, Vieytes MR, Botana LM.

Bioengineered. 2013 Mar-Apr;4(2):72-7. doi: 10.4161/bioe.22461. Epub 2012 Oct 23.

45.

Resveratrol inhibits proliferation of primary rat hepatocytes in G0/G1 by inhibiting DNA synthesis.

Rubiolo JA, López-Alonso H, Martín-Vázquez V, Fol-Rodríguéz NM, Vieytes MR, Botana LM, Vega FV.

Folia Biol (Praha). 2012;58(4):166-72.

46.

Effect of gambierol and its tetracyclic and heptacyclic analogues in cultured cerebellar neurons: a structure-activity relationships study.

Pérez S, Vale C, Alonso E, Fuwa H, Sasaki M, Konno Y, Goto T, Suga Y, Vieytes MR, Botana LM.

Chem Res Toxicol. 2012 Sep 17;25(9):1929-37. doi: 10.1021/tx300242m. Epub 2012 Aug 29.

PMID:
22894724
47.

Characterization and activity determination of the human protein phosphatase 2A catalytic subunit α expressed in insect larvae.

Rubiolo JA, López-Alonso H, Alfonso A, Vega FV, Vieytes MR, Botana LM.

Appl Biochem Biotechnol. 2012 Jun;167(4):918-28. doi: 10.1007/s12010-012-9737-1. Epub 2012 May 26.

PMID:
22639363
48.

Detection of paralytic shellfish toxins by a solid-phase inhibition immunoassay using a microsphere-flow cytometry system.

Fraga M, Vilariño N, Louzao MC, Campbell K, Elliott CT, Kawatsu K, Vieytes MR, Botana LM.

Anal Chem. 2012 May 15;84(10):4350-6. doi: 10.1021/ac203449f. Epub 2012 Apr 26.

PMID:
22500610
49.

Design and synthesis of skeletal analogues of gambierol: attenuation of amyloid-β and tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications.

Alonso E, Fuwa H, Vale C, Suga Y, Goto T, Konno Y, Sasaki M, LaFerla FM, Vieytes MR, Giménez-Llort L, Botana LM.

J Am Chem Soc. 2012 May 2;134(17):7467-79. doi: 10.1021/ja300565t. Epub 2012 Apr 18.

PMID:
22475455
50.

Palytoxin detection and quantification using the fluorescence polarization technique.

Alfonso A, Fernández-Araujo A, Alfonso C, Caramés B, Tobio A, Louzao MC, Vieytes MR, Botana LM.

Anal Biochem. 2012 May 1;424(1):64-70. doi: 10.1016/j.ab.2012.02.014. Epub 2012 Feb 25.

PMID:
22370274

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