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Items: 1 to 50 of 57


Host-derived fecal microRNAs can indicate gut microbiota healthiness and ability to induce inflammation.

Viennois E, Chassaing B, Tahsin A, Pujada A, Wang L, Gewirtz AT, Merlin D.

Theranostics. 2019 Jun 9;9(15):4542-4557. doi: 10.7150/thno.35282. eCollection 2019.


Chronic Inflammatory Diseases: Are We Ready for Microbiota-based Dietary Intervention?

Viennois E, Gewirtz AT, Chassaing B.

Cell Mol Gastroenterol Hepatol. 2019;8(1):61-71. doi: 10.1016/j.jcmgh.2019.02.008. Epub 2019 Mar 2. Review.


Early-Life Microbiota Exposure Restricts Myeloid-Derived Suppressor Cell-Driven Colonic Tumorigenesis.

Harusato A, Viennois E, Etienne-Mesmin L, Matsuyama S, Abo H, Osuka S, Lukacs NW, Naito Y, Itoh Y, Li JD, Merlin D, Gewirtz AT, Denning TL.

Cancer Immunol Res. 2019 Apr;7(4):544-551. doi: 10.1158/2326-6066.CIR-18-0444. Epub 2019 Feb 19.


Overexpression of CD98 in intestinal epithelium dysregulates miRNAs and their targeted proteins along the ileal villus-crypt axis.

Han MK, Baker M, Zhang Y, Yang C, Zhang M, Garg P, Viennois E, Merlin D.

Sci Rep. 2018 Nov 1;8(1):16220. doi: 10.1038/s41598-018-34474-9.


Purification of Total RNA from DSS-treated Murine Tissue via Lithium Chloride Precipitation.

Viennois E, Tahsin A, Merlin D.

Bio Protoc. 2018 May 5;8(9). pii: e2829. doi: 10.21769/BioProtoc.2829.


Silencing of Intestinal Glycoprotein CD98 by Orally Targeted Nanoparticles Enhances Chemosensitization of Colon Cancer.

Xiao B, Viennois E, Chen Q, Wang L, Han MK, Zhang Y, Zhang Z, Kang Y, Wan Y, Merlin D.

ACS Nano. 2018 Jun 26;12(6):5253-5265. doi: 10.1021/acsnano.7b08499. Epub 2018 Jun 8.


Function, Regulation, and Pathophysiological Relevance of the POT Superfamily, Specifically PepT1 in Inflammatory Bowel Disease.

Viennois E, Pujada A, Zen J, Merlin D.

Compr Physiol. 2018 Mar 25;8(2):731-760. doi: 10.1002/cphy.c170032. Review.


First victim, later aggressor: How the intestinal microbiota drives the pro-inflammatory effects of dietary emulsifiers?

Viennois E, Chassaing B.

Gut Microbes. 2018 Feb 13:1-4. doi: 10.1080/19490976.2017.1421885. [Epub ahead of print]


Protein secondary structure analysis of dried blood serum using infrared spectroscopy to identify markers for colitis screening.

Titus J, Ghimire H, Viennois E, Merlin D, Unil Perera AG.

J Biophotonics. 2018 Mar;11(3). doi: 10.1002/jbio.201700057. Epub 2017 Sep 12.


Serum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans.

Viennois E, Zhao Y, Han MK, Xiao B, Zhang M, Prasad M, Wang L, Merlin D.

Sci Rep. 2017 May 31;7(1):2520. doi: 10.1038/s41598-017-02782-1.


Ectopic Expression of Innate Immune Protein, Lipocalin-2, in Lactococcus lactis Protects Against Gut and Environmental Stressors.

Saha P, Chassaing B, Yeoh BS, Viennois E, Xiao X, Kennett MJ, Singh V, Vijay-Kumar M.

Inflamm Bowel Dis. 2017 Jul;23(7):1120-1132. doi: 10.1097/MIB.0000000000001134.


MiRNA Quantitation with Microelectrode Sensors Enabled by Enzymeless Electrochemical Signal Amplification.

Wang T, Wang G, Merlin D, Viennois E.

Methods Mol Biol. 2017;1580:249-263. doi: 10.1007/978-1-4939-6866-4_17.


Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis.

Xiao B, Xu Z, Viennois E, Zhang Y, Zhang Z, Zhang M, Han MK, Kang Y, Merlin D.

Mol Ther. 2017 Jul 5;25(7):1628-1640. doi: 10.1016/j.ymthe.2016.11.020. Epub 2017 Jan 28.


Combination Therapy for Ulcerative Colitis: Orally Targeted Nanoparticles Prevent Mucosal Damage and Relieve Inflammation.

Xiao B, Zhang Z, Viennois E, Kang Y, Zhang M, Han MK, Chen J, Merlin D.

Theranostics. 2016 Sep 25;6(12):2250-2266. eCollection 2016.


Dietary Emulsifier-Induced Low-Grade Inflammation Promotes Colon Carcinogenesis.

Viennois E, Merlin D, Gewirtz AT, Chassaing B.

Cancer Res. 2017 Jan 1;77(1):27-40. doi: 10.1158/0008-5472.CAN-16-1359. Epub 2016 Nov 7.


A Hyaluronidase-Responsive Nanoparticle-Based Drug Delivery System for Targeting Colon Cancer Cells.

Zhang M, Xu C, Wen L, Han MK, Xiao B, Zhou J, Zhang Y, Zhang Z, Viennois E, Merlin D.

Cancer Res. 2016 Dec 15;76(24):7208-7218. Epub 2016 Oct 14.


Edible Ginger-derived Nano-lipids Loaded with Doxorubicin as a Novel Drug-delivery Approach for Colon Cancer Therapy.

Zhang M, Xiao B, Wang H, Han MK, Zhang Z, Viennois E, Xu C, Merlin D.

Mol Ther. 2016 Oct;24(10):1783-1796. doi: 10.1038/mt.2016.159. Epub 2016 Aug 5.


Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model.

Viennois E, Ingersoll SA, Ayyadurai S, Zhao Y, Wang L, Zhang M, Han MK, Garg P, Xiao B, Merlin D.

Cell Mol Gastroenterol Hepatol. 2016 May;2(3):340-357.


Plant derived edible nanoparticles as a new therapeutic approach against diseases.

Zhang M, Viennois E, Xu C, Merlin D.

Tissue Barriers. 2016 Feb 11;4(2):e1134415. doi: 10.1080/21688370.2015.1134415. eCollection 2016 Apr-Jun. Review.


Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer.

Zhang M, Viennois E, Prasad M, Zhang Y, Wang L, Zhang Z, Han MK, Xiao B, Xu C, Srinivasan S, Merlin D.

Biomaterials. 2016 Sep;101:321-40. doi: 10.1016/j.biomaterials.2016.06.018. Epub 2016 Jun 9.


PepT1 Expression Helps Maintain Intestinal Homeostasis by Mediating the Differential Expression of miRNAs along the Crypt-Villus Axis.

Zhang Y, Viennois E, Zhang M, Xiao B, Han MK, Walter L, Garg P, Merlin D.

Sci Rep. 2016 Jun 1;6:27119. doi: 10.1038/srep27119.


Minimally invasive screening for colitis using attenuated total internal reflectance fourier transform infrared spectroscopy.

Titus J, Viennois E, Merlin D, Unil Perera AG.

J Biophotonics. 2017 Mar;10(3):465-472. doi: 10.1002/jbio.201600041. Epub 2016 Apr 20.


Urocanic acid-modified chitosan nanoparticles can confer anti-inflammatory effect by delivering CD98 siRNA to macrophages.

Xiao B, Ma P, Viennois E, Merlin D.

Colloids Surf B Biointerfaces. 2016 Jul 1;143:186-193. doi: 10.1016/j.colsurfb.2016.03.035. Epub 2016 Mar 14.


Co-delivery of camptothecin and curcumin by cationic polymeric nanoparticles for synergistic colon cancer combination chemotherapy.

Xiao B, Si X, Han MK, Viennois E, Zhang M, Merlin D.

J Mater Chem B. 2015 Oct 21;3(39):7724-7733. Epub 2015 Sep 1.


Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy.

Xiao B, Han MK, Viennois E, Wang L, Zhang M, Si X, Merlin D.

Nanoscale. 2015 Nov 14;7(42):17745-55. doi: 10.1039/c5nr04831a. Epub 2015 Oct 12.


Identification of the Functions of Liver X Receptor-β in Sertoli Cells Using a Targeted Expression-Rescue Model.

Maqdasy S, El Hajjaji FZ, Baptissart M, Viennois E, Oumeddour A, Brugnon F, Trousson A, Tauveron I, Volle D, Lobaccaro JM, Baron S.

Endocrinology. 2015 Dec;156(12):4545-57. doi: 10.1210/en.2015-1382. Epub 2015 Sep 24.


Proceedings of the Second Shanthi V. Sitaraman Intestinal Pathobiology Symposium.

Etienne-Mesmin L, Wang T, Viennois E, Chassaing B, Gewirtz AT, Merlin D.

Inflamm Bowel Dis. 2015 Aug;21(8):1942-7. doi: 10.1097/MIB.0000000000000528.


Microelectrode miRNA sensors enabled by enzymeless electrochemical signal amplification.

Wang T, Viennois E, Merlin D, Wang G.

Anal Chem. 2015 Aug 18;87(16):8173-80. doi: 10.1021/acs.analchem.5b00780. Epub 2015 Aug 4.


Granulocyte-Macrophage Colony-Stimulating Factor-Activated Monocytes as an Anti-inflammatory Player in the Intestine.

Viennois E, Merlin D.

Cell Mol Gastroenterol Hepatol. 2015 Jun 4;1(4):354-355. doi: 10.1016/j.jcmgh.2015.05.002. eCollection 2015 Jul. No abstract available.


Biomarkers of Inflammatory Bowel Disease: From Classical Laboratory Tools to Personalized Medicine.

Viennois E, Zhao Y, Merlin D.

Inflamm Bowel Dis. 2015 Oct;21(10):2467-74. doi: 10.1097/MIB.0000000000000444. Review.


Inhibition of MDR1 gene expression and enhancing cellular uptake for effective colon cancer treatment using dual-surface-functionalized nanoparticles.

Xiao B, Zhang M, Viennois E, Zhang Y, Wei N, Baker MT, Jung Y, Merlin D.

Biomaterials. 2015 Apr;48:147-60. doi: 10.1016/j.biomaterials.2015.01.014. Epub 2015 Feb 11.


A click-and-release approach to CO prodrugs.

Wang D, Viennois E, Ji K, Damera K, Draganov A, Zheng Y, Dai C, Merlin D, Wang B.

Chem Commun (Camb). 2014 Dec 28;50(100):15890-3. doi: 10.1039/c4cc07748b.


Longitudinal study of circulating protein biomarkers in inflammatory bowel disease.

Viennois E, Baker MT, Xiao B, Wang L, Laroui H, Merlin D.

J Proteomics. 2015 Jan 1;112:166-79. doi: 10.1016/j.jprot.2014.09.002. Epub 2014 Sep 16.


Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer.

Viennois E, Xiao B, Ayyadurai S, Wang L, Wang PG, Zhang Q, Chen Y, Merlin D.

Lab Invest. 2014 Sep;94(9):950-65. doi: 10.1038/labinvest.2014.89. Epub 2014 Jul 28.


Fab'-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis.

Laroui H, Viennois E, Xiao B, Canup BS, Geem D, Denning TL, Merlin D.

J Control Release. 2014 Jul 28;186:41-53. doi: 10.1016/j.jconrel.2014.04.046. Epub 2014 May 5.


Glycoprotein CD98 as a receptor for colitis-targeted delivery of nanoparticle.

Xiao B, Yang Y, Viennois E, Zhang Y, Ayyadurai S, Baker M, Laroui H, Merlin D.

J Mater Chem B. 2014 Mar 21;2(11):1499-1508.


Colonic miRNA expression/secretion, regulated by intestinal epithelial PepT1, plays an important role in cell-to-cell communication during colitis.

Ayyadurai S, Charania MA, Xiao B, Viennois E, Zhang Y, Merlin D.

PLoS One. 2014 Feb 19;9(2):e87614. doi: 10.1371/journal.pone.0087614. eCollection 2014.


Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice.

Xiao B, Laroui H, Viennois E, Ayyadurai S, Charania MA, Zhang Y, Zhang Z, Baker MT, Zhang B, Gewirtz AT, Merlin D.

Gastroenterology. 2014 May;146(5):1289-300.e1-19. doi: 10.1053/j.gastro.2014.01.056. Epub 2014 Feb 4.


Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology.

Oumeddour A, Viennois E, Caira F, Decourbey C, Maqdasy S, Tahraoui A, Baron S, Volle DH, Lobaccaro JM.

Biochem Biophys Res Commun. 2014 Apr 11;446(3):656-62. doi: 10.1016/j.bbrc.2013.12.005. Epub 2013 Dec 11.


Targeting intestinal inflammation with CD98 siRNA/PEI-loaded nanoparticles.

Laroui H, Geem D, Xiao B, Viennois E, Rakhya P, Denning T, Merlin D.

Mol Ther. 2014 Jan;22(1):69-80. doi: 10.1038/mt.2013.214. Epub 2013 Sep 12.


Oxysterol receptors and their therapeutic applications in cancer conditions.

De Boussac H, Alioui A, Viennois E, Dufour J, Trousson A, Vega A, Guy L, Volle DH, Lobaccaro JM, Baron S.

Expert Opin Ther Targets. 2013 Sep;17(9):1029-38. doi: 10.1517/14728222.2013.820708. Epub 2013 Jul 22. Review.


Mannosylated bioreducible nanoparticle-mediated macrophage-specific TNF-α RNA interference for IBD therapy.

Xiao B, Laroui H, Ayyadurai S, Viennois E, Charania MA, Zhang Y, Merlin D.

Biomaterials. 2013 Oct;34(30):7471-82. doi: 10.1016/j.biomaterials.2013.06.008. Epub 2013 Jun 29.


PepT1 expressed in immune cells has an important role in promoting the immune response during experimentally induced colitis.

Ayyadurai S, Charania MA, Xiao B, Viennois E, Merlin D.

Lab Invest. 2013 Aug;93(8):888-99. doi: 10.1038/labinvest.2013.77. Epub 2013 Jun 24.


Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.

Pommier AJ, Dufour J, Alves G, Viennois E, De Boussac H, Trousson A, Volle DH, Caira F, Val P, Arnaud P, Lobaccaro JM, Baron S.

PLoS Genet. 2013 May;9(5):e1003483. doi: 10.1371/journal.pgen.1003483. Epub 2013 May 9.


Nanotechnology in diagnostics and therapeutics for gastrointestinal disorders.

Laroui H, Rakhya P, Xiao B, Viennois E, Merlin D.

Dig Liver Dis. 2013 Dec;45(12):995-1002. doi: 10.1016/j.dld.2013.03.019. Epub 2013 May 7. Review.


NF-κB pathway in colitis-associated cancers.

Viennois E, Chen F, Merlin D.

Transl Gastrointest Cancer. 2013 Jan 1;2(1):21-29.


Knockout of Ste20-like proline/alanine-rich kinase (SPAK) attenuates intestinal inflammation in mice.

Zhang Y, Viennois E, Xiao B, Baker MT, Yang S, Okoro I, Yan Y.

Am J Pathol. 2013 May;182(5):1617-28. doi: 10.1016/j.ajpath.2013.01.028. Epub 2013 Mar 13.


Intestinal epithelial CD98 directly modulates the innate host response to enteric bacterial pathogens.

Charania MA, Laroui H, Liu H, Viennois E, Ayyadurai S, Xiao B, Ingersoll SA, Kalman D, Merlin D.

Infect Immun. 2013 Mar;81(3):923-34. doi: 10.1128/IAI.01388-12. Epub 2013 Jan 7.


Oxysterol receptors, AKT and prostate cancer.

Dufour J, Viennois E, De Boussac H, Baron S, Lobaccaro JM.

Curr Opin Pharmacol. 2012 Dec;12(6):724-8. doi: 10.1016/j.coph.2012.06.012. Epub 2012 Jul 19. Review.


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