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BD-2 and BD-3 increase skin flap survival in a model of ischemia and Pseudomonas aeruginosa infection.

Casal D, Iria I, Ramalho JS, Alves S, Mota-Silva E, Mascarenhas-Lemos L, Pontinha C, Guadalupe-Cabral M, Ferreira-Silva J, Ferraz-Oliveira M, Vassilenko V, Goyri-O'Neill J, Pais D, Videira PA.

Sci Rep. 2019 May 27;9(1):7854. doi: 10.1038/s41598-019-44153-y.


CDG and immune response: From bedside to bench and back.

Pascoal C, Francisco R, Ferro T, Dos Reis Ferreira V, Jaeken J, Videira PA.

J Inherit Metab Dis. 2019 May 16. doi: 10.1002/jimd.12126. [Epub ahead of print] Review.


Patient and observer reported outcome measures to evaluate health-related quality of life in inherited metabolic diseases: a scoping review.

Pascoal C, Brasil S, Francisco R, Marques-da-Silva D, Rafalko A, Jaeken J, Videira PA, Barros L, Dos Reis Ferreira V.

Orphanet J Rare Dis. 2018 Nov 28;13(1):215. doi: 10.1186/s13023-018-0953-9. Review.


Exploring sialyl-Tn expression in microfluidic-isolated circulating tumour cells: A novel biomarker and an analytical tool for precision oncology applications.

Neves M, Azevedo R, Lima L, Oliveira MI, Peixoto A, Ferreira D, Soares J, Fernandes E, Gaiteiro C, Palmeira C, Cotton S, Mereiter S, Campos D, Afonso LP, Ribeiro R, Fraga A, Tavares A, Mansinho H, Monteiro E, Videira PA, Freitas PP, Reis CA, Santos LL, Dieguez L, Ferreira JA.

N Biotechnol. 2019 Mar 25;49:77-87. doi: 10.1016/j.nbt.2018.09.004. Epub 2018 Sep 28.


Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glycans terminated by alpha-2-6 sialic acids.

Loureiro LR, Sousa DP, Ferreira D, Chai W, Lima L, Pereira C, Lopes CB, Correia VG, Silva LM, Li C, Santos LL, Ferreira JA, Barbas A, Palma AS, Novo C, Videira PA.

Sci Rep. 2018 Aug 15;8(1):12196. doi: 10.1038/s41598-018-30421-w.


An Electronic Questionnaire for Liver Assessment in Congenital Disorders of Glycosylation (LeQCDG): A Patient-Centered Study.

Marques-da-Silva D, Francisco R, Dos Reis Ferreira V, Forbat L, Lagoa R, Videira PA, Witters P, Jaeken J, Cassiman D.

JIMD Rep. 2019;44:55-64. doi: 10.1007/8904_2018_121. Epub 2018 Jul 15.


Ligation of the CD44 Glycoform HCELL on Culture-Expanded Human Monocyte-Derived Dendritic Cells Programs Transendothelial Migration.

Videira PA, Silva M, Martin KC, Sackstein R.

J Immunol. 2018 Aug 1;201(3):1030-1043. doi: 10.4049/jimmunol.1800188. Epub 2018 Jun 25.


Linking Glycation and Glycosylation With Inflammation and Mitochondrial Dysfunction in Parkinson's Disease.

Videira PAQ, Castro-Caldas M.

Front Neurosci. 2018 Jun 7;12:381. doi: 10.3389/fnins.2018.00381. eCollection 2018. Review.


A functional glycoproteomics approach identifies CD13 as a novel E-selectin ligand in breast cancer.

Carrascal MA, Silva M, Ferreira JA, Azevedo R, Ferreira D, Silva AMN, Ligeiro D, Santos LL, Sackstein R, Videira PA.

Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):2069-2080. doi: 10.1016/j.bbagen.2018.05.013. Epub 2018 May 17.


Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue.

Carrascal MA, Talina C, Borralho P, Gonçalo Mineiro A, Henriques AR, Pen C, Martins M, Braga S, Sackstein R, Videira PA.

BMC Cancer. 2018 May 2;18(1):495. doi: 10.1186/s12885-018-4410-x.


CDG Therapies: From Bench to Bedside.

Brasil S, Pascoal C, Francisco R, Marques-da-Silva D, Andreotti G, Videira PA, Morava E, Jaeken J, Dos Reis Ferreira V.

Int J Mol Sci. 2018 Apr 27;19(5). pii: E1304. doi: 10.3390/ijms19051304. Review.


Reconstruction of a 10-mm-long median nerve gap in an ischemic environment using autologous conduits with different patterns of blood supply: A comparative study in the rat.

Casal D, Mota-Silva E, Iria I, Alves S, Farinho A, Pen C, Lourenço-Silva N, Mascarenhas-Lemos L, Silva-Ferreira J, Ferraz-Oliveira M, Vassilenko V, Videira PA, Goyri-O'Neill J, Pais D.

PLoS One. 2018 Apr 16;13(4):e0195692. doi: 10.1371/journal.pone.0195692. eCollection 2018.


Oxidative damage and response to Bacillus Calmette-Guérin in bladder cancer cells expressing sialyltransferase ST3GAL1.

Severino PF, Silva M, Carrascal M, Malagolini N, Chiricolo M, Venturi G, Barbaro Forleo R, Astolfi A, Catera M, Videira PA, Dall'Olio F.

BMC Cancer. 2018 Feb 17;18(1):198. doi: 10.1186/s12885-018-4107-1.


Antitumor Efficacy of Human Monocyte-Derived Dendritic Cells: Comparing Effects of two Monocyte Isolation Methods.

Marques GS, Silva Z, Videira PA.

Biol Proced Online. 2018 Feb 2;20:4. doi: 10.1186/s12575-018-0069-6. eCollection 2018.


E-Selectin Ligands in the Human Mononuclear Phagocyte System: Implications for Infection, Inflammation, and Immunotherapy.

Silva M, Videira PA, Sackstein R.

Front Immunol. 2018 Jan 19;8:1878. doi: 10.3389/fimmu.2017.01878. eCollection 2017. Review.


Inhibition of fucosylation in human invasive ductal carcinoma reduces E-selectin ligand expression, cell proliferation, and ERK1/2 and p38 MAPK activation.

Carrascal MA, Silva M, Ramalho JS, Pen C, Martins M, Pascoal C, Amaral C, Serrano I, Oliveira MJ, Sackstein R, Videira PA.

Mol Oncol. 2018 May;12(5):579-593. doi: 10.1002/1878-0261.12163. Epub 2018 Mar 30.


Antibacterial activity of a new lectin isolated from the marine sponge Chondrilla caribensis.

Marques DN, Almeida AS, Sousa ARO, Pereira R, Andrade AL, Chaves RP, Carneiro RF, Vasconcelos MA, Nascimento-Neto LGD, Pinheiro U, Videira PA, Teixeira EH, Nagano CS, Sampaio AH.

Int J Biol Macromol. 2018 Apr 1;109:1292-1301. doi: 10.1016/j.ijbiomac.2017.11.140. Epub 2017 Nov 22.


Halilectin-3, a Lectin from the Marine Sponge Haliclona caerulea, Induces Apoptosis and Autophagy in Human Breast Cancer MCF7 Cells Through Caspase-9 Pathway and LC3-II Protein Expression.

do Nascimento-Neto LG, Cabral MG, Carneiro RF, Silva Z, Arruda FVS, Nagano CS, Fernandes AR, Sampaio AH, Teixeira EH, Videira PA.

Anticancer Agents Med Chem. 2018;18(4):521-528. doi: 10.2174/1871520617666171114094847.


Reconstruction of a long defect of the ulnar artery and nerve with an arterialized neurovenous free flap in a teenager: A case report and literature review.

Casal D, Pais D, Mota-Silva E, Pelliccia G, Iria I, Videira PA, Mendes MM, Goyri-O'Neill J, Mouzinho MM.

Microsurgery. 2018 Feb;38(2):209-217. doi: 10.1002/micr.30265. Epub 2017 Nov 2. Review.


Blood Supply to the Integument of the Abdomen of the Rat: A Surgical Perspective.

Casal D, Pais D, Iria I, Videira PA, Mota-Silva E, Alves S, Mascarenhas-Lemos L, Pen C, Vassilenko V, Goyri-O'Neill J.

Plast Reconstr Surg Glob Open. 2017 Sep 11;5(9):e1454. doi: 10.1097/GOX.0000000000001454. eCollection 2017 Sep.


Structural characterization of two isolectins from the marine red alga Solieria filiformis (Kützing) P.W. Gabrielson and their anticancer effect on MCF-7 breast cancer cells.

Chaves RP, Silva SRD, Nascimento Neto LG, Carneiro RF, Silva ALCD, Sampaio AH, Sousa BL, Cabral MG, Videira PA, Teixeira EH, Nagano CS.

Int J Biol Macromol. 2018 Feb;107(Pt A):1320-1329. doi: 10.1016/j.ijbiomac.2017.09.116. Epub 2017 Sep 29.


Public and patient involvement in needs assessment and social innovation: a people-centred approach to care and research for congenital disorders of glycosylation.

de Freitas C, Dos Reis V, Silva S, Videira PA, Morava E, Jaeken J.

BMC Health Serv Res. 2017 Sep 26;17(1):682. doi: 10.1186/s12913-017-2625-1.


Expression of sialyl-Tn sugar antigen in bladder cancer cells affects response to Bacillus Calmette Guérin (BCG) and to oxidative damage.

Severino PF, Silva M, Carrascal M, Malagolini N, Chiricolo M, Venturi G, Astolfi A, Catera M, Videira PA, Dall'Olio F.

Oncotarget. 2017 Apr 17;8(33):54506-54517. doi: 10.18632/oncotarget.17138. eCollection 2017 Aug 15.


Optimization of an Arterialized Venous Fasciocutaneous Flap in the Abdomen of the Rat.

Casal D, Mota-Silva E, Pais D, Iria I, Videira PA, Tanganho D, Alves S, Mascarenhas-Lemos L, Martins Ferreira J, Ferraz-Oliveira M, Vassilenko V, O'Neill JG.

Plast Reconstr Surg Glob Open. 2017 Aug 17;5(8):e1436. doi: 10.1097/GOX.0000000000001436. eCollection 2017 Aug.


Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases.

Viegas CSB, Costa RM, Santos L, Videira PA, Silva Z, Araújo N, Macedo AL, Matos AP, Vermeer C, Simes DC.

PLoS One. 2017 May 18;12(5):e0177829. doi: 10.1371/journal.pone.0177829. eCollection 2017. Erratum in: PLoS One. 2018 Feb 8;13(2):e0192875.


Cell-Specific Variation in E-Selectin Ligand Expression among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology.

Silva M, Fung RKF, Donnelly CB, Videira PA, Sackstein R.

J Immunol. 2017 May 1;198(9):3576-3587. doi: 10.4049/jimmunol.1601636. Epub 2017 Mar 22.


A Model of Free Tissue Transfer: The Rat Epigastric Free Flap.

Casal D, Pais D, Iria I, Mota-Silva E, Almeida MA, Alves S, Pen C, Farinho A, Mascarenhas-Lemos L, Ferreira-Silva J, Ferraz-Oliveira M, Vassilenko V, Videira PA, Gory O'Neill J.

J Vis Exp. 2017 Jan 15;(119). doi: 10.3791/55281.


Liver involvement in congenital disorders of glycosylation (CDG). A systematic review of the literature.

Marques-da-Silva D, Dos Reis Ferreira V, Monticelli M, Janeiro P, Videira PA, Witters P, Jaeken J, Cassiman D.

J Inherit Metab Dis. 2017 Mar;40(2):195-207. doi: 10.1007/s10545-016-0012-4. Epub 2017 Jan 20. Review.


Using dendritic cells to evaluate how Burkholderia cenocepacia clonal isolates from a chronically infected cystic fibrosis patient subvert immune functions.

Guadalupe Cabral M, Pereira M, Silva Z, Iria I, Coutinho C, Lopes A, Sá-Correia I, Videira PA.

Med Microbiol Immunol. 2017 Apr;206(2):111-123. doi: 10.1007/s00430-016-0488-4. Epub 2016 Dec 16.


Immunological aspects of congenital disorders of glycosylation (CDG): a review.

Monticelli M, Ferro T, Jaeken J, Dos Reis Ferreira V, Videira PA.

J Inherit Metab Dis. 2016 Nov;39(6):765-780. Epub 2016 Jul 8. Review.


Sialic acid removal from dendritic cells improves antigen cross-presentation and boosts anti-tumor immune responses.

Silva M, Silva Z, Marques G, Ferro T, Gonçalves M, Monteiro M, van Vliet SJ, Mohr E, Lino AC, Fernandes AR, Lima FA, van Kooyk Y, Matos T, Tadokoro CE, Videira PA.

Oncotarget. 2016 Jul 5;7(27):41053-41066. doi: 10.18632/oncotarget.9419.


Challenges in Antibody Development against Tn and Sialyl-Tn Antigens.

Loureiro LR, Carrascal MA, Barbas A, Ramalho JS, Novo C, Delannoy P, Videira PA.

Biomolecules. 2015 Aug 11;5(3):1783-809. doi: 10.3390/biom5031783. Review.


Immature myeloid cells and tolerogenic cytokine profile in lung adenocarcinoma metastatic lymph nodes assessed by endobronchial ultrasound.

Bugalho A, Martins C, Silva Z, Nunes G, Mendes AS, Ferreira I, Videira PA.

Tumour Biol. 2016 Jan;37(1):953-61. doi: 10.1007/s13277-015-3885-1. Epub 2015 Aug 12.


Characterization of antiproliferative potential and biological targets of a copper compound containing 4'-phenyl terpyridine.

Mendo AS, Figueiredo S, Roma-Rodrigues C, Videira PA, Ma Z, Diniz M, Larguinho M, Costa PM, Lima JC, Pombeiro AJ, Baptista PV, Fernandes AR.

J Biol Inorg Chem. 2015 Sep;20(6):935-48. doi: 10.1007/s00775-015-1277-z. Epub 2015 Jun 16.


Protein disulfide isomerases: Impact of thapsigargin treatment on their expression in melanoma cell lines.

Silva Z, Veríssimo T, Videira PA, Novo C.

Int J Biol Macromol. 2015 Aug;79:44-8. doi: 10.1016/j.ijbiomac.2015.04.029. Epub 2015 Apr 23.


Meeting report on EMBO workshop: glycobiology and glycochemistry, applications to human health and disease.

Ferreira V, Reis CA, Perez S, Rauter AP, Videira PA.

Glycobiology. 2014 Sep;24(9):782-3. doi: 10.1093/glycob/cwu070. Epub 2014 Jul 14. No abstract available.


Sialyl Tn-expressing bladder cancer cells induce a tolerogenic phenotype in innate and adaptive immune cells.

Carrascal MA, Severino PF, Guadalupe Cabral M, Silva M, Ferreira JA, Calais F, Quinto H, Pen C, Ligeiro D, Santos LL, Dall'Olio F, Videira PA.

Mol Oncol. 2014 May;8(3):753-65. doi: 10.1016/j.molonc.2014.02.008. Epub 2014 Mar 6.


Dendritic cells: a spot on sialic Acid.

Crespo HJ, Lau JT, Videira PA.

Front Immunol. 2013 Dec 27;4:491. doi: 10.3389/fimmu.2013.00491. Review.


Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines.

Monteiro AS, Almeida J, Cabral G, Severino P, Videira PA, Sousa A, Nunes R, Pereira JD, Francisco AP, Perry MJ, Mendes E.

Eur J Med Chem. 2013;70:1-9. doi: 10.1016/j.ejmech.2013.09.040. Epub 2013 Oct 2.


Response of high-risk of recurrence/progression bladder tumours expressing sialyl-Tn and sialyl-6-T to BCG immunotherapy.

Lima L, Severino PF, Silva M, Miranda A, Tavares A, Pereira S, Fernandes E, Cruz R, Amaro T, Reis CA, Dall'Olio F, Amado F, Videira PA, Santos L, Ferreira JA.

Br J Cancer. 2013 Oct 15;109(8):2106-14. doi: 10.1038/bjc.2013.571. Epub 2013 Sep 24.


FASL polymorphism is associated with response to bacillus Calmette-Guérin immunotherapy in bladder cancer.

Lima L, Ferreira JA, Tavares A, Oliveira D, Morais A, Videira PA, Medeiros R, Santos L.

Urol Oncol. 2014 Jan;32(1):44.e1-7. doi: 10.1016/j.urolonc.2013.05.009. Epub 2013 Aug 12.


Cytokeratin 19, carcinoembryonic antigen, and epithelial cell adhesion molecule detect lung cancer lymph node metastasis in endobronchial ultrasound-guided transbronchial aspiration samples.

Bugalho A, Martins C, Dias SS, Nunes G, Silva Z, Correia M, Marques Gomes MJ, Videira PA.

Clin Lung Cancer. 2013 Nov;14(6):704-12. doi: 10.1016/j.cllc.2013.06.004. Epub 2013 Jul 22.


Intravital microscopy technique to study parasite dynamics in the labyrinth layer of the mouse placenta.

Lima FA, Gómez-Conde I, Videira PA, Marinho CR, Olivieri DN, Tadokoro CE.

Parasitol Int. 2014 Feb;63(1):254-9. doi: 10.1016/j.parint.2013.06.012. Epub 2013 Jul 8.


Biological characterization of the antiproliferative potential of Co(II) and Sn(IV) coordination compounds in human cancer cell lines: a comparative proteomic approach.

Silva A, Luís D, Santos S, Silva J, Mendo AS, Coito L, Silva TF, da Silva MF, Martins LM, Pombeiro AJ, Borralho PM, Rodrigues CM, Cabral MG, Videira PA, Monteiro C, Fernandes AR.

Drug Metabol Drug Interact. 2013;28(3):167-76. doi: 10.1515/dmdi-2013-0015.


Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours.

Ferreira JA, Videira PA, Lima L, Pereira S, Silva M, Carrascal M, Severino PF, Fernandes E, Almeida A, Costa C, Vitorino R, Amaro T, Oliveira MJ, Reis CA, Dall'Olio F, Amado F, Santos LL.

Mol Oncol. 2013 Jun;7(3):719-31. doi: 10.1016/j.molonc.2013.03.001. Epub 2013 Mar 21.


Diagnostic value of endobronchial and endoscopic ultrasound-guided fine needle aspiration for accessible lung cancer lesions after non-diagnostic conventional techniques: a prospective study.

Bugalho A, Ferreira D, Eberhardt R, Dias SS, Videira PA, Herth FJ, Carreiro L.

BMC Cancer. 2013 Mar 19;13:130. doi: 10.1186/1471-2407-13-130.


The phagocytic capacity and immunological potency of human dendritic cells is improved by α2,6-sialic acid deficiency.

Cabral MG, Silva Z, Ligeiro D, Seixas E, Crespo H, Carrascal MA, Silva M, Piteira AR, Paixão P, Lau JT, Videira PA.

Immunology. 2013 Mar;138(3):235-45. doi: 10.1111/imm.12025.


Postprandial insulin resistance in Zucker diabetic fatty rats is associated with parasympathetic-nitric oxide axis deficiencies.

Afonso RA, Fernandes AB, Santos C, Ligeiro D, Ribeiro RT, Lima IS, Patarrao RS, Videira PA, Caldeira J, Macedo MP.

J Neuroendocrinol. 2012 Oct;24(10):1346-55. doi: 10.1111/j.1365-2826.2012.02341.x.


Sialyl-tn in cancer: (how) did we miss the target?

Julien S, Videira PA, Delannoy P.

Biomolecules. 2012 Oct 11;2(4):435-66. doi: 10.3390/biom2040435.


IL-4 and TNF-α polymorphisms are associated with risk of multiple superficial tumors or carcinoma in situ development.

Lima L, Silva J, Amaro T, Morais A, Lopes C, Medeiros R, Videira PA, Santos L.

Urol Int. 2011;87(4):457-63. doi: 10.1159/000331882. Epub 2011 Nov 18.


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