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Items: 1 to 50 of 74

1.

Identification of Primary Natural Killer Cell Modulators by Chemical Library Screening with a Luciferase-Based Functional Assay.

Hayek S, Bekaddour N, Besson L, Alves de Sousa R, Pietrancosta N, Viel S, Smith N, Jacob Y, Nisole S, Mandal R, Wishart DS, Walzer T, Herbeuval JP, Vidalain PO.

SLAS Discov. 2018 Sep 5:2472555218797078. doi: 10.1177/2472555218797078. [Epub ahead of print]

PMID:
30184441
2.

A Global Interactome Map of the Dengue Virus NS1 Identifies Virus Restriction and Dependency Host Factors.

Hafirassou ML, Meertens L, Umaña-Diaz C, Labeau A, Dejarnac O, Bonnet-Madin L, Kümmerer BM, Delaugerre C, Roingeard P, Vidalain PO, Amara A.

Cell Rep. 2018 Jan 30;22(5):1364. doi: 10.1016/j.celrep.2018.01.038. No abstract available.

3.

A Global Interactome Map of the Dengue Virus NS1 Identifies Virus Restriction and Dependency Host Factors.

Hafirassou ML, Meertens L, Umaña-Diaz C, Labeau A, Dejarnac O, Bonnet-Madin L, Kümmerer BM, Delaugerre C, Roingeard P, Vidalain PO, Amara A.

Cell Rep. 2017 Dec 26;21(13):3900-3913. doi: 10.1016/j.celrep.2017.11.094. Erratum in: Cell Rep. 2018 Jan 30;22(5):1364.

4.

Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition.

Arnould S, Rodier G, Matar G, Vincent C, Pirot N, Delorme Y, Berthet C, Buscail Y, Noël JY, Lachambre S, Jarlier M, Bernex F, Delpech H, Vidalain PO, Janin YL, Theillet C, Sardet C.

Oncotarget. 2017 Jul 12;8(56):95206-95222. doi: 10.18632/oncotarget.19199. eCollection 2017 Nov 10.

5.

Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response.

Lucas-Hourani M, Dauzonne D, Munier-Lehmann H, Khiar S, Nisole S, Dairou J, Helynck O, Afonso PV, Tangy F, Vidalain PO.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00383-17. doi: 10.1128/AAC.00383-17. Print 2017 Oct.

6.

Identification of a small molecule that primes the type I interferon response to cytosolic DNA.

Khiar S, Lucas-Hourani M, Nisole S, Smith N, Helynck O, Bourgine M, Ruffié C, Herbeuval JP, Munier-Lehmann H, Tangy F, Vidalain PO.

Sci Rep. 2017 May 31;7(1):2561. doi: 10.1038/s41598-017-02776-z.

7.

Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity.

Zhivaki D, Lemoine S, Lim A, Morva A, Vidalain PO, Schandene L, Casartelli N, Rameix-Welti MA, Hervé PL, Dériaud E, Beitz B, Ripaux-Lefevre M, Miatello J, Lemercier B, Lorin V, Descamps D, Fix J, Eléouët JF, Riffault S, Schwartz O, Porcheray F, Mascart F, Mouquet H, Zhang X, Tissières P, Lo-Man R.

Immunity. 2017 Feb 21;46(2):301-314. doi: 10.1016/j.immuni.2017.01.010.

8.
9.

The CREB3-Herp signalling module limits the cytosolic calcium concentration increase and apoptosis induced by poliovirus.

Mirabelli C, Pelletier I, Téoulé F, Vidalain PO, Brisac C, Tangy F, Delpeyroux F, Blondel B.

J Gen Virol. 2016 Sep;97(9):2194-200. doi: 10.1099/jgv.0.000544. Epub 2016 Jul 12.

PMID:
27405867
10.

Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors.

Grandin C, Hourani ML, Janin YL, Dauzonne D, Munier-Lehmann H, Paturet A, Taborik F, Vabret A, Contamin H, Tangy F, Vidalain PO.

Antiviral Res. 2016 Jan;125:58-62. doi: 10.1016/j.antiviral.2015.11.006. Epub 2015 Nov 22.

PMID:
26593978
11.

[Stimulating Type I interferon response with small molecules: revival of an old idea].

Khiar S, Pietrancosta N, Vidalain PO.

Biol Aujourdhui. 2015;209(2):145-59. doi: 10.1051/jbio/2015015. Epub 2015 Oct 29. Review. French.

PMID:
26514384
12.

Viral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide Depletion.

Stapleford KA, Rozen-Gagnon K, Das PK, Saul S, Poirier EZ, Blanc H, Vidalain PO, Merits A, Vignuzzi M.

J Virol. 2015 Nov;89(22):11233-44. doi: 10.1128/JVI.01553-15. Epub 2015 Aug 26.

13.

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).

Lucas-Hourani M, Munier-Lehmann H, El Mazouni F, Malmquist NA, Harpon J, Coutant EP, Guillou S, Helynck O, Noel A, Scherf A, Phillips MA, Tangy F, Vidalain PO, Janin YL.

J Med Chem. 2015 Jul 23;58(14):5579-98. doi: 10.1021/acs.jmedchem.5b00606. Epub 2015 Jun 30.

14.

A field-proven yeast two-hybrid protocol used to identify coronavirus-host protein-protein interactions.

Vidalain PO, Jacob Y, Hagemeijer MC, Jones LM, Neveu G, Roussarie JP, Rottier PJ, Tangy F, de Haan CA.

Methods Mol Biol. 2015;1282:213-29. doi: 10.1007/978-1-4939-2438-7_18.

PMID:
25720483
15.

[Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening].

Vidalain PO, Lucas-Hourani M, Helynck O, Tangy F, Munier-Lehmann H.

Med Sci (Paris). 2015 Jan;31(1):98-104. doi: 10.1051/medsci/20153101019. Epub 2015 Feb 6. Review. French.

16.

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH).

Munier-Lehmann H, Lucas-Hourani M, Guillou S, Helynck O, Zanghi G, Noel A, Tangy F, Vidalain PO, Janin YL.

J Med Chem. 2015 Jan 22;58(2):860-77. doi: 10.1021/jm501446r. Epub 2015 Jan 6.

PMID:
25558988
17.

Evidence for an intranasal immune response to human respiratory syncytial virus infection in cynomolgus macaques.

Grandin C, Lucas-Hourani M, Clavel M, Taborik F, Vabret A, Tangy F, Contamin H, Vidalain PO.

J Gen Virol. 2015 Apr;96(Pt 4):782-92. doi: 10.1099/vir.0.000039. Epub 2014 Dec 23.

PMID:
25537374
18.

Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.

Fernandez J, Portilho DM, Danckaert A, Munier S, Becker A, Roux P, Zambo A, Shorte S, Jacob Y, Vidalain PO, Charneau P, Clavel F, Arhel NJ.

J Biol Chem. 2015 Feb 20;290(8):4631-46. doi: 10.1074/jbc.M114.613133. Epub 2014 Dec 11.

19.

Patchwork structure-function analysis of the Sendai virus matrix protein.

Mottet-Osman G, Miazza V, Vidalain PO, Roux L.

Virology. 2014 Sep;464-465:330-340. doi: 10.1016/j.virol.2014.07.024. Epub 2014 Aug 9.

20.

Recruitment of RED-SMU1 complex by Influenza A Virus RNA polymerase to control Viral mRNA splicing.

Fournier G, Chiang C, Munier S, Tomoiu A, Demeret C, Vidalain PO, Jacob Y, Naffakh N.

PLoS Pathog. 2014 Jun 12;10(6):e1004164. doi: 10.1371/journal.ppat.1004164. eCollection 2014 Jun. Erratum in: PLoS Pathog. 2014 Jul;10(7):e1004317.

21.

High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses.

Lucas-Hourani M, Munier-Lehmann H, Helynck O, Komarova A, Desprès P, Tangy F, Vidalain PO.

J Vis Exp. 2014 May 5;(87). doi: 10.3791/51222.

22.

Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity.

Lucas-Hourani M, Dauzonne D, Jorda P, Cousin G, Lupan A, Helynck O, Caignard G, Janvier G, André-Leroux G, Khiar S, Escriou N, Desprès P, Jacob Y, Munier-Lehmann H, Tangy F, Vidalain PO.

PLoS Pathog. 2013;9(10):e1003678. doi: 10.1371/journal.ppat.1003678. Epub 2013 Oct 3.

23.

The Golgi protein ACBD3, an interactor for poliovirus protein 3A, modulates poliovirus replication.

Téoulé F, Brisac C, Pelletier I, Vidalain PO, Jégouic S, Mirabelli C, Bessaud M, Combelas N, Autret A, Tangy F, Delpeyroux F, Blondel B.

J Virol. 2013 Oct;87(20):11031-46. doi: 10.1128/JVI.00304-13. Epub 2013 Aug 7.

24.

NS3 of bluetongue virus interferes with the induction of type I interferon.

Chauveau E, Doceul V, Lara E, Breard E, Sailleau C, Vidalain PO, Meurs EF, Dabo S, Schwartz-Cornil I, Zientara S, Vitour D.

J Virol. 2013 Jul;87(14):8241-6. doi: 10.1128/JVI.00678-13. Epub 2013 May 8.

25.

Species-specific impact of the autophagy machinery on Chikungunya virus infection.

Judith D, Mostowy S, Bourai M, Gangneux N, Lelek M, Lucas-Hourani M, Cayet N, Jacob Y, Prévost MC, Pierre P, Tangy F, Zimmer C, Vidalain PO, Couderc T, Lecuit M.

EMBO Rep. 2013 Jun;14(6):534-44. doi: 10.1038/embor.2013.51. Epub 2013 Apr 26.

26.

Identification of RNA partners of viral proteins in infected cells.

Komarova AV, Combredet C, Sismeiro O, Dillies MA, Jagla B, Sanchez David RY, Vabret N, Coppée JY, Vidalain PO, Tangy F.

RNA Biol. 2013 Jun;10(6):944-56. doi: 10.4161/rna.24453. Epub 2013 Apr 1.

27.

On dihydroorotate dehydrogenases and their inhibitors and uses.

Munier-Lehmann H, Vidalain PO, Tangy F, Janin YL.

J Med Chem. 2013 Apr 25;56(8):3148-67. doi: 10.1021/jm301848w. Epub 2013 Mar 20. Review.

PMID:
23452331
28.

The cellular protein TIP47 restricts Respirovirus multiplication leading to decreased virus particle production.

Bampi C, Grenet AS, Caignard G, Vidalain PO, Roux L.

Virus Res. 2013 May;173(2):354-63. doi: 10.1016/j.virusres.2013.01.006. Epub 2013 Jan 22.

PMID:
23348195
29.

The V protein of Tioman virus is incapable of blocking type I interferon signaling in human cells.

Caignard G, Lucas-Hourani M, Dhondt KP, Labernardière JL, Petit T, Jacob Y, Horvat B, Tangy F, Vidalain PO.

PLoS One. 2013;8(1):e53881. doi: 10.1371/journal.pone.0053881. Epub 2013 Jan 14.

30.

RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection.

Luco S, Delmas O, Vidalain PO, Tangy F, Weil R, Bourhy H.

PLoS Pathog. 2012;8(12):e1003060. doi: 10.1371/journal.ppat.1003060. Epub 2012 Dec 13.

31.

A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2.

Lucas-Hourani M, Lupan A, Desprès P, Thoret S, Pamlard O, Dubois J, Guillou C, Tangy F, Vidalain PO, Munier-Lehmann H.

J Biomol Screen. 2013 Feb;18(2):172-9. doi: 10.1177/1087057112460091. Epub 2012 Sep 14.

PMID:
22983165
32.

Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A.

Aynaud MM, Suspène R, Vidalain PO, Mussil B, Guétard D, Tangy F, Wain-Hobson S, Vartanian JP.

J Biol Chem. 2012 Nov 9;287(46):39182-92. doi: 10.1074/jbc.M112.372722. Epub 2012 Sep 13.

33.

Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase.

Neveu G, Cassonnet P, Vidalain PO, Rolloy C, Mendoza J, Jones L, Tangy F, Muller M, Demeret C, Tafforeau L, Lotteau V, Rabourdin-Combe C, Travé G, Dricot A, Hill DE, Vidal M, Favre M, Jacob Y.

Methods. 2012 Dec;58(4):349-59. doi: 10.1016/j.ymeth.2012.07.029. Epub 2012 Aug 8.

34.

A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes.

Mesel-Lemoine M, Millet J, Vidalain PO, Law H, Vabret A, Lorin V, Escriou N, Albert ML, Nal B, Tangy F.

J Virol. 2012 Jul;86(14):7577-87. doi: 10.1128/JVI.00269-12. Epub 2012 May 2.

35.

Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component.

Bouraï M, Lucas-Hourani M, Gad HH, Drosten C, Jacob Y, Tafforeau L, Cassonnet P, Jones LM, Judith D, Couderc T, Lecuit M, André P, Kümmerer BM, Lotteau V, Desprès P, Tangy F, Vidalain PO.

J Virol. 2012 Mar;86(6):3121-34. doi: 10.1128/JVI.06390-11. Epub 2012 Jan 18.

36.

IRGM is a common target of RNA viruses that subvert the autophagy network.

Grégoire IP, Richetta C, Meyniel-Schicklin L, Borel S, Pradezynski F, Diaz O, Deloire A, Azocar O, Baguet J, Le Breton M, Mangeot PE, Navratil V, Joubert PE, Flacher M, Vidalain PO, André P, Lotteau V, Biard-Piechaczyk M, Rabourdin-Combe C, Faure M.

PLoS Pathog. 2011 Dec;7(12):e1002422. doi: 10.1371/journal.ppat.1002422. Epub 2011 Dec 8.

37.

Benchmarking a luciferase complementation assay for detecting protein complexes.

Cassonnet P, Rolloy C, Neveu G, Vidalain PO, Chantier T, Pellet J, Jones L, Muller M, Demeret C, Gaud G, Vuillier F, Lotteau V, Tangy F, Favre M, Jacob Y.

Nat Methods. 2011 Nov 29;8(12):990-2. doi: 10.1038/nmeth.1773. No abstract available.

PMID:
22127214
38.

Identification of a functional, CRM-1-dependent nuclear export signal in hepatitis C virus core protein.

Cerutti A, Maillard P, Minisini R, Vidalain PO, Roohvand F, Pecheur EI, Pirisi M, Budkowska A.

PLoS One. 2011;6(10):e25854. doi: 10.1371/journal.pone.0025854. Epub 2011 Oct 24.

39.

Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network.

Tafforeau L, Chantier T, Pradezynski F, Pellet J, Mangeot PE, Vidalain PO, Andre P, Rabourdin-Combe C, Lotteau V.

J Virol. 2011 Dec;85(24):13010-8. doi: 10.1128/JVI.02651-10. Epub 2011 Oct 12.

40.

Proteomic analysis of virus-host interactions in an infectious context using recombinant viruses.

Komarova AV, Combredet C, Meyniel-Schicklin L, Chapelle M, Caignard G, Camadro JM, Lotteau V, Vidalain PO, Tangy F.

Mol Cell Proteomics. 2011 Dec;10(12):M110.007443. doi: 10.1074/mcp.M110.007443. Epub 2011 Sep 12.

41.

The interaction of flavivirus M protein with light chain Tctex-1 of human dynein plays a role in late stages of virus replication.

Brault JB, Kudelko M, Vidalain PO, Tangy F, Desprès P, Pardigon N.

Virology. 2011 Sep 1;417(2):369-78. doi: 10.1016/j.virol.2011.06.022. Epub 2011 Jul 20.

42.

Virus-host protein interactions in RNA viruses.

Vidalain PO, Tangy F.

Microbes Infect. 2010 Dec;12(14-15):1134-43. doi: 10.1016/j.micinf.2010.09.001. Epub 2010 Sep 9. Review.

43.

TACC3-TSC2 maintains nuclear envelope structure and controls cell division.

Gómez-Baldó L, Schmidt S, Maxwell CA, Bonifaci N, Gabaldón T, Vidalain PO, Senapedis W, Kletke A, Rosing M, Barnekow A, Rottapel R, Capellá G, Vidal M, Astrinidis A, Piekorz RP, Pujana MA.

Cell Cycle. 2010 Mar 15;9(6):1143-55. Epub 2010 Mar 15.

PMID:
20237422
44.

ViralORFeome: an integrated database to generate a versatile collection of viral ORFs.

Pellet J, Tafforeau L, Lucas-Hourani M, Navratil V, Meyniel L, Achaz G, Guironnet-Paquet A, Aublin-Gex A, Caignard G, Cassonnet P, Chaboud A, Chantier T, Deloire A, Demeret C, Le Breton M, Neveu G, Jacotot L, Vaglio P, Delmotte S, Gautier C, Combet C, Deleage G, Favre M, Tangy F, Jacob Y, Andre P, Lotteau V, Rabourdin-Combe C, Vidalain PO.

Nucleic Acids Res. 2010 Jan;38(Database issue):D371-8. doi: 10.1093/nar/gkp1000. Epub 2009 Dec 8.

45.

Structure of the nucleoprotein binding domain of Mokola virus phosphoprotein.

Assenberg R, Delmas O, Ren J, Vidalain PO, Verma A, Larrous F, Graham SC, Tangy F, Grimes JM, Bourhy H.

J Virol. 2010 Jan;84(2):1089-96. doi: 10.1128/JVI.01520-09. Epub 2009 Nov 11.

46.

pISTil: a pipeline for yeast two-hybrid Interaction Sequence Tags identification and analysis.

Pellet J, Meyniel L, Vidalain PO, de Chassey B, Tafforeau L, Lotteau V, Rabourdin-Combe C, Navratil V.

BMC Res Notes. 2009 Oct 29;2:220. doi: 10.1186/1756-0500-2-220.

47.

Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response.

Pothlichet J, Burtey A, Kubarenko AV, Caignard G, Solhonne B, Tangy F, Ben-Ali M, Quintana-Murci L, Heinzmann A, Chiche JD, Vidalain PO, Weber AN, Chignard M, Si-Tahar M.

PLoS One. 2009 Oct 27;4(10):e7582. doi: 10.1371/journal.pone.0007582.

48.

'Edgetic' perturbation of a C. elegans BCL2 ortholog.

Dreze M, Charloteaux B, Milstein S, Vidalain PO, Yildirim MA, Zhong Q, Svrzikapa N, Romero V, Laloux G, Brasseur R, Vandenhaute J, Boxem M, Cusick ME, Hill DE, Vidal M.

Nat Methods. 2009 Nov;6(11):843-9. doi: 10.1038/nmeth.1394. Epub 2009 Oct 25. Erratum in: Nat Methods. 2009 Dec;6(12):935.

49.

Autophagy induction by the pathogen receptor CD46.

Joubert PE, Meiffren G, Grégoire IP, Pontini G, Richetta C, Flacher M, Azocar O, Vidalain PO, Vidal M, Lotteau V, Codogno P, Rabourdin-Combe C, Faure M.

Cell Host Microbe. 2009 Oct 22;6(4):354-66. doi: 10.1016/j.chom.2009.09.006.

50.

Differential regulation of type I interferon and epidermal growth factor pathways by a human Respirovirus virulence factor.

Caignard G, Komarova AV, Bouraï M, Mourez T, Jacob Y, Jones LM, Rozenberg F, Vabret A, Freymuth F, Tangy F, Vidalain PO.

PLoS Pathog. 2009 Sep;5(9):e1000587. doi: 10.1371/journal.ppat.1000587. Epub 2009 Sep 18.

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