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Brown and beige fat: From molecules to physiology and pathophysiology.

Carobbio S, Guénantin AC, Samuelson I, Bahri M, Vidal-Puig A.

Biochim Biophys Acta. 2018 May 28. pii: S1388-1981(18)30106-9. doi: 10.1016/j.bbalip.2018.05.013. [Epub ahead of print] Review.


P465L pparγ mutation confers partial resistance to the hypolipidemic action of fibrates.

Rodriguez-Cuenca S, Carobbio S, Barceló-Coblijn G, Prieur X, Relat J, Amat R, Campbell M, Dias AR, Bahri M, Gray SL, Vidal-Puig A.

Diabetes Obes Metab. 2018 May 22. doi: 10.1111/dom.13370. [Epub ahead of print]


Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice.

Girousse A, Virtue S, Hart D, Vidal-Puig A, Murgatroyd PR, Mouisel E, Sengenès C, Savage DB.

Mol Metab. 2018 May 16. pii: S2212-8778(18)30345-4. doi: 10.1016/j.molmet.2018.05.006. [Epub ahead of print]


Fed-EXosome: extracellular vesicles and cell-cell communication in metabolic regulation.

Samuelson I, Vidal-Puig AJ.

Essays Biochem. 2018 May 15;62(2):165-175. doi: 10.1042/EBC20170087. Print 2018 May 15. Review.


Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.

Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MTG, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S.

Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525e.


Defective glucose and lipid metabolism in rheumatoid arthritis is determined by chronic inflammation in metabolic tissues.

Arias de la Rosa I, Escudero-Contreras A, Rodríguez-Cuenca S, Ruiz-Ponce M, Jiménez-Gómez Y, Ruiz-Limón P, Pérez-Sánchez C, Ábalos-Aguilera MC, Cecchi I, Ortega R, Calvo J, Guzmán-Ruiz R, Malagón MM, Collantes-Estevez E, Vidal-Puig A, López-Pedrera C, Barbarroja N.

J Intern Med. 2018 Jul;284(1):61-77. doi: 10.1111/joim.12743. Epub 2018 Mar 12.


'Basic and Applied Thermogenesis Research' Bridging the Gap.

Carobbio S, Guénantin AC, Vidal-Puig A.

Trends Endocrinol Metab. 2018 Jan;29(1):5-7. doi: 10.1016/j.tem.2017.10.002. Epub 2017 Oct 27.


No metabolic effects of mustard allyl-isothiocyanate compared with placebo in men.

Langeveld M, Tan CY, Soeters MR, Virtue S, Watson LP, Murgatroyd PR, Ambler GK, Vidal-Puig S, Chatterjee KV, Vidal-Puig A.

Am J Clin Nutr. 2017 Nov;106(5):1197-1205. doi: 10.3945/ajcn.116.148395. Epub 2017 Oct 25.


Dietary (Poly)phenols, Brown Adipose Tissue Activation, and Energy Expenditure: A Narrative Review.

Mele L, Bidault G, Mena P, Crozier A, Brighenti F, Vidal-Puig A, Del Rio D.

Adv Nutr. 2017 Sep 15;8(5):694-704. doi: 10.3945/an.117.015792. Print 2017 Sep. Review.


Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M.

Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014.


SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes.

Yeo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Yassin MS, Tai ES, Vidal-Puig A, Toh SA.

Sci Rep. 2017 Jun 22;7(1):4031. doi: 10.1038/s41598-017-04369-2.


Adipose Tissue Function and Expandability as Determinants of Lipotoxicity and the Metabolic Syndrome.

Carobbio S, Pellegrinelli V, Vidal-Puig A.

Adv Exp Med Biol. 2017;960:161-196. doi: 10.1007/978-3-319-48382-5_7. Review.


Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells.

Tsuchiya Y, Peak-Chew SY, Newell C, Miller-Aidoo S, Mangal S, Zhyvoloup A, Bakovic J, Malanchuk O, Pereira GC, Kotiadis V, Szabadkai G, Duchen MR, Campbell M, Cuenca SR, Vidal-Puig A, James AM, Murphy MP, Filonenko V, Skehel M, Gout I.

Biochem J. 2017 Jul 11;474(14):2489-2508. doi: 10.1042/BCJ20170129.


Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function.

Mele L, Carobbio S, Brindani N, Curti C, Rodriguez-Cuenca S, Bidault G, Mena P, Zanotti I, Vacca M, Vidal-Puig A, Del Rio D.

Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201700074. Epub 2017 Apr 12.


Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases.

Rodriguez-Cuenca S, Pellegrinelli V, Campbell M, Oresic M, Vidal-Puig A.

Prog Lipid Res. 2017 Apr;66:14-29. doi: 10.1016/j.plipres.2017.01.002. Epub 2017 Jan 16. Review.


Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity.

Parvaresh Rizi E, Baig S, Shabeer M, Teo Y, Mok SF, Loh TP, Magkos F, Virtue S, Vidal-Puig A, Tai ES, Khoo CM, Toh SA.

Nutr J. 2016 Dec 1;15(1):100.


Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease.

Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL.

Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6.


Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease.

Huang-Doran I, Zhang CY, Vidal-Puig A.

Trends Endocrinol Metab. 2017 Jan;28(1):3-18. doi: 10.1016/j.tem.2016.10.003. Epub 2016 Oct 31. Review.


Metabolic gene expression profile in circulating mononuclear cells reflects obesity-associated metabolic inflexibility.

Baig S, Parvaresh Rizi E, Shabeer M, Chhay V, Mok SF, Loh TP, Magkos F, Vidal-Puig A, Tai ES, Khoo CM, Toh SA.

Nutr Metab (Lond). 2016 Oct 27;13:74. doi: 10.1186/s12986-016-0135-5. eCollection 2016.


Stearoyl-CoA Desaturase 1 Is a Key Determinant of Membrane Lipid Composition in 3T3-L1 Adipocytes.

Rodriguez-Cuenca S, Whyte L, Hagen R, Vidal-Puig A, Fuller M.

PLoS One. 2016 Sep 15;11(9):e0162047. doi: 10.1371/journal.pone.0162047. eCollection 2016.


Assessment of plasma acylcarnitines before and after weight loss in obese subjects.

Schooneman MG, Napolitano A, Houten SM, Ambler GK, Murgatroyd PR, Miller SR, Hollak CE, Tan CY, Virtue S, Vidal-Puig A, Nunez DJ, Soeters MR.

Arch Biochem Biophys. 2016 Sep 15;606:73-80. doi: 10.1016/ Epub 2016 Jul 19.


Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.

Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S.

Nat Med. 2016 Jul;22(7):771-9. doi: 10.1038/nm.4115. Epub 2016 Jun 6. Erratum in: Nat Med. 2018 Apr 10;24(4):525.


Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues.

Pellegrinelli V, Carobbio S, Vidal-Puig A.

Diabetologia. 2016 Jun;59(6):1075-88. doi: 10.1007/s00125-016-3933-4. Epub 2016 Apr 4. Review.


Erratum: Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance.

Tan CY, Virtue S, Murfitt S, Roberts LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A.

Sci Rep. 2016 Mar 30;6:23873. doi: 10.1038/srep23873. No abstract available.


Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.

Van De Pette M, Tunster SJ, McNamara GI, Shelkovnikova T, Millership S, Benson L, Peirson S, Christian M, Vidal-Puig A, John RM.

PLoS Genet. 2016 Mar 10;12(3):e1005916. doi: 10.1371/journal.pgen.1005916. eCollection 2016 Mar.


Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice.

Sanghez V, Cubuk C, Sebastián-Leon P, Carobbio S, Dopazo J, Vidal-Puig A, Bartolomucci A.

Stress. 2016;19(2):214-24. doi: 10.3109/10253890.2016.1151491. Epub 2016 Mar 7.


Deriving functional beige fat from capillaries.

Pellegrinelli V, Vidal-Puig A.

Nat Med. 2016 Mar;22(3):234-6. doi: 10.1038/nm.4056. No abstract available.


Mild cold effects on hunger, food intake, satiety and skin temperature in humans.

Langeveld M, Tan CY, Soeters MR, Virtue S, Ambler GK, Watson LP, Murgatroyd PR, Chatterjee VK, Vidal-Puig A.

Endocr Connect. 2016 Mar;5(2):65-73. doi: 10.1530/EC-16-0004. Epub 2016 Feb 10.


Mitochondria are required for pro-ageing features of the senescent phenotype.

Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF.

EMBO J. 2016 Apr 1;35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4.


Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis.

Razzoli M, Frontini A, Gurney A, Mondini E, Cubuk C, Katz LS, Cero C, Bolan PJ, Dopazo J, Vidal-Puig A, Cinti S, Bartolomucci A.

Mol Metab. 2015 Nov 11;5(1):19-33. doi: 10.1016/j.molmet.2015.10.005. eCollection 2016 Jan.


Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance.

Yew Tan C, Virtue S, Murfitt S, Roberts LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A.

Sci Rep. 2015 Dec 17;5:18366. doi: 10.1038/srep18366. Erratum in: Sci Rep. 2016;6:23873. Robert, Lee D [corrected to Roberts, Lee D].


Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6.

Tan CY, Virtue S, Bidault G, Dale M, Hagen R, Griffin JL, Vidal-Puig A.

Cell Rep. 2015 Dec 15;13(10):2039-47. doi: 10.1016/j.celrep.2015.11.004. Epub 2015 Nov 25.


Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet.

Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T.

Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565.


Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans.

Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H.

Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.


Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity.

Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27.


Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD.

Vacca M, Allison M, Griffin JL, Vidal-Puig A.

Semin Liver Dis. 2015 Aug;35(3):250-61. doi: 10.1055/s-0035-1562945. Epub 2015 Sep 17. Review.


Regulation of mitochondrial morphology and function by stearoylation of TFR1.

Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA.

Nature. 2015 Sep 3;525(7567):124-8. doi: 10.1038/nature14601. Epub 2015 Jul 27.


Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation.

Moreno-Navarrete JM, Escoté X, Ortega F, Camps M, Ricart W, Zorzano A, Vendrell J, Vidal-Puig A, Fernández-Real JM.

Diabetologia. 2015 Oct;58(10):2424-34. doi: 10.1007/s00125-015-3692-7. Epub 2015 Jul 23.


Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice.

Smith MA, Katsouri L, Irvine EE, Hankir MK, Pedroni SM, Voshol PJ, Gordon MW, Choudhury AI, Woods A, Vidal-Puig A, Carling D, Withers DJ.

Cell Rep. 2015 Apr 21;11(3):335-43. doi: 10.1016/j.celrep.2015.03.029. Epub 2015 Apr 9.


Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans.

Virtue S, Masoodi M, de Weijer BA, van Eijk M, Mok CY, Eiden M, Dale M, Pirraco A, Serlie MJ, Griffin JL, Vidal-Puig A.

Int J Obes (Lond). 2015 Jul;39(7):1151-60. doi: 10.1038/ijo.2015.34. Epub 2015 Mar 24.


Human Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity.

Pellegrinelli V, Rouault C, Rodriguez-Cuenca S, Albert V, Edom-Vovard F, Vidal-Puig A, Clément K, Butler-Browne GS, Lacasa D.

Diabetes. 2015 Sep;64(9):3121-34. doi: 10.2337/db14-0796. Epub 2015 Feb 18.


Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation.

Patel MN, Bernard WG, Milev NB, Cawthorn WP, Figg N, Hart D, Prieur X, Virtue S, Hegyi K, Bonnafous S, Bailly-Maitre B, Chu Y, Griffin JL, Mallat Z, Considine RV, Tran A, Gual P, Takeuchi O, Akira S, Vidal-Puig A, Bennett MR, Sethi JK.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):506-11. doi: 10.1073/pnas.1414536112. Epub 2014 Dec 24.


A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations.

Clemente FJ, Cardona A, Inchley CE, Peter BM, Jacobs G, Pagani L, Lawson DJ, Antão T, Vicente M, Mitt M, DeGiorgio M, Faltyskova Z, Xue Y, Ayub Q, Szpak M, Mägi R, Eriksson A, Manica A, Raghavan M, Rasmussen M, Rasmussen S, Willerslev E, Vidal-Puig A, Tyler-Smith C, Villems R, Nielsen R, Metspalu M, Malyarchuk B, Derenko M, Kivisild T.

Am J Hum Genet. 2014 Oct 23;95(5):584-589. doi: 10.1016/j.ajhg.2014.09.016. [Epub ahead of print]


Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.

Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A.

Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28.


DLK1/PREF1 regulates nutrient metabolism and protects from steatosis.

Charalambous M, Da Rocha ST, Radford EJ, Medina-Gomez G, Curran S, Pinnock SB, Ferrón SR, Vidal-Puig A, Ferguson-Smith AC.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16088-93. doi: 10.1073/pnas.1406119111. Epub 2014 Oct 27.


Understanding disease mechanisms with models of signaling pathway activities.

Sebastian-Leon P, Vidal E, Minguez P, Conesa A, Tarazona S, Amadoz A, Armero C, Salavert F, Vidal-Puig A, Montaner D, Dopazo J.

BMC Syst Biol. 2014 Oct 25;8:121. doi: 10.1186/s12918-014-0121-3.


Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity.

Rodriguez-Cuenca S, Barbarroja N, Vidal-Puig A.

Biochim Biophys Acta. 2015 Jan;1851(1):40-50. doi: 10.1016/j.bbalip.2014.09.021. Epub 2014 Oct 2. Review.


Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.

Ortega FJ, Serrano M, Rodriguez-Cuenca S, Moreno-Navarrete JM, Gómez-Serrano M, Sabater M, Rodriguez-Hermosa JI, Xifra G, Ricart W, Peral B, Vidal-Puig A, Fernández-Real JM.

J Mol Med (Berl). 2015 Jan;93(1):83-92. doi: 10.1007/s00109-014-1207-5. Epub 2014 Sep 25.


The different shades of fat.

Peirce V, Carobbio S, Vidal-Puig A.

Nature. 2014 Jun 5;510(7503):76-83. doi: 10.1038/nature13477. Review.


Response to letter regarding article, "Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans".

Yu E, Calvert PA, Mercer JR, Harrison J, Baker L, Figg NL, Kumar S, Wang JJ, Hurst LA, Obaid DR, Logan A, West NE, Clarke MC, Vidal-Puig A, Murphy MP, Bennett MR.

Circulation. 2014 Mar 25;129(12):e408. doi: 10.1161/CIRCULATIONAHA.113.008032. No abstract available.

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