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Items: 1 to 50 of 269

1.

Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity.

Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie M, Koulman A, Vidal-Puig A.

Elife. 2019 Aug 16;8. pii: e47990. doi: 10.7554/eLife.47990. [Epub ahead of print]

PMID:
31418690
2.

A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue.

Rana BMJ, Jou E, Barlow JL, Rodriguez-Rodriguez N, Walker JA, Knox C, Jolin HE, Hardman CS, Sivasubramaniam M, Szeto A, Cohen ES, Scott IC, Sleeman MA, Chidomere CI, Cruz Migoni S, Caamano J, Jorgensen HF, Carobbio S, Vidal-Puig A, McKenzie ANJ.

J Exp Med. 2019 Jun 27. pii: jem.20190689. doi: 10.1084/jem.20190689. [Epub ahead of print]

PMID:
31248899
3.

Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption.

Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, López M, Heeren J, Dalley JW, Backes H, Mittag J.

Cell Rep. 2019 Jun 11;27(11):3385-3400.e3. doi: 10.1016/j.celrep.2019.05.054.

4.

Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function.

Ortega FJ, Moreno-Navarrete JM, Mercader JM, Gómez-Serrano M, García-Santos E, Latorre J, Lluch A, Sabater M, Caballano-Infantes E, Guzmán R, Macías-González M, Buxo M, Gironés J, Vilallonga R, Naon D, Botas P, Delgado E, Corella D, Burcelin R, Frühbeck G, Ricart W, Simó R, Castrillon-Rodríguez I, Tinahones FJ, Bosch F, Vidal-Puig A, Malagón MM, Peral B, Zorzano A, Fernández-Real JM.

FASEB J. 2019 Aug;33(8):9656-9671. doi: 10.1096/fj.201900479R. Epub 2019 May 30.

PMID:
31145872
5.

Genes Involved in Oxidative Stress Pathways Are Differentially Expressed in Circulating Mononuclear Cells Derived From Obese Insulin-Resistant and Lean Insulin-Sensitive Individuals Following a Single Mixed-Meal Challenge.

Baig S, Parvaresh Rizi E, Chia C, Shabeer M, Aung N, Loh TP, Magkos F, Vidal-Puig A, Seet RCS, Khoo CM, Toh SA.

Front Endocrinol (Lausanne). 2019 Apr 24;10:256. doi: 10.3389/fendo.2019.00256. eCollection 2019.

6.

Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue.

Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC.

Nat Commun. 2019 Apr 4;10(1):1546. doi: 10.1038/s41467-019-09514-1.

7.

Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice.

Patel V, Bidault G, Chambers JE, Carobbio S, Everden AJT, Garcés C, Dalton LE, Gribble FM, Vidal-Puig A, Marciniak SJ.

Sci Rep. 2019 Feb 27;9(1):2903. doi: 10.1038/s41598-019-39562-y.

8.

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.

Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O'Rahilly S.

Cell Metab. 2019 Mar 5;29(3):707-718.e8. doi: 10.1016/j.cmet.2018.12.016. Epub 2019 Jan 10.

9.

Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity.

Rached MT, Millership SJ, Pedroni SMA, Choudhury AI, Costa ASH, Hardy DG, Glegola JA, Irvine EE, Selman C, Woodberry MC, Yadav VK, Khadayate S, Vidal-Puig A, Virtue S, Frezza C, Withers DJ.

Mol Metab. 2019 Feb;20:38-50. doi: 10.1016/j.molmet.2018.11.010. Epub 2018 Nov 28.

10.

Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue.

Pellegrinelli V, Peirce VJ, Howard L, Virtue S, Türei D, Senzacqua M, Frontini A, Dalley JW, Horton AR, Bidault G, Severi I, Whittle A, Rahmouni K, Saez-Rodriguez J, Cinti S, Davies AM, Vidal-Puig A.

Nat Commun. 2018 Nov 26;9(1):4974. doi: 10.1038/s41467-018-07453-x.

11.

Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue.

Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M.

Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069.

12.

Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons.

Smith MA, Katsouri L, Virtue S, Choudhury AI, Vidal-Puig A, Ashford MLJ, Withers DJ.

Cell Rep. 2018 Oct 9;25(2):278-287.e4. doi: 10.1016/j.celrep.2018.09.024.

13.

GPER and ERα mediate estradiol enhancement of mitochondrial function in inflamed adipocytes through a PKA dependent mechanism.

Bauzá-Thorbrügge M, Rodríguez-Cuenca S, Vidal-Puig A, Galmés-Pascual BM, Sbert-Roig M, Gianotti M, Lladó I, Proenza AM.

J Steroid Biochem Mol Biol. 2019 Jan;185:256-267. doi: 10.1016/j.jsbmb.2018.09.013. Epub 2018 Sep 22.

PMID:
30253224
14.

"Obesity-associated metabolic complications, the second wave of the tsunami" 14th Key Symposium.

Vidal-Puig A, Enerback S.

J Intern Med. 2018 Nov;284(5):447-449. doi: 10.1111/joim.12828. No abstract available.

PMID:
30141829
15.

Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility.

Virtue S, Petkevicius K, Moreno-Navarrete JM, Jenkins B, Hart D, Dale M, Koulman A, Fernández-Real JM, Vidal-Puig A.

Cell Rep. 2018 Aug 21;24(8):2005-2012.e7. doi: 10.1016/j.celrep.2018.07.063.

16.

Dietary stearic acid regulates mitochondria in vivo in humans.

Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA.

Nat Commun. 2018 Aug 7;9(1):3129. doi: 10.1038/s41467-018-05614-6.

17.

PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity.

Corrales P, Vidal-Puig A, Medina-Gómez G.

Int J Mol Sci. 2018 Jul 21;19(7). pii: E2124. doi: 10.3390/ijms19072124. Review.

18.

Fat storage-inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes, and regulates triglyceride accumulation and insulin sensitivity in adipocytes.

Agrawal M, Yeo CR, Shabbir A, Chhay V, Silver DL, Magkos F, Vidal-Puig A, Toh SA.

FASEB J. 2019 Jan;33(1):430-440. doi: 10.1096/fj.201701321RR. Epub 2018 Jul 18.

PMID:
30020828
19.

Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption.

Sanders FWB, Acharjee A, Walker C, Marney L, Roberts LD, Imamura F, Jenkins B, Case J, Ray S, Virtue S, Vidal-Puig A, Kuh D, Hardy R, Allison M, Forouhi N, Murray AJ, Wareham N, Vacca M, Koulman A, Griffin JL.

Genome Biol. 2018 Jun 20;19(1):79. doi: 10.1186/s13059-018-1439-8.

20.

Brown and beige fat: From molecules to physiology and pathophysiology.

Carobbio S, Guénantin AC, Samuelson I, Bahri M, Vidal-Puig A.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jan;1864(1):37-50. doi: 10.1016/j.bbalip.2018.05.013. Epub 2018 May 28. Review.

PMID:
29852279
21.

P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates.

Rodriguez-Cuenca S, Carobbio S, Barceló-Coblijn G, Prieur X, Relat J, Amat R, Campbell M, Dias AR, Bahri M, Gray SL, Vidal-Puig A.

Diabetes Obes Metab. 2018 Oct;20(10):2339-2350. doi: 10.1111/dom.13370. Epub 2018 Jun 27.

22.

Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice.

Girousse A, Virtue S, Hart D, Vidal-Puig A, Murgatroyd PR, Mouisel E, Sengenès C, Savage DB.

Mol Metab. 2018 Jul;13:24-29. doi: 10.1016/j.molmet.2018.05.006. Epub 2018 May 16.

23.

Fed-EXosome: extracellular vesicles and cell-cell communication in metabolic regulation.

Samuelson I, Vidal-Puig AJ.

Essays Biochem. 2018 May 15;62(2):165-175. doi: 10.1042/EBC20170087. Print 2018 May 15. Review.

PMID:
29717059
24.

Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.

Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MTG, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S.

Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525e.

PMID:
29634685
25.

Defective glucose and lipid metabolism in rheumatoid arthritis is determined by chronic inflammation in metabolic tissues.

Arias de la Rosa I, Escudero-Contreras A, Rodríguez-Cuenca S, Ruiz-Ponce M, Jiménez-Gómez Y, Ruiz-Limón P, Pérez-Sánchez C, Ábalos-Aguilera MC, Cecchi I, Ortega R, Calvo J, Guzmán-Ruiz R, Malagón MM, Collantes-Estevez E, Vidal-Puig A, López-Pedrera C, Barbarroja N.

J Intern Med. 2018 Jul;284(1):61-77. doi: 10.1111/joim.12743. Epub 2018 Mar 12.

PMID:
29532531
26.

'Basic and Applied Thermogenesis Research' Bridging the Gap.

Carobbio S, Guénantin AC, Vidal-Puig A.

Trends Endocrinol Metab. 2018 Jan;29(1):5-7. doi: 10.1016/j.tem.2017.10.002. Epub 2017 Oct 27. Review.

PMID:
29110964
27.

No metabolic effects of mustard allyl-isothiocyanate compared with placebo in men.

Langeveld M, Tan CY, Soeters MR, Virtue S, Watson LP, Murgatroyd PR, Ambler GK, Vidal-Puig S, Chatterjee KV, Vidal-Puig A.

Am J Clin Nutr. 2017 Nov;106(5):1197-1205. doi: 10.3945/ajcn.116.148395. Epub 2017 Oct 25. Erratum in: Am J Clin Nutr. 2018 Apr 1;107(4):676.

28.

Dietary (Poly)phenols, Brown Adipose Tissue Activation, and Energy Expenditure: A Narrative Review.

Mele L, Bidault G, Mena P, Crozier A, Brighenti F, Vidal-Puig A, Del Rio D.

Adv Nutr. 2017 Sep 15;8(5):694-704. doi: 10.3945/an.117.015792. Print 2017 Sep. Review.

29.

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M.

Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014.

30.

SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes.

Yeo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Yassin MS, Tai ES, Vidal-Puig A, Toh SA.

Sci Rep. 2017 Jun 22;7(1):4031. doi: 10.1038/s41598-017-04369-2.

31.

Adipose Tissue Function and Expandability as Determinants of Lipotoxicity and the Metabolic Syndrome.

Carobbio S, Pellegrinelli V, Vidal-Puig A.

Adv Exp Med Biol. 2017;960:161-196. doi: 10.1007/978-3-319-48382-5_7. Review.

PMID:
28585199
32.

Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells.

Tsuchiya Y, Peak-Chew SY, Newell C, Miller-Aidoo S, Mangal S, Zhyvoloup A, Bakovic J, Malanchuk O, Pereira GC, Kotiadis V, Szabadkai G, Duchen MR, Campbell M, Cuenca SR, Vidal-Puig A, James AM, Murphy MP, Filonenko V, Skehel M, Gout I.

Biochem J. 2017 Jul 11;474(14):2489-2508. doi: 10.1042/BCJ20170129.

33.

Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function.

Mele L, Carobbio S, Brindani N, Curti C, Rodriguez-Cuenca S, Bidault G, Mena P, Zanotti I, Vacca M, Vidal-Puig A, Del Rio D.

Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201700074. Epub 2017 Apr 12.

PMID:
28276197
34.

Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases.

Rodriguez-Cuenca S, Pellegrinelli V, Campbell M, Oresic M, Vidal-Puig A.

Prog Lipid Res. 2017 Apr;66:14-29. doi: 10.1016/j.plipres.2017.01.002. Epub 2017 Jan 16. Review.

PMID:
28104532
35.

Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity.

Parvaresh Rizi E, Baig S, Shabeer M, Teo Y, Mok SF, Loh TP, Magkos F, Virtue S, Vidal-Puig A, Tai ES, Khoo CM, Toh SA.

Nutr J. 2016 Dec 1;15(1):100.

36.

Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease.

Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL.

Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6.

37.

Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease.

Huang-Doran I, Zhang CY, Vidal-Puig A.

Trends Endocrinol Metab. 2017 Jan;28(1):3-18. doi: 10.1016/j.tem.2016.10.003. Epub 2016 Oct 31. Review.

PMID:
27810172
38.

Metabolic gene expression profile in circulating mononuclear cells reflects obesity-associated metabolic inflexibility.

Baig S, Parvaresh Rizi E, Shabeer M, Chhay V, Mok SF, Loh TP, Magkos F, Vidal-Puig A, Tai ES, Khoo CM, Toh SA.

Nutr Metab (Lond). 2016 Oct 27;13:74. doi: 10.1186/s12986-016-0135-5. eCollection 2016.

39.

Stearoyl-CoA Desaturase 1 Is a Key Determinant of Membrane Lipid Composition in 3T3-L1 Adipocytes.

Rodriguez-Cuenca S, Whyte L, Hagen R, Vidal-Puig A, Fuller M.

PLoS One. 2016 Sep 15;11(9):e0162047. doi: 10.1371/journal.pone.0162047. eCollection 2016.

40.

Assessment of plasma acylcarnitines before and after weight loss in obese subjects.

Schooneman MG, Napolitano A, Houten SM, Ambler GK, Murgatroyd PR, Miller SR, Hollak CE, Tan CY, Virtue S, Vidal-Puig A, Nunez DJ, Soeters MR.

Arch Biochem Biophys. 2016 Sep 15;606:73-80. doi: 10.1016/j.abb.2016.07.013. Epub 2016 Jul 19.

PMID:
27444119
41.

Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.

Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S.

Nat Med. 2016 Jul;22(7):771-9. doi: 10.1038/nm.4115. Epub 2016 Jun 6. Erratum in: Nat Med. 2018 Apr 10;24(4):525.

42.

Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues.

Pellegrinelli V, Carobbio S, Vidal-Puig A.

Diabetologia. 2016 Jun;59(6):1075-88. doi: 10.1007/s00125-016-3933-4. Epub 2016 Apr 4. Review.

43.

Erratum: Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance.

Tan CY, Virtue S, Murfitt S, Roberts LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A.

Sci Rep. 2016 Mar 30;6:23873. doi: 10.1038/srep23873. No abstract available.

44.

Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.

Van De Pette M, Tunster SJ, McNamara GI, Shelkovnikova T, Millership S, Benson L, Peirson S, Christian M, Vidal-Puig A, John RM.

PLoS Genet. 2016 Mar 10;12(3):e1005916. doi: 10.1371/journal.pgen.1005916. eCollection 2016 Mar.

45.

Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice.

Sanghez V, Cubuk C, Sebastián-Leon P, Carobbio S, Dopazo J, Vidal-Puig A, Bartolomucci A.

Stress. 2016;19(2):214-24. doi: 10.3109/10253890.2016.1151491. Epub 2016 Mar 7.

46.

Deriving functional beige fat from capillaries.

Pellegrinelli V, Vidal-Puig A.

Nat Med. 2016 Mar;22(3):234-6. doi: 10.1038/nm.4056. No abstract available.

PMID:
26937616
47.

Mild cold effects on hunger, food intake, satiety and skin temperature in humans.

Langeveld M, Tan CY, Soeters MR, Virtue S, Ambler GK, Watson LP, Murgatroyd PR, Chatterjee VK, Vidal-Puig A.

Endocr Connect. 2016 Mar;5(2):65-73. doi: 10.1530/EC-16-0004. Epub 2016 Feb 10.

48.

Mitochondria are required for pro-ageing features of the senescent phenotype.

Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF.

EMBO J. 2016 Apr 1;35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4.

49.

Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis.

Razzoli M, Frontini A, Gurney A, Mondini E, Cubuk C, Katz LS, Cero C, Bolan PJ, Dopazo J, Vidal-Puig A, Cinti S, Bartolomucci A.

Mol Metab. 2015 Nov 11;5(1):19-33. doi: 10.1016/j.molmet.2015.10.005. eCollection 2016 Jan.

50.

Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance.

Yew Tan C, Virtue S, Murfitt S, Roberts LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A.

Sci Rep. 2015 Dec 17;5:18366. doi: 10.1038/srep18366. Erratum in: Sci Rep. 2016;6:23873. Robert, Lee D [corrected to Roberts, Lee D].

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