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ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis.

Kennedy JM, Georges A, Bassenden AV, Vidal SM, Berghuis AM, Taniuchi I, Majewski J, Lathrop M, Behr MA, Langlais D, Gros P.

Infect Immun. 2020 Jan 22;88(2). pii: e00845-19. doi: 10.1128/IAI.00845-19. Print 2020 Jan 22.


A point mutation in the linker domain of mouse STAT5A is associated with impaired NK-cell regulation.

Chehboun S, Leiva-Torres GA, Charbonneau B, Eveleigh R, Bourque G, Vidal SM.

Genes Immun. 2019 Oct 8. doi: 10.1038/s41435-019-0088-6. [Epub ahead of print]


CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection.

Yuki KE, Marei H, Fiskin E, Eva MM, Gopal AA, Schwartzentruber JA, Majewski J, Cellier M, Mandl JN, Vidal SM, Malo D, Dikic I.

Nat Microbiol. 2019 Sep;4(9):1516-1531. doi: 10.1038/s41564-019-0484-8. Epub 2019 Jul 8.


The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors.

Železnjak J, Lisnić VJ, Popović B, Lisnić B, Babić M, Halenius A, L'Hernault A, Roviš TL, Hengel H, Erhard F, Redwood AJ, Vidal SM, Dölken L, Krmpotić A, Jonjić S.

J Exp Med. 2019 Aug 5;216(8):1809-1827. doi: 10.1084/jem.20182213. Epub 2019 May 29.


Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis.

Mancini M, Caignard G, Charbonneau B, Dumaine A, Wu N, Leiva-Torres GA, Gerondakis S, Pearson A, Qureshi ST, Sladek R, Vidal SM.

J Immunol. 2019 Mar 1;202(5):1479-1493. doi: 10.4049/jimmunol.1800063. Epub 2019 Jan 25.


Insights into the pathogenesis of herpes simplex encephalitis from mouse models.

Mancini M, Vidal SM.

Mamm Genome. 2018 Aug;29(7-8):425-445. doi: 10.1007/s00335-018-9772-5. Epub 2018 Aug 23. Review.


The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes.

Rodrigue-Gervais IG, Doiron K, Champagne C, Mayes L, Leiva-Torres GA, Vanié P Jr, Douglas T, Vidal SM, Alnemri ES, Saleh M.

Sci Rep. 2018 May 31;8(1):8446. doi: 10.1038/s41598-018-26603-1.


Discovery of Variants Underlying Host Susceptibility to Virus Infection Using Whole-Exome Sequencing.

Leiva-Torres GA, Nebesio N, Vidal SM.

Methods Mol Biol. 2017;1656:209-227. doi: 10.1007/978-1-4939-7237-1_14.


Mouse Chromosome 4 Is Associated with the Baseline and Allergic IgE Phenotypes.

Kanagaratham C, Camateros P, Ren J, Sladek R, Vidal SM, Radzioch D.

G3 (Bethesda). 2017 Aug 7;7(8):2559-2564. doi: 10.1534/g3.117.042739.


Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.

Nat Immunol. 2016 Nov 16;17(12):1479. doi: 10.1038/ni1216-1479c. No abstract available.


USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.

Nat Immunol. 2017 Jan;18(1):54-63. doi: 10.1038/ni.3581. Epub 2016 Oct 10. Erratum in: Nat Immunol. 2016 Nov 16;17 (12 ):1479.


Expansion and Protection by a Virus-Specific NK Cell Subset Lacking Expression of the Inhibitory NKR-P1B Receptor during Murine Cytomegalovirus Infection.

Rahim MM, Wight A, Mahmoud AB, Aguilar OA, Lee SH, Vidal SM, Carlyle JR, Makrigiannis AP.

J Immunol. 2016 Sep 15;197(6):2325-37. doi: 10.4049/jimmunol.1600776. Epub 2016 Aug 10.


Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells.

Duerr CU, McCarthy CD, Mindt BC, Rubio M, Meli AP, Pothlichet J, Eva MM, Gauchat JF, Qureshi ST, Mazer BD, Mossman KL, Malo D, Gamero AM, Vidal SM, King IL, Sarfati M, Fritz JH.

Nat Immunol. 2016 Jan;17(1):65-75. doi: 10.1038/ni.3308. Epub 2015 Nov 23.


Survival analysis and microarray profiling identify Cd40 as a candidate for the Salmonella susceptibility locus, Ity5.

Beatty SC, Yuki KE, Eva MM, Dauphinee S, Larivière L, Vidal SM, Malo D.

Genes Immun. 2016 Jan-Feb;17(1):19-29. doi: 10.1038/gene.2015.41. Epub 2015 Nov 12.


Cyclosporine A Treatment Inhibits Abcc6-Dependent Cardiac Necrosis and Calcification following Coxsackievirus B3 Infection in Mice.

Marton J, Albert D, Wiltshire SA, Park R, Bergen A, Qureshi S, Malo D, Burelle Y, Vidal SM.

PLoS One. 2015 Sep 16;10(9):e0138222. doi: 10.1371/journal.pone.0138222. eCollection 2015.


Correction: Viral MHC class I-like molecule allows evasion of NK cell effector responses in vivo.

Pyzik M, Dumaine A, Charbonneau B, Fodil-Cornu N, Jonjic S, Vidal SM.

J Immunol. 2015 Jun 15;194(12):6192. doi: 10.4049/jimmunol.1500965. No abstract available.


Whole exome sequencing identifies the TNNI3K gene as a cause of familial conduction system disease and congenital junctional ectopic tachycardia.

Xi Y, Honeywell C, Zhang D, Schwartzentruber J, Beaulieu CL, Tetreault M, Hartley T, Marton J, Vidal SM, Majewski J, Aravind L; Care4Rare Canada Consortium, Gollob M, Boycott KM, Gow RM.

Int J Cardiol. 2015 Apr 15;185:114-6. doi: 10.1016/j.ijcard.2015.03.130. Epub 2015 Mar 11. No abstract available.


Mapping of a quantitative trait locus controlling susceptibility to Coxsackievirus B3-induced viral hepatitis.

Wiltshire SA, Marton J, Leiva-Torres GA, Vidal SM.

Genes Immun. 2015 Jun;16(4):261-7. doi: 10.1038/gene.2015.5. Epub 2015 Mar 19.


Reduced MCMV Δm157 viral clearance in the absence of TSAd.

Moussa P, Abrahamsen G, Fodil N, Gopalakrishnan RP, Mancini M, Dissen E, Sæther PC, Wiltshire SA, Boivin GA, Caignard G, Spurkland A, Vidal SM.

Sci Rep. 2015 Mar 18;5:9219. doi: 10.1038/srep09219.


Unc93b1 -Dependent Endosomal Toll-Like Receptor Signaling Regulates Inflammation and Mortality during Coxsackievirus B3 Infection.

Lafferty EI, Wiltshire SA, Angers I, Vidal SM, Qureshi ST.

J Innate Immun. 2015;7(3):315-30. doi: 10.1159/000369342. Epub 2015 Feb 11.


Specific dysregulation of IFNγ production by natural killer cells confers susceptibility to viral infection.

Fodil N, Langlais D, Moussa P, Boivin GA, Di Pietrantonio T, Radovanovic I, Dumaine A, Blanchette M, Schurr E, Gros P, Vidal SM.

PLoS Pathog. 2014 Dec 4;10(12):e1004511. doi: 10.1371/journal.ppat.1004511. eCollection 2014 Dec.


THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis.

Torre S, Faucher SP, Fodil N, Bongfen SE, Berghout J, Schwartzentruber JA, Majewski J, Lathrop M, Cooper AM, Vidal SM, Gros P.

Infect Immun. 2015 Feb;83(2):759-68. doi: 10.1128/IAI.02586-14. Epub 2014 Dec 1.


CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation.

Kennedy JM, Fodil N, Torre S, Bongfen SE, Olivier JF, Leung V, Langlais D, Meunier C, Berghout J, Langat P, Schwartzentruber J, Majewski J, Lathrop M, Vidal SM, Gros P.

J Exp Med. 2014 Dec 15;211(13):2519-35. doi: 10.1084/jem.20140455. Epub 2014 Nov 17.


Viral MHC class I-like molecule allows evasion of NK cell effector responses in vivo.

Pyzik M, Dumaine A, Charbonneau B, Fodil-Cornu N, Jonjic S, Vidal SM.

J Immunol. 2014 Dec 15;193(12):6061-9. doi: 10.4049/jimmunol.1401386. Epub 2014 Nov 12. Erratum in: J Immunol. 2015 Jun 15;194(12):6192. Dumaine, Anne A [Corrected to Dumaine, Anne].


Mouse ENU Mutagenesis to Understand Immunity to Infection: Methods, Selected Examples, and Perspectives.

Caignard G, Eva MM, van Bruggen R, Eveleigh R, Bourque G, Malo D, Gros P, Vidal SM.

Genes (Basel). 2014 Sep 29;5(4):887-925. doi: 10.3390/genes5040887. Review.


Mapping of a chromosome 12 region associated with airway hyperresponsiveness in a recombinant congenic mouse strain and selection of potential candidate genes by expression and sequence variation analyses.

Kanagaratham C, Marino R, Camateros P, Ren J, Houle D, Sladek R, Vidal SM, Radzioch D.

PLoS One. 2014 Aug 11;9(8):e104234. doi: 10.1371/journal.pone.0104234. eCollection 2014.


An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection.

Lafferty EI, Flaczyk A, Angers I, Homer R, d'Hennezel E, Malo D, Piccirillo CA, Vidal SM, Qureshi ST.

Genes Immun. 2014 Jul-Aug;15(5):320-32. doi: 10.1038/gene.2014.22. Epub 2014 May 22.


Increased resistance to malaria in mice with methylenetetrahydrofolate reductase (Mthfr) deficiency suggests a mechanism for selection of the MTHFR 677C>T (c.665C>T) variant.

Meadows DN, Pyzik M, Wu Q, Torre S, Gros P, Vidal SM, Rozen R.

Hum Mutat. 2014 May;35(5):594-600. doi: 10.1002/humu.22533. Epub 2014 Mar 31.


Veterinary education in the area of food safety (including animal health, food pathogens and surveillance of foodborne diseases).

Vidal SM, Fajardo PI, González CG.

Rev Sci Tech. 2013 Aug;32(2):425-31, 417-24. Review. English, Spanish.


Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival.

Rodrigue-Gervais IG, Labbé K, Dagenais M, Dupaul-Chicoine J, Champagne C, Morizot A, Skeldon A, Brincks EL, Vidal SM, Griffith TS, Saleh M.

Cell Host Microbe. 2014 Jan 15;15(1):23-35. doi: 10.1016/j.chom.2013.12.003.


Altered IFN-γ-mediated immunity and transcriptional expression patterns in N-Ethyl-N-nitrosourea-induced STAT4 mutants confer susceptibility to acute typhoid-like disease.

Eva MM, Yuki KE, Dauphinee SM, Schwartzentruber JA, Pyzik M, Paquet M, Lathrop M, Majewski J, Vidal SM, Malo D.

J Immunol. 2014 Jan 1;192(1):259-70. doi: 10.4049/jimmunol.1301370. Epub 2013 Nov 27.


Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.

Caignard G, Leiva-Torres GA, Leney-Greene M, Charbonneau B, Dumaine A, Fodil-Cornu N, Pyzik M, Cingolani P, Schwartzentruber J, Dupaul-Chicoine J, Guo H, Saleh M, Veillette A, Lathrop M, Blanchette M, Majewski J, Pearson A, Vidal SM.

PLoS Pathog. 2013 Sep;9(9):e1003637. doi: 10.1371/journal.ppat.1003637. Epub 2013 Sep 12.


Characterization of two ENU-induced mutations affecting mouse skeletal morphology.

Dauphinee SM, Eva MM, Yuki KE, Herman M, Vidal SM, Malo D.

G3 (Bethesda). 2013 Oct 3;3(10):1753-8. doi: 10.1534/g3.113.007310.


Management of acute ischemic stroke.

Vidal SM, Chaudhry FS, Schneck M.

Hosp Pract (1995). 2013 Apr;41(2):108-22. doi: 10.3810/hp.2013.04.1060. Review.


Susceptibility to lethal cerebral malaria is regulated by epistatic interaction between chromosome 4 (Berr6) and chromosome 1 (Berr7) loci in mice.

Torre S, van Bruggen R, Kennedy JM, Berghout J, Bongfen SE, Langat P, Lathrop M, Vidal SM, Gros P.

Genes Immun. 2013 Jun;14(4):249-57. doi: 10.1038/gene.2013.16. Epub 2013 Apr 18. Erratum in: Genes Immun. 2013 Oct;14(7):470.


Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells.

Pothlichet J, Meunier I, Davis BK, Ting JP, Skamene E, von Messling V, Vidal SM.

PLoS Pathog. 2013;9(4):e1003256. doi: 10.1371/journal.ppat.1003256. Epub 2013 Apr 11.


Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant.

Yuki KE, Eva MM, Richer E, Chung D, Paquet M, Cellier M, Canonne-Hergaux F, Vaulont S, Vidal SM, Malo D.

PLoS One. 2013;8(2):e55331. doi: 10.1371/journal.pone.0055331. Epub 2013 Feb 4.


Genetic dissection of NK cell responses.

Moussa P, Marton J, Vidal SM, Fodil-Cornu N.

Front Immunol. 2013 Jan 18;3:425. doi: 10.3389/fimmu.2012.00425. eCollection 2012.


TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy.

Marcoe JP, Lim JR, Schaubert KL, Fodil-Cornu N, Matka M, McCubbrey AL, Farr AR, Vidal SM, Laouar Y.

Nat Immunol. 2012 Sep;13(9):843-50. doi: 10.1038/ni.2388. Epub 2012 Aug 5. Erratum in: Nat Immunol. 2013 Aug;14(8):876.


Genetic control of high density lipoprotein-cholesterol in AcB/BcA recombinant congenic strains of mice.

Wiltshire SA, Diez E, Miao Q, Dubé MP, Gagné M, Paquette O, Lafrenière RG, Ndao M, Castellani LW, Skamene E, Vidal SM, Fortin A.

Physiol Genomics. 2012 Sep 1;44(17):843-52. doi: 10.1152/physiolgenomics.00025.2012. Epub 2012 Jul 17.


Mapping of clinical and expression quantitative trait loci in a sex-dependent effect of host susceptibility to mouse-adapted influenza H3N2/HK/1/68.

Boivin GA, Pothlichet J, Skamene E, Brown EG, Loredo-Osti JC, Sladek R, Vidal SM.

J Immunol. 2012 Apr 15;188(8):3949-60. doi: 10.4049/jimmunol.1103320. Epub 2012 Mar 16.


An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria.

Bongfen SE, Rodrigue-Gervais IG, Berghout J, Torre S, Cingolani P, Wiltshire SA, Leiva-Torres GA, Letourneau L, Sladek R, Blanchette M, Lathrop M, Behr MA, Gruenheid S, Vidal SM, Saleh M, Gros P.

PLoS One. 2012;7(2):e31012. doi: 10.1371/journal.pone.0031012. Epub 2012 Feb 21.


Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience.

Vidal SM, Khakoo SI, Biron CA.

Curr Opin Virol. 2011 Dec;1(6):497-512. doi: 10.1016/j.coviro.2011.10.017. Review.


The NK cell response to mouse cytomegalovirus infection affects the level and kinetics of the early CD8(+) T-cell response.

Mitrović M, Arapović J, Jordan S, Fodil-Cornu N, Ebert S, Vidal SM, Krmpotić A, Reddehase MJ, Jonjić S.

J Virol. 2012 Feb;86(4):2165-75. doi: 10.1128/JVI.06042-11. Epub 2011 Dec 7.


The impact of Ly49-NK cell-dependent recognition of MCMV infection on innate and adaptive immune responses.

Pyzik M, Gendron-Pontbriand EM, Vidal SM.

J Biomed Biotechnol. 2011;2011:641702. doi: 10.1155/2011/641702. Epub 2011 May 22. Review.


NK cell receptor/H2-Dk-dependent host resistance to viral infection is quantitatively modulated by H2q inhibitory signals.

Fodil-Cornu N, Loredo-Osti JC, Vidal SM.

PLoS Genet. 2011 Apr;7(4):e1001368. doi: 10.1371/journal.pgen.1001368. Epub 2011 Apr 21.


Quantitative trait locus analysis, pathway analysis, and consomic mapping show genetic variants of Tnni3k, Fpgt, or H28 control susceptibility to viral myocarditis.

Wiltshire SA, Leiva-Torres GA, Vidal SM.

J Immunol. 2011 Jun 1;186(11):6398-405. doi: 10.4049/jimmunol.1100159. Epub 2011 Apr 27.


Distinct MHC class I-dependent NK cell-activating receptors control cytomegalovirus infection in different mouse strains.

Pyzik M, Charbonneau B, Gendron-Pontbriand EM, Babić M, Krmpotić A, Jonjić S, Vidal SM.

J Exp Med. 2011 May 9;208(5):1105-17. doi: 10.1084/jem.20101831. Epub 2011 Apr 25.


Cytomegalovirus immunoevasin reveals the physiological role of "missing self" recognition in natural killer cell dependent virus control in vivo.

Babić M, Pyzik M, Zafirova B, Mitrović M, Butorac V, Lanier LL, Krmpotić A, Vidal SM, Jonjić S.

J Exp Med. 2010 Nov 22;207(12):2663-73. doi: 10.1084/jem.20100921. Epub 2010 Nov 15.


Bulk segregation mapping of mutations in closely related strains of mice.

Xia Y, Won S, Du X, Lin P, Ross C, La Vine D, Wiltshire S, Leiva G, Vidal SM, Whittle B, Goodnow CC, Koziol J, Moresco EM, Beutler B.

Genetics. 2010 Dec;186(4):1139-46. doi: 10.1534/genetics.110.121160. Epub 2010 Oct 5.

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