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Items: 1 to 50 of 63


Positive and negative conditioning in the neonatal brain.

Vexler ZS, Mallard C, Hagberg H.

Cond Med. 2018 Oct;1(6):279-293.


CX3CR1-CCR2-dependent monocyte-microglial signaling modulates neurovascular leakage and acute injury in a mouse model of childhood stroke.

Faustino J, Chip S, Derugin N, Jullienne A, Hamer M, Haddad E, Butovsky O, Obenaus A, Vexler ZS.

J Cereb Blood Flow Metab. 2019 Oct;39(10):1919-1935. doi: 10.1177/0271678X18817663. Epub 2019 Jan 10.


A Novel Technique for Visualizing and Analyzing the Cerebral Vasculature in Rodents.

Salehi A, Jullienne A, Wendel KM, Hamer M, Tang J, Zhang JH, Pearce WJ, DeFazio RA, Vexler ZS, Obenaus A.

Transl Stroke Res. 2018 May 15. doi: 10.1007/s12975-018-0632-0. [Epub ahead of print]


The myth of the immature barrier systems in the developing brain: role in perinatal brain injury.

Mallard C, Ek CJ, Vexler ZS.

J Physiol. 2018 Dec;596(23):5655-5664. doi: 10.1113/JP274938. Epub 2018 Apr 16. Review.


Microglia and Neonatal Brain Injury.

Mallard C, Tremblay ME, Vexler ZS.

Neuroscience. 2019 May 1;405:68-76. doi: 10.1016/j.neuroscience.2018.01.023. Epub 2018 Jan 17. Review.


Live imaging of the innate immune response in neonates reveals differential TLR2 dependent activation patterns in sterile inflammation and infection.

Lalancette-Hébert M, Faustino J, Thammisetty SS, Chip S, Vexler ZS, Kriz J.

Brain Behav Immun. 2017 Oct;65:312-327. doi: 10.1016/j.bbi.2017.05.020. Epub 2017 Jun 1.


Effects of therapeutic hypothermia on white matter injury from murine neonatal hypoxia-ischemia.

Koo E, Sheldon RA, Lee BS, Vexler ZS, Ferriero DM.

Pediatr Res. 2017 Sep;82(3):518-526. doi: 10.1038/pr.2017.75. Epub 2017 May 31.


Genetic deletion of galectin-3 enhances neuroinflammation, affects microglial activation and contributes to sub-chronic injury in experimental neonatal focal stroke.

Chip S, Fernández-López D, Li F, Faustino J, Derugin N, Vexler ZS.

Brain Behav Immun. 2017 Feb;60:270-281. doi: 10.1016/j.bbi.2016.11.005. Epub 2016 Nov 9.


Mesenchymal stem cells attenuate MRI-identifiable injury, protect white matter, and improve long-term functional outcomes after neonatal focal stroke in rats.

van Velthoven CT, Dzietko M, Wendland MF, Derugin N, Faustino J, Heijnen CJ, Ferriero DM, Vexler ZS.

J Neurosci Res. 2017 May;95(5):1225-1236. doi: 10.1002/jnr.23954. Epub 2016 Oct 26.


Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke.

Fernández-López D, Faustino J, Klibanov AL, Derugin N, Blanchard E, Simon F, Leib SL, Vexler ZS.

J Neurosci. 2016 Mar 9;36(10):2881-93. doi: 10.1523/JNEUROSCI.0140-15.2016.


Modeling Ischemia in the Immature Brain: How Translational Are Animal Models?

Mallard C, Vexler ZS.

Stroke. 2015 Oct;46(10):3006-11. doi: 10.1161/STROKEAHA.115.007776. Epub 2015 Aug 13. Review. No abstract available.


Lack of the scavenger receptor CD36 alters microglial phenotypes after neonatal stroke.

Li F, Faustino J, Woo MS, Derugin N, Vexler ZS.

J Neurochem. 2015 Nov;135(3):445-52. doi: 10.1111/jnc.13239. Epub 2015 Sep 3.


Pathophysiology and neuroprotection of global and focal perinatal brain injury: lessons from animal models.

Titomanlio L, Fernández-López D, Manganozzi L, Moretti R, Vexler ZS, Gressens P.

Pediatr Neurol. 2015 Jun;52(6):566-584. doi: 10.1016/j.pediatrneurol.2015.01.016. Epub 2015 Jan 31. Review.


LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation.

Sohet F, Lin C, Munji RN, Lee SY, Ruderisch N, Soung A, Arnold TD, Derugin N, Vexler ZS, Yen FT, Daneman R.

J Cell Biol. 2015 Mar 16;208(6):703-11. doi: 10.1083/jcb.201410131. Epub 2015 Mar 9.


The role of inflammation in perinatal brain injury.

Hagberg H, Mallard C, Ferriero DM, Vannucci SJ, Levison SW, Vexler ZS, Gressens P.

Nat Rev Neurol. 2015 Apr;11(4):192-208. doi: 10.1038/nrneurol.2015.13. Epub 2015 Feb 17. Review.


Barrier mechanisms in neonatal stroke.

Kratzer I, Chip S, Vexler ZS.

Front Neurosci. 2014 Nov 7;8:359. doi: 10.3389/fnins.2014.00359. eCollection 2014. Review.


Stem cells for neonatal stroke- the future is here.

van Velthoven CT, Gonzalez F, Vexler ZS, Ferriero DM.

Front Cell Neurosci. 2014 Jul 25;8:207. doi: 10.3389/fncel.2014.00207. eCollection 2014. No abstract available.


Mechanisms of perinatal arterial ischemic stroke.

Fernández-López D, Natarajan N, Ashwal S, Vexler ZS.

J Cereb Blood Flow Metab. 2014 Jun;34(6):921-32. doi: 10.1038/jcbfm.2014.41. Epub 2014 Mar 26. Review.


Delayed VEGF treatment enhances angiogenesis and recovery after neonatal focal rodent stroke.

Dzietko M, Derugin N, Wendland MF, Vexler ZS, Ferriero DM.

Transl Stroke Res. 2013 Apr;4(2):189-200. doi: 10.1007/s12975-012-0221-6.


Acute and chronic vascular responses to experimental focal arterial stroke in the neonate rat.

Fernández-López D, Faustino J, Derugin N, Vexler ZS.

Transl Stroke Res. 2013 Apr;4(2):179-88. doi: 10.1007/s12975-012-0214-5.


Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke.

van Velthoven CT, Sheldon RA, Kavelaars A, Derugin N, Vexler ZS, Willemen HL, Maas M, Heijnen CJ, Ferriero DM.

Stroke. 2013 May;44(5):1426-32. doi: 10.1161/STROKEAHA.111.000326. Epub 2013 Mar 28.


Genetic deletion of CD36 enhances injury after acute neonatal stroke.

Woo MS, Wang X, Faustino JV, Derugin N, Wendland MF, Zhou P, Iadecola C, Vexler ZS.

Ann Neurol. 2012 Dec;72(6):961-70. doi: 10.1002/ana.23727.


Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat.

Fernández-López D, Faustino J, Daneman R, Zhou L, Lee SY, Derugin N, Wendland MF, Vexler ZS.

J Neurosci. 2012 Jul 11;32(28):9588-600. doi: 10.1523/JNEUROSCI.5977-11.2012.


Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke.

Fernández-López D, Faustino J, Derugin N, Wendland M, Lizasoain I, Moro MA, Vexler ZS.

Neuroscience. 2012 Apr 5;207:307-15. doi: 10.1016/j.neuroscience.2012.01.008. Epub 2012 Jan 12.


Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke.

Faustino JV, Wang X, Johnson CE, Klibanov A, Derugin N, Wendland MF, Vexler ZS.

J Neurosci. 2011 Sep 7;31(36):12992-3001. doi: 10.1523/JNEUROSCI.2102-11.2011.


Cerebrovascular disease in children: recent advances in diagnosis and management.

Bowers KJ, Deveber GA, Ferriero DM, Roach ES, Vexler ZS, Maria BL.

J Child Neurol. 2011 Sep;26(9):1074-100. doi: 10.1177/0883073811413585. Epub 2011 Jul 21. Review. No abstract available.


Magnetic resonance imaging (MRI) as a translational tool for the study of neonatal stroke.

Dzietko M, Wendland M, Derugin N, Ferriero DM, Vexler ZS.

J Child Neurol. 2011 Sep;26(9):1145-53. doi: 10.1177/0883073811408308. Epub 2011 Jun 13.


Cerebellar abnormalities following hypoxia alone compared to hypoxic-ischemic forebrain injury in the developing rat brain.

Biran V, Heine VM, Verney C, Sheldon RA, Spadafora R, Vexler ZS, Rowitch DH, Ferriero DM.

Neurobiol Dis. 2011 Jan;41(1):138-46. doi: 10.1016/j.nbd.2010.09.001. Epub 2010 Sep 16.


Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke.

Shimotake J, Derugin N, Wendland M, Vexler ZS, Ferriero DM.

Stroke. 2010 Feb;41(2):343-9. doi: 10.1161/STROKEAHA.109.564229.


Does inflammation after stroke affect the developing brain differently than adult brain?

Vexler ZS, Yenari MA.

Dev Neurosci. 2009;31(5):378-93. doi: 10.1159/000232556. Epub 2009 Aug 11. Review.


Early diffusion-weighted MRI as a predictor of caspase-3 activation after hypoxic-ischemic insult in neonatal rodents.

Wendland MF, Faustino J, West T, Manabat C, Holtzman DM, Vexler ZS.

Stroke. 2008 Jun;39(6):1862-8. doi: 10.1161/STROKEAHA.107.506352. Epub 2008 Apr 17.


Macrophages are comprised of resident brain microglia not infiltrating peripheral monocytes acutely after neonatal stroke.

Denker SP, Ji S, Dingman A, Lee SY, Derugin N, Wendland MF, Vexler ZS.

J Neurochem. 2007 Feb;100(4):893-904. Epub 2006 Dec 22.


Inflammation in adult and neonatal stroke.

Vexler ZS, Tang XN, Yenari MA.

Clin Neurosci Res. 2006 Dec 1;6(5):293-313.


Translational stroke research in the developing brain.

Vexler ZS, Sharp FR, Feuerstein GZ, Ashwal S, Thoresen M, Yager JY, Ferriero DM.

Pediatr Neurol. 2006 Jun;34(6):459-63.


Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient cerebral ischemia.

Dingman A, Lee SY, Derugin N, Wendland MF, Vexler ZS.

J Neurochem. 2006 Mar;96(5):1467-79. Epub 2006 Feb 8.


Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70.

Matsumori Y, Northington FJ, Hong SM, Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR, Liu J.

Stroke. 2006 Feb;37(2):507-12. Epub 2006 Jan 5.


Magnetic resonance imaging as a surrogate measure for histological sub-chronic endpoint in a neonatal rat stroke model.

Derugin N, Dingman A, Wendland MF, Fox C, Bollen A, Vexler ZS.

Brain Res. 2005 Dec 20;1066(1-2):49-56. Epub 2005 Dec 5.


Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection.

Yenari MA, Liu J, Zheng Z, Vexler ZS, Lee JE, Giffard RG.

Ann N Y Acad Sci. 2005 Aug;1053:74-83. Review.


Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke.

Mu D, Chang YS, Vexler ZS, Ferriero DM.

Exp Neurol. 2005 Oct;195(2):407-15.


Erythropoietin improves functional and histological outcome in neonatal stroke.

Chang YS, Mu D, Wendland M, Sheldon RA, Vexler ZS, McQuillen PS, Ferriero DM.

Pediatr Res. 2005 Jul;58(1):106-11. Epub 2005 May 5.


Minocycline confers early but transient protection in the immature brain following focal cerebral ischemia-reperfusion.

Fox C, Dingman A, Derugin N, Wendland MF, Manabat C, Ji S, Ferriero DM, Vexler ZS.

J Cereb Blood Flow Metab. 2005 Sep;25(9):1138-49. Erratum in: J Cereb Blood Flow Metab. 2006 Mar;26(3):446.


Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury.

Matsumori Y, Hong SM, Aoyama K, Fan Y, Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR, Liu J.

J Cereb Blood Flow Metab. 2005 Jul;25(7):899-910.


Differential vulnerability of immature murine neurons to oxygen-glucose deprivation.

Jiang X, Mu D, Manabat C, Koshy AA, Christen S, Täuber MG, Vexler ZS, Ferriero DM.

Exp Neurol. 2004 Nov;190(1):224-32.


Manipulation of antioxidant pathways in neonatal murine brain.

Sheldon RA, Jiang X, Francisco C, Christen S, Vexler ZS, Täuber MG, Ferriero DM.

Pediatr Res. 2004 Oct;56(4):656-62. Epub 2004 Aug 4.


Regulation of hypoxia-inducible factor 1alpha and induction of vascular endothelial growth factor in a rat neonatal stroke model.

Mu D, Jiang X, Sheldon RA, Fox CK, Hamrick SE, Vexler ZS, Ferriero DM.

Neurobiol Dis. 2003 Dec;14(3):524-34.


Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain.

Manabat C, Han BH, Wendland M, Derugin N, Fox CK, Choi J, Holtzman DM, Ferriero DM, Vexler ZS.

Stroke. 2003 Jan;34(1):207-13.


Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress.

Vexler ZS, Wong A, Francisco C, Manabat C, Christen S, Täuber M, Ferriero DM, Gregory G.

Brain Res. 2003 Jan 17;960(1-2):90-8.


Rat forebrain neurogenesis and striatal neuron replacement after focal stroke.

Parent JM, Vexler ZS, Gong C, Derugin N, Ferriero DM.

Ann Neurol. 2002 Dec;52(6):802-13.


Molecular and biochemical mechanisms of perinatal brain injury.

Vexler ZS, Ferriero DM.

Semin Neonatol. 2001 Apr;6(2):99-108. Review.


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