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Novel Metabolic Pathways and Regulons for Hexuronate Utilization in Proteobacteria.

Bouvier JT, Sernova NV, Ghasempur S, Rodionova IA, Vetting MW, Al-Obaidi NF, Almo SC, Gerlt JA, Rodionov DA.

J Bacteriol. 2018 Dec 20;201(2). pii: e00431-18. doi: 10.1128/JB.00431-18. Print 2019 Jan 15.


Functional assignment of multiple catabolic pathways for D-apiose.

Carter MS, Zhang X, Huang H, Bouvier JT, Francisco BS, Vetting MW, Al-Obaidi N, Bonanno JB, Ghosh A, Zallot RG, Andersen HM, Almo SC, Gerlt JA.

Nat Chem Biol. 2018 Jul;14(7):696-705. doi: 10.1038/s41589-018-0067-7. Epub 2018 Jun 4.


Prediction of enzymatic pathways by integrative pathway mapping.

Calhoun S, Korczynska M, Wichelecki DJ, San Francisco B, Zhao S, Rodionov DA, Vetting MW, Al-Obaidi NF, Lin H, O'Meara MJ, Scott DA, Morris JH, Russel D, Almo SC, Osterman AL, Gerlt JA, Jacobson MP, Shoichet BK, Sali A.

Elife. 2018 Jan 29;7. pii: e31097. doi: 10.7554/eLife.31097.


A novel bifunctional transcriptional regulator of riboflavin metabolism in Archaea.

Rodionova IA, Vetting MW, Li X, Almo SC, Osterman AL, Rodionov DA.

Nucleic Acids Res. 2017 Apr 20;45(7):3785-3799. doi: 10.1093/nar/gkw1331.


Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars.

Zhang X, Carter MS, Vetting MW, San Francisco B, Zhao S, Al-Obaidi NF, Solbiati JO, Thiaville JJ, de Crécy-Lagard V, Jacobson MP, Almo SC, Gerlt JA.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4161-9. doi: 10.1073/pnas.1605546113. Epub 2016 Jul 11.


Structure of an ABC transporter solute-binding protein specific for the amino sugars glucosamine and galactosamine.

Yadava U, Vetting MW, Al Obaidi N, Carter MS, Gerlt JA, Almo SC.

Acta Crystallogr F Struct Biol Commun. 2016 Jun;72(Pt 6):467-72. doi: 10.1107/S2053230X16007500. Epub 2016 May 23.


Correction to "A General Strategy for the Discovery of Metabolic Pathways: D-Threitol, L-Threitol, and Erythritol Utilization in Mycobacterium smegmatis".

Huang H, Carter MS, Vetting MW, Al-Obaidi N, Patskovsky Y, Almo SC, Gerlt JA.

J Am Chem Soc. 2016 Mar 30;138(12):4267. doi: 10.1021/jacs.6b01906. Epub 2016 Mar 15. No abstract available.


Purification, crystallization and structural elucidation of D-galactaro-1,4-lactone cycloisomerase from Agrobacterium tumefaciens involved in pectin degradation.

Vetting MW, Bouvier JT, Gerlt JA, Almo SC.

Acta Crystallogr F Struct Biol Commun. 2016 Jan;72(Pt 1):36-41. doi: 10.1107/S2053230X15023286. Epub 2016 Jan 1.


A General Strategy for the Discovery of Metabolic Pathways: d-Threitol, l-Threitol, and Erythritol Utilization in Mycobacterium smegmatis.

Huang H, Carter MS, Vetting MW, Al-Obaidi N, Patskovsky Y, Almo SC, Gerlt JA.

J Am Chem Soc. 2015 Nov 25;137(46):14570-3. doi: 10.1021/jacs.5b08968. Epub 2015 Nov 12. Erratum in: J Am Chem Soc. 2016 Mar 30;138(12):4267.


ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel d-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58.

Wichelecki DJ, Vetting MW, Chou L, Al-Obaidi N, Bouvier JT, Almo SC, Gerlt JA.

J Biol Chem. 2015 Nov 27;290(48):28963-76. doi: 10.1074/jbc.M115.686857. Epub 2015 Oct 15.


A unique cis-3-hydroxy-l-proline dehydratase in the enolase superfamily.

Zhang X, Kumar R, Vetting MW, Zhao S, Jacobson MP, Almo SC, Gerlt JA.

J Am Chem Soc. 2015 Feb 4;137(4):1388-91. doi: 10.1021/ja5103986. Epub 2015 Jan 26.


Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes.

Vetting MW, Al-Obaidi N, Zhao S, San Francisco B, Kim J, Wichelecki DJ, Bouvier JT, Solbiati JO, Vu H, Zhang X, Rodionov DA, Love JD, Hillerich BS, Seidel RD, Quinn RJ, Osterman AL, Cronan JE, Jacobson MP, Gerlt JA, Almo SC.

Biochemistry. 2015 Jan 27;54(3):909-31. doi: 10.1021/bi501388y. Epub 2015 Jan 16.


Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks.

Zhao S, Sakai A, Zhang X, Vetting MW, Kumar R, Hillerich B, San Francisco B, Solbiati J, Steves A, Brown S, Akiva E, Barber A, Seidel RD, Babbitt PC, Almo SC, Gerlt JA, Jacobson MP.

Elife. 2014 Jun 30;3. doi: 10.7554/eLife.03275.


Evolution of enzymatic activities in the enolase superfamily: galactarate dehydratase III from Agrobacterium tumefaciens C58.

Groninger-Poe FP, Bouvier JT, Vetting MW, Kalyanaraman C, Kumar R, Almo SC, Jacobson MP, Gerlt JA.

Biochemistry. 2014 Jul 1;53(25):4192-203. doi: 10.1021/bi5005377. Epub 2014 Jun 19.


Large-scale determination of sequence, structure, and function relationships in cytosolic glutathione transferases across the biosphere.

Mashiyama ST, Malabanan MM, Akiva E, Bhosle R, Branch MC, Hillerich B, Jagessar K, Kim J, Patskovsky Y, Seidel RD, Stead M, Toro R, Vetting MW, Almo SC, Armstrong RN, Babbitt PC.

PLoS Biol. 2014 Apr 22;12(4):e1001843. doi: 10.1371/journal.pbio.1001843. eCollection 2014 Apr.


Discovery of function in the enolase superfamily: D-mannonate and d-gluconate dehydratases in the D-mannonate dehydratase subgroup.

Wichelecki DJ, Balthazor BM, Chau AC, Vetting MW, Fedorov AA, Fedorov EV, Lukk T, Patskovsky YV, Stead MB, Hillerich BS, Seidel RD, Almo SC, Gerlt JA.

Biochemistry. 2014 Apr 29;53(16):2722-31. doi: 10.1021/bi500264p. Epub 2014 Apr 15.


Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine.

Kumar R, Zhao S, Vetting MW, Wood BM, Sakai A, Cho K, Solbiati J, Almo SC, Sweedler JV, Jacobson MP, Gerlt JA, Cronan JE.

MBio. 2014 Feb 11;5(1):e00933-13. doi: 10.1128/mBio.00933-13.


Discovery of new enzymes and metabolic pathways by using structure and genome context.

Zhao S, Kumar R, Sakai A, Vetting MW, Wood BM, Brown S, Bonanno JB, Hillerich BS, Seidel RD, Babbitt PC, Almo SC, Sweedler JV, Gerlt JA, Cronan JE, Jacobson MP.

Nature. 2013 Oct 31;502(7473):698-702. doi: 10.1038/nature12576. Epub 2013 Sep 22.


Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily.

Lukk T, Sakai A, Kalyanaraman C, Brown SD, Imker HJ, Song L, Fedorov AA, Fedorov EV, Toro R, Hillerich B, Seidel R, Patskovsky Y, Vetting MW, Nair SK, Babbitt PC, Almo SC, Gerlt JA, Jacobson MP.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4122-7. doi: 10.1073/pnas.1112081109. Epub 2012 Mar 5.


Structure of QnrB1, a plasmid-mediated fluoroquinolone resistance factor.

Vetting MW, Hegde SS, Wang M, Jacoby GA, Hooper DC, Blanchard JS.

J Biol Chem. 2011 Jul 15;286(28):25265-73. doi: 10.1074/jbc.M111.226936. Epub 2011 May 19.


Pentapeptide-repeat proteins that act as topoisomerase poison resistance factors have a common dimer interface.

Vetting MW, Hegde SS, Zhang Y, Blanchard JS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Mar 1;67(Pt 3):296-302. doi: 10.1107/S1744309110053315. Epub 2011 Feb 18.


Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor.

Hegde SS, Vetting MW, Mitchenall LA, Maxwell A, Blanchard JS.

Antimicrob Agents Chemother. 2011 Jan;55(1):110-7. doi: 10.1128/AAC.01158-10. Epub 2010 Oct 11.


The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase.

Vetting MW, Hegde SS, Blanchard JS.

Nat Chem Biol. 2010 Nov;6(11):797-9. doi: 10.1038/nchembio.440. Epub 2010 Sep 19.


Structures and mechanisms of the mycothiol biosynthetic enzymes.

Fan F, Vetting MW, Frantom PA, Blanchard JS.

Curr Opin Chem Biol. 2009 Oct;13(4):451-9. doi: 10.1016/j.cbpa.2009.07.018. Epub 2009 Aug 19. Review.


Structure of the ternary complex of phosphomevalonate kinase: the enzyme and its family.

Andreassi JL 2nd, Vetting MW, Bilder PW, Roderick SL, Leyh TS.

Biochemistry. 2009 Jul 14;48(27):6461-8. doi: 10.1021/bi900537u.


Crystallization of a pentapeptide-repeat protein by reductive cyclic pentylation of free amines with glutaraldehyde.

Vetting MW, Hegde SS, Blanchard JS.

Acta Crystallogr D Biol Crystallogr. 2009 May;65(Pt 5):462-9. doi: 10.1107/S0907444909008324. Epub 2009 Apr 18.


The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway.

Tremblay LW, Fan F, Vetting MW, Blanchard JS.

Biochemistry. 2008 Dec 16;47(50):13326-35. doi: 10.1021/bi801708f.


Rv0802c from Mycobacterium tuberculosis: the first structure of a succinyltransferase with the GNAT fold.

Vetting MW, Errey JC, Blanchard JS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Nov 1;64(Pt 11):978-85. doi: 10.1107/S1744309108031679. Epub 2008 Oct 31.


Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6')-Ib and its bifunctional, fluoroquinolone-active AAC(6')-Ib-cr variant.

Vetting MW, Park CH, Hegde SS, Jacoby GA, Hooper DC, Blanchard JS.

Biochemistry. 2008 Sep 16;47(37):9825-35. doi: 10.1021/bi800664x. Epub 2008 Aug 19.


Crystal structure of RimI from Salmonella typhimurium LT2, the GNAT responsible for N(alpha)-acetylation of ribosomal protein S18.

Vetting MW, Bareich DC, Yu M, Blanchard JS.

Protein Sci. 2008 Oct;17(10):1781-90. doi: 10.1110/ps.035899.108. Epub 2008 Jul 2.


Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: substrate-assisted catalysis.

Vetting MW, Frantom PA, Blanchard JS.

J Biol Chem. 2008 Jun 6;283(23):15834-44. doi: 10.1074/jbc.M801017200. Epub 2008 Apr 4.


Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6'-N-acetyltransferase.

Magalhães ML, Vetting MW, Gao F, Freiburger L, Auclair K, Blanchard JS.

Biochemistry. 2008 Jan 15;47(2):579-84. Epub 2007 Dec 21.


New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.

Argyrou A, Vetting MW, Blanchard JS.

J Am Chem Soc. 2007 Aug 8;129(31):9582-3. Epub 2007 Jul 18. No abstract available.


Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase.

Hegde SS, Chandler J, Vetting MW, Yu M, Blanchard JS.

Biochemistry. 2007 Jun 19;46(24):7187-95. Epub 2007 May 22.


Structure of the E. coli bifunctional GlmU acetyltransferase active site with substrates and products.

Olsen LR, Vetting MW, Roderick SL.

Protein Sci. 2007 Jun;16(6):1230-5. Epub 2007 May 1.


Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate.

Andreassi JL 2nd, Bilder PW, Vetting MW, Roderick SL, Leyh TS.

Protein Sci. 2007 May;16(5):983-9. Epub 2007 Mar 30.


Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid.

Argyrou A, Vetting MW, Aladegbami B, Blanchard JS.

Nat Struct Mol Biol. 2006 May;13(5):408-13. Epub 2006 Apr 30.


Pentapeptide repeat proteins.

Vetting MW, Hegde SS, Fajardo JE, Fiser A, Roderick SL, Takiff HE, Blanchard JS.

Biochemistry. 2006 Jan 10;45(1):1-10.


The substrate-induced conformational change of Mycobacterium tuberculosis mycothiol synthase.

Vetting MW, Yu M, Rendle PM, Blanchard JS.

J Biol Chem. 2006 Feb 3;281(5):2795-802. Epub 2005 Dec 2.


Structure of catechol 1,2-dioxygenase from Pseudomonas arvilla.

Earhart CA, Vetting MW, Gosu R, Michaud-Soret I, Que L Jr, Ohlendorf DH.

Biochem Biophys Res Commun. 2005 Dec 9;338(1):198-205. Epub 2005 Sep 8.


Roles of the equatorial tyrosyl iron ligand of protocatechuate 3,4-dioxygenase in catalysis.

Valley MP, Brown CK, Burk DL, Vetting MW, Ohlendorf DH, Lipscomb JD.

Biochemistry. 2005 Aug 23;44(33):11024-39.


A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.

Hegde SS, Vetting MW, Roderick SL, Mitchenall LA, Maxwell A, Takiff HE, Blanchard JS.

Science. 2005 Jun 3;308(5727):1480-3.


A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium.

Vetting MW, de Carvalho LP, Roderick SL, Blanchard JS.

J Biol Chem. 2005 Jun 10;280(23):22108-14. Epub 2005 Apr 6.


Structure and functions of the GNAT superfamily of acetyltransferases.

Vetting MW, S de Carvalho LP, Yu M, Hegde SS, Magnet S, Roderick SL, Blanchard JS.

Arch Biochem Biophys. 2005 Jan 1;433(1):212-26. Review.


Biophysical analyses of designed and selected mutants of protocatechuate 3,4-dioxygenase1.

Brown CK, Vetting MW, Earhart CA, Ohlendorf DH.

Annu Rev Microbiol. 2004;58:555-85. Review.


Characterization of a new member of the flavoprotein disulfide reductase family of enzymes from Mycobacterium tuberculosis.

Argyrou A, Vetting MW, Blanchard JS.

J Biol Chem. 2004 Dec 10;279(50):52694-702. Epub 2004 Sep 29.


Structure of serine acetyltransferase in complexes with CoA and its cysteine feedback inhibitor.

Olsen LR, Huang B, Vetting MW, Roderick SL.

Biochemistry. 2004 May 25;43(20):6013-9.


A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones.

Vetting MW, Magnet S, Nieves E, Roderick SL, Blanchard JS.

Chem Biol. 2004 Apr;11(4):565-73.

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