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Items: 1 to 50 of 217

1.

Enzymatic ligation of a pore blocker toxin and gating modifier toxin; creating double-knotted peptides with improved sodium channel NaV1.7 inhibition.

Tran H, Tran P, Deuis JR, Agwa AJ, Zhang AH, Vetter I, Schroeder CI.

Bioconjug Chem. 2019 Dec 2. doi: 10.1021/acs.bioconjchem.9b00744. [Epub ahead of print]

PMID:
31790574
2.

Missiles of Mass Disruption: Composition and Glandular Origin of Venom Used as a Projectile Defensive Weapon by the Assassin Bug Platymeris rhadamanthus.

Walker AA, Robinson SD, Undheim EAB, Jin J, Han X, Fry BG, Vetter I, King GF.

Toxins (Basel). 2019 Nov 18;11(11). pii: E673. doi: 10.3390/toxins11110673.

3.

High-Throughput Fluorescence Assays for Ion Channels and GPCRs.

Vetter I, Carter D, Bassett J, Deuis JR, Tay B, Jami S, Robinson SD.

Adv Exp Med Biol. 2020;1131:27-72. doi: 10.1007/978-3-030-12457-1_3. Review.

PMID:
31646506
4.

Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell-induced bone pain.

Shenoy PA, Kuo A, Leparc G, Hildebrandt T, Rust W, Nicholson JR, Corradini L, Vetter I, Smith MT.

Clin Exp Pharmacol Physiol. 2019 Dec;46(12):1201-1215. doi: 10.1111/1440-1681.13165. Epub 2019 Sep 15.

PMID:
31429474
5.

Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen.

Mueller A, Starobova H, Morgan M, Dekan Z, Cheneval O, Schroeder CI, Alewood PF, Deuis JR, Vetter I.

Pain. 2019 Aug;160(8):1766-1780. doi: 10.1097/j.pain.0000000000001567.

PMID:
31335646
6.

Minocycline Prevents the Development of Mechanical Allodynia in Mouse Models of Vincristine-Induced Peripheral Neuropathy.

Starobova H, Mueller A, Allavena R, Lohman RJ, Sweet MJ, Vetter I.

Front Neurosci. 2019 Jun 27;13:653. doi: 10.3389/fnins.2019.00653. eCollection 2019.

7.

Inflammatory and Neuropathic Gene Expression Signatures of Chemotherapy-Induced Neuropathy Induced by Vincristine, Cisplatin, and Oxaliplatin in C57BL/6J Mice.

Starobova H, Mueller A, Deuis JR, Carter DA, Vetter I.

J Pain. 2019 Jun 29. pii: S1526-5900(19)30751-5. doi: 10.1016/j.jpain.2019.06.008. [Epub ahead of print]

PMID:
31260808
8.

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis.

Laraia L, Friese A, Corkery DP, Konstantinidis G, Erwin N, Hofer W, Karatas H, Klewer L, Brockmeyer A, Metz M, Schölermann B, Dwivedi M, Li L, Rios-Munoz P, Köhn M, Winter R, Vetter IR, Ziegler S, Janning P, Wu YW, Waldmann H.

Nat Chem Biol. 2019 Jul;15(7):710-720. doi: 10.1038/s41589-019-0307-5. Epub 2019 Jun 20.

PMID:
31222192
9.

NaV 1.6 regulates excitability of mechanosensitive sensory neurons.

Israel MR, Tanaka BS, Castro J, Thongyoo P, Robinson SD, Zhao P, Deuis JR, Craik DJ, Durek T, Brierley SM, Waxman SG, Dib-Hajj SD, Vetter I.

J Physiol. 2019 Jul;597(14):3751-3768. doi: 10.1113/JP278148. Epub 2019 May 13.

PMID:
31087362
10.

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels.

Jin AH, Cristofori-Armstrong B, Rash LD, Román-González SA, Espinosa RA, Lewis RJ, Alewood PF, Vetter I.

Biochem Pharmacol. 2019 Jun;164:342-348. doi: 10.1016/j.bcp.2019.04.025. Epub 2019 Apr 24.

PMID:
31028742
11.

Development of a high-throughput fluorescent no-wash sodium influx assay.

Tay B, Stewart TA, Davis FM, Deuis JR, Vetter I.

PLoS One. 2019 Mar 11;14(3):e0213751. doi: 10.1371/journal.pone.0213751. eCollection 2019.

12.

Development of an N-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic Pain.

Mostyn SN, Rawling T, Mohammadi S, Shimmon S, Frangos ZJ, Sarker S, Yousuf A, Vetter I, Ryan RM, Christie MJ, Vandenberg RJ.

J Med Chem. 2019 Mar 14;62(5):2466-2484. doi: 10.1021/acs.jmedchem.8b01775. Epub 2019 Feb 20.

13.

Graduate medical education scholarly activities initiatives: a systematic review and meta-analysis.

Wood W, McCollum J, Kukreja P, Vetter IL, Morgan CJ, Hossein Zadeh Maleki A, Riesenberg LA.

BMC Med Educ. 2018 Dec 22;18(1):318. doi: 10.1186/s12909-018-1407-8.

14.

A Centipede Toxin Family Defines an Ancient Class of CSαβ Defensins.

Dash TS, Shafee T, Harvey PJ, Zhang C, Peigneur S, Deuis JR, Vetter I, Tytgat J, Anderson MA, Craik DJ, Durek T, Undheim EAB.

Structure. 2019 Feb 5;27(2):315-326.e7. doi: 10.1016/j.str.2018.10.022. Epub 2018 Dec 13.

PMID:
30554841
15.

Buzz Kill: Function and Proteomic Composition of Venom from the Giant Assassin Fly Dolopus genitalis (Diptera: Asilidae).

Walker AA, Dobson J, Jin J, Robinson SD, Herzig V, Vetter I, King GF, Fry BG.

Toxins (Basel). 2018 Nov 5;10(11). pii: E456. doi: 10.3390/toxins10110456.

16.

Transcriptomics in pain research: insights from new and old technologies.

Starobova H, S W A H, Lewis RJ, Vetter I.

Mol Omics. 2018 Dec 3;14(6):389-404. doi: 10.1039/c8mo00181b. Review.

PMID:
30374497
17.

A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family.

Robinson SD, Mueller A, Clayton D, Starobova H, Hamilton BR, Payne RJ, Vetter I, King GF, Undheim EAB.

Sci Adv. 2018 Sep 12;4(9):eaau4640. doi: 10.1126/sciadv.aau4640. eCollection 2018 Sep.

18.

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides.

Sousa SR, McArthur JR, Brust A, Bhola RF, Rosengren KJ, Ragnarsson L, Dutertre S, Alewood PF, Christie MJ, Adams DJ, Vetter I, Lewis RJ.

Sci Rep. 2018 Sep 7;8(1):13397. doi: 10.1038/s41598-018-31245-4.

19.

Chemotactic responses of growing neurites to precisely controlled gradients of nerve growth factor.

Bicknell BA, Pujic Z, Feldner J, Vetter I, Goodhill GJ.

Sci Data. 2018 Sep 4;5:180183. doi: 10.1038/sdata.2018.183.

20.

Membrane insertion of α-xenorhabdolysin in near-atomic detail.

Schubert E, Vetter IR, Prumbaum D, Penczek PA, Raunser S.

Elife. 2018 Jul 16;7. pii: e38017. doi: 10.7554/eLife.38017.

21.

The Somatostatin Receptor-4 Agonist J-2156 Alleviates Mechanical Hypersensitivity in a Rat Model of Breast Cancer Induced Bone Pain.

Shenoy PA, Kuo A, Khan N, Gorham L, Nicholson JR, Corradini L, Vetter I, Smith MT.

Front Pharmacol. 2018 May 15;9:495. doi: 10.3389/fphar.2018.00495. eCollection 2018.

22.

An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay.

Stevenson RJ, Azimi I, Flanagan JU, Inserra M, Vetter I, Monteith GR, Denny WA.

Bioorg Med Chem. 2018 Jul 23;26(12):3406-3413. doi: 10.1016/j.bmc.2018.05.012. Epub 2018 May 9.

PMID:
29776832
23.

Toxins in Neurobiology: New tools from old molecules.

Vetter I.

Neurosci Lett. 2018 Jul 13;679:1-3. doi: 10.1016/j.neulet.2018.05.008. Epub 2018 May 5. No abstract available.

PMID:
29738846
24.

Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes.

Bongard J, Lorenz M, Vetter IR, Stege P, Porfetye AT, Schmitz AL, Kaschani F, Wolf A, Koch U, Nussbaumer P, Klebl B, Kaiser M, Ehrmann M.

ACS Chem Biol. 2018 May 18;13(5):1307-1312. doi: 10.1021/acschembio.8b00101. Epub 2018 Apr 16.

PMID:
29658704
25.

Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels.

Yapa KTDS, Deuis J, Peters AA, Kenny PA, Roberts-Thomson SJ, Vetter I, Monteith GR.

Life Sci. 2018 Apr 1;198:128-135. doi: 10.1016/j.lfs.2018.02.030. Epub 2018 Feb 26.

PMID:
29496495
26.

The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6.

Israel MR, Thongyoo P, Deuis JR, Craik DJ, Vetter I, Durek T.

J Med Chem. 2018 Feb 22;61(4):1730-1736. doi: 10.1021/acs.jmedchem.7b01609. Epub 2018 Feb 3.

PMID:
29378414
27.

Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology.

Jami S, Erickson A, Brierley SM, Vetter I.

Toxins (Basel). 2017 Dec 27;10(1). pii: E15. doi: 10.3390/toxins10010015. Review.

28.

Decoding the centromeric nucleosome through CENP-N.

Pentakota S, Zhou K, Smith C, Maffini S, Petrovic A, Morgan GP, Weir JR, Vetter IR, Musacchio A, Luger K.

Elife. 2017 Dec 27;6. pii: e33442. doi: 10.7554/eLife.33442.

29.

Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain.

Morgan M, Deuis JR, Woodruff TM, Lewis RJ, Vetter I.

Mol Immunol. 2018 Feb;94:68-74. doi: 10.1016/j.molimm.2017.12.016. Epub 2017 Dec 21.

PMID:
29274925
30.

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species.

Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF.

Sci Signal. 2017 Dec 5;10(508). pii: eaan3398. doi: 10.1126/scisignal.aan3398.

31.

WITHDRAWN: Toxins in Neurobiology: new tools from old molecules.

Vetter I.

Neurosci Lett. 2017 Nov 4. pii: S0304-3940(17)30900-X. doi: 10.1016/j.neulet.2017.11.002. [Epub ahead of print] No abstract available.

PMID:
29113827
32.

Burn Pain: A Systematic and Critical Review of Epidemiology, Pathophysiology, and Treatment.

Morgan M, Deuis JR, Frøsig-Jørgensen M, Lewis RJ, Cabot PJ, Gray PD, Vetter I.

Pain Med. 2018 Apr 1;19(4):708-734. doi: 10.1093/pm/pnx228.

PMID:
29036469
33.

Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity.

Jin AH, Dekan Z, Smout MJ, Wilson D, Dutertre S, Vetter I, Lewis RJ, Loukas A, Daly NL, Alewood PF.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14973-14976. doi: 10.1002/anie.201708927. Epub 2017 Oct 24.

PMID:
28984021
34.

Methods Used to Evaluate Pain Behaviors in Rodents.

Deuis JR, Dvorakova LS, Vetter I.

Front Mol Neurosci. 2017 Sep 6;10:284. doi: 10.3389/fnmol.2017.00284. eCollection 2017.

35.

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.

Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ.

PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.

36.
37.

Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy.

Starobova H, Vetter I.

Front Mol Neurosci. 2017 May 31;10:174. doi: 10.3389/fnmol.2017.00174. eCollection 2017. Review.

38.

Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. No abstract available.

39.

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.

Cardoso FC, Dekan Z, Smith JJ, Deuis JR, Vetter I, Herzig V, Alewood PF, King GF, Lewis RJ.

Br J Pharmacol. 2017 Aug;174(15):2528-2544. doi: 10.1111/bph.13865. Epub 2017 Jun 27.

40.

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes.

Casewell NR, Visser JC, Baumann K, Dobson J, Han H, Kuruppu S, Morgan M, Romilio A, Weisbecker V, Mardon K, Ali SA, Debono J, Koludarov I, Que I, Bird GC, Cooke GM, Nouwens A, Hodgson WC, Wagstaff SC, Cheney KL, Vetter I, van der Weerd L, Richardson MK, Fry BG.

Curr Biol. 2017 May 22;27(10):1549-1550. doi: 10.1016/j.cub.2017.05.009. No abstract available.

41.

Sodium Channels and Venom Peptide Pharmacology.

Israel MR, Tay B, Deuis JR, Vetter I.

Adv Pharmacol. 2017;79:67-116. doi: 10.1016/bs.apha.2017.01.004. Epub 2017 Apr 8. Review.

PMID:
28528674
42.

Δ-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities.

Dekan Z, Headey SJ, Scanlon M, Baldo BA, Lee TH, Aguilar MI, Deuis JR, Vetter I, Elliott AG, Amado M, Cooper MA, Alewood D, Alewood PF.

Angew Chem Int Ed Engl. 2017 Jul 10;56(29):8495-8499. doi: 10.1002/anie.201703360. Epub 2017 Jun 13.

PMID:
28513074
43.

Transthoracic Echocardiography for Diagnosing Pulmonary Embolism: A Systematic Review and Meta-Analysis.

Fields JM, Davis J, Girson L, Au A, Potts J, Morgan CJ, Vetter I, Riesenberg LA.

J Am Soc Echocardiogr. 2017 Jul;30(7):714-723.e4. doi: 10.1016/j.echo.2017.03.004. Epub 2017 May 9. Review.

PMID:
28495379
44.

The pharmacology of voltage-gated sodium channel activators.

Deuis JR, Mueller A, Israel MR, Vetter I.

Neuropharmacology. 2017 Dec;127:87-108. doi: 10.1016/j.neuropharm.2017.04.014. Epub 2017 Apr 14. Review.

PMID:
28416444
45.

Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors.

Windley MJ, Vetter I, Lewis RJ, Nicholson GM.

Neuropharmacology. 2017 Dec;127:224-242. doi: 10.1016/j.neuropharm.2017.04.008. Epub 2017 Apr 8.

PMID:
28396143
46.

Pharmacological screening technologies for venom peptide discovery.

Prashanth JR, Hasaballah N, Vetter I.

Neuropharmacology. 2017 Dec;127:4-19. doi: 10.1016/j.neuropharm.2017.03.038. Epub 2017 Apr 1. Review.

PMID:
28377116
47.

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes.

Casewell NR, Visser JC, Baumann K, Dobson J, Han H, Kuruppu S, Morgan M, Romilio A, Weisbecker V, Mardon K, Ali SA, Debono J, Koludarov I, Que I, Bird GC, Cooke GM, Nouwens A, Hodgson WC, Wagstaff SC, Cheney KL, Vetter I, van der Weerd L, Richardson MK, Fry BG.

Curr Biol. 2017 Apr 24;27(8):1184-1191. doi: 10.1016/j.cub.2017.02.067. Epub 2017 Mar 30. Erratum in: Curr Biol. 2017 May 22;27(10):1549-1550.

48.

How hot is it Down Under?

Mündel T, Nalivaiko E, Kent S, Maloney SK, Vetter I.

Temperature (Austin). 2016 Aug 17;3(3):355-357. doi: 10.1080/23328940.2016.1218991. eCollection 2016. No abstract available.

49.

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.

Rahnama S, Deuis JR, Cardoso FC, Ramanujam V, Lewis RJ, Rash LD, King GF, Vetter I, Mobli M.

PLoS One. 2017 Mar 16;12(3):e0173551. doi: 10.1371/journal.pone.0173551. eCollection 2017.

50.

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.

Inserra MC, Israel MR, Caldwell A, Castro J, Deuis JR, Harrington AM, Keramidas A, Garcia-Caraballo S, Maddern J, Erickson A, Grundy L, Rychkov GY, Zimmermann K, Lewis RJ, Brierley SM, Vetter I.

Sci Rep. 2017 Feb 22;7:42810. doi: 10.1038/srep42810.

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