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Items: 1 to 50 of 201

1.

A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family.

Robinson SD, Mueller A, Clayton D, Starobova H, Hamilton BR, Payne RJ, Vetter I, King GF, Undheim EAB.

Sci Adv. 2018 Sep 12;4(9):eaau4640. doi: 10.1126/sciadv.aau4640. eCollection 2018 Sep.

2.

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides.

Sousa SR, McArthur JR, Brust A, Bhola RF, Rosengren KJ, Ragnarsson L, Dutertre S, Alewood PF, Christie MJ, Adams DJ, Vetter I, Lewis RJ.

Sci Rep. 2018 Sep 7;8(1):13397. doi: 10.1038/s41598-018-31245-4.

3.

Chemotactic responses of growing neurites to precisely controlled gradients of nerve growth factor.

Bicknell BA, Pujic Z, Feldner J, Vetter I, Goodhill GJ.

Sci Data. 2018 Sep 4;5:180183. doi: 10.1038/sdata.2018.183.

4.

Membrane insertion of α-xenorhabdolysin in near-atomic detail.

Schubert E, Vetter IR, Prumbaum D, Penczek PA, Raunser S.

Elife. 2018 Jul 16;7. pii: e38017. doi: 10.7554/eLife.38017.

5.

The Somatostatin Receptor-4 Agonist J-2156 Alleviates Mechanical Hypersensitivity in a Rat Model of Breast Cancer Induced Bone Pain.

Shenoy PA, Kuo A, Khan N, Gorham L, Nicholson JR, Corradini L, Vetter I, Smith MT.

Front Pharmacol. 2018 May 15;9:495. doi: 10.3389/fphar.2018.00495. eCollection 2018.

6.

An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay.

Stevenson RJ, Azimi I, Flanagan JU, Inserra M, Vetter I, Monteith GR, Denny WA.

Bioorg Med Chem. 2018 Jul 23;26(12):3406-3413. doi: 10.1016/j.bmc.2018.05.012. Epub 2018 May 9.

PMID:
29776832
7.

Toxins in Neurobiology: New tools from old molecules.

Vetter I.

Neurosci Lett. 2018 Jul 13;679:1-3. doi: 10.1016/j.neulet.2018.05.008. Epub 2018 May 5. No abstract available.

PMID:
29738846
8.

Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes.

Bongard J, Lorenz M, Vetter IR, Stege P, Porfetye AT, Schmitz AL, Kaschani F, Wolf A, Koch U, Nussbaumer P, Klebl B, Kaiser M, Ehrmann M.

ACS Chem Biol. 2018 May 18;13(5):1307-1312. doi: 10.1021/acschembio.8b00101. Epub 2018 Apr 16.

PMID:
29658704
9.

Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels.

Yapa KTDS, Deuis J, Peters AA, Kenny PA, Roberts-Thomson SJ, Vetter I, Monteith GR.

Life Sci. 2018 Apr 1;198:128-135. doi: 10.1016/j.lfs.2018.02.030. Epub 2018 Feb 26.

PMID:
29496495
10.

The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6.

Israel MR, Thongyoo P, Deuis JR, Craik DJ, Vetter I, Durek T.

J Med Chem. 2018 Feb 22;61(4):1730-1736. doi: 10.1021/acs.jmedchem.7b01609. Epub 2018 Feb 3.

PMID:
29378414
11.

Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology.

Jami S, Erickson A, Brierley SM, Vetter I.

Toxins (Basel). 2017 Dec 27;10(1). pii: E15. doi: 10.3390/toxins10010015. Review.

12.

Decoding the centromeric nucleosome through CENP-N.

Pentakota S, Zhou K, Smith C, Maffini S, Petrovic A, Morgan GP, Weir JR, Vetter IR, Musacchio A, Luger K.

Elife. 2017 Dec 27;6. pii: e33442. doi: 10.7554/eLife.33442.

13.

Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain.

Morgan M, Deuis JR, Woodruff TM, Lewis RJ, Vetter I.

Mol Immunol. 2018 Feb;94:68-74. doi: 10.1016/j.molimm.2017.12.016. Epub 2017 Dec 21.

PMID:
29274925
14.

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species.

Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF.

Sci Signal. 2017 Dec 5;10(508). pii: eaan3398. doi: 10.1126/scisignal.aan3398.

15.

WITHDRAWN: Toxins in Neurobiology: new tools from old molecules.

Vetter I.

Neurosci Lett. 2017 Nov 4. pii: S0304-3940(17)30900-X. doi: 10.1016/j.neulet.2017.11.002. [Epub ahead of print] No abstract available.

PMID:
29113827
16.

Burn Pain: A Systematic and Critical Review of Epidemiology, Pathophysiology, and Treatment.

Morgan M, Deuis JR, Frøsig-Jørgensen M, Lewis RJ, Cabot PJ, Gray PD, Vetter I.

Pain Med. 2018 Apr 1;19(4):708-734. doi: 10.1093/pm/pnx228.

PMID:
29036469
17.

Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity.

Jin AH, Dekan Z, Smout MJ, Wilson D, Dutertre S, Vetter I, Lewis RJ, Loukas A, Daly NL, Alewood PF.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14973-14976. doi: 10.1002/anie.201708927. Epub 2017 Oct 24.

PMID:
28984021
18.

Methods Used to Evaluate Pain Behaviors in Rodents.

Deuis JR, Dvorakova LS, Vetter I.

Front Mol Neurosci. 2017 Sep 6;10:284. doi: 10.3389/fnmol.2017.00284. eCollection 2017.

19.

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.

Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ.

PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.

20.
21.

Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy.

Starobova H, Vetter I.

Front Mol Neurosci. 2017 May 31;10:174. doi: 10.3389/fnmol.2017.00174. eCollection 2017. Review.

22.

Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. No abstract available.

23.

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.

Cardoso FC, Dekan Z, Smith JJ, Deuis JR, Vetter I, Herzig V, Alewood PF, King GF, Lewis RJ.

Br J Pharmacol. 2017 Aug;174(15):2528-2544. doi: 10.1111/bph.13865. Epub 2017 Jun 27.

24.

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes.

Casewell NR, Visser JC, Baumann K, Dobson J, Han H, Kuruppu S, Morgan M, Romilio A, Weisbecker V, Mardon K, Ali SA, Debono J, Koludarov I, Que I, Bird GC, Cooke GM, Nouwens A, Hodgson WC, Wagstaff SC, Cheney KL, Vetter I, van der Weerd L, Richardson MK, Fry BG.

Curr Biol. 2017 May 22;27(10):1549-1550. doi: 10.1016/j.cub.2017.05.009. No abstract available.

25.

Sodium Channels and Venom Peptide Pharmacology.

Israel MR, Tay B, Deuis JR, Vetter I.

Adv Pharmacol. 2017;79:67-116. doi: 10.1016/bs.apha.2017.01.004. Epub 2017 Apr 8. Review.

PMID:
28528674
26.

Δ-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities.

Dekan Z, Headey SJ, Scanlon M, Baldo BA, Lee TH, Aguilar MI, Deuis JR, Vetter I, Elliott AG, Amado M, Cooper MA, Alewood D, Alewood PF.

Angew Chem Int Ed Engl. 2017 Jul 10;56(29):8495-8499. doi: 10.1002/anie.201703360. Epub 2017 Jun 13.

PMID:
28513074
27.

Transthoracic Echocardiography for Diagnosing Pulmonary Embolism: A Systematic Review and Meta-Analysis.

Fields JM, Davis J, Girson L, Au A, Potts J, Morgan CJ, Vetter I, Riesenberg LA.

J Am Soc Echocardiogr. 2017 Jul;30(7):714-723.e4. doi: 10.1016/j.echo.2017.03.004. Epub 2017 May 9. Review.

PMID:
28495379
28.

The pharmacology of voltage-gated sodium channel activators.

Deuis JR, Mueller A, Israel MR, Vetter I.

Neuropharmacology. 2017 Dec;127:87-108. doi: 10.1016/j.neuropharm.2017.04.014. Epub 2017 Apr 14. Review.

PMID:
28416444
29.

Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors.

Windley MJ, Vetter I, Lewis RJ, Nicholson GM.

Neuropharmacology. 2017 Dec;127:224-242. doi: 10.1016/j.neuropharm.2017.04.008. Epub 2017 Apr 8.

PMID:
28396143
30.

Pharmacological screening technologies for venom peptide discovery.

Prashanth JR, Hasaballah N, Vetter I.

Neuropharmacology. 2017 Dec;127:4-19. doi: 10.1016/j.neuropharm.2017.03.038. Epub 2017 Apr 1. Review.

PMID:
28377116
31.

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes.

Casewell NR, Visser JC, Baumann K, Dobson J, Han H, Kuruppu S, Morgan M, Romilio A, Weisbecker V, Mardon K, Ali SA, Debono J, Koludarov I, Que I, Bird GC, Cooke GM, Nouwens A, Hodgson WC, Wagstaff SC, Cheney KL, Vetter I, van der Weerd L, Richardson MK, Fry BG.

Curr Biol. 2017 Apr 24;27(8):1184-1191. doi: 10.1016/j.cub.2017.02.067. Epub 2017 Mar 30.

32.

How hot is it Down Under?

Mündel T, Nalivaiko E, Kent S, Maloney SK, Vetter I.

Temperature (Austin). 2016 Aug 17;3(3):355-357. doi: 10.1080/23328940.2016.1218991. eCollection 2016. No abstract available.

33.

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.

Rahnama S, Deuis JR, Cardoso FC, Ramanujam V, Lewis RJ, Rash LD, King GF, Vetter I, Mobli M.

PLoS One. 2017 Mar 16;12(3):e0173551. doi: 10.1371/journal.pone.0173551. eCollection 2017.

34.

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.

Inserra MC, Israel MR, Caldwell A, Castro J, Deuis JR, Harrington AM, Keramidas A, Garcia-Caraballo S, Maddern J, Erickson A, Grundy L, Rychkov GY, Zimmermann K, Lewis RJ, Brierley SM, Vetter I.

Sci Rep. 2017 Feb 22;7:42810. doi: 10.1038/srep42810.

35.

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883. Erratum in: Sci Rep. 2017 May 26;7:46816.

36.

The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states.

Barry G, Briggs JA, Hwang DW, Nayler SP, Fortuna PR, Jonkhout N, Dachet F, Maag JL, Mestdagh P, Singh EM, Avesson L, Kaczorowski DC, Ozturk E, Jones NC, Vetter I, Arriola-Martinez L, Hu J, Franco GR, Warn VM, Gong A, Dinger ME, Rigo F, Lipovich L, Morris MJ, O'Brien TJ, Lee DS, Loeb JA, Blackshaw S, Mattick JS, Wolvetang EJ.

Sci Rep. 2017 Jan 5;7:40127. doi: 10.1038/srep40127.

37.

Role of the NLRP3 inflammasome in a model of acute burn-induced pain.

Deuis JR, Yin K, Cooper MA, Schroder K, Vetter I.

Burns. 2017 Mar;43(2):304-309. doi: 10.1016/j.burns.2016.09.001. Epub 2016 Dec 28.

PMID:
28040362
38.

Interface analysis of small GTP binding protein complexes suggests preferred membrane orientations.

Vetter IR.

Biol Chem. 2017 May 1;398(5-6):637-651. doi: 10.1515/hsz-2016-0287. Review.

PMID:
28002022
39.

NaV1.7 as a pain target - From gene to pharmacology.

Vetter I, Deuis JR, Mueller A, Israel MR, Starobova H, Zhang A, Rash LD, Mobli M.

Pharmacol Ther. 2017 Apr;172:73-100. doi: 10.1016/j.pharmthera.2016.11.015. Epub 2016 Dec 2. Review. No abstract available.

PMID:
27916648
40.

New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives.

Lolignier S, Gkika D, Andersson D, Leipold E, Vetter I, Viana F, Noël J, Busserolles J.

J Neurosci. 2016 Nov 9;36(45):11435-11439. Review.

41.

Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores.

Petrovic A, Keller J, Liu Y, Overlack K, John J, Dimitrova YN, Jenni S, van Gerwen S, Stege P, Wohlgemuth S, Rombaut P, Herzog F, Harrison SC, Vetter IR, Musacchio A.

Cell. 2016 Nov 3;167(4):1028-1040.e15. doi: 10.1016/j.cell.2016.10.005. Epub 2016 Oct 27.

42.

The thermal probe test: A novel behavioral assay to quantify thermal paw withdrawal thresholds in mice.

Deuis JR, Vetter I.

Temperature (Austin). 2016 Feb 26;3(2):199-207. eCollection 2016 Apr-Jun.

43.

Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay.

Azimi I, Flanagan JU, Stevenson RJ, Inserra M, Vetter I, Monteith GR, Denny WA.

Bioorg Med Chem. 2017 Jan 1;25(1):440-449. doi: 10.1016/j.bmc.2016.11.007. Epub 2016 Nov 7.

PMID:
27856238
44.

Regional anesthesia or patient-controlled analgesia and compartment syndrome in orthopedic surgical procedures: a systematic review.

Driscoll EB, Maleki AH, Jahromi L, Hermecz BN, Nelson LE, Vetter IL, Evenhuis S, Riesenberg LA.

Local Reg Anesth. 2016 Oct 6;9:65-81. eCollection 2016. Review.

45.

The Snake with the Scorpion's Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus).

Yang DC, Deuis JR, Dashevsky D, Dobson J, Jackson TN, Brust A, Xie B, Koludarov I, Debono J, Hendrikx I, Hodgson WC, Josh P, Nouwens A, Baillie GJ, Bruxner TJ, Alewood PF, Lim KK, Frank N, Vetter I, Fry BG.

Toxins (Basel). 2016 Oct 18;8(10). pii: E303.

46.

Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia.

Bressan E, Touska F, Vetter I, Kistner K, Kichko TI, Teixeira NB, Picolo G, Cury Y, Lewis RJ, Fischer MJ, Zimmermann K, Reeh PW.

Pain. 2016 Nov;157(11):2504-2516.

PMID:
27434506
47.

The Walker 256 Breast Cancer Cell- Induced Bone Pain Model in Rats.

Shenoy PA, Kuo A, Vetter I, Smith MT.

Front Pharmacol. 2016 Aug 31;7:286. doi: 10.3389/fphar.2016.00286. eCollection 2016. Review.

48.

Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.

Yin K, Deuis JR, Lewis RJ, Vetter I.

Mol Pain. 2016 Aug 28;12. pii: 1744806916665366. doi: 10.1177/1744806916665366. Print 2016.

49.

Rapid Extraction and Identification of Maitotoxin and Ciguatoxin-Like Toxins from Caribbean and Pacific Gambierdiscus Using a New Functional Bioassay.

Lewis RJ, Inserra M, Vetter I, Holland WC, Hardison DR, Tester PA, Litaker RW.

PLoS One. 2016 Jul 28;11(7):e0160006. doi: 10.1371/journal.pone.0160006. eCollection 2016.

50.

Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.

Henriques ST, Deplazes E, Lawrence N, Cheneval O, Chaousis S, Inserra M, Thongyoo P, King GF, Mark AE, Vetter I, Craik DJ, Schroeder CI.

J Biol Chem. 2016 Aug 12;291(33):17049-65. doi: 10.1074/jbc.M116.729095. Epub 2016 Jun 16.

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