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Items: 24

1.

Inflammation leads through PGE/EP3 signaling to HDAC5/MEF2-dependent transcription in cardiac myocytes.

Tóth AD, Schell R, Lévay M, Vettel C, Theis P, Haslinger C, Alban F, Werhahn S, Frischbier L, Krebs-Haupenthal J, Thomas D, Gröne HJ, Avkiran M, Katus HA, Wieland T, Backs J.

EMBO Mol Med. 2018 Jul;10(7). pii: e8536. doi: 10.15252/emmm.201708536.

2.

Targeting altered Nme heterooligomerization in disease?

Abu-Taha IH, Vettel C, Wieland T.

Oncotarget. 2017 Nov 27;9(2):1492-1493. doi: 10.18632/oncotarget.22716. eCollection 2018 Jan 5. No abstract available.

3.

AAV-9 mediated phosphatase-1 inhibitor-1 overexpression improves cardiac contractility in unchallenged mice but is deleterious in pressure-overload.

Schwab DM, Tilemann L, Bauer R, Heckmann M, Jungmann A, Wagner M, Burgis J, Vettel C, Katus HA, El-Armouche A, Müller OJ.

Gene Ther. 2018 Jan;25(1):13-19. doi: 10.1038/gt.2017.97. Epub 2018 Jan 19.

PMID:
29350681
4.

Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.

Perera RK, Fischer TH, Wagner M, Dewenter M, Vettel C, Bork NI, Maier LS, Conti M, Wess J, El-Armouche A, Hasenfuß G, Nikolaev VO.

Sci Rep. 2017 Nov 9;7(1):15222. doi: 10.1038/s41598-017-15632-x.

5.

Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update.

Abu-Taha IH, Heijman J, Feng Y, Vettel C, Dobrev D, Wieland T.

Lab Invest. 2018 Feb;98(2):190-197. doi: 10.1038/labinvest.2017.103. Epub 2017 Oct 16. Review.

6.

Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure.

Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A.

Circ Heart Fail. 2017 May;10(5):e003840. doi: 10.1161/CIRCHEARTFAILURE.117.003840.

7.

Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure.

Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T.

Circulation. 2017 Feb 28;135(9):881-897. doi: 10.1161/CIRCULATIONAHA.116.022852. Epub 2016 Dec 7.

PMID:
27927712
8.

Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction.

Vettel C, Lindner M, Dewenter M, Lorenz K, Schanbacher C, Riedel M, Lämmle S, Meinecke S, Mason FE, Sossalla S, Geerts A, Hoffmann M, Wunder F, Brunner FJ, Wieland T, Mehel H, Karam S, Lechêne P, Leroy J, Vandecasteele G, Wagner M, Fischmeister R, El-Armouche A.

Circ Res. 2017 Jan 6;120(1):120-132. doi: 10.1161/CIRCRESAHA.116.310069. Epub 2016 Oct 31.

PMID:
27799254
9.

Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice.

Swain L, Kesemeyer A, Meyer-Roxlau S, Vettel C, Zieseniss A, Güntsch A, Jatho A, Becker A, Nanadikar MS, Morgan B, Dennerlein S, Shah AM, El-Armouche A, Nikolaev VO, Katschinski DM.

Circ Res. 2016 Oct 14;119(9):1004-1016. Epub 2016 Aug 23.

PMID:
27553648
10.

p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts.

Ongherth A, Pasch S, Wuertz CM, Nowak K, Kittana N, Weis CA, Jatho A, Vettel C, Tiburcy M, Toischer K, Hasenfuss G, Zimmermann WH, Wieland T, Lutz S.

J Mol Cell Cardiol. 2015 Nov;88:39-54. doi: 10.1016/j.yjmcc.2015.09.009. Epub 2015 Sep 21.

PMID:
26392029
11.

A systemic Pasteurella multocida toxin aggravates cardiac hypertrophy and fibrosis in mice.

Weise M, Vettel C, Spiger K, Gilsbach R, Hein L, Lorenz K, Wieland T, Aktories K, Orth JH.

Cell Microbiol. 2015 Sep;17(9):1320-31. doi: 10.1111/cmi.12436. Epub 2015 Mar 30.

PMID:
25759205
12.

The Janus face of BNP therapy in chronic heart failure: beneficial effects unmasked by β blockers?

Dewenter M, Vettel C, El-Armouche A.

Heart. 2014 Jun;100(11):819-20. doi: 10.1136/heartjnl-2014-305503. Epub 2014 Mar 25. No abstract available.

PMID:
24667282
13.

PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways.

Vettel C, Lämmle S, Ewens S, Cervirgen C, Emons J, Ongherth A, Dewenter M, Lindner D, Westermann D, Nikolaev VO, Lutz S, Zimmermann WH, El-Armouche A.

Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1246-52. doi: 10.1152/ajpheart.00852.2013. Epub 2014 Feb 14.

14.

Dopamine and lipophilic derivates protect cardiomyocytes against cold preservation injury.

Vettel C, Hottenrott MC, Spindler R, Benck U, Schnuelle P, Tsagogiorgas C, Krämer BK, Hoeger S, El-Armouche A, Wieland T, Yard BA.

J Pharmacol Exp Ther. 2014 Jan;348(1):77-85. doi: 10.1124/jpet.113.207001. Epub 2013 Oct 17.

PMID:
24135075
15.

The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis.

Del Galdo S, Vettel C, Heringdorf DM, Wieland T.

Cell Signal. 2013 Dec;25(12):2478-84. doi: 10.1016/j.cellsig.2013.08.017. Epub 2013 Aug 30.

PMID:
23993968
16.

Enhanced Ca²+ influx through cardiac L-type Ca²+ channels maintains the systolic Ca²+ transient in early cardiac atrophy induced by mechanical unloading.

Schwoerer AP, Neef S, Broichhausen I, Jacubeit J, Tiburcy M, Wagner M, Biermann D, Didié M, Vettel C, Maier LS, Zimmermann WH, Carrier L, Eschenhagen T, Volk T, El-Armouche A, Ehmke H.

Pflugers Arch. 2013 Dec;465(12):1763-73. doi: 10.1007/s00424-013-1316-y. Epub 2013 Jul 11.

17.

Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.

Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A.

J Am Coll Cardiol. 2013 Oct 22;62(17):1596-606. doi: 10.1016/j.jacc.2013.05.057. Epub 2013 Jun 26.

18.

[Losmapimod: a novel drug against cardiovascular diseases?].

Dewenter M, Vettel C, El-Armouche A.

Dtsch Med Wochenschr. 2013 Jan;138(1-2):39-42. doi: 10.1055/s-0032-1327368. Epub 2012 Dec 18. Review. German.

PMID:
23250695
19.

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling.

Felcht M, Luck R, Schering A, Seidel P, Srivastava K, Hu J, Bartol A, Kienast Y, Vettel C, Loos EK, Kutschera S, Bartels S, Appak S, Besemfelder E, Terhardt D, Chavakis E, Wieland T, Klein C, Thomas M, Uemura A, Goerdt S, Augustin HG.

J Clin Invest. 2012 Jun;122(6):1991-2005. doi: 10.1172/JCI58832. Epub 2012 May 15.

20.

A novel player in cellular hypertrophy: Giβγ/PI3K-dependent activation of the RacGEF TIAM-1 is required for α₁-adrenoceptor induced hypertrophy in neonatal rat cardiomyocytes.

Vettel C, Wittig K, Vogt A, Wuertz CM, El-Armouche A, Lutz S, Wieland T.

J Mol Cell Cardiol. 2012 Aug;53(2):165-75. doi: 10.1016/j.yjmcc.2012.04.015. Epub 2012 May 4.

PMID:
22564263
21.

p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells.

Wuertz CM, Lorincz A, Vettel C, Thomas MA, Wieland T, Lutz S.

FASEB J. 2010 Dec;24(12):4865-76. doi: 10.1096/fj.10-155499. Epub 2010 Aug 25.

PMID:
20739613
22.

Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF.

Shankaranarayanan A, Boguth CA, Lutz S, Vettel C, Uhlemann F, Aittaleb M, Wieland T, Tesmer JJ.

Cell Signal. 2010 Jul;22(7):1114-23. doi: 10.1016/j.cellsig.2010.03.006. Epub 2010 Mar 7.

23.

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.

Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ.

Science. 2007 Dec 21;318(5858):1923-7.

24.

Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans.

Williams SL, Lutz S, Charlie NK, Vettel C, Ailion M, Coco C, Tesmer JJ, Jorgensen EM, Wieland T, Miller KG.

Genes Dev. 2007 Nov 1;21(21):2731-46. Epub 2007 Oct 17.

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