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Items: 1 to 50 of 261

1.

Vascular endothelial receptor tyrosine phosphatase: Identification of novel substrates related to junctions and a ternary complex with EphB4 and Tie-2.

Drexler HCA, Vockel M, Polaschegg C, Frye M, Peters K, Vestweber D.

Mol Cell Proteomics. 2019 Aug 19. pii: mcp.RA119.001716. doi: 10.1074/mcp.RA119.001716. [Epub ahead of print]

2.

Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α.

Li YT, Goswami D, Follmer M, Artz A, Pacheco-Blanco M, Vestweber D.

Elife. 2019 Aug 6;8. pii: e47642. doi: 10.7554/eLife.47642.

3.

VE-PTP inhibition stabilizes endothelial junctions by activating FGD5.

Braun LJ, Zinnhardt M, Vockel M, Drexler HC, Peters K, Vestweber D.

EMBO Rep. 2019 Jul;20(7):e47046. doi: 10.15252/embr.201847046. Epub 2019 May 14.

PMID:
31267715
4.

VE-PTP inhibition stabilizes endothelial junctions by activating FGD5.

Braun LJ, Zinnhardt M, Vockel M, Drexler HC, Peters K, Vestweber D.

EMBO Rep. 2019 May 14. pii: e47046. doi: 10.15252/embr.201847046. [Epub ahead of print]

PMID:
31088862
5.

Targeting VE-PTP phosphatase protects the kidney from diabetic injury.

Carota IA, Kenig-Kozlovsky Y, Onay T, Scott R, Thomson BR, Souma T, Bartlett CS, Li Y, Procissi D, Ramirez V, Yamaguchi S, Tarjus A, Tanna CE, Li C, Eremina V, Vestweber D, Oladipupo SS, Breyer MD, Quaggin SE.

J Exp Med. 2019 Apr 1;216(4):936-949. doi: 10.1084/jem.20180009. Epub 2019 Mar 18.

PMID:
30886059
6.

Distinct roles of VE-cadherin for development and maintenance of specific lymph vessel beds.

Hägerling R, Hoppe E, Dierkes C, Stehling M, Makinen T, Butz S, Vestweber D, Kiefer F.

EMBO J. 2018 Nov 15;37(22). pii: e98271. doi: 10.15252/embj.201798271. Epub 2018 Oct 8.

PMID:
30297530
7.

Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin.

Reckzeh K, Kizilkaya H, Helbo AS, Alrich ME, Deslauriers AG, Grover A, Rapin N, Asmar F, Grønbæk K, Porse B, Borregaard N, Vestweber D, Nerlov C, Theilgaard-Mönch K.

Blood Adv. 2018 Jul 10;2(13):1628-1632. doi: 10.1182/bloodadvances.2018015743. No abstract available.

8.

CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation.

Samus M, Seelige R, Schäfer K, Sorokin L, Vestweber D.

J Leukoc Biol. 2018 Oct;104(4):787-797. doi: 10.1002/JLB.1A0617-228R. Epub 2018 May 23.

PMID:
29791026
9.

A unifying concept in vascular health and disease.

Schwartz MA, Vestweber D, Simons M.

Science. 2018 Apr 20;360(6386):270-271. doi: 10.1126/science.aat3470. No abstract available.

10.

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.

Souma T, Thomson BR, Heinen S, Carota IA, Yamaguchi S, Onay T, Liu P, Ghosh AK, Li C, Eremina V, Hong YK, Economides AN, Vestweber D, Peters KG, Jin J, Quaggin SE.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1298-1303. doi: 10.1073/pnas.1714446115. Epub 2018 Jan 22.

11.

Reversible retinal vessel closure from VEGF-induced leukocyte plugging.

Liu Y, Shen J, Fortmann SD, Wang J, Vestweber D, Campochiaro PA.

JCI Insight. 2017 Sep 21;2(18). pii: 95530. doi: 10.1172/jci.insight.95530. eCollection 2017 Sep 21.

12.

VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN.

Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA.

Curr Biol. 2017 Sep 11;27(17):2727. doi: 10.1016/j.cub.2017.08.064. No abstract available.

13.

VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations.

Hägerling R, Drees D, Scherzinger A, Dierkes C, Martin-Almedina S, Butz S, Gordon K, Schäfers M, Hinrichs K, Ostergaard P, Vestweber D, Goerge T, Mansour S, Jiang X, Mortimer PS, Kiefer F.

JCI Insight. 2017 Aug 17;2(16). pii: 93424. doi: 10.1172/jci.insight.93424. eCollection 2017 Aug 17.

14.

VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN.

Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA.

Curr Biol. 2017 Jul 24;27(14):2219-2225.e5. doi: 10.1016/j.cub.2017.06.020. Epub 2017 Jul 14. Erratum in: Curr Biol. 2017 Sep 11;27(17):2727.

15.

Expression of receptor-type protein tyrosine phosphatase in developing and adult renal vasculature.

Takahashi K, Kim R, Lauhan C, Park Y, Nguyen NG, Vestweber D, Dominguez MG, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gale NW, Takahashi T.

PLoS One. 2017 May 25;12(5):e0177192. doi: 10.1371/journal.pone.0177192. eCollection 2017.

16.

Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies.

Döring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig L, Jansen Y, Schröder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers L, van Gorp R, Ries C, Kusters PJH, van der Wal A, Hackeng TM, Gäbel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C.

Circulation. 2017 Jul 25;136(4):388-403. doi: 10.1161/CIRCULATIONAHA.117.027646. Epub 2017 Apr 27.

17.

A Novel Cervical Spinal Cord Window Preparation Allows for Two-Photon Imaging of T-Cell Interactions with the Cervical Spinal Cord Microvasculature during Experimental Autoimmune Encephalomyelitis.

Haghayegh Jahromi N, Tardent H, Enzmann G, Deutsch U, Kawakami N, Bittner S, Vestweber D, Zipp F, Stein JV, Engelhardt B.

Front Immunol. 2017 Apr 11;8:406. doi: 10.3389/fimmu.2017.00406. eCollection 2017.

18.

Endothelial CD99 supports arrest of mouse neutrophils in venules and binds to neutrophil PILRs.

Goswami D, März S, Li YT, Artz A, Schäfer K, Seelige R, Pacheco-Blanco M, Jing D, Bixel MG, Araki M, Araki K, Yamamura KI, Vestweber D.

Blood. 2017 Mar 30;129(13):1811-1822. doi: 10.1182/blood-2016-08-733394. Epub 2017 Feb 21.

19.

Flow Dynamics and HSPC Homing in Bone Marrow Microvessels.

Bixel MG, Kusumbe AP, Ramasamy SK, Sivaraj KK, Butz S, Vestweber D, Adams RH.

Cell Rep. 2017 Feb 14;18(7):1804-1816. doi: 10.1016/j.celrep.2017.01.042.

20.

Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration.

Song J, Zhang X, Buscher K, Wang Y, Wang H, Di Russo J, Li L, Lütke-Enking S, Zarbock A, Stadtmann A, Striewski P, Wirth B, Kuzmanov I, Wiendl H, Schulte D, Vestweber D, Sorokin L.

Cell Rep. 2017 Jan 31;18(5):1256-1269. doi: 10.1016/j.celrep.2016.12.092.

21.

Conformational equilibria and intrinsic affinities define integrin activation.

Li J, Su Y, Xia W, Qin Y, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA.

EMBO J. 2017 Mar 1;36(5):629-645. doi: 10.15252/embj.201695803. Epub 2017 Jan 25.

22.

HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1.

Latasiewicz J, Artz A, Jing D, Blanco MP, Currie SM, Avila MV, Schnoor M, Vestweber D.

J Leukoc Biol. 2017 May;101(5):1133-1142. doi: 10.1189/jlb.1A0416-195R. Epub 2017 Jan 25.

PMID:
28122813
23.

MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane.

Kurz AR, Pruenster M, Rohwedder I, Ramadass M, Schäfer K, Harrison U, Gouveia G, Nussbaum C, Immler R, Wiessner JR, Margraf A, Lim DS, Walzog B, Dietzel S, Moser M, Klein C, Vestweber D, Haas R, Catz SD, Sperandio M.

J Clin Invest. 2016 Nov 1;126(11):4125-4139. doi: 10.1172/JCI87043. Epub 2016 Oct 4.

24.

How leukocytes trigger opening and sealing of gaps in the endothelial barrier.

Goswami D, Vestweber D.

F1000Res. 2016 Sep 14;5. pii: F1000 Faculty Rev-2321. eCollection 2016. Review.

25.

Loss of cortactin causes endothelial barrier dysfunction via disturbed adrenomedullin secretion and actomyosin contractility.

García Ponce A, Citalán Madrid AF, Vargas Robles H, Chánez Paredes S, Nava P, Betanzos A, Zarbock A, Rottner K, Vestweber D, Schnoor M.

Sci Rep. 2016 Jun 30;6:29003. doi: 10.1038/srep29003.

26.

Relating conformation to function in integrin α5β1.

Su Y, Xia W, Li J, Walz T, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3872-81. doi: 10.1073/pnas.1605074113. Epub 2016 Jun 17.

27.

Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair.

Barreiro O, Cibrian D, Clemente C, Alvarez D, Moreno V, Valiente Í, Bernad A, Vestweber D, Arroyo AG, Martín P, von Andrian UH, Sánchez Madrid F.

Elife. 2016 Jun 15;5. pii: e15251. doi: 10.7554/eLife.15251.

28.

GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimer.

Artz A, Butz S, Vestweber D.

Blood. 2016 Jul 28;128(4):529-41. doi: 10.1182/blood-2016-01-696617. Epub 2016 May 27.

29.

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread.

Li X, Padhan N, Sjöström EO, Roche FP, Testini C, Honkura N, Sáinz-Jaspeado M, Gordon E, Bentley K, Philippides A, Tolmachev V, Dejana E, Stan RV, Vestweber D, Ballmer-Hofer K, Betsholtz C, Pietras K, Jansson L, Claesson-Welsh L.

Nat Commun. 2016 Mar 23;7:11017. doi: 10.1038/ncomms11017.

30.

Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin.

Frye M, Dierkes M, Küppers V, Vockel M, Tomm J, Zeuschner D, Rossaint J, Zarbock A, Koh GY, Peters K, Nottebaum AF, Vestweber D.

J Exp Med. 2015 Dec 14;212(13):2267-87. doi: 10.1084/jem.20150718. Epub 2015 Dec 7.

31.

How leukocytes cross the vascular endothelium.

Vestweber D.

Nat Rev Immunol. 2015 Nov;15(11):692-704. doi: 10.1038/nri3908. Epub 2015 Oct 16. Review.

PMID:
26471775
32.

Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression.

Anderson H, Patch TC, Reddy PN, Hagedorn EJ, Kim PG, Soltis KA, Chen MJ, Tamplin OJ, Frye M, MacLean GA, Hübner K, Bauer DE, Kanki JP, Vogin G, Huston NC, Nguyen M, Fujiwara Y, Paw BH, Vestweber D, Zon LI, Orkin SH, Daley GQ, Shah DI.

Blood. 2015 Dec 24;126(26):2811-20. doi: 10.1182/blood-2015-07-659276. Epub 2015 Sep 18.

33.

Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia.

Hillgruber C, Pöppelmann B, Weishaupt C, Steingräber AK, Wessel F, Berdel WE, Gessner JE, Ho-Tin-Noé B, Vestweber D, Goerge T.

J Exp Med. 2015 Jul 27;212(8):1255-66. doi: 10.1084/jem.20142076. Epub 2015 Jul 13.

34.

Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion.

Pruenster M, Kurz AR, Chung KJ, Cao-Ehlker X, Bieber S, Nussbaum CF, Bierschenk S, Eggersmann TK, Rohwedder I, Heinig K, Immler R, Moser M, Koedel U, Gran S, McEver RP, Vestweber D, Verschoor A, Leanderson T, Chavakis T, Roth J, Vogl T, Sperandio M.

Nat Commun. 2015 Apr 20;6:6915. doi: 10.1038/ncomms7915.

35.

Integrin β1 controls VE-cadherin localization and blood vessel stability.

Yamamoto H, Ehling M, Kato K, Kanai K, van Lessen M, Frye M, Zeuschner D, Nakayama M, Vestweber D, Adams RH.

Nat Commun. 2015 Mar 10;6:6429. doi: 10.1038/ncomms7429.

PMID:
25752958
36.

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier.

Abadier M, Haghayegh Jahromi N, Cardoso Alves L, Boscacci R, Vestweber D, Barnum S, Deutsch U, Engelhardt B, Lyck R.

Eur J Immunol. 2015 Apr;45(4):1043-58. doi: 10.1002/eji.201445125. Epub 2015 Jan 23.

37.

Cadherins in tissue architecture and disease.

Vestweber D.

J Mol Med (Berl). 2015 Jan;93(1):5-11. doi: 10.1007/s00109-014-1231-5. Epub 2014 Dec 10.

PMID:
25488198
38.

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature.

Shen J, Frye M, Lee BL, Reinardy JL, McClung JM, Ding K, Kojima M, Xia H, Seidel C, Lima e Silva R, Dong A, Hackett SF, Wang J, Howard BW, Vestweber D, Kontos CD, Peters KG, Campochiaro PA.

J Clin Invest. 2014 Oct;124(10):4564-76. doi: 10.1172/JCI74527. Epub 2014 Sep 2.

39.

VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells.

Schneider-Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H.

J Exp Med. 2014 Aug 25;211(9):1833-46. doi: 10.1084/jem.20140540. Epub 2014 Aug 18.

40.

Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability.

Rocha SF, Schiller M, Jing D, Li H, Butz S, Vestweber D, Biljes D, Drexler HC, Nieminen-Kelhä M, Vajkoczy P, Adams S, Benedito R, Adams RH.

Circ Res. 2014 Aug 29;115(6):581-90. doi: 10.1161/CIRCRESAHA.115.304718. Epub 2014 Jul 23.

PMID:
25057127
41.

The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis.

Bentley K, Franco CA, Philippides A, Blanco R, Dierkes M, Gebala V, Stanchi F, Jones M, Aspalter IM, Cagna G, Weström S, Claesson-Welsh L, Vestweber D, Gerhardt H.

Nat Cell Biol. 2014 Apr;16(4):309-21. doi: 10.1038/ncb2926. Epub 2014 Mar 23.

PMID:
24658686
42.

Similarities and differences in the regulation of leukocyte extravasation and vascular permeability.

Vestweber D, Wessel F, Nottebaum AF.

Semin Immunopathol. 2014 Mar;36(2):177-92. doi: 10.1007/s00281-014-0419-7. Epub 2014 Mar 18. Review.

PMID:
24638889
43.

Fusing VE-cadherin to α-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation.

Dartsch N, Schulte D, Hägerling R, Kiefer F, Vestweber D.

Mol Cell Biol. 2014 May;34(9):1634-48. doi: 10.1128/MCB.01526-13. Epub 2014 Feb 24.

44.

Phosphatases and kinases as regulators of the endothelial barrier function.

Küppers V, Vockel M, Nottebaum AF, Vestweber D.

Cell Tissue Res. 2014 Mar;355(3):577-86. doi: 10.1007/s00441-014-1812-1. Epub 2014 Feb 25. Review.

PMID:
24566520
45.

Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin.

Wessel F, Winderlich M, Holm M, Frye M, Rivera-Galdos R, Vockel M, Linnepe R, Ipe U, Stadtmann A, Zarbock A, Nottebaum AF, Vestweber D.

Nat Immunol. 2014 Mar;15(3):223-30. doi: 10.1038/ni.2824. Epub 2014 Feb 9.

PMID:
24487320
46.

A feeder-free differentiation system identifies autonomously proliferating B cell precursors in human bone marrow.

Kraus H, Kaiser S, Aumann K, Bönelt P, Salzer U, Vestweber D, Erlacher M, Kunze M, Burger M, Pieper K, Sic H, Rolink A, Eibel H, Rizzi M.

J Immunol. 2014 Feb 1;192(3):1044-54. doi: 10.4049/jimmunol.1301815. Epub 2013 Dec 30.

47.

β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier.

Gorina R, Lyck R, Vestweber D, Engelhardt B.

J Immunol. 2014 Jan 1;192(1):324-37. doi: 10.4049/jimmunol.1300858. Epub 2013 Nov 20.

48.

NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases.

Sehnert B, Burkhardt H, Wessels JT, Schröder A, May MJ, Vestweber D, Zwerina J, Warnatz K, Nimmerjahn F, Schett G, Dübel S, Voll RE.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16556-61. doi: 10.1073/pnas.1218219110. Epub 2013 Sep 23.

49.

How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin.

Vockel M, Vestweber D.

Blood. 2013 Oct 3;122(14):2512-22. doi: 10.1182/blood-2013-04-499228. Epub 2013 Aug 1.

50.

Blocking von Willebrand factor for treatment of cutaneous inflammation.

Hillgruber C, Steingräber AK, Pöppelmann B, Denis CV, Ware J, Vestweber D, Nieswandt B, Schneider SW, Goerge T.

J Invest Dermatol. 2014 Jan;134(1):77-86. doi: 10.1038/jid.2013.292. Epub 2013 Jun 28.

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