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Items: 1 to 50 of 99

1.

Mapping of ribosomal 23S ribosomal RNA modifications in Clostridium sporogenes.

Kirpekar F, Hansen LH, Mundus J, Tryggedsson S, Teixeira Dos Santos P, Ntokou E, Vester B.

RNA Biol. 2018;15(8):1060-1070. doi: 10.1080/15476286.2018.1486662. Epub 2018 Aug 13.

2.

The cfr and cfr-like multiple resistance genes.

Vester B.

Res Microbiol. 2018 Feb - Mar;169(2):61-66. doi: 10.1016/j.resmic.2017.12.003. Epub 2018 Mar 2. Review.

PMID:
29378339
3.

Combined Effect of the Cfr Methyltransferase and Ribosomal Protein L3 Mutations on Resistance to Ribosome-Targeting Antibiotics.

Pakula KK, Hansen LH, Vester B.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00862-17. doi: 10.1128/AAC.00862-17. Print 2017 Sep.

4.

Oligonucleotides Containing Aminated 2'-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA.

Lou C, Samuelsen SV, Christensen NJ, Vester B, Wengel J.

Bioconjug Chem. 2017 Apr 19;28(4):1214-1220. doi: 10.1021/acs.bioconjchem.7b00061. Epub 2017 Apr 5.

PMID:
28332825
5.

Antisense Oligonucleotides Internally Labeled with Peptides Show Improved Target Recognition and Stability to Enzymatic Degradation.

Taskova M, Madsen CS, Jensen KJ, Hansen LH, Vester B, Astakhova K.

Bioconjug Chem. 2017 Mar 15;28(3):768-774. doi: 10.1021/acs.bioconjchem.6b00567. Epub 2016 Dec 1.

PMID:
28292178
6.

Lincosamides, Streptogramins, Phenicols, and Pleuromutilins: Mode of Action and Mechanisms of Resistance.

Schwarz S, Shen J, Kadlec K, Wang Y, Brenner Michael G, Feßler AT, Vester B.

Cold Spring Harb Perspect Med. 2016 Nov 1;6(11). pii: a027037. doi: 10.1101/cshperspect.a027037. Review.

7.

Biochemical and Computational Analysis of the Substrate Specificities of Cfr and RlmN Methyltransferases.

Ntokou E, Hansen LH, Kongsted J, Vester B.

PLoS One. 2015 Dec 23;10(12):e0145655. doi: 10.1371/journal.pone.0145655. eCollection 2015.

8.

A cfr-like gene from Clostridium difficile confers multiple antibiotic resistance by the same mechanism as the cfr gene.

Hansen LH, Vester B.

Antimicrob Agents Chemother. 2015 Sep;59(9):5841-3. doi: 10.1128/AAC.01274-15. Epub 2015 Jul 6.

9.

Mutations in the bacterial ribosomal protein l3 and their association with antibiotic resistance.

Klitgaard RN, Ntokou E, Nørgaard K, Biltoft D, Hansen LH, Trædholm NM, Kongsted J, Vester B.

Antimicrob Agents Chemother. 2015;59(6):3518-28. doi: 10.1128/AAC.00179-15. Epub 2015 Apr 6.

10.

Oligonucleotides containing a piperazino-modified 2'-amino-LNA monomer exhibit very high duplex stability and remarkable nuclease resistance.

Lou C, Vester B, Wengel J.

Chem Commun (Camb). 2015 Mar 7;51(19):4024-7. doi: 10.1039/c5cc00322a.

PMID:
25659978
11.

Double-coding nucleic acids: introduction of a nucleobase sequence in the major groove of the DNA duplex using double-headed nucleotides.

Kumar P, Sorinas AF, Nielsen LJ, Slot M, Skytte K, Nielsen AS, Jensen MD, Sharma PK, Vester B, Petersen M, Nielsen P.

J Org Chem. 2014 Sep 5;79(17):8020-30. doi: 10.1021/jo501151w. Epub 2014 Aug 13.

PMID:
25089572
12.

Improvement of a streptavidin-binding aptamer by LNA- and α-l-LNA-substitutions.

Jørgensen AS, Hansen LH, Vester B, Wengel J.

Bioorg Med Chem Lett. 2014 May 15;24(10):2273-7. doi: 10.1016/j.bmcl.2014.03.082. Epub 2014 Apr 3.

PMID:
24745966
13.

A click chemistry approach to pleuromutilin derivatives. Part 3: extended footprinting analysis and excellent MRSA inhibition for a derivative with an adenine phenyl side chain.

Dreier I, Hansen LH, Nielsen P, Vester B.

Bioorg Med Chem Lett. 2014 Feb 15;24(4):1043-6. doi: 10.1016/j.bmcl.2014.01.019. Epub 2014 Jan 15.

PMID:
24486133
14.

Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase.

Atkinson GC, Hansen LH, Tenson T, Rasmussen A, Kirpekar F, Vester B.

Antimicrob Agents Chemother. 2013 Aug;57(8):4019-26. doi: 10.1128/AAC.00448-13. Epub 2013 Jun 10.

15.

Peptide-LNA oligonucleotide conjugates.

Astakhova IK, Hansen LH, Vester B, Wengel J.

Org Biomol Chem. 2013 Jul 7;11(25):4240-9. doi: 10.1039/c3ob40786a.

PMID:
23681061
16.

Amplification and re-generation of LNA-modified libraries.

Doessing H, Hansen LH, Veedu RN, Wengel J, Vester B.

Molecules. 2012 Nov 5;17(11):13087-97. doi: 10.3390/molecules171113087.

17.

Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides.

Højland T, Veedu RN, Vester B, Wengel J.

Artif DNA PNA XNA. 2012 Jan-Mar;3(1):14-21. doi: 10.4161/adna.19272.

18.

Serum metabolites, ghrelin and leptin are modified by age and/or diet in weanling kittens fed either a high- or moderate-protein diet.

Vester BM, Belsito KR, Swanson KS.

Anim Sci J. 2012 May;83(5):426-33. doi: 10.1111/j.1740-0929.2011.00974.x. Epub 2011 Nov 16.

PMID:
22574795
19.

The order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance gene.

Hansen LH, Planellas MH, Long KS, Vester B.

Antimicrob Agents Chemother. 2012 Jul;56(7):3563-7. doi: 10.1128/AAC.00673-12. Epub 2012 Apr 30.

20.

A click chemistry approach to pleuromutilin derivatives, part 2: conjugates with acyclic nucleosides and their ribosomal binding and antibacterial activity.

Dreier I, Kumar S, Søndergaard H, Rasmussen ML, Hansen LH, List NH, Kongsted J, Vester B, Nielsen P.

J Med Chem. 2012 Mar 8;55(5):2067-77. doi: 10.1021/jm201266b. Epub 2012 Feb 16.

PMID:
22280300
21.

Resistance to linezolid caused by modifications at its binding site on the ribosome.

Long KS, Vester B.

Antimicrob Agents Chemother. 2012 Feb;56(2):603-12. doi: 10.1128/AAC.05702-11. Epub 2011 Dec 5. Review.

22.

Duplex and triplex formation of mixed pyrimidine oligonucleotides with stacking of phenyl-triazole moieties in the major groove.

Andersen NK, Døssing H, Jensen F, Vester B, Nielsen P.

J Org Chem. 2011 Aug 5;76(15):6177-87. doi: 10.1021/jo200919y. Epub 2011 Jul 1.

PMID:
21692520
23.

Locked and unlocked nucleosides in functional nucleic acids.

Doessing H, Vester B.

Molecules. 2011 May 27;16(6):4511-26. doi: 10.3390/molecules16064511.

24.

Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain.

Hidalgo Á, Carvajal A, Vester B, Pringle M, Naharro G, Rubio P.

Antimicrob Agents Chemother. 2011 Jul;55(7):3330-7. doi: 10.1128/AAC.01749-10. Epub 2011 May 9.

25.

Minimal substrate features for Erm methyltransferases defined by using a combinatorial oligonucleotide library.

Hansen LH, Lobedanz S, Douthwaite S, Arar K, Wengel J, Kirpekar F, Vester B.

Chembiochem. 2011 Mar 7;12(4):610-4. doi: 10.1002/cbic.201000606. Epub 2011 Jan 24.

PMID:
21264994
26.

Selection of G-quadruplex folding topology with LNA-modified human telomeric sequences in K+ solution.

Pradhan D, Hansen LH, Vester B, Petersen M.

Chemistry. 2011 Feb 18;17(8):2405-13. doi: 10.1002/chem.201001961. Epub 2011 Jan 24.

PMID:
21264960
27.

Phylogenetic and gene-centric metagenomics of the canine intestinal microbiome reveals similarities with humans and mice.

Swanson KS, Dowd SE, Suchodolski JS, Middelbos IS, Vester BM, Barry KA, Nelson KE, Torralba M, Henrissat B, Coutinho PM, Cann IK, White BA, Fahey GC Jr.

ISME J. 2011 Apr;5(4):639-49. doi: 10.1038/ismej.2010.162. Epub 2010 Oct 21.

28.

Polymerase-directed synthesis of C5-ethynyl locked nucleic acids.

Veedu RN, Burri HV, Kumar P, Sharma PK, Hrdlicka PJ, Vester B, Wengel J.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6565-8. doi: 10.1016/j.bmcl.2010.09.044. Epub 2010 Sep 21.

PMID:
20932755
29.

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer.

Pasternak A, Hernandez FJ, Rasmussen LM, Vester B, Wengel J.

Nucleic Acids Res. 2011 Feb;39(3):1155-64. doi: 10.1093/nar/gkq823. Epub 2010 Sep 24.

30.

Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance.

Long KS, Munck C, Andersen TM, Schaub MA, Hobbie SN, Böttger EC, Vester B.

Antimicrob Agents Chemother. 2010 Nov;54(11):4705-13. doi: 10.1128/AAC.00644-10. Epub 2010 Aug 9.

31.

Dietary cellulose, fructooligosaccharides, and pectin modify fecal protein catabolites and microbial populations in adult cats.

Barry KA, Wojcicki BJ, Middelbos IS, Vester BM, Swanson KS, Fahey GC Jr.

J Anim Sci. 2010 Sep;88(9):2978-87. doi: 10.2527/jas.2009-2464. Epub 2010 May 21.

PMID:
20495116
32.

Influence of feeding raw or extruded feline diets on nutrient digestibility and nitrogen metabolism of African wildcats (Felis lybica).

Vester BM, Burke SL, Liu KJ, Dikeman CL, Simmons LG, Swanson KS.

Zoo Biol. 2010 Nov-Dec;29(6):676-86. doi: 10.1002/zoo.20305.

PMID:
20095004
33.

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria.

Kaminska KH, Purta E, Hansen LH, Bujnicki JM, Vester B, Long KS.

Nucleic Acids Res. 2010 Mar;38(5):1652-63. doi: 10.1093/nar/gkp1142. Epub 2009 Dec 10.

34.

Aptamers as a model for functional evaluation of LNA and 2'-amino LNA.

Hernandez FJ, Kalra N, Wengel J, Vester B.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6585-7. doi: 10.1016/j.bmcl.2009.10.039. Epub 2009 Oct 13.

PMID:
19864131
35.

Evaluation of nutrient digestibility and fecal characteristics of exotic felids fed horse- or beef-based diets: use of the domestic cat as a model for exotic felids.

Vester BM, Beloshapka AN, Middelbos IS, Burke SL, Dikeman CL, Simmons LG, Swanson KS.

Zoo Biol. 2010 Jul-Aug;29(4):432-48. doi: 10.1002/zoo.20275.

PMID:
19830746
36.

Ovariohysterectomy alters body composition and adipose and skeletal muscle gene expression in cats fed a high-protein or moderate-protein diet.

Vester BM, Sutter SM, Keel TL, Graves TK, Swanson KS.

Animal. 2009 Sep;3(9):1287-98. doi: 10.1017/S1751731109004868.

PMID:
22444905
37.

Adipose tissue gene expression profiles of healthy young adult and geriatric dogs.

Swanson KS, Belsito KR, Vester BM, Schook LB.

Arch Anim Nutr. 2009 Apr;63(2):160-71. doi: 10.1080/17450390902733934.

PMID:
19489458
38.

In utero and postnatal exposure to a high-protein or high-carbohydrate diet leads to differences in adipose tissue mRNA expression and blood metabolites in kittens.

Vester BM, Liu KJ, Keel TL, Graves TK, Swanson KS.

Br J Nutr. 2009 Oct;102(8):1136-44. doi: 10.1017/S0007114509371652. Epub 2009 May 18.

PMID:
19445818
39.

Dietary protein concentration affects intestinal microbiota of adult cats: a study using DGGE and qPCR to evaluate differences in microbial populations in the feline gastrointestinal tract.

Lubbs DC, Vester BM, Fastinger ND, Swanson KS.

J Anim Physiol Anim Nutr (Berl). 2009 Feb;93(1):113-21. doi: 10.1111/j.1439-0396.2007.00788.x.

PMID:
19386015
40.

Nutrient digestibility and fecal characteristics are different among captive exotic felids fed a beef-based raw diet.

Vester BM, Burke SL, Dikeman CL, Simmons LG, Swanson KS.

Zoo Biol. 2008 Mar;27(2):126-36. doi: 10.1002/zoo.20172.

PMID:
19360610
41.

Efficient enzymatic synthesis of LNA-modified DNA duplexes using KOD DNA polymerase.

Veedu RN, Vester B, Wengel J.

Org Biomol Chem. 2009 Apr 7;7(7):1404-9. doi: 10.1039/b819946a. Epub 2009 Feb 24.

PMID:
19300826
42.

Age and diet affect gene expression profile in canine skeletal muscle.

Middelbos IS, Vester BM, Karr-Lilienthal LK, Schook LB, Swanson KS.

PLoS One. 2009;4(2):e4481. doi: 10.1371/journal.pone.0004481. Epub 2009 Feb 16.

43.

Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket.

Long KS, Poehlsgaard J, Hansen LH, Hobbie SN, Böttger EC, Vester B.

Mol Microbiol. 2009 Mar;71(5):1218-27. doi: 10.1111/j.1365-2958.2009.06596.x. Epub 2009 Jan 16.

44.

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria.

Giessing AM, Jensen SS, Rasmussen A, Hansen LH, Gondela A, Long K, Vester B, Kirpekar F.

RNA. 2009 Feb;15(2):327-36. doi: 10.1261/rna.1371409.

45.

Impact of ovariohysterectomy and food intake on body composition, physical activity, and adipose gene expression in cats.

Belsito KR, Vester BM, Keel T, Graves TK, Swanson KS.

J Anim Sci. 2009 Feb;87(2):594-602. doi: 10.2527/jas.2008-0887. Epub 2008 Nov 7.

PMID:
18997063
46.

Antibiotic Resistance Mechanisms, with an Emphasis on Those Related to the Ribosome.

Long KS, Vester B.

EcoSal Plus. 2008 Sep;3(1). doi: 10.1128/ecosalplus.2.5.7.

PMID:
26443725
47.

Short-chain fructooligosaccharides influence insulin sensitivity and gene expression of fat tissue in obese dogs.

Respondek F, Swanson KS, Belsito KR, Vester BM, Wagner A, Istasse L, Diez M.

J Nutr. 2008 Sep;138(9):1712-8.

PMID:
18716174
48.

A click chemistry approach to pleuromutilin conjugates with nucleosides or acyclic nucleoside derivatives and their binding to the bacterial ribosome.

Lolk L, Pøhlsgaard J, Jepsen AS, Hansen LH, Nielsen H, Steffansen SI, Sparving L, Nielsen AB, Vester B, Nielsen P.

J Med Chem. 2008 Aug 28;51(16):4957-67. doi: 10.1021/jm800261u. Epub 2008 Aug 5.

PMID:
18680270
49.

Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates.

Veedu RN, Vester B, Wengel J.

J Am Chem Soc. 2008 Jul 2;130(26):8124-5. doi: 10.1021/ja801389n. Epub 2008 Jun 6.

PMID:
18533656
50.

Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach.

Kalek M, Benediktson P, Vester B, Wengel J.

Chem Commun (Camb). 2008 Feb 14;(6):762-4.

PMID:
18478716

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