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Items: 1 to 50 of 118

1.

Phase I and pharmacokinetic study of the novel anthracycline derivative 5-imino-13-deoxydoxorubicin (GPX-150) in patients with advanced solid tumors.

Holstein SA, Bigelow JC, Olson RD, Vestal RE, Walsh GM, Hohl RJ.

Invest New Drugs. 2015 Jun;33(3):594-602. doi: 10.1007/s10637-015-0220-z. Epub 2015 Feb 21.

PMID:
25698442
2.

Doxorubicin cardiac dysfunction: effects on calcium regulatory proteins, sarcoplasmic reticulum, and triiodothyronine.

Olson RD, Gambliel HA, Vestal RE, Shadle SE, Charlier HA Jr, Cusack BJ.

Cardiovasc Toxicol. 2005;5(3):269-83.

PMID:
16244372
3.

Species comparison of adenosine A1 receptors in isolated mammalian atrial and ventricular myocardium.

Kapicka CL, Montamat SC, Olson RD, Musser B, Mudumbi RV, Vestal RE.

Life Sci. 2003 May 9;72(25):2825-38.

PMID:
12697266
4.

Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells.

Hadjokas NE, Dai R, Friedman FK, Spence MJ, Cusack BJ, Vestal RE, Ma Y.

Br J Pharmacol. 2002 Jun;136(3):347-52.

5.

Oncostatin M suppresses EGF-mediated protein tyrosine phosphorylation in breast cancer cells.

Spence MJ, Vestal RE, Ma Y, Streiff R, Liu J.

Cytokine. 2000 Jul;12(7):922-33.

PMID:
10880237
6.

Effects of cyclopentyladenosine on isoproterenol response in adult and senescent cardiac tissue from Fischer 344 rats.

Kapicka CL, Montamat SC, Mudumbi RV, Jacks SM, Olson RD, Vestal RE.

J Pharmacol Exp Ther. 2000 May;293(2):599-606.

PMID:
10773034
7.

Cloning and characterization of human oncostatin M promoter.

Ma Y, Streiff RJ, Liu J, Spence MJ, Vestal RE.

Nucleic Acids Res. 1999 Dec 1;27(23):4649-57.

8.

Inhibition of human liver cytochrome P-450 1A2 by the class IB antiarrhythmics mexiletine, lidocaine, and tocainide.

Wei X, Dai R, Zhai S, Thummel KE, Friedman FK, Vestal RE.

J Pharmacol Exp Ther. 1999 May;289(2):853-8.

PMID:
10215663
9.

Adenosine A1 receptor-dependent and -independent effects of the allosteric enhancer PD 81,723.

Musser B, Mudumbi RV, Liu J, Olson RD, Vestal RE.

J Pharmacol Exp Ther. 1999 Feb;288(2):446-54.

PMID:
9918544
10.

Inhibition of human cytochrome P450 1A2 by flavones: a molecular modeling study.

Dai R, Zhai S, Wei X, Pincus MR, Vestal RE, Friedman FK.

J Protein Chem. 1998 Oct;17(7):643-50.

PMID:
9853678
11.

The clinical pharmacologist: an endangered species?

Vestal RE.

Clin Pharmacol Ther. 1998 Nov;64(5):471-6. No abstract available.

PMID:
9834038
12.

CD40 is functionally expressed on human breast carcinomas: variable inducibility by cytokines and enhancement of Fas-mediated apoptosis.

Wingett DG, Vestal RE, Forcier K, Hadjokas N, Nielson CP.

Breast Cancer Res Treat. 1998 Jul;50(1):27-36.

PMID:
9802617
13.

Comparative inhibition of human cytochromes P450 1A1 and 1A2 by flavonoids.

Zhai S, Dai R, Friedman FK, Vestal RE.

Drug Metab Dispos. 1998 Oct;26(10):989-92.

PMID:
9763404
14.

Inhibition of methoxyresorufin demethylase activity by flavonoids in human liver microsomes.

Zhai S, Dai R, Wei X, Friedman FK, Vestal RE.

Life Sci. 1998;63(8):PL119-23.

PMID:
9718089
15.

Oncostatin M-specific receptor expression and function in regulating cell proliferation of normal and malignant mammary epithelial cells.

Liu J, Hadjokas N, Mosley B, Estrov Z, Spence MJ, Vestal RE.

Cytokine. 1998 Apr;10(4):295-302.

PMID:
9617575
16.

Notes of the American Society for Clinical Pharmacology and Therapeutics. A letter to the members.

Vestal RE.

Clin Pharmacol Ther. 1998 Apr;63(4):496-7. No abstract available.

PMID:
9606093
17.

Liver LDL receptor mRNA expression is decreased in human ApoB/CETP double transgenic mice and is regulated by diet as well as the cytokine oncostatin M.

Liu J, Zhang YL, Spence MJ, Vestal RE, Wallace PM, Grass DS.

Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2948-54.

PMID:
9409281
18.

Novel mechanism of transcriptional activation of hepatic LDL receptor by oncostatin M.

Liu J, Streiff R, Zhang YL, Vestal RE, Spence MJ, Briggs MR.

J Lipid Res. 1997 Oct;38(10):2035-48.

19.

Geriatric clinical pharmacologist and medical oncologist: a new partnership?

Vestal RE, Calabresi P.

Clin Pharmacol Ther. 1997 Oct;62(4):361-4. No abstract available.

PMID:
9357386
20.

Aging and pharmacology.

Vestal RE.

Cancer. 1997 Oct 1;80(7):1302-10. Review.

PMID:
9317183
21.

Oncostatin M-mediated transcriptional suppression of the c-myc gene in breast cancer cells.

Spence MJ, Vestal RE, Liu J.

Cancer Res. 1997 Jun 1;57(11):2223-8.

22.

Oncostatin M-specific receptor mediates inhibition of breast cancer cell growth and down-regulation of the c-myc proto-oncogene.

Liu J, Spence MJ, Wallace PM, Forcier K, Hellström I, Vestal RE.

Cell Growth Differ. 1997 Jun;8(6):667-76.

23.

Acetylator phenotype in relation to age and gender in the Baltimore Longitudinal Study of Aging.

Korrapati MR, Sorkin JD, Andres R, Muller DC, Loi CM, Vesell ES, Vestal RE.

J Clin Pharmacol. 1997 Feb;37(2):83-91.

PMID:
9055133
25.

Age-related pharmacokinetics of daunorubicin and daunorubicinol following intravenous bolus daunorubicin administration in the rat.

Cusack BJ, Young SP, Vestal RE, Olson RD.

Cancer Chemother Pharmacol. 1997;39(6):505-12.

PMID:
9118462
26.

Relation between plasma and saliva concentrations of enoxacin, ciprofloxacin, and theophylline.

Zhai S, Wei X, Parker BM, Kunze KL, Vestal RE.

Ther Drug Monit. 1996 Dec;18(6):666-71.

PMID:
8946663
27.

Aging increases the cardiotoxicity of daunorubicin and daunorubicinol in the rat.

Cusack BJ, Mushlin PS, Johnson CJ, Vestal RE, Olson RD.

J Gerontol A Biol Sci Med Sci. 1996 Sep;51(5):B376-84.

PMID:
8808986
28.

Age-related characterization of atrial adenosine A1 receptor activation: direct effects on chronotropic and inotropic function in the Fischer 344 rat.

Montamat SC, Olson RD, Mudumbi RV, Vestal RE.

J Gerontol A Biol Sci Med Sci. 1996 Jul;51(4):B239-46.

PMID:
8680987
29.

Clinical pharmacology: present status and projections for the future.

Vestal RE.

J Clin Pharmacol. 1996 Apr;36(4):286-91. No abstract available.

PMID:
8728341
30.
31.

Relative potency of mexiletine, lidocaine, and tocainide as inhibitors of rat liver CYP1A1 activity.

Wei X, Loi CM, Jarvi EJ, Vestal RE.

Drug Metab Dispos. 1995 Dec;23(12):1335-8.

PMID:
8689940
32.

Age-related effects in rabbit hearts of N6-R-phenylisopropyladenosine, an adenosine A1 receptor agonist.

Mudumbi RV, Olson RD, Hubler BE, Montamat SC, Vestal RE.

J Gerontol A Biol Sci Med Sci. 1995 Nov;50(6):B351-7.

PMID:
7583791
33.

Impaired bronchodilator response to albuterol in healthy elderly men and women.

Connolly MJ, Crowley JJ, Charan NB, Nielson CP, Vestal RE.

Chest. 1995 Aug;108(2):401-6.

PMID:
7634874
34.

Simultaneous determination of theophylline, enoxacin and ciprofloxacin in human plasma and saliva by high-performance liquid chromatography.

Zhai S, Korrapati MR, Wei X, Muppalla S, Vestal RE.

J Chromatogr B Biomed Appl. 1995 Jul 21;669(2):372-6.

PMID:
7581914
35.

Pharmacokinetic optimisation of drug therapy in elderly patients.

Parker BM, Cusack BJ, Vestal RE.

Drugs Aging. 1995 Jul;7(1):10-8. Review.

PMID:
7579777
36.

Characterization of the independent and combined effects of two inhibitors on oxidative drug metabolism in rat liver microsomes.

Wei X, Loi CM, Schmucker DL, Vestal RE.

Biochem Pharmacol. 1995 May 26;49(11):1657-63.

PMID:
7786307
37.

Theophylline metabolism in healthy nonsmokers and in patients with insulin-dependent diabetes mellitus.

Korrapati MR, Vestal RE, Loi CM.

Clin Pharmacol Ther. 1995 Apr;57(4):413-8.

PMID:
7712669
38.
39.

Streptococcus pneumoniae-induced pulmonary hypertension and systemic hypotension in anesthetized sheep.

Charan NB, Mudumbi RV, Hawk P, Vestal RE, Carvalho P.

J Appl Physiol (1985). 1994 Nov;77(5):2071-8.

PMID:
7868418
40.

A solid-phase radioimmunoassay for cyclic AMP.

Daniels CK, Zhang L, Musser B, Vestal RE.

J Pharmacol Toxicol Methods. 1994 Feb;31(1):41-6.

PMID:
8186443
42.

Species comparison of adenosine and beta-adrenoceptors in mammalian atrial and ventricular myocardium.

Musser B, Morgan ME, Leid M, Murray TF, Linden J, Vestal RE.

Eur J Pharmacol. 1993 Jul 15;246(2):105-11. Erratum in: Eur J Pharmacol 1996 Jul 25;308(3):357.

PMID:
8397091
43.

Effect of adenosine on heart rate in isolated muskrat and guinea pig hearts.

McKean TA, Sterling H, Streeby DR, Lynch AE, Lacroix C, Vestal RE.

Am J Physiol. 1993 Jul;265(1 Pt 2):H307-15.

PMID:
8342647
44.

Aging and the response to inhibition and induction of theophylline metabolism.

Vestal RE, Cusack BJ, Crowley JJ, Loi CM.

Exp Gerontol. 1993 Jul-Oct;28(4-5):421-33. Review.

PMID:
8224039
45.

The effect of tocainide on theophylline metabolism.

Loi CM, Wei X, Parker BM, Korrapati MR, Vestal RE.

Br J Clin Pharmacol. 1993 Apr;35(4):437-40.

46.

Cardiac functional responses to adenosine by PD 81,723, an allosteric enhancer of the adenosine A1 receptor.

Mudumbi RV, Montamat SC, Bruns RF, Vestal RE.

Am J Physiol. 1993 Mar;264(3 Pt 2):H1017-22.

PMID:
8456969
47.

Acute metabolic effects of clonidine and adenosine in man.

Swislocki AL, Vestal RE, Reaven GM, Hoffman BB.

Horm Metab Res. 1993 Feb;25(2):90-5.

PMID:
8458615
48.

Effects of adenosine in combination with calcium channel blockers in patients with primary pulmonary hypertension.

Inbar S, Schrader BJ, Kaufmann E, Vestal RE, Rich S.

J Am Coll Cardiol. 1993 Feb;21(2):413-8.

49.

Impaired beta-adrenoceptor function, increased leukocyte respiratory burst, and bronchial hyperresponsiveness.

Nielson CP, Crowley JJ, Vestal RE, Connolly MJ.

J Allergy Clin Immunol. 1992 Nov;90(5):825-32.

PMID:
1331219
50.

Workshop on problem-based learning as a method for teaching clinical pharmacology and therapeutics in medical school.

Vestal RE, Benowitz NL.

J Clin Pharmacol. 1992 Sep;32(9):779-97. No abstract available.

PMID:
1430298

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