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Items: 27

1.

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion.

Freeman AJ, Vervoort SJ, Ramsbottom KM, Kelly MJ, Michie J, Pijpers L, Johnstone RW, Kearney CJ, Oliaro J.

Cell Rep. 2019 Sep 10;28(11):2784-2794.e5. doi: 10.1016/j.celrep.2019.08.017.

2.

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis.

Kelly MJ, So J, Rogers AJ, Gregory G, Li J, Zethoven M, Gearhart MD, Bardwell VJ, Johnstone RW, Vervoort SJ, Kats LM.

Nat Commun. 2019 Mar 22;10(1):1347. doi: 10.1038/s41467-019-09250-6.

3.

Antagonism of IAPs Enhances CAR T-cell Efficacy.

Michie J, Beavis PA, Freeman AJ, Vervoort SJ, Ramsbottom KM, Narasimhan V, Lelliott EJ, Lalaoui N, Ramsay RG, Johnstone RW, Silke J, Darcy PK, Voskoboinik I, Kearney CJ, Oliaro J.

Cancer Immunol Res. 2019 Feb;7(2):183-192. doi: 10.1158/2326-6066.CIR-18-0428. Epub 2019 Jan 16.

PMID:
30651288
4.

Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis.

Vervoort SJ, de Jong OG, Roukens MG, Frederiks CL, Vermeulen JF, Lourenço AR, Bella L, Vidakovic AT, Sandoval JL, Moelans C, van Amersfoort M, Dallman MJ, Bruna A, Caldas C, Nieuwenhuis E, van der Wall E, Derksen P, van Diest P, Verhaar MC, Lam EW, Mokry M, Coffer PJ.

Elife. 2018 Dec 3;7. pii: e27706. doi: 10.7554/eLife.27706.

5.

SOX4 inhibits oligodendrocyte differentiation of embryonic neural stem cells in vitro by inducing Hes5 expression.

Braccioli L, Vervoort SJ, Puma G, Nijboer CH, Coffer PJ.

Stem Cell Res. 2018 Dec;33:110-119. doi: 10.1016/j.scr.2018.10.005. Epub 2018 Oct 4.

6.

Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy.

Peeters JGC, Picavet LW, Coenen SGJM, Mauthe M, Vervoort SJ, Mocholi E, de Heus C, Klumperman J, Vastert SJ, Reggiori F, Coffer PJ, Mokry M, van Loosdregt J.

Autophagy. 2019 Jan;15(1):98-112. doi: 10.1080/15548627.2018.1509608. Epub 2018 Sep 11.

7.

SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis.

Vervoort SJ, Lourenço AR, Tufegdzic Vidakovic A, Mocholi E, Sandoval JL, Rueda OM, Frederiks C, Pals C, Peeters JGC, Caldas C, Bruna A, Coffer PJ.

Nucleic Acids Res. 2018 Oct 12;46(18):9578-9590. doi: 10.1093/nar/gky755.

8.

Tumor immune evasion arises through loss of TNF sensitivity.

Kearney CJ, Vervoort SJ, Hogg SJ, Ramsbottom KM, Freeman AJ, Lalaoui N, Pijpers L, Michie J, Brown KK, Knight DA, Sutton V, Beavis PA, Voskoboinik I, Darcy PK, Silke J, Trapani JA, Johnstone RW, Oliaro J.

Sci Immunol. 2018 May 18;3(23). pii: eaar3451. doi: 10.1126/sciimmunol.aar3451.

PMID:
29776993
9.

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML.

Duarte D, Hawkins ED, Akinduro O, Ang H, De Filippo K, Kong IY, Haltalli M, Ruivo N, Straszkowski L, Vervoort SJ, McLean C, Weber TS, Khorshed R, Pirillo C, Wei A, Ramasamy SK, Kusumbe AP, Duffy K, Adams RH, Purton LE, Carlin LM, Lo Celso C.

Cell Stem Cell. 2018 Jan 4;22(1):64-77.e6. doi: 10.1016/j.stem.2017.11.006. Epub 2017 Dec 21.

10.

FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression.

Braccioli L, Vervoort SJ, Adolfs Y, Heijnen CJ, Basak O, Pasterkamp RJ, Nijboer CH, Coffer PJ.

Stem Cell Reports. 2017 Nov 14;9(5):1530-1545. doi: 10.1016/j.stemcr.2017.10.012.

11.

Epigenetic targeting of Notch1-driven transcription using the HDACi panobinostat is a potential therapy against T-cell acute lymphoblastic leukemia.

Waibel M, Vervoort SJ, Kong IY, Heinzel S, Ramsbottom KM, Martin BP, Hawkins ED, Johnstone RW.

Leukemia. 2018 Jan;32(1):237-241. doi: 10.1038/leu.2017.282. Epub 2017 Sep 15. No abstract available.

PMID:
28914259
12.

DOCK8 Drives Src-Dependent NK Cell Effector Function.

Kearney CJ, Vervoort SJ, Ramsbottom KM, Freeman AJ, Michie J, Peake J, Casanova JL, Picard C, Tangye SG, Ma CS, Johnstone RW, Randall KL, Oliaro J.

J Immunol. 2017 Aug 9. pii: ji1700751. doi: 10.4049/jimmunol.1700751. [Epub ahead of print]

PMID:
28794229
13.

A pharmacogenomic approach validates AG-221 as an effective and on-target therapy in IDH2 mutant AML.

Kats LM, Vervoort SJ, Cole R, Rogers AJ, Gregory GP, Vidacs E, Li J, Nagaraja R, Yen KE, Johnstone RW.

Leukemia. 2017 Jun;31(6):1466-1470. doi: 10.1038/leu.2017.84. Epub 2017 Mar 10. No abstract available.

PMID:
28280273
14.

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2+ Tumors.

Medon M, Vidacs E, Vervoort SJ, Li J, Jenkins MR, Ramsbottom KM, Trapani JA, Smyth MJ, Darcy PK, Atadja PW, Henderson MA, Johnstone RW, Haynes NM.

Cancer Res. 2017 May 15;77(10):2594-2606. doi: 10.1158/0008-5472.CAN-16-2247. Epub 2017 Mar 1.

15.

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1.

Hogg SJ, Vervoort SJ, Deswal S, Ott CJ, Li J, Cluse LA, Beavis PA, Darcy PK, Martin BP, Spencer A, Traunbauer AK, Sadovnik I, Bauer K, Valent P, Bradner JE, Zuber J, Shortt J, Johnstone RW.

Cell Rep. 2017 Feb 28;18(9):2162-2174. doi: 10.1016/j.celrep.2017.02.011.

16.

BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members.

Hogg SJ, Newbold A, Vervoort SJ, Cluse LA, Martin BP, Gregory GP, Lefebure M, Vidacs E, Tothill RW, Bradner JE, Shortt J, Johnstone RW.

Mol Cancer Ther. 2016 Sep;15(9):2030-41. doi: 10.1158/1535-7163.MCT-15-0924. Epub 2016 Jul 12.

17.

Autoimmune disease-associated gene expression is reduced by BET-inhibition.

Peeters JG, Vervoort SJ, Mijnheer G, de Roock S, Vastert SJ, Nieuwenhuis EE, van Wijk F, Prakken BJ, Mokry M, van Loosdregt J.

Genom Data. 2015 Nov 7;7:14-7. doi: 10.1016/j.gdata.2015.11.004. eCollection 2016 Mar.

18.

In Vitro Evaluation of Spider Silk Meshes as a Potential Biomaterial for Bladder Reconstruction.

Steins A, Dik P, Müller WH, Vervoort SJ, Reimers K, Kuhbier JW, Vogt PM, van Apeldoorn AA, Coffer PJ, Schepers K.

PLoS One. 2015 Dec 21;10(12):e0145240. doi: 10.1371/journal.pone.0145240. eCollection 2015.

19.

Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome.

Tufegdzic Vidakovic A, Rueda OM, Vervoort SJ, Sati Batra A, Goldgraben MA, Uribe-Lewis S, Greenwood W, Coffer PJ, Bruna A, Caldas C.

Cell Rep. 2015 Dec 22;13(11):2480-2490. doi: 10.1016/j.celrep.2015.11.040. Epub 2015 Dec 10.

20.

Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression.

Peeters JG, Vervoort SJ, Tan SC, Mijnheer G, de Roock S, Vastert SJ, Nieuwenhuis EE, van Wijk F, Prakken BJ, Creyghton MP, Coffer PJ, Mokry M, van Loosdregt J.

Cell Rep. 2015 Sep 29;12(12):1986-96. doi: 10.1016/j.celrep.2015.08.046. Epub 2015 Sep 17.

21.

Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins.

Langereis MA, Bakkers MJ, Deng L, Padler-Karavani V, Vervoort SJ, Hulswit RJ, van Vliet AL, Gerwig GJ, de Poot SA, Boot W, van Ederen AM, Heesters BA, van der Loos CM, van Kuppeveld FJ, Yu H, Huizinga EG, Chen X, Varki A, Kamerling JP, de Groot RJ.

Cell Rep. 2015 Jun 30;11(12):1966-78. doi: 10.1016/j.celrep.2015.05.044. Epub 2015 Jun 18.

22.

Acetylation of C/EBPε is a prerequisite for terminal neutrophil differentiation.

Bartels M, Govers AM, Fleskens V, Lourenço AR, Pals CE, Vervoort SJ, van Gent R, Brenkman AB, Bierings MB, Ackerman SJ, van Loosdregt J, Coffer PJ.

Blood. 2015 Mar 12;125(11):1782-92. doi: 10.1182/blood-2013-12-543850. Epub 2015 Jan 7.

23.

SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition.

Vervoort SJ, Lourenço AR, van Boxtel R, Coffer PJ.

PLoS One. 2013;8(1):e53238. doi: 10.1371/journal.pone.0053238. Epub 2013 Jan 3.

24.

The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?

Vervoort SJ, van Boxtel R, Coffer PJ.

Oncogene. 2013 Jul 18;32(29):3397-409. doi: 10.1038/onc.2012.506. Epub 2012 Dec 17. Review.

PMID:
23246969
25.

Induction of autophagy does not alter the anti-tumor effects of HDAC inhibitors.

Newbold A, Vervoort SJ, Martin BP, Bots M, Johnstone RW.

Cell Death Dis. 2012 Sep 6;3:e387. doi: 10.1038/cddis.2012.128. No abstract available.

26.

Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.

van der Vos KE, Eliasson P, Proikas-Cezanne T, Vervoort SJ, van Boxtel R, Putker M, van Zutphen IJ, Mauthe M, Zellmer S, Pals C, Verhagen LP, Groot Koerkamp MJ, Braat AK, Dansen TB, Holstege FC, Gebhardt R, Burgering BM, Coffer PJ.

Nat Cell Biol. 2012 Aug;14(8):829-37. doi: 10.1038/ncb2536. Epub 2012 Jul 22.

PMID:
22820375
27.

Syntenin-mediated regulation of Sox4 proteasomal degradation modulates transcriptional output.

Beekman JM, Vervoort SJ, Dekkers F, van Vessem ME, Vendelbosch S, Brugulat-Panès A, van Loosdregt J, Braat AK, Coffer PJ.

Oncogene. 2012 May 24;31(21):2668-79. doi: 10.1038/onc.2011.445. Epub 2011 Oct 10.

PMID:
21986941

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