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Items: 1 to 50 of 78

1.

Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes.

Zoeller EL, Pedro B, Konen J, Dwivedi B, Rupji M, Sundararaman N, Wang L, Horton JR, Zhong C, Barwick BG, Cheng X, Martinez ED, Torres MP, Kowalski J, Marcus AI, Vertino PM.

J Cell Sci. 2019 Oct 9;132(19). pii: jcs231514. doi: 10.1242/jcs.231514.

PMID:
31515279
2.

Cell of Origin and Genetic Alterations in the Pathogenesis of Multiple Myeloma.

Barwick BG, Gupta VA, Vertino PM, Boise LH.

Front Immunol. 2019 May 21;10:1121. doi: 10.3389/fimmu.2019.01121. eCollection 2019. Review.

3.

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis.

Barwick BG, Neri P, Bahlis NJ, Nooka AK, Dhodapkar MV, Jaye DL, Hofmeister CC, Kaufman JL, Gupta VA, Auclair D, Keats JJ, Lonial S, Vertino PM, Boise LH.

Nat Commun. 2019 Apr 23;10(1):1911. doi: 10.1038/s41467-019-09555-6.

4.

Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.

Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Cheng X.

J Med Chem. 2018 Dec 13;61(23):10588-10601. doi: 10.1021/acs.jmedchem.8b01219. Epub 2018 Nov 15.

5.

Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer.

Kennedy EM, Powell DR, Li Z, Bell JSK, Barwick BG, Feng H, McCrary MR, Dwivedi B, Kowalski J, Dynan WS, Conneely KN, Vertino PM.

Sci Rep. 2018 Apr 30;8(1):6709. doi: 10.1038/s41598-018-24755-8.

6.

Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.

Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X.

J Med Chem. 2018 Apr 12;61(7):3193-3208. doi: 10.1021/acs.jmedchem.8b00261. Epub 2018 Mar 23.

7.

Orphan CpG islands define a novel class of highly active enhancers.

Bell JSK, Vertino PM.

Epigenetics. 2017 Jun 3;12(6):449-464. doi: 10.1080/15592294.2017.1297910. Epub 2017 Apr 27.

8.

MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma.

Wang D, Hashimoto H, Zhang X, Barwick BG, Lonial S, Boise LH, Vertino PM, Cheng X.

Nucleic Acids Res. 2017 Mar 17;45(5):2396-2407. doi: 10.1093/nar/gkw1184.

9.

Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.

Horton JR, Liu X, Gale M, Wu L, Shanks JR, Zhang X, Webber PJ, Bell JSK, Kales SC, Mott BT, Rai G, Jansen DJ, Henderson MJ, Urban DJ, Hall MD, Simeonov A, Maloney DJ, Johns MA, Fu H, Jadhav A, Vertino PM, Yan Q, Cheng X.

Cell Chem Biol. 2016 Jul 21;23(7):769-781. doi: 10.1016/j.chembiol.2016.06.006. Epub 2016 Jul 14.

10.

A hot L1 retrotransposon evades somatic repression and initiates human colorectal cancer.

Scott EC, Gardner EJ, Masood A, Chuang NT, Vertino PM, Devine SE.

Genome Res. 2016 Jun;26(6):745-55. doi: 10.1101/gr.201814.115. Epub 2016 May 10.

11.

Factors affecting the persistence of drug-induced reprogramming of the cancer methylome.

Bell JS, Kagey JD, Barwick BG, Dwivedi B, McCabe MT, Kowalski J, Vertino PM.

Epigenetics. 2016 Apr 2;11(4):273-87. doi: 10.1080/15592294.2016.1158364. Epub 2016 Apr 15.

12.

Gene integrated set profile analysis: a context-based approach for inferring biological endpoints.

Kowalski J, Dwivedi B, Newman S, Switchenko JM, Pauly R, Gutman DA, Arora J, Gandhi K, Ainslie K, Doho G, Qin Z, Moreno CS, Rossi MR, Vertino PM, Lonial S, Bernal-Mizrachi L, Boise LH.

Nucleic Acids Res. 2016 Apr 20;44(7):e69. doi: 10.1093/nar/gkv1503. Epub 2016 Jan 29.

13.

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

Horton JR, Engstrom A, Zoeller EL, Liu X, Shanks JR, Zhang X, Johns MA, Vertino PM, Fu H, Cheng X.

J Biol Chem. 2016 Feb 5;291(6):2631-46. doi: 10.1074/jbc.M115.698449. Epub 2015 Dec 8.

14.

Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer.

Brodie SA, Li G, Harvey D, Khuri FR, Vertino PM, Brandes JC.

Oncotarget. 2015 Oct 13;6(31):30773-86. doi: 10.18632/oncotarget.5040.

15.

GC skew defines distinct RNA polymerase pause sites in CpG island promoters.

Kellner WA, Bell JS, Vertino PM.

Genome Res. 2015 Nov;25(11):1600-9. doi: 10.1101/gr.189068.114. Epub 2015 Aug 14.

16.

HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation.

Farkas AE, Hilgarth RS, Capaldo CT, Gerner-Smidt C, Powell DR, Vertino PM, Koval M, Parkos CA, Nusrat A.

Am J Pathol. 2015 Aug;185(8):2206-18. doi: 10.1016/j.ajpath.2015.04.023.

17.

The Mechanisms of Generation, Recognition, and Erasure of DNA 5-Methylcytosine and Thymine Oxidations.

Hashimoto H, Zhang X, Vertino PM, Cheng X.

J Biol Chem. 2015 Aug 21;290(34):20723-33. doi: 10.1074/jbc.R115.656884. Epub 2015 Jul 7. Review.

18.

Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis.

Stoyanov E, Ludwig G, Mizrahi L, Olam D, Schnitzer-Perlman T, Tasika E, Sass G, Tiegs G, Jiang Y, Nie T, Kohler J, Schinazi RF, Vertino PM, Cedar H, Galun E, Goldenberg D.

Oncotarget. 2015 May 10;6(13):11047-60.

19.

Integrated analysis of whole-genome paired-end and mate-pair sequencing data for identifying genomic structural variations in multiple myeloma.

Yang R, Chen L, Newman S, Gandhi K, Doho G, Moreno CS, Vertino PM, Bernal-Mizarchi L, Lonial S, Boise LH, Rossi M, Kowalski J, Qin ZS.

Cancer Inform. 2014 Sep 21;13(Suppl 2):49-53. doi: 10.4137/CIN.S13783. eCollection 2014. Review.

20.

Aberrant promoter methylation of caveolin-1 is associated with favorable response to taxane-platinum combination chemotherapy in advanced NSCLC.

Brodie SA, Lombardo C, Li G, Kowalski J, Gandhi K, You S, Khuri FR, Marcus A, Vertino PM, Brandes JC.

PLoS One. 2014 Sep 15;9(9):e107124. doi: 10.1371/journal.pone.0107124. eCollection 2014.

21.

CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences.

Lin Y, Cradick TJ, Brown MT, Deshmukh H, Ranjan P, Sarode N, Wile BM, Vertino PM, Stewart FJ, Bao G.

Nucleic Acids Res. 2014 Jun;42(11):7473-85. doi: 10.1093/nar/gku402. Epub 2014 May 16.

22.

Epigenetic changes associated with inflammation in breast cancer patients treated with chemotherapy.

Smith AK, Conneely KN, Pace TW, Mister D, Felger JC, Kilaru V, Akel MJ, Vertino PM, Miller AH, Torres MA.

Brain Behav Immun. 2014 May;38:227-36. doi: 10.1016/j.bbi.2014.02.010. Epub 2014 Feb 28.

23.

A dual role for the histone methyltransferase PR-SET7/SETD8 and histone H4 lysine 20 monomethylation in the local regulation of RNA polymerase II pausing.

Kapoor-Vazirani P, Vertino PM.

J Biol Chem. 2014 Mar 14;289(11):7425-37. doi: 10.1074/jbc.M113.520783. Epub 2014 Jan 23.

24.

Class I HDACs are mediators of smoke carcinogen-induced stabilization of DNMT1 and serve as promising targets for chemoprevention of lung cancer.

Brodie SA, Li G, El-Kommos A, Kang H, Ramalingam SS, Behera M, Gandhi K, Kowalski J, Sica GL, Khuri FR, Vertino PM, Brandes JC.

Cancer Prev Res (Phila). 2014 Mar;7(3):351-61. doi: 10.1158/1940-6207.CAPR-13-0254. Epub 2014 Jan 17.

25.

Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition.

Yang Z, Garcia A, Xu S, Powell DR, Vertino PM, Singh S, Marcus AI.

PLoS One. 2013 Sep 12;8(9):e75069. doi: 10.1371/journal.pone.0075069. eCollection 2013.

26.

Dysregulation of mTOR activity through LKB1 inactivation.

Zhou W, Marcus AI, Vertino PM.

Chin J Cancer. 2013 Aug;32(8):427-33. doi: 10.5732/cjc.013.10086. Epub 2013 May 14. Review.

27.

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.

Duncan CG, Barwick BG, Jin G, Rago C, Kapoor-Vazirani P, Powell DR, Chi JT, Bigner DD, Vertino PM, Yan H.

Genome Res. 2012 Dec;22(12):2339-55. doi: 10.1101/gr.132738.111. Epub 2012 Aug 16.

28.

R loops: lassoing DNA methylation at CpGi.

Vertino PM, Wade PA.

Mol Cell. 2012 Mar 30;45(6):708-9. doi: 10.1016/j.molcel.2012.03.014.

29.

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation.

Hashimoto H, Liu Y, Upadhyay AK, Chang Y, Howerton SB, Vertino PM, Zhang X, Cheng X.

Nucleic Acids Res. 2012 Jun;40(11):4841-9. doi: 10.1093/nar/gks155. Epub 2012 Feb 22.

30.

Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1.

Zhu D, Hunter SB, Vertino PM, Van Meir EG.

Cancer Res. 2011 Sep 1;71(17):5859-70. doi: 10.1158/0008-5472.CAN-11-1157. Epub 2011 Jul 1.

31.

Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation.

Thaiparambil JT, Bender L, Ganesh T, Kline E, Patel P, Liu Y, Tighiouart M, Vertino PM, Harvey RD, Garcia A, Marcus AI.

Int J Cancer. 2011 Dec 1;129(11):2744-55. doi: 10.1002/ijc.25938. Epub 2011 May 2.

32.

Molecular coupling of DNA methylation and histone methylation.

Hashimoto H, Vertino PM, Cheng X.

Epigenomics. 2010 Oct;2(5):657-69. Review.

33.

SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation.

Kapoor-Vazirani P, Kagey JD, Vertino PM.

Mol Cell Biol. 2011 Apr;31(8):1594-609. doi: 10.1128/MCB.00524-10. Epub 2011 Feb 14.

34.

Natural mutagenesis of human genomes by endogenous retrotransposons.

Iskow RC, McCabe MT, Mills RE, Torene S, Pittard WS, Neuwald AF, Van Meir EG, Vertino PM, Devine SE.

Cell. 2010 Jun 25;141(7):1253-61. doi: 10.1016/j.cell.2010.05.020.

35.

Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy.

Kagey JD, Kapoor-Vazirani P, McCabe MT, Powell DR, Vertino PM.

Mol Cancer Res. 2010 Jul;8(7):1048-59. doi: 10.1158/1541-7786.MCR-10-0189. Epub 2010 Jun 29.

36.

Age/race differences in HER2 testing and in incidence rates for breast cancer triple subtypes: a population-based study and first report.

Lund MJ, Butler EN, Hair BY, Ward KC, Andrews JH, Oprea-Ilies G, Bayakly AR, O'Regan RM, Vertino PM, Eley JW.

Cancer. 2010 Jun 1;116(11):2549-59. doi: 10.1002/cncr.25016.

37.

Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells.

McCabe MT, Powell DR, Zhou W, Vertino PM.

Cancer Genet Cytogenet. 2010 Mar;197(2):130-41. doi: 10.1016/j.cancergencyto.2009.11.017.

38.

Cancer DNA methylation: molecular mechanisms and clinical implications.

McCabe MT, Brandes JC, Vertino PM.

Clin Cancer Res. 2009 Jun 15;15(12):3927-37. doi: 10.1158/1078-0432.CCR-08-2784. Epub 2009 Jun 9.

39.

Methylation-sensitive regulation of TMS1/ASC by the Ets factor, GA-binding protein-alpha.

Lucas ME, Crider KS, Powell DR, Kapoor-Vazirani P, Vertino PM.

J Biol Chem. 2009 May 29;284(22):14698-709. doi: 10.1074/jbc.M901104200. Epub 2009 Mar 25.

40.

Silencing of TMS1/ASC promotes resistance to anoikis in breast epithelial cells.

Parsons MJ, Patel P, Brat DJ, Colbert L, Vertino PM.

Cancer Res. 2009 Mar 1;69(5):1706-11. doi: 10.1158/0008-5472.CAN-08-2351. Epub 2009 Feb 17.

41.

A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation.

McCabe MT, Lee EK, Vertino PM.

Cancer Res. 2009 Jan 1;69(1):282-91. doi: 10.1158/0008-5472.CAN-08-3274.

42.

Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells.

Guo L, Zhong D, Lau S, Liu X, Dong XY, Sun X, Yang VW, Vertino PM, Moreno CS, Varma V, Dong JT, Zhou W.

Mol Cancer Res. 2008 Sep;6(9):1421-30. doi: 10.1158/1541-7786.MCR-07-2175.

43.

LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins.

Zhong D, Liu X, Khuri FR, Sun SY, Vertino PM, Zhou W.

Cancer Res. 2008 Sep 15;68(18):7270-7. doi: 10.1158/0008-5472.CAN-08-1484.

44.

Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity.

Kapoor-Vazirani P, Kagey JD, Powell DR, Vertino PM.

Cancer Res. 2008 Aug 15;68(16):6810-21. doi: 10.1158/0008-5472.CAN-08-0141.

45.

Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase.

Subramanian K, Jia D, Kapoor-Vazirani P, Powell DR, Collins RE, Sharma D, Peng J, Cheng X, Vertino PM.

Mol Cell. 2008 May 9;30(3):336-47. doi: 10.1016/j.molcel.2008.03.022.

46.

The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity.

Zhang S, Schafer-Hales K, Khuri FR, Zhou W, Vertino PM, Marcus AI.

Cancer Res. 2008 Feb 1;68(3):740-8. doi: 10.1158/0008-5472.CAN-07-2989.

47.

Molecular pathogenesis of human prolactinomas identified by gene expression profiling, RT-qPCR, and proteomic analyses.

Evans CO, Moreno CS, Zhan X, McCabe MT, Vertino PM, Desiderio DM, Oyesiku NM.

Pituitary. 2008;11(3):231-45. doi: 10.1007/s11102-007-0082-2.

PMID:
18183490
48.
49.

Infrequent mutation of ATBF1 in human breast cancer.

Sun X, Zhou Y, Otto KB, Wang M, Chen C, Zhou W, Subramanian K, Vertino PM, Dong JT.

J Cancer Res Clin Oncol. 2007 Feb;133(2):103-5. Epub 2006 Aug 24.

PMID:
16932943
50.

LKB1 mutation in large cell carcinoma of the lung.

Zhong D, Guo L, de Aguirre I, Liu X, Lamb N, Sun SY, Gal AA, Vertino PM, Zhou W.

Lung Cancer. 2006 Sep;53(3):285-94. Epub 2006 Jul 5.

PMID:
16822578

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