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Items: 1 to 50 of 105

1.

Parkinson's disease: convergence on synaptic homeostasis.

Soukup SF, Vanhauwaert R, Verstreken P.

EMBO J. 2018 Jul 31. pii: e98960. doi: 10.15252/embj.201898960. [Epub ahead of print] Review.

PMID:
30065071
2.

Imaging mitophagy in the fruit fly.

Cornelissen T, Verstreken P, Vandenberghe W.

Autophagy. 2018 Aug 2:1-2. doi: 10.1080/15548627.2018.1496720. [Epub ahead of print]

PMID:
29995555
3.

A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain.

Davie K, Janssens J, Koldere D, De Waegeneer M, Pech U, Kreft Ł, Aibar S, Makhzami S, Christiaens V, Bravo González-Blas C, Poovathingal S, Hulselmans G, Spanier KI, Moerman T, Vanspauwen B, Geurs S, Voet T, Lammertyn J, Thienpont B, Liu S, Konstantinides N, Fiers M, Verstreken P, Aerts S.

Cell. 2018 Aug 9;174(4):982-998.e20. doi: 10.1016/j.cell.2018.05.057. Epub 2018 Jun 18.

4.

ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson's Disease.

Valadas JS, Esposito G, Vandekerkhove D, Miskiewicz K, Deaulmerie L, Raitano S, Seibler P, Klein C, Verstreken P.

Neuron. 2018 Jun 27;98(6):1155-1169.e6. doi: 10.1016/j.neuron.2018.05.022. Epub 2018 Jun 7.

PMID:
29887339
5.

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila.

Cornelissen T, Vilain S, Vints K, Gounko N, Verstreken P, Vandenberghe W.

Elife. 2018 May 29;7. pii: e35878. doi: 10.7554/eLife.35878.

6.

Publisher Correction: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters.

Bademosi AT, Lauwers E, Padmanabhan P, Odierna L, Chai YJ, Papadopulos A, Goodhill GJ, Verstreken P, van Swinderen B, Meunier FA.

Nat Commun. 2018 Apr 10;9:16191. doi: 10.1038/ncomms16191.

7.

p13 protects against Parkinson's disease.

Valadas JS, Verstreken P.

EMBO Rep. 2018 Mar;19(3). pii: e45900. doi: 10.15252/embr.201845900. Epub 2018 Feb 19. No abstract available.

PMID:
29459485
8.

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.

McInnes J, Wierda K, Snellinx A, Bounti L, Wang YC, Stancu IC, Apóstolo N, Gevaert K, Dewachter I, Spires-Jones TL, De Strooper B, De Wit J, Zhou L, Verstreken P.

Neuron. 2018 Feb 21;97(4):823-835.e8. doi: 10.1016/j.neuron.2018.01.022. Epub 2018 Feb 1.

PMID:
29398363
9.

In Vivo Single-Molecule Tracking at the Drosophila Presynaptic Motor Nerve Terminal.

Bademosi AT, Lauwers E, Amor R, Verstreken P, van Swinderen B, Meunier FA.

J Vis Exp. 2018 Jan 14;(131). doi: 10.3791/56952.

10.

Reprogramming neurodegeneration in the big data era.

Zhou L, Verstreken P.

Curr Opin Neurobiol. 2018 Feb;48:167-173. doi: 10.1016/j.conb.2017.12.015. Epub 2018 Jan 10. Review.

PMID:
29331684
11.

Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic.

Bademosi AT, Steeves J, Karunanithi S, Zalucki OH, Gormal RS, Liu S, Lauwers E, Verstreken P, Anggono V, Meunier FA, van Swinderen B.

Cell Rep. 2018 Jan 9;22(2):427-440. doi: 10.1016/j.celrep.2017.12.054.

12.

α-Synuclein and Tau: Mitochondrial Kill Switches.

Pech U, Verstreken P.

Neuron. 2018 Jan 3;97(1):3-4. doi: 10.1016/j.neuron.2017.12.024.

PMID:
29301103
13.

Autophagy in the presynaptic compartment in health and disease.

Vijayan V, Verstreken P.

J Cell Biol. 2017 Jul 3;216(7):1895-1906. doi: 10.1083/jcb.201611113. Epub 2017 May 17. Review.

14.

Tau association with synaptic vesicles causes presynaptic dysfunction.

Zhou L, McInnes J, Wierda K, Holt M, Herrmann AG, Jackson RJ, Wang YC, Swerts J, Beyens J, Miskiewicz K, Vilain S, Dewachter I, Moechars D, De Strooper B, Spires-Jones TL, De Wit J, Verstreken P.

Nat Commun. 2017 May 11;8:15295. doi: 10.1038/ncomms15295.

15.

The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals.

Vanhauwaert R, Kuenen S, Masius R, Bademosi A, Manetsberger J, Schoovaerts N, Bounti L, Gontcharenko S, Swerts J, Vilain S, Picillo M, Barone P, Munshi ST, de Vrij FM, Kushner SA, Gounko NV, Mandemakers W, Bonifati V, Meunier FA, Soukup SF, Verstreken P.

EMBO J. 2017 May 15;36(10):1392-1411. doi: 10.15252/embj.201695773. Epub 2017 Mar 22.

16.

Neurons eat glutamate to stay alive.

Fendt SM, Verstreken P.

J Cell Biol. 2017 Apr 3;216(4):863-865. doi: 10.1083/jcb.201702003. Epub 2017 Mar 15.

17.

EndoA/Endophilin-A creates docking stations for autophagic proteins at synapses.

Soukup SF, Verstreken P.

Autophagy. 2017 May 4;13(5):971-972. doi: 10.1080/15548627.2017.1286440. Epub 2017 Feb 15. Review.

18.

Presynaptic protein homeostasis and neuronal function.

Wang YC, Lauwers E, Verstreken P.

Curr Opin Genet Dev. 2017 Jun;44:38-46. doi: 10.1016/j.gde.2017.01.015. Epub 2017 Feb 16. Review.

PMID:
28213157
19.

Erratum: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters.

Bademosi AT, Lauwers E, Padmanabhan P, Odierna L, Chai YJ, Papadopulos A, Goodhill GJ, Verstreken P, van Swinderen B, Meunier FA.

Nat Commun. 2017 Feb 9;8:14492. doi: 10.1038/ncomms14492. No abstract available.

20.

Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency.

Vos M, Geens A, Böhm C, Deaulmerie L, Swerts J, Rossi M, Craessaerts K, Leites EP, Seibler P, Rakovic A, Lohnau T, De Strooper B, Fendt SM, Morais VA, Klein C, Verstreken P.

J Cell Biol. 2017 Mar 6;216(3):695-708. doi: 10.1083/jcb.201511044. Epub 2017 Jan 30.

21.

In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters.

Bademosi AT, Lauwers E, Padmanabhan P, Odierna L, Chai YJ, Papadopulos A, Goodhill GJ, Verstreken P, van Swinderen B, Meunier FA.

Nat Commun. 2017 Jan 3;8:13660. doi: 10.1038/ncomms13660. Erratum in: Nat Commun. 2018 Apr 10;9:16191.

22.

Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors.

Lorendeau D, Rinaldi G, Boon R, Spincemaille P, Metzger K, Jäger C, Christen S, Dong X, Kuenen S, Voordeckers K, Verstreken P, Cassiman D, Vermeersch P, Verfaillie C, Hiller K, Fendt SM.

Metab Eng. 2017 Sep;43(Pt B):187-197. doi: 10.1016/j.ymben.2016.11.005. Epub 2016 Nov 12.

PMID:
27847310
23.

Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.

Fischer B, Lüthy K, Paesmans J, De Koninck C, Maes I, Swerts J, Kuenen S, Uytterhoeven V, Verstreken P, Versées W.

Nat Struct Mol Biol. 2016 Nov;23(11):965-973. doi: 10.1038/nsmb.3297. Epub 2016 Sep 26.

PMID:
27669036
24.

Loss of Bin1 Promotes the Propagation of Tau Pathology.

Calafate S, Flavin W, Verstreken P, Moechars D.

Cell Rep. 2016 Oct 18;17(4):931-940. doi: 10.1016/j.celrep.2016.09.063.

25.

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System.

Murdoch JD, Rostosky CM, Gowrisankaran S, Arora AS, Soukup SF, Vidal R, Capece V, Freytag S, Fischer A, Verstreken P, Bonn S, Raimundo N, Milosevic I.

Cell Rep. 2016 Oct 18;17(4):1071-1086. doi: 10.1016/j.celrep.2016.09.058. Epub 2016 Oct 6.

26.

A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals.

Soukup SF, Kuenen S, Vanhauwaert R, Manetsberger J, Hernández-Díaz S, Swerts J, Schoovaerts N, Vilain S, Gounko NV, Vints K, Geens A, De Strooper B, Verstreken P.

Neuron. 2016 Nov 23;92(4):829-844. doi: 10.1016/j.neuron.2016.09.037. Epub 2016 Oct 6.

27.

Torsins Are Essential Regulators of Cellular Lipid Metabolism.

Grillet M, Dominguez Gonzalez B, Sicart A, Pöttler M, Cascalho A, Billion K, Hernandez Diaz S, Swerts J, Naismith TV, Gounko NV, Verstreken P, Hanson PI, Goodchild RE.

Dev Cell. 2016 Aug 8;38(3):235-47. doi: 10.1016/j.devcel.2016.06.017. Epub 2016 Jul 21.

28.

TBC1D24 genotype-phenotype correlation: Epilepsies and other neurologic features.

Balestrini S, Milh M, Castiglioni C, Lüthy K, Finelli MJ, Verstreken P, Cardon A, Stražišar BG, Holder JL Jr, Lesca G, Mancardi MM, Poulat AL, Repetto GM, Banka S, Bilo L, Birkeland LE, Bosch F, Brockmann K, Cross JH, Doummar D, Félix TM, Giuliano F, Hori M, Hüning I, Kayserili H, Kini U, Lees MM, Meenakshi G, Mewasingh L, Pagnamenta AT, Peluso S, Mey A, Rice GM, Rosenfeld JA, Taylor JC, Troester MM, Stanley CM, Ville D, Walkiewicz M, Falace A, Fassio A, Lemke JR, Biskup S, Tardif J, Ajeawung NF, Tolun A, Corbett M, Gecz J, Afawi Z, Howell KB, Oliver KL, Berkovic SF, Scheffer IE, de Falco FA, Oliver PL, Striano P, Zara F, Campeau PM, Sisodiya SM.

Neurology. 2016 Jul 5;87(1):77-85. doi: 10.1212/WNL.0000000000002807. Epub 2016 Jun 8.

29.

Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification.

Dejonghe W, Kuenen S, Mylle E, Vasileva M, Keech O, Viotti C, Swerts J, Fendrych M, Ortiz-Morea FA, Mishev K, Delang S, Scholl S, Zarza X, Heilmann M, Kourelis J, Kasprowicz J, Nguyen le SL, Drozdzecki A, Van Houtte I, Szatmári AM, Majda M, Baisa G, Bednarek SY, Robert S, Audenaert D, Testerink C, Munnik T, Van Damme D, Heilmann I, Schumacher K, Winne J, Friml J, Verstreken P, Russinova E.

Nat Commun. 2016 Jun 8;7:11710. doi: 10.1038/ncomms11710.

30.

Membrane Lipids in Presynaptic Function and Disease.

Lauwers E, Goodchild R, Verstreken P.

Neuron. 2016 Apr 6;90(1):11-25. doi: 10.1016/j.neuron.2016.02.033. Review.

31.

Shawn, the Drosophila Homolog of SLC25A39/40, Is a Mitochondrial Carrier That Promotes Neuronal Survival.

Slabbaert JR, Kuenen S, Swerts J, Maes I, Uytterhoeven V, Kasprowicz J, Fernandes AC, Blust R, Verstreken P.

J Neurosci. 2016 Feb 10;36(6):1914-29. doi: 10.1523/JNEUROSCI.3432-15.2016.

32.

De novo loss-of-function mutations in WAC cause a recognizable intellectual disability syndrome and learning deficits in Drosophila.

Lugtenberg D, Reijnders MR, Fenckova M, Bijlsma EK, Bernier R, van Bon BW, Smeets E, Vulto-van Silfhout AT, Bosch D, Eichler EE, Mefford HC, Carvill GL, Bongers EM, Schuurs-Hoeijmakers JH, Ruivenkamp CA, Santen GW, van den Maagdenberg AM, Peeters-Scholte CM, Kuenen S, Verstreken P, Pfundt R, Yntema HG, de Vries PF, Veltman JA, Hoischen A, Gilissen C, de Vries BB, Schenck A, Kleefstra T, Vissers LE.

Eur J Hum Genet. 2016 Aug;24(8):1145-53. doi: 10.1038/ejhg.2015.282. Epub 2016 Jan 13.

33.

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy.

Uytterhoeven V, Lauwers E, Maes I, Miskiewicz K, Melo MN, Swerts J, Kuenen S, Wittocx R, Corthout N, Marrink SJ, Munck S, Verstreken P.

Neuron. 2015 Nov 18;88(4):735-48. doi: 10.1016/j.neuron.2015.10.012.

34.

Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.

Dubos A, Castells-Nobau A, Meziane H, Oortveld MA, Houbaert X, Iacono G, Martin C, Mittelhaeuser C, Lalanne V, Kramer JM, Bhukel A, Quentin C, Slabbert J, Verstreken P, Sigrist SJ, Messaddeq N, Birling MC, Selloum M, Stunnenberg HG, Humeau Y, Schenck A, Herault Y.

Hum Mol Genet. 2015 Dec 1;24(23):6736-55. doi: 10.1093/hmg/ddv380. Epub 2015 Sep 16.

35.

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation.

Calafate S, Buist A, Miskiewicz K, Vijayan V, Daneels G, de Strooper B, de Wit J, Verstreken P, Moechars D.

Cell Rep. 2015 May 26;11(8):1176-83. doi: 10.1016/j.celrep.2015.04.043. Epub 2015 May 14.

36.

Stimulation of electron transport as potential novel therapy in Parkinson's disease with mitochondrial dysfunction.

Vos M, Verstreken P, Klein C.

Biochem Soc Trans. 2015 Apr;43(2):275-9. doi: 10.1042/BST20140325. Review.

PMID:
25849929
37.

Flies with Parkinson's disease.

Vanhauwaert R, Verstreken P.

Exp Neurol. 2015 Dec;274(Pt A):42-51. doi: 10.1016/j.expneurol.2015.02.020. Epub 2015 Feb 20. Review.

PMID:
25708988
38.

Therapeutic strategies in Parkinson's disease: what we have learned from animal models.

Valadas JS, Vos M, Verstreken P.

Ann N Y Acad Sci. 2015 Mar;1338:16-37. doi: 10.1111/nyas.12577. Epub 2014 Dec 16. Review.

PMID:
25515068
39.

LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism.

Arranz AM, Delbroek L, Van Kolen K, Guimarães MR, Mandemakers W, Daneels G, Matta S, Calafate S, Shaban H, Baatsen P, De Bock PJ, Gevaert K, Vanden Berghe P, Verstreken P, De Strooper B, Moechars D.

J Cell Sci. 2015 Feb 1;128(3):541–52.

40.

Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration.

Fernandes AC, Uytterhoeven V, Kuenen S, Wang YC, Slabbaert JR, Swerts J, Kasprowicz J, Aerts S, Verstreken P.

J Cell Biol. 2014 Nov 24;207(4):453-62. doi: 10.1083/jcb.201406026.

41.

Fast and efficient Drosophila melanogaster gene knock-ins using MiMIC transposons.

Vilain S, Vanhauwaert R, Maes I, Schoovaerts N, Zhou L, Soukup S, da Cunha R, Lauwers E, Fiers M, Verstreken P.

G3 (Bethesda). 2014 Oct 8;4(12):2381-7. doi: 10.1534/g3.114.014803.

42.

Chronological requirements of TDP-43 function in synaptic organization and locomotive control.

Romano G, Klima R, Buratti E, Verstreken P, Baralle FE, Feiguin F.

Neurobiol Dis. 2014 Nov;71:95-109. doi: 10.1016/j.nbd.2014.07.007. Epub 2014 Aug 1.

43.

HDAC6 is a Bruchpilot deacetylase that facilitates neurotransmitter release.

Miskiewicz K, Jose LE, Yeshaw WM, Valadas JS, Swerts J, Munck S, Feiguin F, Dermaut B, Verstreken P.

Cell Rep. 2014 Jul 10;8(1):94-102. doi: 10.1016/j.celrep.2014.05.051. Epub 2014 Jun 26.

44.

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy.

Cornelissen T, Haddad D, Wauters F, Van Humbeeck C, Mandemakers W, Koentjoro B, Sue C, Gevaert K, De Strooper B, Verstreken P, Vandenberghe W.

Hum Mol Genet. 2014 Oct 1;23(19):5227-42. doi: 10.1093/hmg/ddu244. Epub 2014 May 22.

PMID:
24852371
45.

Dynamin photoinactivation blocks Clathrin and α-adaptin recruitment and induces bulk membrane retrieval.

Kasprowicz J, Kuenen S, Swerts J, Miskiewicz K, Verstreken P.

J Cell Biol. 2014 Mar 31;204(7):1141-56. doi: 10.1083/jcb.201310090. Epub 2014 Mar 24.

46.

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Morais VA, Haddad D, Craessaerts K, De Bock PJ, Swerts J, Vilain S, Aerts L, Overbergh L, Grünewald A, Seibler P, Klein C, Gevaert K, Verstreken P, De Strooper B.

Science. 2014 Apr 11;344(6180):203-7. doi: 10.1126/science.1249161. Epub 2014 Mar 20.

47.

PIWIL1 protein power targets tau therapy.

Soukup SF, Verstreken P.

Nat Neurosci. 2014 Mar;17(3):334-5. doi: 10.1038/nn.3659. No abstract available.

PMID:
24569826
48.

Directing traffic into the future.

Antonny B, Audhya J, l Bagnat M, von Blume J, Briggs JA, Giraudo C, Kaeser PS, Miller E, Reinisch K, Sbalzarini IF, Schuldiner M, Shen J, Takamori S, Verstreken P, Walther T.

Dev Cell. 2013 Dec 9;27(5):480-4. No abstract available.

49.

Ultrafast synaptic endocytosis cycles to the center stage.

Zhou L, McInnes J, Verstreken P.

Dev Cell. 2014 Jan 13;28(1):5-6. doi: 10.1016/j.devcel.2013.12.017.

50.

Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability.

Vandewalle J, Langen M, Zschätzsch M, Nijhof B, Kramer JM, Brems H, Bauters M, Lauwers E, Srahna M, Marynen P, Verstreken P, Schenck A, Hassan BA, Froyen G.

PLoS One. 2013 Nov 26;8(11):e81791. doi: 10.1371/journal.pone.0081791. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/5a4ac42e-a148-4a89-b148-e47de0d72d16. Zschaetzsch, Marlen [corrected to Zschätzsch, Marlen].

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