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Items: 36

1.

Large-scale Production of LGR5-positive Bipotential Human Liver Stem Cells.

Schneeberger K, Sánchez-Romero N, Ye S, van Steenbeek FG, Oosterhoff LA, Pla Palacin I, Chen C, van Wolferen ME, van Tienderen G, Lieshout R, Colemonts-Vroninks H, Schene I, Hoekstra R, Verstegen MMA, van der Laan LJW, Penning LC, Fuchs SA, Clevers H, De Kock J, Baptista PM, Spee B.

Hepatology. 2019 Nov 12. doi: 10.1002/hep.31037. [Epub ahead of print]

PMID:
31715015
2.

Recreating Tumour Complexity in a Dish: Organoid Models to Study Liver Cancer Cells and their Extracellular Environment.

van Tienderen GS, Groot Koerkamp B, IJzermans JNM, van der Laan LJW, Verstegen MMA.

Cancers (Basel). 2019 Nov 1;11(11). pii: E1706. doi: 10.3390/cancers11111706. Review.

3.

Bioengineering Liver Transplantation.

Verstegen MMA, Spee B, van der Laan LJW.

Bioengineering (Basel). 2019 Oct 16;6(4). pii: E96. doi: 10.3390/bioengineering6040096.

4.

First Report on Ex vivo Delivery of Paracrine Active Human Mesenchymal Stromal Cells to Liver Grafts During Machine Perfusion.

Verstegen MMA, Mezzanotte L, Ridwan RY, Wang K, de Haan J, Schurink IJ, Sierra Parraga JM, Hoogduijn M, Kessler BM, Huang H, Hall SRR, IJzermans JNM, Löwik CWGM, van der Laan LJW, de Jonge J.

Transplantation. 2019 Oct 11. doi: 10.1097/TP.0000000000002986. [Epub ahead of print] No abstract available.

PMID:
31609902
5.

Necroptotic Cell Death in Liver Transplantation and Underlying Diseases: Mechanisms and Clinical Perspective.

Shi S, Verstegen MMA, Mezzanotte L, de Jonge J, Löwik CWGM, van der Laan LJW.

Liver Transpl. 2019 Jul;25(7):1091-1104. doi: 10.1002/lt.25488. Review.

6.

Experimental models to unravel the molecular pathogenesis, cell of origin and stem cell properties of cholangiocarcinoma.

Vicent S, Lieshout R, Saborowski A, Verstegen MMA, Raggi C, Recalcati S, Invernizzi P, van der Laan LJW, Alvaro D, Calvisi DF, Cardinale V.

Liver Int. 2019 May;39 Suppl 1:79-97. doi: 10.1111/liv.14094. Review.

PMID:
30851232
7.

Modeling liver cancer and therapy responsiveness using organoids derived from primary mouse liver tumors.

Cao W, Liu J, Wang L, Li M, Verstegen MMA, Yin Y, Ma B, Chen K, Bolkestein M, Sprengers D, van der Laan LJW, Doukas M, Kwekkeboom J, Smits R, Peppelenbosch MP, Pan Q.

Carcinogenesis. 2019 Mar 12;40(1):145-154. doi: 10.1093/carcin/bgy129.

PMID:
30289434
8.

Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.

Broutier L, Mastrogiovanni G, Verstegen MM, Francies HE, Gavarró LM, Bradshaw CR, Allen GE, Arnes-Benito R, Sidorova O, Gaspersz MP, Georgakopoulos N, Koo BK, Dietmann S, Davies SE, Praseedom RK, Lieshout R, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJ, Huch M.

Nat Med. 2017 Dec;23(12):1424-1435. doi: 10.1038/nm.4438. Epub 2017 Nov 13.

9.

Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury.

Cao W, Chen K, Bolkestein M, Yin Y, Verstegen MMA, Bijvelds MJC, Wang W, Tuysuz N, Ten Berge D, Sprengers D, Metselaar HJ, van der Laan LJW, Kwekkeboom J, Smits R, Peppelenbosch MP, Pan Q.

Gastroenterology. 2017 Oct;153(4):1133-1147. doi: 10.1053/j.gastro.2017.07.006. Epub 2017 Jul 14.

PMID:
28716722
10.

Decellularization of Whole Human Liver Grafts Using Controlled Perfusion for Transplantable Organ Bioscaffolds.

Verstegen MMA, Willemse J, van den Hoek S, Kremers GJ, Luider TM, van Huizen NA, Willemssen FEJA, Metselaar HJ, IJzermans JNM, van der Laan LJW, de Jonge J.

Stem Cells Dev. 2017 Sep 15;26(18):1304-1315. doi: 10.1089/scd.2017.0095. Epub 2017 Jul 31.

PMID:
28665233
11.

From organoids to organs: Bioengineering liver grafts from hepatic stem cells and matrix.

Willemse J, Lieshout R, van der Laan LJW, Verstegen MMA.

Best Pract Res Clin Gastroenterol. 2017 Apr;31(2):151-159. doi: 10.1016/j.bpg.2017.03.003. Epub 2017 Apr 12. Review.

PMID:
28624103
12.

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis.

Kruitwagen HS, Oosterhoff LA, Vernooij IGWH, Schrall IM, van Wolferen ME, Bannink F, Roesch C, van Uden L, Molenaar MR, Helms JB, Grinwis GCM, Verstegen MMA, van der Laan LJW, Huch M, Geijsen N, Vries RG, Clevers H, Rothuizen J, Schotanus BA, Penning LC, Spee B.

Stem Cell Reports. 2017 Apr 11;8(4):822-830. doi: 10.1016/j.stemcr.2017.02.015. Epub 2017 Mar 23.

13.

Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells.

Tüysüz N, van Bloois L, van den Brink S, Begthel H, Verstegen MM, Cruz LJ, Hui L, van der Laan LJ, de Jonge J, Vries R, Braakman E, Mastrobattista E, Cornelissen JJ, Clevers H, Ten Berge D.

Nat Commun. 2017 Mar 6;8:14578. doi: 10.1038/ncomms14578.

14.

Tissue-specific mutation accumulation in human adult stem cells during life.

Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R.

Nature. 2016 Oct 13;538(7624):260-264. doi: 10.1038/nature19768. Epub 2016 Oct 3.

15.

Characterization and Comparison of Canine Multipotent Stromal Cells Derived from Liver and Bone Marrow.

Malagola E, Teunissen M, van der Laan LJ, Verstegen MM, Schotanus BA, van Steenbeek FG, Penning LC, van Wolferen ME, Tryfonidou MA, Spee B.

Stem Cells Dev. 2016 Jan 15;25(2):139-50. doi: 10.1089/scd.2015.0125. Epub 2015 Dec 14.

16.

Mesenchymal Stromal Cell-Derived Factors Promote Tissue Repair in a Small-for-Size Ischemic Liver Model but Do Not Protect against Early Effects of Ischemia and Reperfusion Injury.

Fouraschen SM, Wolf JH, van der Laan LJ, de Ruiter PE, Hancock WW, van Kooten JP, Verstegen MM, Olthoff KM, de Jonge J.

J Immunol Res. 2015;2015:202975. doi: 10.1155/2015/202975. Epub 2015 Aug 24.

17.

Gene therapies for hepatitis C virus.

Verstegen MM, Pan Q, van der Laan LJ.

Adv Exp Med Biol. 2015;848:1-29. doi: 10.1007/978-1-4939-2432-5_1. Review.

PMID:
25757613
18.

Human graft-derived mesenchymal stromal cells potently suppress alloreactive T-cell responses.

de Mare-Bredemeijer EL, Mancham S, Verstegen MM, de Ruiter PE, van Gent R, O'Neill D, Tilanus HW, Metselaar HJ, de Jonge J, Kwekkeboom J, Hall SR, van der Laan LJ.

Stem Cells Dev. 2015 Jun 15;24(12):1436-47. doi: 10.1089/scd.2014.0485. Epub 2015 Apr 28.

PMID:
25744002
19.

Long-term culture of genome-stable bipotent stem cells from adult human liver.

Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J, van de Wetering M, Sasaki N, Boers SJ, Kemperman H, de Jonge J, Ijzermans JN, Nieuwenhuis EE, Hoekstra R, Strom S, Vries RR, van der Laan LJ, Cuppen E, Clevers H.

Cell. 2015 Jan 15;160(1-2):299-312. doi: 10.1016/j.cell.2014.11.050. Epub 2014 Dec 18.

20.

Angiopoietin-like protein 3 promotes preservation of stemness during ex vivo expansion of murine hematopoietic stem cells.

Farahbakhshian E, Verstegen MM, Visser TP, Kheradmandkia S, Geerts D, Arshad S, Riaz N, Grosveld F, van Til NP, Meijerink JP.

PLoS One. 2014 Aug 29;9(8):e105642. doi: 10.1371/journal.pone.0105642. eCollection 2014.

21.

No evidence for circulating mesenchymal stem cells in patients with organ injury.

Hoogduijn MJ, Verstegen MM, Engela AU, Korevaar SS, Roemeling-van Rhijn M, Merino A, Franquesa M, de Jonge J, Ijzermans JN, Weimar W, Betjes MG, Baan CC, van der Laan LJ.

Stem Cells Dev. 2014 Oct 1;23(19):2328-35. doi: 10.1089/scd.2014.0269. Epub 2014 Aug 25.

PMID:
25105211
22.

Recombination-activating gene 1 (Rag1)-deficient mice with severe combined immunodeficiency treated with lentiviral gene therapy demonstrate autoimmune Omenn-like syndrome.

van Til NP, Sarwari R, Visser TP, Hauer J, Lagresle-Peyrou C, van der Velden G, Malshetty V, Cortes P, Jollet A, Danos O, Cassani B, Zhang F, Thrasher AJ, Fontana E, Poliani PL, Cavazzana M, Verstegen MM, Villa A, Wagemaker G.

J Allergy Clin Immunol. 2014 Apr;133(4):1116-23. doi: 10.1016/j.jaci.2013.10.009. Epub 2013 Dec 9.

PMID:
24332219
23.

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.

Deichmann A, Brugman MH, Bartholomae CC, Schwarzwaelder K, Verstegen MM, Howe SJ, Arens A, Ott MG, Hoelzer D, Seger R, Grez M, Hacein-Bey-Abina S, Cavazzana-Calvo M, Fischer A, Paruzynski A, Gabriel R, Glimm H, Abel U, Cattoglio C, Mavilio F, Cassani B, Aiuti A, Dunbar CE, Baum C, Gaspar HB, Thrasher AJ, von Kalle C, Schmidt M, Wagemaker G.

Mol Ther. 2011 Nov;19(11):2031-9. doi: 10.1038/mt.2011.178. Epub 2011 Aug 23.

24.

Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning.

Huston MW, van Til NP, Visser TP, Arshad S, Brugman MH, Cattoglio C, Nowrouzi A, Li Y, Schambach A, Schmidt M, Baum C, von Kalle C, Mavilio F, Zhang F, Blundell MP, Thrasher AJ, Verstegen MM, Wagemaker G.

Mol Ther. 2011 Oct;19(10):1867-77. doi: 10.1038/mt.2011.127. Epub 2011 Jul 12.

25.

Mobilization of hepatic mesenchymal stem cells from human liver grafts.

Pan Q, Fouraschen SM, Kaya FS, Verstegen MM, Pescatori M, Stubbs AP, van Ijcken W, van der Sloot A, Smits R, Kwekkeboom J, Metselaar HJ, Kazemier G, de Jonge J, Tilanus HW, Wagemaker G, Janssen HL, van der Laan LJ.

Liver Transpl. 2011 May;17(5):596-609. doi: 10.1002/lt.22260.

26.

Lentiviral gene therapy of murine hematopoietic stem cells ameliorates the Pompe disease phenotype.

van Til NP, Stok M, Aerts Kaya FS, de Waard MC, Farahbakhshian E, Visser TP, Kroos MA, Jacobs EH, Willart MA, van der Wegen P, Scholte BJ, Lambrecht BN, Duncker DJ, van der Ploeg AT, Reuser AJ, Verstegen MM, Wagemaker G.

Blood. 2010 Jul 1;115(26):5329-37. doi: 10.1182/blood-2009-11-252874. Epub 2010 Apr 12.

PMID:
20385789
27.

Intrinsic differentiation potential of adolescent human tendon tissue: an in-vitro cell differentiation study.

de Mos M, Koevoet WJ, Jahr H, Verstegen MM, Heijboer MP, Kops N, van Leeuwen JP, Weinans H, Verhaar JA, van Osch GJ.

BMC Musculoskelet Disord. 2007 Feb 23;8:16.

28.

Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.

Pike-Overzet K, de Ridder D, Weerkamp F, Baert MR, Verstegen MM, Brugman MH, Howe SJ, Reinders MJ, Thrasher AJ, Wagemaker G, van Dongen JJ, Staal FJ.

Leukemia. 2007 Apr;21(4):754-63. Epub 2007 Feb 1.

PMID:
17268520
29.

Gene therapy: is IL2RG oncogenic in T-cell development?

Pike-Overzet K, de Ridder D, Weerkamp F, Baert MR, Verstegen MM, Brugman MH, Howe SJ, Reinders MJ, Thrasher AJ, Wagemaker G, van Dongen JJ, Staal FJ.

Nature. 2006 Sep 21;443(7109):E5; discussion E6-7.

PMID:
16988660
30.

Overcoming promoter competition in packaging cells improves production of self-inactivating retroviral vectors.

Schambach A, Mueller D, Galla M, Verstegen MM, Wagemaker G, Loew R, Baum C, Bohne J.

Gene Ther. 2006 Nov;13(21):1524-33. Epub 2006 Jun 8.

PMID:
16763662
32.

Intracisternal granules in the adipokinetic cells of locusts are not degraded and apparently function as supplementary stores of secretory material.

Harthoorn LF, Diederen JH, Oudejans RC, Verstegen MM, Vullings HG, Van der Horst DJ.

Eur J Cell Biol. 2000 Jan;79(1):27-34.

PMID:
10711423
33.
34.

Highly efficient transduction of the green fluorescent protein gene in human umbilical cord blood stem cells capable of cobblestone formation in long-term cultures and multilineage engraftment of immunodeficient mice.

van Hennik PB, Verstegen MM, Bierhuizen MF, Limón A, Wognum AW, Cancelas JA, Barquinero J, Ploemacher RE, Wagemaker G.

Blood. 1998 Dec 1;92(11):4013-22.

PMID:
9834203
35.

Transplantation of human umbilical cord blood cells in macrophage-depleted SCID mice: evidence for accessory cell involvement in expansion of immature CD34+CD38- cells.

Verstegen MM, van Hennik PB, Terpstra W, van den Bos C, Wielenga JJ, van Rooijen N, Ploemacher RE, Wagemaker G, Wognum AW.

Blood. 1998 Mar 15;91(6):1966-76.

PMID:
9490679
36.

Facilitated engraftment of human hematopoietic cells in severe combined immunodeficient mice following a single injection of Cl2MDP liposomes.

Terpstra W, Leenen PJ, van den Bos C, Prins A, Loenen WA, Verstegen MM, van Wyngaardt S, van Rooijen N, Wognum AW, Wagemaker G, Wielenga JJ, Löwenberg B.

Leukemia. 1997 Jul;11(7):1049-54.

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