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Items: 24

1.

Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras-Mutant Lung Cancers.

Talwelkar SS, Nagaraj AS, Devlin JR, Hemmes A, Potdar S, Kiss EA, Saharinen P, Salmenkivi K, Mäyränpää MI, Wennerberg K, Verschuren EW.

Mol Cancer Ther. 2019 Oct;18(10):1863-1874. doi: 10.1158/1535-7163.MCT-18-0573. Epub 2019 Jul 18.

PMID:
31320402
2.

Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing.

Nagaraj AS, Bao J, Hemmes A, Machado M, Närhi K, Verschuren EW.

J Vis Exp. 2018 Nov 29;(141). doi: 10.3791/58569.

PMID:
30582602
3.

More than a Tumor Suppressor: E-Cadherin Loss Drives Lung Cancer Metastasis.

Devlin JR, Verschuren EW.

Am J Respir Cell Mol Biol. 2018 Aug;59(2):141-142. doi: 10.1165/rcmb.2018-0063ED. No abstract available.

PMID:
29688752
4.

Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours.

Närhi K, Nagaraj AS, Parri E, Turkki R, van Duijn PW, Hemmes A, Lahtela J, Uotinen V, Mäyränpää MI, Salmenkivi K, Räsänen J, Linder N, Trapman J, Rannikko A, Kallioniemi O, Af Hällström TM, Lundin J, Sommergruber W, Anders S, Verschuren EW.

J Pathol. 2018 May;245(1):101-113. doi: 10.1002/path.5059. Epub 2018 Apr 2. Erratum in: J Pathol. 2019 Jan;247(1):147.

5.

Protocols and characterization data for 2D, 3D, and slice-based tumor models from the PREDECT project.

de Hoogt R, Estrada MF, Vidic S, Davies EJ, Osswald A, Barbier M, Santo VE, Gjerde K, van Zoggel HJAA, Blom S, Dong M, Närhi K, Boghaert E, Brito C, Chong Y, Sommergruber W, van der Kuip H, van Weerden WM, Verschuren EW, Hickman J, Graeser R.

Sci Data. 2017 Nov 21;4:170170. doi: 10.1038/sdata.2017.170.

6.

Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1.

Nagaraj AS, Lahtela J, Hemmes A, Pellinen T, Blom S, Devlin JR, Salmenkivi K, Kallioniemi O, Mäyränpää MI, Närhi K, Verschuren EW.

Cell Rep. 2017 Jan 17;18(3):673-684. doi: 10.1016/j.celrep.2016.12.059.

7.

Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices.

Davies EJ, Dong M, Gutekunst M, Närhi K, van Zoggel HJ, Blom S, Nagaraj A, Metsalu T, Oswald E, Erkens-Schulze S, Delgado San Martin JA, Turkki R, Wedge SR, af Hällström TM, Schueler J, van Weerden WM, Verschuren EW, Barry ST, van der Kuip H, Hickman JA.

Sci Rep. 2015 Dec 9;5:17187. doi: 10.1038/srep17187.

8.

The putative tumor suppressor gene EphA3 fails to demonstrate a crucial role in murine lung tumorigenesis or morphogenesis.

Lahtela J, Pradhan B, Närhi K, Hemmes A, Särkioja M, Kovanen PE, Brown A, Verschuren EW.

Dis Model Mech. 2015 Apr;8(4):393-401. doi: 10.1242/dmm.019257. Epub 2015 Feb 20.

9.

KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo.

Pekkonen P, Järviluoma A, Zinovkina N, Cvrljevic A, Prakash S, Westermarck J, Evan GI, Cesarman E, Verschuren EW, Ojala PM.

Cell Cycle. 2014;13(23):3670-84. doi: 10.4161/15384101.2014.964118.

10.

Extendable blocking probe in reverse transcription for analysis of RNA variants with superior selectivity.

Ho TH, Dang KX, Lintula S, Hotakainen K, Feng L, Olkkonen VM, Verschuren EW, Tenkanen T, Haglund C, Kolho KL, Stenman UH, Stenman J.

Nucleic Acids Res. 2015 Jan;43(1):e4. doi: 10.1093/nar/gku1048. Epub 2014 Nov 5.

11.

Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice.

Kakkola L, Denisova OV, Tynell J, Viiliäinen J, Ysenbaert T, Matos RC, Nagaraj A, Ohman T, Kuivanen S, Paavilainen H, Feng L, Yadav B, Julkunen I, Vapalahti O, Hukkanen V, Stenman J, Aittokallio T, Verschuren EW, Ojala PM, Nyman T, Saelens X, Dzeyk K, Kainov DE.

Cell Death Dis. 2013 Jul 25;4:e742. doi: 10.1038/cddis.2013.267.

12.

A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3.

Lahtela J, Corson LB, Hemmes A, Brauer MJ, Koopal S, Lee J, Hunsaker TL, Jackson PK, Verschuren EW.

Cell Cycle. 2013 Feb 15;12(4):625-34. doi: 10.4161/cc.23515. Epub 2013 Jan 16.

13.

APC/C(Cdc20) targets E2F1 for degradation in prometaphase.

Peart MJ, Poyurovsky MV, Kass EM, Urist M, Verschuren EW, Summers MK, Jackson PK, Prives C.

Cell Cycle. 2010 Oct 1;9(19):3956-64. Epub 2010 Oct 26.

14.

Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence.

Verschuren EW, Ban KH, Masek MA, Lehman NL, Jackson PK.

Mol Cell Biol. 2007 Nov;27(22):7955-65. Epub 2007 Sep 17.

15.

Putting transcription repression and protein destruction in pRb's pocket.

Verschuren EW, Jackson PK.

Dev Cell. 2007 Feb;12(2):169-70.

16.

Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1).

Marangos P, Verschuren EW, Chen R, Jackson PK, Carroll J.

J Cell Biol. 2007 Jan 1;176(1):65-75. Epub 2006 Dec 26.

17.

Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells.

Lehman NL, Verschuren EW, Hsu JY, Cherry AM, Jackson PK.

Cell Cycle. 2006 Jul;5(14):1569-73. Epub 2006 Jul 17.

PMID:
16861914
18.

The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1.

Eldridge AG, Loktev AV, Hansen DV, Verschuren EW, Reimann JD, Jackson PK.

Cell. 2006 Jan 27;124(2):367-80.

19.

Temporal dissection of p53 function in vitro and in vivo.

Christophorou MA, Martin-Zanca D, Soucek L, Lawlor ER, Brown-Swigart L, Verschuren EW, Evan GI.

Nat Genet. 2005 Jul;37(7):718-26. Epub 2005 May 29.

20.

The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin.

Verschuren EW, Jones N, Evan GI.

J Gen Virol. 2004 Jun;85(Pt 6):1347-61. Review.

PMID:
15166416
21.

The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis.

Verschuren EW, Hodgson JG, Gray JW, Kogan S, Jones N, Evan GI.

Cancer Res. 2004 Jan 15;64(2):581-9.

22.
23.

c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway.

Klefstrom J, Verschuren EW, Evan G.

J Biol Chem. 2002 Nov 8;277(45):43224-32. Epub 2002 Aug 28.

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