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Items: 1 to 50 of 66

1.

Plasma metabolic profiling reveals age-dependency of systemic effects of green tea polyphenols in mice with and without prostate cancer.

Teichert F, Verschoyle RD, Greaves P, Jones DJ, Wilson ID, Farmer PB, Steward WP, Gescher AJ, Keun HC.

Mol Biosyst. 2010 Oct;6(10):1911-6. doi: 10.1039/c004702c. Epub 2010 Jun 25.

PMID:
20577699
2.

Determination of 8-oxo-2'-deoxyguanosine and creatinine in murine and human urine by liquid chromatography/tandem mass spectrometry: application to chemoprevention studies.

Teichert F, Verschoyle RD, Greaves P, Thorpe JF, Mellon JK, Steward WP, Farmer PB, Gescher AJ, Singh R.

Rapid Commun Mass Spectrom. 2009 Jan;23(2):258-66. doi: 10.1002/rcm.3873. Erratum in: Rapid Commun Mass Spectrom. 2010 Jul;24(14):2175.

PMID:
19072863
3.

Simultaneous determination of 8-oxo-2'-deoxyguanosine and 8-oxo-2'-deoxyadenosine in DNA using online column-switching liquid chromatography/tandem mass spectrometry.

Singh R, Teichert F, Verschoyle RD, Kaur B, Vives M, Sharma RA, Steward WP, Gescher AJ, Farmer PB.

Rapid Commun Mass Spectrom. 2009 Jan;23(1):151-60. doi: 10.1002/rcm.3866.

PMID:
19065576
4.

Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.

Teichert F, Verschoyle RD, Greaves P, Edwards RE, Teahan O, Jones DJ, Wilson ID, Farmer PB, Steward WP, Gant TW, Gescher AJ, Keun HC.

Prostate. 2008 Jul 1;68(10):1035-47. doi: 10.1002/pros.20761.

PMID:
18459103
5.

Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: relationship with silibinin levels.

Verschoyle RD, Greaves P, Patel K, Marsden DA, Brown K, Steward WP, Gescher AJ.

Eur J Cancer. 2008 Apr;44(6):898-906. doi: 10.1016/j.ejca.2008.02.020. Epub 2008 Mar 17.

PMID:
18343654
6.

Androgen manipulation alters oxidative DNA adduct levels in androgen-sensitive prostate cancer cells grown in vitro and in vivo.

Pathak S, Singh R, Verschoyle RD, Greaves P, Farmer PB, Steward WP, Mellon JK, Gescher AJ, Sharma RA.

Cancer Lett. 2008 Mar 8;261(1):74-83. Epub 2007 Dec 21.

PMID:
18096312
7.

Putative cancer chemopreventive agents of dietary origin-how safe are they?

Verschoyle RD, Steward WP, Gescher AJ.

Nutr Cancer. 2007;59(2):152-62. Review.

PMID:
18001209
8.

Consumption of silibinin, a flavonolignan from milk thistle, and mammary cancer development in the C3(1) SV40 T,t antigen transgenic multiple mammary adenocarcinoma (TAg) mouse.

Verschoyle RD, Brown K, Steward WP, Gescher AJ.

Cancer Chemother Pharmacol. 2008 Jul;62(2):369-72. Epub 2007 Oct 2.

PMID:
17909802
9.

Cytotoxic action of phorbol esters on human pancreatic cancer cells.

Bond JA, Gescher AJ, Verschoyle RD, Lemoine NR, Errington R, Wiltshire M, Smith PJ, Wynford-Thomas D.

Int J Cancer. 2007 Oct 1;121(7):1445-54.

10.

Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis.

Verschoyle RD, Greaves P, Cai H, Edwards RE, Steward WP, Gescher AJ.

Br J Cancer. 2007 Jan 29;96(2):248-54. Epub 2007 Jan 9.

11.

Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine.

Marczylo TH, Verschoyle RD, Cooke DN, Morazzoni P, Steward WP, Gescher AJ.

Cancer Chemother Pharmacol. 2007 Jul;60(2):171-7. Epub 2006 Oct 19.

PMID:
17051370
12.

A synthetic approach to the generation of quercetin sulfates and the detection of quercetin 3'-O-sulfate as a urinary metabolite in the rat.

Jones DJ, Jukes-Jones R, Verschoyle RD, Farmer PB, Gescher A.

Bioorg Med Chem. 2005 Dec 15;13(24):6727-31. Epub 2005 Aug 18.

PMID:
16105739
13.

Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone.

Verschoyle RD, Greaves P, Cai H, Borkhardt A, Broggini M, D'Incalci M, Riccio E, Doppalapudi R, Kapetanovic IM, Steward WP, Gescher AJ.

Cancer Chemother Pharmacol. 2006 Jan;57(1):1-6. Epub 2005 Nov 5.

PMID:
16001171
14.

Growth-inhibitory and cell cycle-arresting properties of the rice bran constituent tricin in human-derived breast cancer cells in vitro and in nude mice in vivo.

Cai H, Hudson EA, Mann P, Verschoyle RD, Greaves P, Manson MM, Steward WP, Gescher AJ.

Br J Cancer. 2004 Oct 4;91(7):1364-71.

15.

Dietary agent indole-3-carbinol protects female rats against the hepatotoxicity of the antitumor drug ET-743 (trabectidin) without compromising efficacy in a rat mammary carcinoma.

Donald S, Verschoyle RD, Greaves P, Colombo T, Zucchetti M, Falcioni C, Zaffaroni M, D'Incalci M, Manson MM, Jimeno J, Steward WP, Gescher AJ.

Int J Cancer. 2004 Oct 10;111(6):961-7.

16.

Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice.

Anderton MJ, Manson MM, Verschoyle RD, Gescher A, Lamb JH, Farmer PB, Steward WP, Williams ML.

Clin Cancer Res. 2004 Aug 1;10(15):5233-41.

17.

Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity.

Jones DJ, Lamb JH, Verschoyle RD, Howells LM, Butterworth M, Lim CK, Ferry D, Farmer PB, Gescher AJ.

Br J Cancer. 2004 Sep 13;91(6):1213-9.

18.

Physiological modeling of formulated and crystalline 3,3'-diindolylmethane pharmacokinetics following oral administration in mice.

Anderton MJ, Manson MM, Verschoyle R, Gescher A, Steward WP, Williams ML, Mager DE.

Drug Metab Dispos. 2004 Jun;32(6):632-8.

PMID:
15155555
19.

Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4'-tetramethoxystilbene.

Sale S, Verschoyle RD, Boocock D, Jones DJ, Wilsher N, Ruparelia KC, Potter GA, Farmer PB, Steward WP, Gescher AJ.

Br J Cancer. 2004 Feb 9;90(3):736-44.

20.

Articular chondromatosis and chrondroid metaplasia in transgenic TAg mice.

Verschoyle RD, Edwards R, Nolan B, Greaves P.

Toxicol Pathol. 2004 Jan-Feb;32(1):22-5.

PMID:
14713544
21.

Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro.

Donald S, Verschoyle RD, Greaves P, Orr S, Jimeno J, Gescher AJ.

Cancer Chemother Pharmacol. 2004 Apr;53(4):305-12. Epub 2003 Dec 11.

PMID:
14669039
22.

Determination of the flavone tricin in human plasma by high-performance liquid chromatography.

Cai H, Verschoyle RD, Steward WP, Gescher AJ.

Biomed Chromatogr. 2003 Oct;17(7):435-9.

PMID:
14598326
23.

Complete protection by high-dose dexamethasone against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the rat.

Donald S, Verschoyle RD, Greaves P, Gant TW, Colombo T, Zaffaroni M, Frapolli R, Zucchetti M, D'Incalci M, Meco D, Riccardi R, Lopez-Lazaro L, Jimeno J, Gescher AJ.

Cancer Res. 2003 Sep 15;63(18):5902-8.

24.

Developmental toxicity of pyrethroids.

Muhammad BY, Verschoyle RD, Ray DD.

Arch Toxicol. 2003 Jan;77(1):48-9. No abstract available.

PMID:
12643254
25.

Hepatobiliary damage and changes in hepatic gene expression caused by the antitumor drug ecteinascidin-743 (ET-743) in the female rat.

Donald S, Verschoyle RD, Edwards R, Judah DJ, Davies R, Riley J, Dinsdale D, Lopez Lazaro L, Smith AG, Gant TW, Greaves P, Gescher AJ.

Cancer Res. 2002 Aug 1;62(15):4256-62.

26.

Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis.

Perkins S, Verschoyle RD, Hill K, Parveen I, Threadgill MD, Sharma RA, Williams ML, Steward WP, Gescher AJ.

Cancer Epidemiol Biomarkers Prev. 2002 Jun;11(6):535-40.

27.

Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels.

Sharma RA, Ireson CR, Verschoyle RD, Hill KA, Williams ML, Leuratti C, Manson MM, Marnett LJ, Steward WP, Gescher A.

Clin Cancer Res. 2001 May;7(5):1452-8.

28.
29.

Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production.

Ireson C, Orr S, Jones DJ, Verschoyle R, Lim CK, Luo JL, Howells L, Plummer S, Jukes R, Williams M, Steward WP, Gescher A.

Cancer Res. 2001 Feb 1;61(3):1058-64.

30.

Refining procedures for the administration of substances. Report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement. British Veterinary Association Animal Welfare Foundation/Fund for the Replacement of Animals in Medical Experiments/Royal Society for the Prevention of Cruelty to Animals/Universities Federation for Animal Welfare.

Morton DB, Jennings M, Buckwell A, Ewbank R, Godfrey C, Holgate B, Inglis I, James R, Page C, Sharman I, Verschoyle R, Westall L, Wilson AB; Joint Working Group on Refinement.

Lab Anim. 2001 Jan;35(1):1-41. No abstract available.

PMID:
11201285
31.

Pulmonary availability of isotretinoin in rats after inhalation of a powder aerosol.

Raleigh SM, Verschoyle RD, Bowskill C, Pastorino U, Staniforth JN, Steele F, Dinsdale D, Carthew P, Lim CK, Silvester J, Gescher A.

Br J Cancer. 2000 Oct;83(7):935-40.

32.

Association of tamoxifen biliary excretion rate with prior tamoxifen exposure and increased mdr1b expression.

Riley J, Styles J, Verschoyle RD, Stanley LA, White IN, Gant TW.

Biochem Pharmacol. 2000 Jul 15;60(2):233-9.

PMID:
10825468
33.

Chemoprevention of aflatoxin B1-induced carcinogenesis by indole-3-carbinol in rat liver--predicting the outcome using early biomarkers.

Manson MM, Hudson EA, Ball HW, Barrett MC, Clark HL, Judah DJ, Verschoyle RD, Neal GE.

Carcinogenesis. 1998 Oct;19(10):1829-36.

PMID:
9806166
35.
36.

The comparative toxicity of chlorambucil and chlorambucil-spermidine conjugate to BALB/c mice.

Verschoyle RD, Carthew P, Holley JL, Cullis P, Cohen GM.

Cancer Lett. 1994 Oct 14;85(2):217-22.

PMID:
7954340
37.

CYP4B1 activates 4-ipomeanol in rat lung.

Verschoyle RD, Philpot RM, Wolf CR, Dinsdale D.

Toxicol Appl Pharmacol. 1993 Dec;123(2):193-8.

PMID:
8248926
38.

1-Nitronaphthalene toxicity in rat lung and liver: effects of inhibiting and inducing cytochrome P450 activity.

Verschoyle RD, Carthew P, Wolf CR, Dinsdale D.

Toxicol Appl Pharmacol. 1993 Oct;122(2):208-13.

PMID:
8212003
40.

Pulmonary cytochrome P450 in rats exposed to formaldehyde vapor.

Dinsdale D, Riley RA, Verschoyle RD.

Environ Res. 1993 Jul;62(1):19-27.

PMID:
8100769
41.

Inhibition and induction of cytochrome P450 isoenzymes in rat lung.

Verschoyle RD, Dinsdale D, Wolf CR.

J Pharmacol Exp Ther. 1993 Apr;265(1):386-91.

PMID:
8474020
42.
43.

Protection against chemical-induced lung injury by inhibition of pulmonary cytochrome P-450.

Verschoyle RD, Dinsdale D.

Environ Health Perspect. 1990 Apr;85:95-100.

45.

Detecting and evaluating chemical-induced lung damage in experimental animals.

Nemery B, Dinsdale D, Verschoyle RD.

Bull Eur Physiopathol Respir. 1987 Sep-Oct;23(5):501-28. Review. English, French. No abstract available.

PMID:
3329920
46.
48.

The toxicity and neuropathology of dimethylethyltin and methyldiethyltin in rats.

Aldridge WN, Verschoyle RD, Thompson CA, Brown AW.

Neuropathol Appl Neurobiol. 1987 Jan-Feb;13(1):55-69.

PMID:
3574599
49.

Pulmonary toxicity of naphthalene derivatives in the rat.

Dinsdale D, Verschoyle RD.

Arch Toxicol Suppl. 1987;11:288-91. No abstract available.

PMID:
3477184
50.

Some aspects of the toxicology of trimethyl and triethyl phosphorothioates.

Aldridge WN, Dinsdale D, Nemery B, Verschoyle RD.

Fundam Appl Toxicol. 1985 Dec;5(6 Pt 2):S47-60.

PMID:
4092896

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