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Dlx5 and Dlx6 expression in GABAergic neurons controls behavior, metabolism, healthy aging and lifespan.

de Lombares C, Heude E, Alfama G, Fontaine A, Hassouna R, Vernochet C, de Chaumont F, Olivo-Marin C, Ey E, Parnaudeau S, Tronche F, Bourgeron T, Luquet S, Levi G, Narboux-Nême N.

Aging (Albany NY). 2019 Sep 12;11(17):6638-6656. doi: 10.18632/aging.102141. Epub 2019 Sep 12.


Role of the captured retroviral envelope syncytin-B gene in the fusion of osteoclast and giant cell precursors and in bone resorption, analyzed ex vivo and in vivo in syncytin-B knockout mice.

Coudert AE, Redelsperger F, Chabbi-Achengli Y, Vernochet C, Marty C, Decrouy X, Heidmann T, de Vernejoul MC, Dupressoir A.

Bone Rep. 2019 Jul 10;11:100214. doi: 10.1016/j.bonr.2019.100214. eCollection 2019 Dec.


Selective activation of Gs signaling in adipocytes causes striking metabolic improvements in mice.

Wang L, Pydi SP, Cui Y, Zhu L, Meister J, Gavrilova O, Berdeaux R, Fortin JP, Bence KK, Vernochet C, Wess J.

Mol Metab. 2019 Sep;27:83-91. doi: 10.1016/j.molmet.2019.06.018. Epub 2019 Jun 20.


Capture of a Hyena-Specific Retroviral Envelope Gene with Placental Expression Associated in Evolution with the Unique Emergence among Carnivorans of Hemochorial Placentation in Hyaenidae.

Funk M, Cornelis G, Vernochet C, Heidmann O, Dupressoir A, Conley A, Glickman S, Heidmann T.

J Virol. 2019 Feb 5;93(4). pii: e01811-18. doi: 10.1128/JVI.01811-18. Print 2019 Feb 15.


An endogenous retroviral envelope syncytin and its cognate receptor identified in the viviparous placental Mabuya lizard.

Cornelis G, Funk M, Vernochet C, Leal F, Tarazona OA, Meurice G, Heidmann O, Dupressoir A, Miralles A, Ramirez-Pinilla MP, Heidmann T.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10991-E11000. doi: 10.1073/pnas.1714590114. Epub 2017 Nov 21.


A Cell Fusion-Based Screening Method Identifies Glycosylphosphatidylinositol-Anchored Protein Ly6e as the Receptor for Mouse Endogenous Retroviral Envelope Syncytin-A.

Bacquin A, Bireau C, Tanguy M, Romanet C, Vernochet C, Dupressoir A, Heidmann T.

J Virol. 2017 Aug 24;91(18). pii: e00832-17. doi: 10.1128/JVI.00832-17. Print 2017 Sep 15.


Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity.

Buzaglo-Azriel L, Kuperman Y, Tsoory M, Zaltsman Y, Shachnai L, Zaidman SL, Bassat E, Michailovici I, Sarver A, Tzahor E, Haran M, Vernochet C, Gross A.

Cell Rep. 2017 Jan 31;18(5):1335-1336. doi: 10.1016/j.celrep.2017.01.046. No abstract available.


Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.

Jones JE, Esler WP, Patel R, Lanba A, Vera NB, Pfefferkorn JA, Vernochet C.

PLoS One. 2017 Jan 12;12(1):e0169566. doi: 10.1371/journal.pone.0169566. eCollection 2017.


Genetic Evidence That Captured Retroviral Envelope syncytins Contribute to Myoblast Fusion and Muscle Sexual Dimorphism in Mice.

Redelsperger F, Raddi N, Bacquin A, Vernochet C, Mariot V, Gache V, Blanchard-Gutton N, Charrin S, Tiret L, Dumonceaux J, Dupressoir A, Heidmann T.

PLoS Genet. 2016 Sep 2;12(9):e1006289. doi: 10.1371/journal.pgen.1006289. eCollection 2016 Sep.


Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism.

Ahn K, Boehm M, Brown MF, Calloway J, Che Y, Chen J, Fennell KF, Geoghegan KF, Gilbert AM, Gutierrez JA, Kalgutkar AS, Lanba A, Limberakis C, Magee TV, O'Doherty I, Oliver R, Pabst B, Pandit J, Parris K, Pfefferkorn JA, Rolph TP, Patel R, Schuff B, Shanmugasundaram V, Starr JT, Varghese AH, Vera NB, Vernochet C, Yan J.

ACS Chem Biol. 2016 Sep 16;11(9):2529-40. doi: 10.1021/acschembio.6b00266. Epub 2016 Jul 19.


Genome-Wide Screening of Retroviral Envelope Genes in the Nine-Banded Armadillo (Dasypus novemcinctus, Xenarthra) Reveals an Unfixed Chimeric Endogenous Betaretrovirus Using the ASCT2 Receptor.

Malicorne S, Vernochet C, Cornelis G, Mulot B, Delsuc F, Heidmann O, Heidmann T, Dupressoir A.

J Virol. 2016 Aug 26;90(18):8132-49. doi: 10.1128/JVI.00483-16. Print 2016 Sep 15.


Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity.

Buzaglo-Azriel L, Kuperman Y, Tsoory M, Zaltsman Y, Shachnai L, Zaidman SL, Bassat E, Michailovici I, Sarver A, Tzahor E, Haran M, Vernochet C, Gross A.

Cell Rep. 2016 Feb 23;14(7):1602-1610. doi: 10.1016/j.celrep.2016.01.046. Epub 2016 Feb 11. Erratum in: Cell Rep. 2017 Jan 31;18(5):1335-1336.


Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).

Huard K, Brown J, Jones JC, Cabral S, Futatsugi K, Gorgoglione M, Lanba A, Vera NB, Zhu Y, Yan Q, Zhou Y, Vernochet C, Riccardi K, Wolford A, Pirman D, Niosi M, Aspnes G, Herr M, Genung NE, Magee TV, Uccello DP, Loria P, Di L, Gosset JR, Hepworth D, Rolph T, Pfefferkorn JA, Erion DM.

Sci Rep. 2015 Dec 1;5:17391. doi: 10.1038/srep17391.


Retroviral envelope gene captures and syncytin exaptation for placentation in marsupials.

Cornelis G, Vernochet C, Carradec Q, Souquere S, Mulot B, Catzeflis F, Nilsson MA, Menzies BR, Renfree MB, Pierron G, Zeller U, Heidmann O, Dupressoir A, Heidmann T.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E487-96. doi: 10.1073/pnas.1417000112. Epub 2015 Jan 20.


The captured retroviral envelope syncytin-A and syncytin-B genes are conserved in the Spalacidae together with hemotrichorial placentation.

Vernochet C, Redelsperger F, Harper F, Souquere S, Catzeflis F, Pierron G, Nevo E, Heidmann T, Dupressoir A.

Biol Reprod. 2014 Dec;91(6):148. doi: 10.1095/biolreprod.114.124818. Epub 2014 Oct 22.


Retroviral envelope syncytin capture in an ancestrally diverged mammalian clade for placentation in the primitive Afrotherian tenrecs.

Cornelis G, Vernochet C, Malicorne S, Souquere S, Tzika AC, Goodman SM, Catzeflis F, Robinson TJ, Milinkovitch MC, Pierron G, Heidmann O, Dupressoir A, Heidmann T.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4332-41. doi: 10.1073/pnas.1412268111. Epub 2014 Sep 29.


Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications.

Vernochet C, Damilano F, Mourier A, Bezy O, Mori MA, Smyth G, Rosenzweig A, Larsson NG, Kahn CR.

FASEB J. 2014 Oct;28(10):4408-19. doi: 10.1096/fj.14-253971. Epub 2014 Jul 8.


Capture of syncytin-Mar1, a fusogenic endogenous retroviral envelope gene involved in placentation in the Rodentia squirrel-related clade.

Redelsperger F, Cornelis G, Vernochet C, Tennant BC, Catzeflis F, Mulot B, Heidmann O, Heidmann T, Dupressoir A.

J Virol. 2014 Jul;88(14):7915-28. doi: 10.1128/JVI.00141-14. Epub 2014 Apr 30.


Brown fat determination and development from muscle precursor cells by novel action of bone morphogenetic protein 6.

Sharma A, Huard C, Vernochet C, Ziemek D, Knowlton KM, Tyminski E, Paradis T, Zhang Y, Jones JE, von Schack D, Brown CT, Milos PM, Coyle AJ, Tremblay F, Martinez RV.

PLoS One. 2014 Mar 21;9(3):e92608. doi: 10.1371/journal.pone.0092608. eCollection 2014.


Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice.

Kang HW, Ozdemir C, Kawano Y, LeClair KB, Vernochet C, Kahn CR, Hagen SJ, Cohen DE.

J Biol Chem. 2013 Nov 15;288(46):33376-86. doi: 10.1074/jbc.M113.481408. Epub 2013 Sep 26.


Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation.

Lavialle C, Cornelis G, Dupressoir A, Esnault C, Heidmann O, Vernochet C, Heidmann T.

Philos Trans R Soc Lond B Biol Sci. 2013 Aug 12;368(1626):20120507. doi: 10.1098/rstb.2012.0507. Print 2013 Sep 19. Review.


Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat.

Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Huang TL, Roberts-Toler C, Weiner LS, Sze C, Chacko AT, Deschamps LN, Herder LM, Truchan N, Glasgow AL, Holman AR, Gavrila A, Hasselgren PO, Mori MA, Molla M, Tseng YH.

Nat Med. 2013 May;19(5):635-9. doi: 10.1038/nm.3112. Epub 2013 Apr 21.


Captured retroviral envelope syncytin gene associated with the unique placental structure of higher ruminants.

Cornelis G, Heidmann O, Degrelle SA, Vernochet C, Lavialle C, Letzelter C, Bernard-Stoecklin S, Hassanin A, Mulot B, Guillomot M, Hue I, Heidmann T, Dupressoir A.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):E828-37. doi: 10.1073/pnas.1215787110. Epub 2013 Feb 11.


Mitochondria, obesity and aging.

Vernochet C, Kahn CR.

Aging (Albany NY). 2012 Dec;4(12):859-60. No abstract available.


Lessons on conditional gene targeting in mouse adipose tissue.

Lee KY, Russell SJ, Ussar S, Boucher J, Vernochet C, Mori MA, Smyth G, Rourk M, Cederquist C, Rosen ED, Kahn BB, Kahn CR.

Diabetes. 2013 Mar;62(3):864-74. doi: 10.2337/db12-1089. Epub 2013 Jan 15.


Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance.

Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN.

Nat Med. 2013 Feb;19(2):217-26. doi: 10.1038/nm.3056. Epub 2013 Jan 6.


Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance.

Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, An D, Lee KY, Ilkayeva OR, Zingaretti CM, Emanuelli B, Smyth G, Cinti S, Newgard CB, Gibson BW, Larsson NG, Kahn CR.

Cell Metab. 2012 Dec 5;16(6):765-76. doi: 10.1016/j.cmet.2012.10.016. Epub 2012 Nov 15.


Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue.

Kiefer FW, Vernochet C, O'Brien P, Spoerl S, Brown JD, Nallamshetty S, Zeyda M, Stulnig TM, Cohen DE, Kahn CR, Plutzky J.

Nat Med. 2012 Jun;18(6):918-25. doi: 10.1038/nm.2757.


A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast.

Dupressoir A, Vernochet C, Harper F, Guégan J, Dessen P, Pierron G, Heidmann T.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1164-73. doi: 10.1073/pnas.1112304108. Epub 2011 Oct 27.


The mouse IAPE endogenous retrovirus can infect cells through any of the five GPI-anchored Ephrin A proteins.

Dewannieux M, Vernochet C, Ribet D, Bartosch B, Cosset FL, Heidmann T.

PLoS Pathog. 2011 Oct;7(10):e1002309. doi: 10.1371/journal.ppat.1002309. Epub 2011 Oct 20.


A syncytin-like endogenous retrovirus envelope gene of the guinea pig specifically expressed in the placenta junctional zone and conserved in Caviomorpha.

Vernochet C, Heidmann O, Dupressoir A, Cornelis G, Dessen P, Catzeflis F, Heidmann T.

Placenta. 2011 Nov;32(11):885-92. doi: 10.1016/j.placenta.2011.08.006. Epub 2011 Sep 3.


Transplantation tolerance to a single noninherited MHC class I maternal alloantigen studied in a TCR-transgenic mouse model.

Akiyama Y, Caucheteux SM, Vernochet C, Iwamoto Y, Tanaka K, Kanellopoulos-Langevin C, Benichou G.

J Immunol. 2011 Feb 1;186(3):1442-9. doi: 10.4049/jimmunol.1003023. Epub 2010 Dec 22.


Brown adipose tissue: a promising target to combat obesity.

Vernochet C, McDonald ME, Farmer SR.

Drug News Perspect. 2010 Sep;23(7):409-17. doi: 10.1358/dnp.2010.23.7.1487083. Review.


Mechanisms regulating repression of haptoglobin production by peroxisome proliferator-activated receptor-gamma ligands in adipocytes.

Vernochet C, Davis KE, Scherer PE, Farmer SR.

Endocrinology. 2010 Feb;151(2):586-94. doi: 10.1210/en.2009-1057. Epub 2009 Dec 1.


Mechanisms of obesity and related pathologies: transcriptional control of adipose tissue development.

Vernochet C, Peres SB, Farmer SR.

FEBS J. 2009 Oct;276(20):5729-37. doi: 10.1111/j.1742-4658.2009.07302.x. Epub 2009 Sep 15. Review.


Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPbeta transcriptional activity.

Alonso-Vale MI, Peres SB, Vernochet C, Farmer SR, Lima FB.

J Pineal Res. 2009 Oct;47(3):221-7. doi: 10.1111/j.1600-079X.2009.00705.x. Epub 2009 Aug 3.


Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene.

Dupressoir A, Vernochet C, Bawa O, Harper F, Pierron G, Opolon P, Heidmann T.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12127-32. doi: 10.1073/pnas.0902925106. Epub 2009 Jun 29.


C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists.

Vernochet C, Peres SB, Davis KE, McDonald ME, Qiang L, Wang H, Scherer PE, Farmer SR.

Mol Cell Biol. 2009 Sep;29(17):4714-28. doi: 10.1128/MCB.01899-08. Epub 2009 Jun 29.


A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2.

Esnault C, Priet S, Ribet D, Vernochet C, Bruls T, Lavialle C, Weissenbach J, Heidmann T.

Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17532-7. doi: 10.1073/pnas.0807413105. Epub 2008 Nov 6.


Commitment of mouse embryonic stem cells to the adipocyte lineage requires retinoic acid receptor beta and active GSK3.

Monteiro MC, Wdziekonski B, Villageois P, Vernochet C, Iehle C, Billon N, Dani C.

Stem Cells Dev. 2009 Apr;18(3):457-63. doi: 10.1089/scd.2008.0154.


Tolerance induction to self-MHC antigens in fetal and neonatal mouse B cells.

Caucheteux SM, Vernochet C, Wantyghem J, Gendron MC, Kanellopoulos-Langevin C.

Int Immunol. 2008 Jan;20(1):11-20. Epub 2007 Nov 20.


TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity.

Bezy O, Vernochet C, Gesta S, Farmer SR, Kahn CR.

Mol Cell Biol. 2007 Oct;27(19):6818-31. Epub 2007 Jul 23.


Bi-directional cell trafficking between mother and fetus in mouse placenta.

Vernochet C, Caucheteux SM, Kanellopoulos-Langevin C.

Placenta. 2007 Jul;28(7):639-49. Epub 2006 Nov 20.


Use of differentiating embryonic stem cells in pharmacological studies.

Wdziekonski B, Villageois P, Vernochet C, Phillips B, Dani C.

Methods Mol Biol. 2006;329:341-51.


Syncytin-A and syncytin-B, two fusogenic placenta-specific murine envelope genes of retroviral origin conserved in Muridae.

Dupressoir A, Marceau G, Vernochet C, Bénit L, Kanellopoulos C, Sapin V, Heidmann T.

Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):725-30. Epub 2005 Jan 11.


Human immunodeficiency virus protease inhibitors accumulate into cultured human adipocytes and alter expression of adipocytokines.

Vernochet C, Azoulay S, Duval D, Guedj R, Cottrez F, Vidal H, Ailhaud G, Dani C.

J Biol Chem. 2005 Jan 21;280(3):2238-43. Epub 2004 Nov 3.


Affinity-dependent alterations of mouse B cell development by noninherited maternal antigen.

Vernochet C, Caucheteux SM, Gendron MC, Wantyghem J, Kanellopoulos-Langevin C.

Biol Reprod. 2005 Feb;72(2):460-9. Epub 2004 Oct 6.


Adipocyte differentiation of multipotent cells established from human adipose tissue.

Rodriguez AM, Elabd C, Delteil F, Astier J, Vernochet C, Saint-Marc P, Guesnet J, Guezennec A, Amri EZ, Dani C, Ailhaud G.

Biochem Biophys Res Commun. 2004 Mar 5;315(2):255-63.


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