Sort by
Items per page

Send to

Choose Destination

Search results

Items: 25


Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex.

Cox RM, Toots M, Yoon JJ, Sourimant J, Ludeke B, Fearns R, Bourque E, Patti J, Lee E, Vernachio J, Plemper RK.

J Biol Chem. 2018 Oct 26;293(43):16761-16777. doi: 10.1074/jbc.RA118.004862. Epub 2018 Sep 11.


Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.

Sun L, Meijer A, Froeyen M, Zhang L, Thibaut HJ, Baggen J, George S, Vernachio J, van Kuppeveld FJ, Leyssen P, Hilgenfeld R, Neyts J, Delang L.

Antimicrob Agents Chemother. 2015 Dec;59(12):7782-5. doi: 10.1128/AAC.01375-15. Epub 2015 Sep 14.


Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides.

McGuigan C, Bourdin C, Derudas M, Hamon N, Hinsinger K, Kandil S, Madela K, Meneghesso S, Pertusati F, Serpi M, Slusarczyk M, Chamberlain S, Kolykhalov A, Vernachio J, Vanpouille C, Introini A, Margolis L, Balzarini J.

Eur J Med Chem. 2013;70:326-40. doi: 10.1016/j.ejmech.2013.09.047. Epub 2013 Oct 9.


Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2'-C-methyl-6-O-methyl guanosine nucleoside and L-Alanine ester phosphoramidates.

Bourdin C, McGuigan C, Brancale A, Chamberlain S, Vernachio J, Hutchins J, Gorovits E, Kolykhalov A, Muhammad J, Patti J, Henson G, Bleiman B, Bryant KD, Ganguly B, Hunley D, Obikhod A, Walters CR, Wang J, Ramamurty CV, Battina SK, Srivinas Rao C.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2260-4. doi: 10.1016/j.bmcl.2012.12.004. Epub 2012 Dec 20.


A recombinant clumping factor A-containing vaccine induces functional antibodies to Staphylococcus aureus that are not observed after natural exposure.

Hawkins J, Kodali S, Matsuka YV, McNeil LK, Mininni T, Scully IL, Vernachio JH, Severina E, Girgenti D, Jansen KU, Anderson AS, Donald RG.

Clin Vaccine Immunol. 2012 Oct;19(10):1641-50. Epub 2012 Aug 15.


Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents.

McGuigan C, Madela K, Aljarah M, Bourdin C, Arrica M, Barrett E, Jones S, Kolykhalov A, Bleiman B, Bryant KD, Ganguly B, Gorovits E, Henson G, Hunley D, Hutchins J, Muhammad J, Obikhod A, Patti J, Walters CR, Wang J, Vernachio J, Ramamurty CV, Battina SK, Chamberlain S.

J Med Chem. 2011 Dec 22;54(24):8632-45. doi: 10.1021/jm2011673. Epub 2011 Nov 16.


Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.

McGuigan C, Madela K, Aljarah M, Gilles A, Battina SK, Ramamurty CV, Srinivas Rao C, Vernachio J, Hutchins J, Hall A, Kolykhalov A, Henson G, Chamberlain S.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):6007-12. doi: 10.1016/j.bmcl.2011.06.013. Epub 2011 Aug 17.


INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties.

Vernachio JH, Bleiman B, Bryant KD, Chamberlain S, Hunley D, Hutchins J, Ames B, Gorovits E, Ganguly B, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters CR, Wang J, Williams K, Patti JM, Henson G, Madela K, Aljarah M, Gilles A, McGuigan C.

Antimicrob Agents Chemother. 2011 May;55(5):1843-51. doi: 10.1128/AAC.01335-10. Epub 2011 Feb 28.


Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus.

McGuigan C, Madela K, Aljarah M, Gilles A, Brancale A, Zonta N, Chamberlain S, Vernachio J, Hutchins J, Hall A, Ames B, Gorovits E, Ganguly B, Kolykhalov A, Wang J, Muhammad J, Patti JM, Henson G.

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4850-4. doi: 10.1016/j.bmcl.2010.06.094. Epub 2010 Jun 20.


Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.

McGuigan C, Gilles A, Madela K, Aljarah M, Holl S, Jones S, Vernachio J, Hutchins J, Ames B, Bryant KD, Gorovits E, Ganguly B, Hunley D, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters R, Wang J, Chamberlain S, Henson G.

J Med Chem. 2010 Jul 8;53(13):4949-57. doi: 10.1021/jm1003792.


Monoclonal antibodies specific for Candida albicans Als3 that immunolabel fungal cells in vitro and in vivo and block adhesion to host surfaces.

Coleman DA, Oh SH, Zhao X, Zhao H, Hutchins JT, Vernachio JH, Patti JM, Hoyer LL.

J Microbiol Methods. 2009 Jul;78(1):71-8. doi: 10.1016/j.mimet.2009.05.002. Epub 2009 May 7.


Monoclonal antibodies recognizing the Enterococcus faecalis collagen-binding MSCRAMM Ace: conditional expression and binding analysis.

Hall AE, Gorovits EL, Syribeys PJ, Domanski PJ, Ames BR, Chang CY, Vernachio JH, Patti JM, Hutchins JT.

Microb Pathog. 2007 Aug-Sep;43(2-3):55-66. Epub 2007 Apr 19.


A panel of monoclonal antibodies recognizing the Staphylococcus epidermidis fibrinogen-binding MSCRAMM SdrG.

Hall AE, Patel PR, Domanski PJ, Prater BD, Gorovits EL, Syribeys PJ, Vernachio JH, Patti JM, Hutchins JT.

Hybridoma (Larchmt). 2007 Feb;26(1):28-34.


Human immunoglobulin G recognizing fibrinogen-binding surface proteins is protective against both Staphylococcus aureus and Staphylococcus epidermidis infections in vivo.

Vernachio JH, Bayer AS, Ames B, Bryant D, Prater BD, Syribeys PJ, Gorovits EL, Patti JM.

Antimicrob Agents Chemother. 2006 Feb;50(2):511-8.


Characterization of a humanized monoclonal antibody recognizing clumping factor A expressed by Staphylococcus aureus.

Domanski PJ, Patel PR, Bayer AS, Zhang L, Hall AE, Syribeys PJ, Gorovits EL, Bryant D, Vernachio JH, Hutchins JT, Patti JM.

Infect Immun. 2005 Aug;73(8):5229-32.


SdrX, a serine-aspartate repeat protein expressed by Staphylococcus capitis with collagen VI binding activity.

Liu Y, Ames B, Gorovits E, Prater BD, Syribeys P, Vernachio JH, Patti JM.

Infect Immun. 2004 Nov;72(11):6237-44.


Inhibition of complement activation by a secreted Staphylococcus aureus protein.

Lee LY, Höök M, Haviland D, Wetsel RA, Yonter EO, Syribeys P, Vernachio J, Brown EL.

J Infect Dis. 2004 Aug 1;190(3):571-9. Epub 2004 Jul 6.


Characterization of a protective monoclonal antibody recognizing Staphylococcus aureus MSCRAMM protein clumping factor A.

Hall AE, Domanski PJ, Patel PR, Vernachio JH, Syribeys PJ, Gorovits EL, Johnson MA, Ross JM, Hutchins JT, Patti JM.

Infect Immun. 2003 Dec;71(12):6864-70.


Anti-clumping factor A immunoglobulin reduces the duration of methicillin-resistant Staphylococcus aureus bacteremia in an experimental model of infective endocarditis.

Vernachio J, Bayer AS, Le T, Chai YL, Prater B, Schneider A, Ames B, Syribeys P, Robbins J, Patti JM.

Antimicrob Agents Chemother. 2003 Nov;47(11):3400-6.


Quantitative RT-PCR to evaluate in vivo expression of multiple transgenes using a common intron.

Fairman J, Roche L, Pieslak I, Lay M, Corson S, Fox E, Luong C, Koe G, Lemos B, Grove R, Fradkin L, Vernachio J.

Biotechniques. 1999 Sep;27(3):566-70, 572-4.


Characterization and in vivo testing of a heterogeneous cationic lipid-DNA formulation.

Smith JG, Wedeking T, Vernachio JH, Way H, Niven RW.

Pharm Res. 1998 Sep;15(9):1356-63.


Metastasizing neuroblastomas in mice transgenic for simian virus 40 large T (SV40T) under the olfactory marker protein gene promoter.

Servenius B, Vernachio J, Price J, Andersson LC, Peterson PA.

Cancer Res. 1994 Oct 1;54(19):5198-205.


Chromosomal location and isoform analysis of mouse Fc epsilon RII/CD23.

Conrad DH, Kozak CA, Vernachio J, Squire CM, Rao M, Eicher EM.

Mol Immunol. 1993 Jan;30(1):27-33. Erratum in: Mol Immunol 1993 Feb;30(3):331.


Qa-2 expression in the adult murine thymus. A unique marker for a mature thymic subset.

Vernachio J, Li M, Donnenberg AD, Soloski MJ.

J Immunol. 1989 Jan 1;142(1):48-56.


Qa gene expression: biosynthesis and secretion of Qa-2 molecules in activated T cells.

Soloski MJ, Vernachio J, Einhorn G, Lattimore A.

Proc Natl Acad Sci U S A. 1986 May;83(9):2949-53.

Supplemental Content

Loading ...
Support Center