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Items: 48

1.

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template.

Andrabi R, Pallesen J, Allen JD, Song G, Zhang J, de Val N, Gegg G, Porter K, Su CY, Pauthner M, Newman A, Bouton-Verville H, Garces F, Wilson IA, Crispin M, Hahn BH, Haynes BF, Verkoczy L, Ward AB, Burton DR.

Cell Rep. 2019 May 21;27(8):2426-2441.e6. doi: 10.1016/j.celrep.2019.04.082.

2.

Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models.

Saunders KO, Verkoczy LK, Jiang C, Zhang J, Parks R, Chen H, Housman M, Bouton-Verville H, Shen X, Trama AM, Scearce R, Sutherland L, Santra S, Newman A, Eaton A, Xu K, Georgiev IS, Joyce MG, Tomaras GD, Bonsignori M, Reed SG, Salazar A, Mascola JR, Moody MA, Cain DW, Centlivre M, Zurawski S, Zurawski G, Erickson HP, Kwong PD, Alam SM, Levy Y, Montefiori DC, Haynes BF.

Cell Rep. 2017 Dec 26;21(13):3681-3690. doi: 10.1016/j.celrep.2017.12.028.

3.

Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.

Williams WB, Zhang J, Jiang C, Nicely NI, Fera D, Luo K, Moody MA, Liao HX, Alam SM, Kepler TB, Ramesh A, Wiehe K, Holland JA, Bradley T, Vandergrift N, Saunders KO, Parks R, Foulger A, Xia SM, Bonsignori M, Montefiori DC, Louder M, Eaton A, Santra S, Scearce R, Sutherland L, Newman A, Bouton-Verville H, Bowman C, Bomze H, Gao F, Marshall DJ, Whitesides JF, Nie X, Kelsoe G, Reed SG, Fox CB, Clary K, Koutsoukos M, Franco D, Mascola JR, Harrison SC, Haynes BF, Verkoczy L.

Nat Commun. 2017 Nov 23;8(1):1732. doi: 10.1038/s41467-017-01336-3.

4.

Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies.

Moody MA, Pedroza-Pacheco I, Vandergrift NA, Chui C, Lloyd KE, Parks R, Soderberg KA, Ogbe AT, Cohen MS, Liao HX, Gao F, McMichael AJ, Montefiori DC, Verkoczy L, Kelsoe G, Huang J, Shea PR, Connors M, Borrow P, Haynes BF.

Sci Immunol. 2016 Jul 29;1(1):aag0851. doi: 10.1126/sciimmunol.aag0851. Epub 2016 Jul 29.

5.
6.

BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance.

Kuraoka M, Snowden PB, Nojima T, Verkoczy L, Haynes BF, Kitamura D, Kelsoe G.

Cell Rep. 2017 Feb 14;18(7):1627-1635. doi: 10.1016/j.celrep.2017.01.050.

7.

Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies.

Verkoczy L, Alt FW, Tian M.

Immunol Rev. 2017 Jan;275(1):89-107. doi: 10.1111/imr.12505. Review.

8.

Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice.

Wiehe K, Nicely NI, Lockwood B, Kuraoka M, Anasti K, Arora S, Bowman CM, Stolarchuk C, Parks R, Lloyd KE, Xia SM, Duffy R, Shen X, Kyratsous CA, Macdonald LE, Murphy AJ, Scearce RM, Moody MA, Alam SM, Verkoczy L, Tomaras GD, Kelsoe G, Haynes BF.

J Immunol. 2017 Feb 1;198(3):1047-1055. doi: 10.4049/jimmunol.1601640. Epub 2016 Dec 23.

9.

HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism.

Bradley T, Yang G, Ilkayeva O, Holl TM, Zhang R, Zhang J, Santra S, Fox CB, Reed SG, Parks R, Bowman CM, Bouton-Verville H, Sutherland LL, Scearce RM, Vandergrift N, Kepler TB, Moody MA, Liao HX, Alam SM, McLendon R, Everitt JI, Newgard CB, Verkoczy L, Kelsoe G, Haynes BF.

J Immunol. 2016 Dec 15;197(12):4663-4673. Epub 2016 Nov 14.

10.

Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages.

Zhang R, Verkoczy L, Wiehe K, Munir Alam S, Nicely NI, Santra S, Bradley T, Pemble CW 4th, Zhang J, Gao F, Montefiori DC, Bouton-Verville H, Kelsoe G, Larimore K, Greenberg PD, Parks R, Foulger A, Peel JN, Luo K, Lu X, Trama AM, Vandergrift N, Tomaras GD, Kepler TB, Moody MA, Liao HX, Haynes BF.

Sci Transl Med. 2016 Apr 27;8(336):336ra62. doi: 10.1126/scitranslmed.aaf0618.

11.

HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence.

Wang Y, Kapoor P, Parks R, Silva-Sanchez A, Alam SM, Verkoczy L, Liao HX, Zhuang Y, Burrows P, Levinson M, Elgavish A, Cui X, Haynes BF, Schroeder H Jr.

Immunogenetics. 2016 Feb;68(2):145-55. doi: 10.1007/s00251-015-0890-x. Epub 2015 Dec 19.

12.

Progress in HIV-1 vaccine development.

Haynes BF, Moody MA, Alam M, Bonsignori M, Verkoczy L, Ferrari G, Gao F, Tomaras GD, Liao HX, Kelsoe G.

J Allergy Clin Immunol. 2014 Jul;134(1):3-10; quiz 11. doi: 10.1016/j.jaci.2014.04.025. Epub 2014 Jun 26. Review.

13.

Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies.

Kelsoe G, Verkoczy L, Haynes BF.

Vaccines (Basel). 2014 Mar;2(1):1-14. doi: 10.3390/vaccines2010001.

14.

Redemption of autoreactive B cells.

Haynes BF, Verkoczy L, Kelsoe G.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9022-3. doi: 10.1073/pnas.1407877111. Epub 2014 Jun 11. No abstract available.

15.

HIV-1 envelope gp41 broadly neutralizing antibodies: hurdles for vaccine development.

Verkoczy L, Kelsoe G, Haynes BF.

PLoS Pathog. 2014 May 22;10(5):e1004073. doi: 10.1371/journal.ppat.1004073. eCollection 2014 May. No abstract available.

16.

AIDS/HIV. Host controls of HIV neutralizing antibodies.

Haynes BF, Verkoczy L.

Science. 2014 May 9;344(6184):588-9. doi: 10.1126/science.1254990. No abstract available.

17.

Autoreactivity in HIV-1 broadly neutralizing antibodies: implications for their function and induction by vaccination.

Verkoczy L, Diaz M.

Curr Opin HIV AIDS. 2014 May;9(3):224-34. doi: 10.1097/COH.0000000000000049. Review.

18.

An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.

Bonsignori M, Wiehe K, Grimm SK, Lynch R, Yang G, Kozink DM, Perrin F, Cooper AJ, Hwang KK, Chen X, Liu M, McKee K, Parks RJ, Eudailey J, Wang M, Clowse M, Criscione-Schreiber LG, Moody MA, Ackerman ME, Boyd SD, Gao F, Kelsoe G, Verkoczy L, Tomaras GD, Liao HX, Kepler TB, Montefiori DC, Mascola JR, Haynes BF.

J Clin Invest. 2014 Apr;124(4):1835-43. doi: 10.1172/JCI73441. Epub 2014 Mar 10.

19.

Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes.

Holl TM, Yang G, Kuraoka M, Verkoczy L, Alam SM, Moody MA, Haynes BF, Kelsoe G.

J Immunol. 2014 Apr 1;192(7):3269-79. doi: 10.4049/jimmunol.1302829. Epub 2014 Mar 3.

20.

Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies.

Zhang J, Alam SM, Bouton-Verville H, Chen Y, Newman A, Stewart S, Jaeger FH, Montefiori DC, Dennison SM, Haynes BF, Verkoczy L.

J Immunol. 2014 Feb 15;192(4):1693-706. doi: 10.4049/jimmunol.1302511. Epub 2014 Jan 24.

21.

Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses.

Verkoczy L, Chen Y, Zhang J, Bouton-Verville H, Newman A, Lockwood B, Scearce RM, Montefiori DC, Dennison SM, Xia SM, Hwang KK, Liao HX, Alam SM, Haynes BF.

J Immunol. 2013 Sep 1;191(5):2538-50. doi: 10.4049/jimmunol.1300971. Epub 2013 Aug 5.

22.

Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10.

Chen Y, Zhang J, Hwang KK, Bouton-Verville H, Xia SM, Newman A, Ouyang YB, Haynes BF, Verkoczy L.

J Immunol. 2013 Aug 1;191(3):1260-75. doi: 10.4049/jimmunol.1300770. Epub 2013 Jul 3.

23.

HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design.

Bonsignori M, Alam SM, Liao HX, Verkoczy L, Tomaras GD, Haynes BF, Moody MA.

Trends Microbiol. 2012 Nov;20(11):532-9. doi: 10.1016/j.tim.2012.08.011. Epub 2012 Sep 13. Review.

24.

Differential reactivity of germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation.

Alam SM, Liao HX, Dennison SM, Jaeger F, Parks R, Anasti K, Foulger A, Donathan M, Lucas J, Verkoczy L, Nicely N, Tomaras GD, Kelsoe G, Chen B, Kepler TB, Haynes BF.

J Virol. 2011 Nov;85(22):11725-31. doi: 10.1128/JVI.05680-11. Epub 2011 Sep 14.

25.

Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls.

Verkoczy L, Chen Y, Bouton-Verville H, Zhang J, Diaz M, Hutchinson J, Ouyang YB, Alam SM, Holl TM, Hwang KK, Kelsoe G, Haynes BF.

J Immunol. 2011 Oct 1;187(7):3785-97. doi: 10.4049/jimmunol.1101633. Epub 2011 Sep 9.

26.

Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies.

Verkoczy L, Kelsoe G, Moody MA, Haynes BF.

Curr Opin Immunol. 2011 Jun;23(3):383-90. doi: 10.1016/j.coi.2011.04.003. Epub 2011 Apr 27. Review.

27.

B cell responses to HIV-1 infection and vaccination: pathways to preventing infection.

Haynes BF, Moody MA, Liao HX, Verkoczy L, Tomaras GD.

Trends Mol Med. 2011 Feb;17(2):108-16. doi: 10.1016/j.molmed.2010.10.008. Epub 2010 Nov 26.

28.

Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution.

Shen X, Dennison SM, Liu P, Gao F, Jaeger F, Montefiori DC, Verkoczy L, Haynes BF, Alam SM, Tomaras GD.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5972-7. doi: 10.1073/pnas.0912381107. Epub 2010 Mar 15.

29.

Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance.

Verkoczy L, Diaz M, Holl TM, Ouyang YB, Bouton-Verville H, Alam SM, Liao HX, Kelsoe G, Haynes BF.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):181-6. doi: 10.1073/pnas.0912914107. Epub 2009 Dec 14.

30.

Functional, non-clonal IgMa-restricted B cell receptor interactions with the HIV-1 envelope gp41 membrane proximal external region.

Verkoczy L, Moody MA, Holl TM, Bouton-Verville H, Scearce RM, Hutchinson J, Alam SM, Kelsoe G, Haynes BF.

PLoS One. 2009 Oct 6;4(10):e7215. doi: 10.1371/journal.pone.0007215.

31.

Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells.

Richter K, Brar S, Ray M, Pisitkun P, Bolland S, Verkoczy L, Diaz M.

J Biol Chem. 2009 Oct 30;284(44):30652-61. doi: 10.1074/jbc.M109.014506. Epub 2009 Sep 4.

32.

Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.

Verkoczy L, Duong B, Skog P, Aït-Azzouzene D, Puri K, Vela JL, Nemazee D.

J Immunol. 2007 May 15;178(10):6332-41.

33.

Antibody polyspecificity and neutralization of HIV-1: a hypothesis.

Haynes BF, Moody MA, Verkoczy L, Kelsoe G, Alam SM.

Hum Antibodies. 2005;14(3-4):59-67. Review.

34.

Split tolerance in peripheral B cell subsets in mice expressing a low level of Igkappa-reactive ligand.

Aït-Azzouzene D, Verkoczy L, Duong B, Skog P, Gavin AL, Nemazee D.

J Immunol. 2006 Jan 15;176(2):939-48.

35.

A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.

Verkoczy L, Aït-Azzouzene D, Skog P, Märtensson A, Lang J, Duong B, Nemazee D.

Immunity. 2005 Apr;22(4):519-31.

36.

An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system.

Ait-Azzouzene D, Verkoczy L, Peters J, Gavin A, Skog P, Vela JL, Nemazee D.

J Exp Med. 2005 Mar 7;201(5):817-28. Epub 2005 Feb 28.

37.

The scope of receptor editing and its association with autoimmunity.

Verkoczy LK, Mårtensson AS, Nemazee D.

Curr Opin Immunol. 2004 Dec;16(6):808-14. Review.

PMID:
15511677
38.

Peripheral B lymphocyte tolerance.

Gavin A, Aït-Azzouzene D, Mårtensson A, Duong B, Verkoczy L, Vela JL, Skog P, Nemazee D.

Keio J Med. 2004 Sep;53(3):151-8. Review. Erratum in: Keio J Med. 2010 Jun;59(2):77. Skog, José Luis [corrected to Vela, José Luis].

39.

Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection.

Aït-Azzouzene D, Skog P, Retter M, Kouskoff V, Hertz M, Lang J, Kench J, Chumley M, Melamed D, Sudaria J, Gavin A, Martensson A, Verkoczy L, Duong B, Vela J, Nemazee D, Alfonso C.

Immunol Rev. 2004 Feb;197:219-30. Review. Erratum in: Immunol Rev. 2004 Aug;200:272.

PMID:
14962198
40.
41.
42.

Haplotype exclusion and receptor editing: irreconcilable differences?

Nemazee D, Mårtensson A, Verkoczy L.

Semin Immunol. 2002 Jun;14(3):191-8; discussion 222-4. Review.

PMID:
12160646
47.

Up-regulation of recombination activating gene expression by signal transduction through the surface Ig receptor.

Verkoczy LK, Stiernhdm BJ, Berinstein NL.

J Immunol. 1995 May 15;154(10):5136-43.

PMID:
7537300
48.

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