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Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation.

Ortiz-Munoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR.

J Clin Invest. 2020 Jan 21. pii: 129635. doi: 10.1172/JCI129635. [Epub ahead of print]


Nanomolar Potency Aminophenyltriazine CFTR Activator Reverses Corneal Epithelial Injury in a Mouse Model of Dry Eye.

Chen X, Lee S, Zhang T, Duan T, Pasricha ND, Schallhorn JM, Levin MH, Koprivica V, Verkman AS.

J Ocul Pharmacol Ther. 2020 Jan 14. doi: 10.1089/jop.2019.0087. [Epub ahead of print]


Nanomolar-potency 'co-potentiator' therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants.

Phuan PW, Tan JA, Rivera AA, Zlock L, Nielson DW, Finkbeiner WE, Haggie PM, Verkman AS.

Sci Rep. 2019 Nov 27;9(1):17640. doi: 10.1038/s41598-019-54158-2.


Affinity-matured 'aquaporumab' anti-aquaporin-4 antibody for therapy of seropositive neuromyelitis optica spectrum disorders.

Duan T, Tradtrantip L, Phuan PW, Bennett JL, Verkman AS.

Neuropharmacology. 2020 Jan 1;162:107827. doi: 10.1016/j.neuropharm.2019.107827. Epub 2019 Oct 22.


Experimental animal models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders: progress and shortcomings.

Duan T, Verkman AS.

Brain Pathol. 2020 Jan;30(1):13-25. doi: 10.1111/bpa.12793. Epub 2019 Oct 21. Review.


Diabetes insipidus.

Christ-Crain M, Bichet DG, Fenske WK, Goldman MB, Rittig S, Verbalis JG, Verkman AS.

Nat Rev Dis Primers. 2019 Aug 8;5(1):54. doi: 10.1038/s41572-019-0103-2. Review.


4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation.

Lee S, Cil O, Haggie PM, Verkman AS.

J Med Chem. 2019 Sep 12;62(17):8330-8337. doi: 10.1021/acs.jmedchem.9b01192. Epub 2019 Sep 3.


CrossTalk opposing view: Going against the flow: interstitial solute transport in brain is diffusive and aquaporin-4 independent.

Smith AJ, Verkman AS.

J Physiol. 2019 Sep;597(17):4421-4424. doi: 10.1113/JP277636. Epub 2019 Aug 6. No abstract available.


Rebuttal from Alex J. Smith and Alan S. Verkman.

Smith AJ, Verkman AS.

J Physiol. 2019 Sep;597(17):4427-4428. doi: 10.1113/JP278461. Epub 2019 Aug 6. No abstract available.


Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity.

Armirotti A, Tomati V, Matthes E, Veit G, Cholon DM, Phuan PW, Braccia C, Guidone D, Gentzsch M, Lukacs GL, Verkman AS, Galietta LJV, Hanrahan JW, Pedemonte N.

Sci Rep. 2019 Jul 16;9(1):10310. doi: 10.1038/s41598-019-46639-1.


Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A.

Cil O, Anderson MO, Yen R, Kelleher B, Huynh TL, Seo Y, Nilsen SP, Turner JR, Verkman AS.

FASEB J. 2019 Oct;33(10):11247-11257. doi: 10.1096/fj.201900858R. Epub 2019 Jul 12.


Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity.

Duan T, Smith AJ, Verkman AS.

Acta Neuropathol Commun. 2019 Jul 11;7(1):112. doi: 10.1186/s40478-019-0766-7.


Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin).

Zhu JS, Lu JY, Tan JA, Rivera AA, Phuan PW, Shatskikh ME, Son JH, Haggie PM, Verkman AS, Kurth MJ.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2119-2123. doi: 10.1016/j.bmcl.2019.07.003. Epub 2019 Jul 3.


Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.

Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS.

FASEB J. 2019 Oct;33(10):10924-10934. doi: 10.1096/fj.201901166R. Epub 2019 Jul 3.


Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer's disease by remodeling peri-plaque astrocyte structure.

Smith AJ, Duan T, Verkman AS.

Acta Neuropathol Commun. 2019 May 8;7(1):74. doi: 10.1186/s40478-019-0728-0.


CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica.

Tradtrantip L, Duan T, Yeaman MR, Verkman AS.

J Neuroinflammation. 2019 Mar 9;16(1):57. doi: 10.1186/s12974-019-1448-x.


Aquaporin-3 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease.

Wang W, Geng X, Lei L, Jia Y, Li Y, Zhou H, Verkman AS, Yang B.

FASEB J. 2019 May;33(5):6185-6196. doi: 10.1096/fj.201801338RRR. Epub 2019 Feb 15.


Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea.

Duan T, Cil O, Thiagarajah JR, Verkman AS.

JCI Insight. 2019 Feb 21;4(4). pii: 126444. doi: 10.1172/jci.insight.126444. eCollection 2019 Feb 21.


cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity.

Tse CM, Yin J, Singh V, Sarker R, Lin R, Verkman AS, Turner JR, Donowitz M.

Cell Mol Gastroenterol Hepatol. 2019;7(3):641-653. doi: 10.1016/j.jcmgh.2019.01.002. Epub 2019 Jan 17.


Noninvasive, Targeted Creation of Neuromyelitis Optica Pathology in AQP4-IgG Seropositive Rats by Pulsed Focused Ultrasound.

Yao X, Adams MS, Jones PD, Diederich CJ, Verkman AS.

J Neuropathol Exp Neurol. 2019 Jan 1;78(1):47-56. doi: 10.1093/jnen/nly107.


Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica.

Duan T, Smith AJ, Verkman AS.

J Neuroinflammation. 2018 Oct 22;15(1):294. doi: 10.1186/s12974-018-1333-z.


SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation.

Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS.

JCI Insight. 2018 Jul 26;3(14). pii: 121370. doi: 10.1172/jci.insight.121370. eCollection 2018 Jul 26.


Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators.

Phuan PW, Son JH, Tan JA, Li C, Musante I, Zlock L, Nielson DW, Finkbeiner WE, Kurth MJ, Galietta LJ, Haggie PM, Verkman AS.

J Cyst Fibros. 2018 Sep;17(5):595-606. doi: 10.1016/j.jcf.2018.05.010. Epub 2018 Jun 12.


Hollow Micropillar Array Method for High-Capacity Drug Screening on Filter-Grown Epithelial Cells.

Jin BJ, Lee S, Verkman AS.

Anal Chem. 2018 Jun 19;90(12):7675-7681. doi: 10.1021/acs.analchem.8b01554. Epub 2018 May 30.


Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis.

Agbani EO, Williams CM, Li Y, van den Bosch MT, Moore SF, Mauroux A, Hodgson L, Verkman AS, Hers I, Poole AW.

JCI Insight. 2018 May 17;3(10). pii: 99062. doi: 10.1172/jci.insight.99062. eCollection 2018 May 17.


Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1.

Lee S, Cil O, Diez-Cecilia E, Anderson MO, Verkman AS.

J Med Chem. 2018 Apr 12;61(7):3209-3217. doi: 10.1021/acs.jmedchem.8b00343. Epub 2018 Apr 3.


ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter.

Phuan PW, Veit G, Tan JA, Roldan A, Finkbeiner WE, Haggie PM, Lukacs GL, Verkman AS.

SLAS Discov. 2018 Sep;23(8):823-831. doi: 10.1177/2472555218763310. Epub 2018 Mar 13.


Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica.

Tradtrantip L, Felix CM, Spirig R, Morelli AB, Verkman AS.

Neuropharmacology. 2018 May 1;133:345-353. doi: 10.1016/j.neuropharm.2018.02.002. Epub 2018 Feb 8.


The evolving mystery of why skeletal muscle is spared in seropositive neuromyelitis optica.

Verkman AS, Yao X, Smith AJ.

J Cell Mol Med. 2018 Mar;22(3):2039-2040. doi: 10.1111/jcmm.13482. Epub 2018 Jan 24. No abstract available.


The "glymphatic" mechanism for solute clearance in Alzheimer's disease: game changer or unproven speculation?

Smith AJ, Verkman AS.

FASEB J. 2018 Feb;32(2):543-551. doi: 10.1096/fj.201700999. Epub 2018 Jan 3. Review.


The aquaporin-4 water channel as a potential drug target in neurological disorders.

Verkman AS, Smith AJ, Phuan PW, Tradtrantip L, Anderson MO.

Expert Opin Ther Targets. 2017 Dec;21(12):1161-1170. doi: 10.1080/14728222.2017.1398236. Epub 2017 Nov 5. Review.


Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders.

Felix CM, Lee S, Levin MH, Verkman AS.

Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4506-4513. doi: 10.1167/iovs.17-22525.


Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma.

Smith AJ, Yao X, Dix JA, Jin BJ, Verkman AS.

Elife. 2017 Aug 21;6. pii: e27679. doi: 10.7554/eLife.27679.


Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G.

Yao X, Verkman AS.

Acta Neuropathol Commun. 2017 Jul 27;5(1):57. doi: 10.1186/s40478-017-0462-4.


Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica.

Tradtrantip L, Yao X, Su T, Smith AJ, Verkman AS.

Acta Neuropathol. 2017 Jul;134(1):35-44. doi: 10.1007/s00401-017-1734-6. Epub 2017 May 31.


Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A).

Truong EC, Phuan PW, Reggi AL, Ferrera L, Galietta LJV, Levy SE, Moises AC, Cil O, Diez-Cecilia E, Lee S, Verkman AS, Anderson MO.

J Med Chem. 2017 Jun 8;60(11):4626-4635. doi: 10.1021/acs.jmedchem.7b00020. Epub 2017 May 24.


Comparative molecular dynamics study of neuromyelitis optica-immunoglobulin G binding to aquaporin-4 extracellular domains.

Alberga D, Trisciuzzi D, Lattanzi G, Bennett JL, Verkman AS, Mangiatordi GF, Nicolotti O.

Biochim Biophys Acta Biomembr. 2017 Aug;1859(8):1326-1334. doi: 10.1016/j.bbamem.2017.05.001. Epub 2017 May 3.


Aquaporin-3 deletion in mice results in renal collecting duct abnormalities and worsens ischemia-reperfusion injury.

Lei L, Wang W, Jia Y, Su L, Zhou H, Verkman AS, Yang B.

Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1231-1241. doi: 10.1016/j.bbadis.2017.03.012. Epub 2017 Mar 23.


Aquaporin-Targeted Therapeutics: State-of-the-Field.

Tradtrantip L, Jin BJ, Yao X, Anderson MO, Verkman AS.

Adv Exp Med Biol. 2017;969:239-250. doi: 10.1007/978-94-024-1057-0_16. Review.


High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators.

Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ.

J Med Chem. 2017 Mar 23;60(6):2401-2410. doi: 10.1021/acs.jmedchem.6b01759. Epub 2017 Mar 9.


Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G.

Yao X, Verkman AS.

Acta Neuropathol Commun. 2017 Feb 17;5(1):15. doi: 10.1186/s40478-017-0417-9.


Microfluidic platform for rapid measurement of transepithelial water transport.

Jin BJ, Verkman AS.

Lab Chip. 2017 Feb 28;17(5):887-895. doi: 10.1039/c6lc01456a.


Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases.

Lee S, Phuan PW, Felix CM, Tan JA, Levin MH, Verkman AS.

J Med Chem. 2017 Feb 9;60(3):1210-1218. doi: 10.1021/acs.jmedchem.6b01792. Epub 2017 Jan 31.


Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia.

Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):568-573. doi: 10.1073/pnas.1612921114. Epub 2017 Jan 3.


Aquaporin Water Channels and Hydrocephalus.

Verkman AS, Tradtrantip L, Smith AJ, Yao X.

Pediatr Neurosurg. 2017;52(6):409-416. doi: 10.1159/000452168. Epub 2016 Dec 16. Review.


Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.

Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14781-14786. doi: 10.1073/pnas.1617859114. Epub 2016 Dec 8.


Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product.

Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman AS.

J Biol Chem. 2017 Jan 20;292(3):771-785. doi: 10.1074/jbc.M116.764720. Epub 2016 Nov 28.


Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.

Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS.

FASEB J. 2017 Feb;31(2):751-760. doi: 10.1096/fj.201600891R. Epub 2016 Nov 8.


Spatial model of convective solute transport in brain extracellular space does not support a "glymphatic" mechanism.

Jin BJ, Smith AJ, Verkman AS.

J Gen Physiol. 2016 Dec;148(6):489-501. Epub 2016 Nov 11.


Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation.

Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS.

Transl Res. 2017 Apr;182:14-26.e4. doi: 10.1016/j.trsl.2016.10.003. Epub 2016 Oct 15.

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