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Platelet storage properties are associated with donor age: in vitro quality of platelets from young donors and older donors with and without Type 2 diabetes.

Bontekoe IJ, van der Meer PF, Verhoeven AJ, de Korte D.

Vox Sang. 2019 Feb;114(2):129-136. doi: 10.1111/vox.12739. Epub 2018 Dec 10.


Use of monomeric and oligomeric flavanols in the dietary management of patients with type 2 diabetes mellitus and microalbuminuria (FLAVA trial): study protocol for a randomized controlled trial.

Rashid M, Verhoeven AJM, Mulder MT, Timman R, van Beek-Nieuwland Y, Athumani AA, Zandbergen AAM, van der Wiel HE, Sijbrands EJG, Berk KA.

Trials. 2018 Jul 16;19(1):379. doi: 10.1186/s13063-018-2762-9.


Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation.

Held NM, Kuipers EN, van Weeghel M, van Klinken JB, Denis SW, Lombès M, Wanders RJ, Vaz FM, Rensen PCN, Verhoeven AJ, Boon MR, Houtkooper RH.

Sci Rep. 2018 Jun 22;8(1):9562. doi: 10.1038/s41598-018-27875-3.


Improved oxygenation dramatically alters metabolism and gene expression in cultured primary mouse hepatocytes.

Gilglioni EH, Chang JC, Duijst S, Go S, Adam AAA, Hoekstra R, Verhoeven AJ, Ishii-Iwamoto EL, Oude Elferink RPJ.

Hepatol Commun. 2018 Feb 9;2(3):299-312. doi: 10.1002/hep4.1140. eCollection 2018 Mar.


HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution.

Tol MJ, van der Lienden MJC, Gabriel TL, Hagen JJ, Scheij S, Veenendaal T, Klumperman J, Donker-Koopman WE, Verhoeven AJ, Overkleeft H, Aerts JM, Argmann CA, van Eijk M.

Autophagy. 2018;14(3):437-449. doi: 10.1080/15548627.2017.1419118. Epub 2018 Feb 17.


Group cognitive behavioural therapy and weight regain after diet in type 2 diabetes: results from the randomised controlled POWER trial.

Berk KA, Buijks HIM, Verhoeven AJM, Mulder MT, Özcan B, van 't Spijker A, Timman R, Busschbach JJ, Sijbrands EJ.

Diabetologia. 2018 Apr;61(4):790-799. doi: 10.1007/s00125-017-4531-9. Epub 2018 Jan 9.


Role of the bicarbonate-responsive soluble adenylyl cyclase in cholangiocyte apoptosis in primary biliary cholangitis; a new hypothesis.

Chang JC, Go S, Verhoeven AJ, Beuers U, Oude Elferink RPJ.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1232-1239. doi: 10.1016/j.bbadis.2017.09.022. Epub 2017 Sep 28. Review.


Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity.

Gao Y, Vidal-Itriago A, Kalsbeek MJ, Layritz C, García-Cáceres C, Tom RZ, Eichmann TO, Vaz FM, Houtkooper RH, van der Wel N, Verhoeven AJ, Yan J, Kalsbeek A, Eckel RH, Hofmann SM, Yi CX.

Cell Rep. 2017 Sep 26;20(13):3034-3042. doi: 10.1016/j.celrep.2017.09.008.


Platelet storage performance is consistent by donor: a pilot study comparing "good" and "poor" storing platelets.

Bontekoe IJ, van der Meer PF, van den Hurk K, Verhoeven AJ, de Korte D.

Transfusion. 2017 Oct;57(10):2373-2380. doi: 10.1111/trf.14238. Epub 2017 Jul 13.


Soluble LR11 associates with aortic root calcification in asymptomatic treated male patients with familial hypercholesterolemia.

Vongpromek R, Bos S, Ten Kate GR, Bujo H, Jiang M, Nieman K, Schneider W, Roeters van Lennep JE, Verhoeven AJM, Sijbrands EJG, Mulder MT.

Atherosclerosis. 2017 Oct;265:299-304. doi: 10.1016/j.atherosclerosis.2017.06.018. Epub 2017 Jun 9.


Diet-induced weight loss and markers of endothelial dysfunction and inflammation in treated patients with type 2 diabetes.

Berk KA, Oudshoorn TP, Verhoeven AJM, Mulder MT, Roks AJM, Dik WA, Timman R, Sijbrands EJG.

Clin Nutr ESPEN. 2016 Oct;15:101-106. doi: 10.1016/j.clnesp.2016.06.011. Epub 2016 Jul 25.


The anti-inflammatory function of high-density lipoprotein in type II diabetes: A systematic review.

Lemmers RFH, van Hoek M, Lieverse AG, Verhoeven AJM, Sijbrands EJG, Mulder MT.

J Clin Lipidol. 2017 May - Jun;11(3):712-724.e5. doi: 10.1016/j.jacl.2017.03.013. Epub 2017 Mar 31. Review.


Novel protein biomarkers associated with coronary artery disease in statin-treated patients with familial hypercholesterolemia.

Bos S, Phillips M, Watts GF, Verhoeven AJM, Sijbrands EJG, Ward NC.

J Clin Lipidol. 2017 May - Jun;11(3):682-693. doi: 10.1016/j.jacl.2017.03.014. Epub 2017 Apr 4.


Effect of diet-induced weight loss on lipoprotein(a) levels in obese individuals with and without type 2 diabetes.

Berk KA, Yahya R, Verhoeven AJM, Touw J, Leijten FP, van Rossum EF, Wester VL, Lips MA, Pijl H, Timman R, Erhart G, Kronenberg F, Roeters van Lennep JE, Sijbrands EJG, Mulder MT.

Diabetologia. 2017 Jun;60(6):989-997. doi: 10.1007/s00125-017-4246-y. Epub 2017 Apr 6.


Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels.

den Hoedt S, Janssen CIF, Astarita G, Piomelli D, Leijten FPJ, Crivelli SM, Verhoeven AJM, de Vries HE, Walter J, Martinez-Martinez P, Sijbrands EJG, Kiliaan AJ, Mulder MT.

J Alzheimers Dis. 2017;60(3):769-781. doi: 10.3233/JAD-160739.


Carotid artery plaques and intima medial thickness in familial hypercholesteraemic patients on long-term statin therapy: A case control study.

Bos S, Duvekot MH, Ten Kate GR, Verhoeven AJ, Mulder MT, Schinkel AF, Nieman K, Watts GF, Sijbrands EJ, Roeters van Lennep JE.

Atherosclerosis. 2017 Jan;256:62-66. doi: 10.1016/j.atherosclerosis.2016.12.005. Epub 2016 Dec 2.


Levels of the soluble LDL receptor-relative LR11 decrease in overweight individuals with type 2 diabetes upon diet-induced weight loss.

Berk KA, Vongpromek R, Jiang M, Schneider WJ, Timman R, Verhoeven AJ, Bujo H, Sijbrands EJ, Mulder MT.

Atherosclerosis. 2016 Nov;254:67-72. doi: 10.1016/j.atherosclerosis.2016.09.066. Epub 2016 Sep 22.


Predictors of Diet-Induced Weight Loss in Overweight Adults with Type 2 Diabetes.

Berk KA, Mulder MT, Verhoeven AJ, van Wietmarschen H, Boessen R, Pellis LP, van T Spijker A, Timman R, Ozcan B, Sijbrands EJ.

PLoS One. 2016 Aug 5;11(8):e0160774. doi: 10.1371/journal.pone.0160774. eCollection 2016.


A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity.

Tol MJ, Ottenhoff R, van Eijk M, Zelcer N, Aten J, Houten SM, Geerts D, van Roomen C, Bierlaagh MC, Scheij S, Hoeksema MA, Aerts JM, Bogan JS, Dorn GW 2nd, Argmann CA, Verhoeven AJ.

Diabetes. 2016 Sep;65(9):2591-605. doi: 10.2337/db16-0243. Epub 2016 Jun 20.


Lomitapide affects HDL composition and function.

Yahya R, Favari E, Calabresi L, Verhoeven AJM, Zimetti F, Adorni MP, Gomaraschi M, Averna M, Cefalù AB, Bernini F, Sijbrands EJG, Mulder MT, Roeters van Lennep JE.

Atherosclerosis. 2016 Aug;251:15-18. doi: 10.1016/j.atherosclerosis.2016.05.005. Epub 2016 May 11.


Discriminative Ability of Plasma Branched-Chain Amino Acid Levels for Glucose Intolerance in Families At Risk for Type 2 Diabetes.

Jainandunsing S, Wattimena JL, Verhoeven AJ, Langendonk JG, Rietveld T, Isaacs AJ, Sijbrands EJ, de Rooij FW.

Metab Syndr Relat Disord. 2016 Apr;14(3):175-81. doi: 10.1089/met.2015.0102. Epub 2015 Dec 14.


LR11/SorLA links triglyceride-rich lipoproteins to risk of developing cardiovascular disease in FH patients.

Vongpromek R, Bujo H, Hoekstra M, Schneider WJ, van der Zee L, Schinkel AF, Korporaal SJ, Dik WA, Ebinuma H, Jiang M, Verhoeven AJ, Sijbrands EJ, Mulder MT.

Atherosclerosis. 2015 Dec;243(2):429-37. doi: 10.1016/j.atherosclerosis.2015.10.009. Epub 2015 Oct 13.


Lipoprotein (a) levels are not associated with carotid plaques and carotid intima media thickness in statin-treated patients with familial hypercholesterolemia.

Bos S, Duvekot MH, Touw-Blommesteijn AC, Verhoeven AJ, Mulder MT, Watts GF, Sijbrands EJ, Roeters van Lennep JE.

Atherosclerosis. 2015 Sep;242(1):226-9. doi: 10.1016/j.atherosclerosis.2015.07.024. Epub 2015 Jul 14.


Lipoprotein(a) levels are associated with aortic valve calcification in asymptomatic patients with familial hypercholesterolaemia.

Vongpromek R, Bos S, Ten Kate GJ, Yahya R, Verhoeven AJ, de Feyter PJ, Kronenberg F, Roeters van Lennep JE, Sijbrands EJ, Mulder MT.

J Intern Med. 2015 Aug;278(2):166-73. doi: 10.1111/joim.12335. Epub 2015 Jan 5.


Gene reprogramming in exercise-induced cardiac hypertrophy in swine: A transcriptional genomics approach.

Kuster DW, Merkus D, Blonden LA, Kremer A, van IJcken WF, Verhoeven AJ, Duncker DJ.

J Mol Cell Cardiol. 2014 Dec;77:168-74. doi: 10.1016/j.yjmcc.2014.10.006. Epub 2014 Oct 22.


Red blood cell storage increases hypoxia-induced nitric oxide bioavailability and methemoglobin formation in vitro and in vivo.

Almac E, Bezemer R, Hilarius-Stokman PM, Goedhart P, de Korte D, Verhoeven AJ, Ince C.

Transfusion. 2014 Dec;54(12):3178-85. doi: 10.1111/trf.12738. Epub 2014 Jun 18.


Inborn defects in the antioxidant systems of human red blood cells.

van Zwieten R, Verhoeven AJ, Roos D.

Free Radic Biol Med. 2014 Feb;67:377-86. doi: 10.1016/j.freeradbiomed.2013.11.022. Epub 2013 Dec 6. Review.


Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy.

Lorin S, Tol MJ, Bauvy C, Strijland A, Poüs C, Verhoeven AJ, Codogno P, Meijer AJ.

Autophagy. 2013 Jun 1;9(6):850-60. doi: 10.4161/auto.24083. Epub 2013 Apr 10.


No difference in glycosphingolipid metabolism and mitochondrial function in glucocorticoid-induced insulin resistance in healthy men.

Brands M, van Raalte DH, João Ferraz M, Sauerwein HP, Verhoeven AJ, Aerts JM, Diamant M, Serlie MJ.

J Clin Endocrinol Metab. 2013 Mar;98(3):1219-25. doi: 10.1210/jc.2012-3266. Epub 2013 Feb 5.


A novel flow cytometry-based platelet aggregation assay.

De Cuyper IM, Meinders M, van de Vijver E, de Korte D, Porcelijn L, de Haas M, Eble JA, Seeger K, Rutella S, Pagliara D, Kuijpers TW, Verhoeven AJ, van den Berg TK, Gutiérrez L.

Blood. 2013 Mar 7;121(10):e70-80. doi: 10.1182/blood-2012-06-437723. Epub 2013 Jan 9.


Hereditary spherocytosis due to band 3 deficiency: 15 novel mutations in SLC4A1.

Van Zwieten R, François JJ, Van Leeuwen K, Van Wesel AC, Van Bruggen R, Van Solinge WW, Roos D, Verhoeven AJ, Van Wijk R.

Am J Hematol. 2013 Feb;88(2):159-60. doi: 10.1002/ajh.23363. Epub 2012 Dec 17. No abstract available.


Potassium leakage primes stored erythrocytes for phosphatidylserine exposure and shedding of pro-coagulant vesicles.

Burger P, Kostova E, Bloem E, Hilarius-Stokman P, Meijer AB, van den Berg TK, Verhoeven AJ, de Korte D, van Bruggen R.

Br J Haematol. 2013 Feb;160(3):377-86. doi: 10.1111/bjh.12133. Epub 2012 Nov 28.


Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism.

Lombardo E, van Roomen CP, van Puijvelde GH, Ottenhoff R, van Eijk M, Aten J, Kuiper J, Overkleeft HS, Groen AK, Verhoeven AJ, Aerts JM, Bietrix F.

PLoS One. 2012;7(10):e38520. doi: 10.1371/journal.pone.0038520. Epub 2012 Oct 8.


The cholesterol content of the erythrocyte membrane is an important determinant of phosphatidylserine exposure.

van Zwieten R, Bochem AE, Hilarius PM, van Bruggen R, Bergkamp F, Hovingh GK, Verhoeven AJ.

Biochim Biophys Acta. 2012 Dec;1821(12):1493-500. doi: 10.1016/j.bbalip.2012.08.008. Epub 2012 Aug 31.


What it takes to understand and cure a living system: computational systems biology and a systems biology-driven pharmacokinetics-pharmacodynamics platform.

Swat M, Kiełbasa SM, Polak S, Olivier B, Bruggeman FJ, Tulloch MQ, Snoep JL, Verhoeven AJ, Westerhoff HV.

Interface Focus. 2011 Feb 6;1(1):16-23. doi: 10.1098/rsfs.2010.0011. Epub 2010 Dec 8.


Role of mitochondrial function in insulin resistance.

Brands M, Verhoeven AJ, Serlie MJ.

Adv Exp Med Biol. 2012;942:215-34. doi: 10.1007/978-94-007-2869-1_9.


Effects of a hypercaloric diet on β-cell responsivity in lean healthy men.

Brands M, Swat M, Lammers NM, Sauerwein HP, Endert E, Ackermans MT, Verhoeven AJ, Serlie MJ.

Clin Endocrinol (Oxf). 2013 Feb;78(2):217-25. doi: 10.1111/j.1365-2265.2012.04364.x.


Collection and storage of red blood cells with anticoagulant and additive solution with a physiologic pH.

Burger P, Korsten H, Verhoeven AJ, de Korte D, van Bruggen R.

Transfusion. 2012 Jun;52(6):1245-52. doi: 10.1111/j.1537-2995.2011.03472.x. Epub 2012 Jan 10.


Defects in Glanzmann thrombasthenia and LAD-III (LAD-1/v) syndrome: the role of integrin β1 and β3 in platelet adhesion to collagen.

van de Vijver E, De Cuyper IM, Gerrits AJ, Verhoeven AJ, Seeger K, Gutiérrez L, van den Berg TK, Kuijpers TW.

Blood. 2012 Jan 12;119(2):583-6. doi: 10.1182/blood-2011-02-337188. Epub 2011 Nov 7.


Left ventricular remodeling in swine after myocardial infarction: a transcriptional genomics approach.

Kuster DW, Merkus D, Kremer A, van Ijcken WF, de Beer VJ, Verhoeven AJ, Duncker DJ.

Basic Res Cardiol. 2011 Nov;106(6):1269-81. doi: 10.1007/s00395-011-0229-1. Epub 2011 Nov 5.


Interorgan coordination of the murine adaptive response to fasting.

Hakvoort TB, Moerland PD, Frijters R, Sokolović A, Labruyère WT, Vermeulen JL, Ver Loren van Themaat E, Breit TM, Wittink FR, van Kampen AH, Verhoeven AJ, Lamers WH, Sokolović M.

J Biol Chem. 2011 May 6;286(18):16332-43. doi: 10.1074/jbc.M110.216986. Epub 2011 Mar 10.


'Integrative Physiology 2.0': integration of systems biology into physiology and its application to cardiovascular homeostasis.

Kuster DW, Merkus D, van der Velden J, Verhoeven AJ, Duncker DJ.

J Physiol. 2011 Mar 1;589(Pt 5):1037-45. doi: 10.1113/jphysiol.2010.201533. Epub 2011 Jan 4. Review.


Nuclear protein extraction from frozen porcine myocardium.

Kuster DW, Merkus D, Jorna HJ, Dekkers DH, Duncker DJ, Verhoeven AJ.

J Physiol Biochem. 2011 Jun;67(2):165-73. doi: 10.1007/s13105-010-0059-x.


Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase.

Krijnen PA, Sipkens JA, Molling JW, Rauwerda JA, Stehouwer CD, Muller A, Paulus WJ, van Nieuw Amerongen GP, Hack CE, Verhoeven AJ, van Hinsbergh VW, Niessen HW.

J Mol Cell Cardiol. 2010 Nov;49(5):781-90. doi: 10.1016/j.yjmcc.2010.07.017. Epub 2010 Aug 5.


Curdlan-mediated regulation of human phagocyte-specific chitotriosidase.

van Eijk M, Voorn-Brouwer T, Scheij SS, Verhoeven AJ, Boot RG, Aerts JM.

FEBS Lett. 2010 Jul 16;584(14):3165-9. doi: 10.1016/j.febslet.2010.06.001. Epub 2010 Jun 10.


An improved red blood cell additive solution maintains 2,3-diphosphoglycerate and adenosine triphosphate levels by an enhancing effect on phosphofructokinase activity during cold storage.

Burger P, Korsten H, De Korte D, Rombout E, Van Bruggen R, Verhoeven AJ.

Transfusion. 2010 Nov;50(11):2386-92. doi: 10.1111/j.1537-2995.2010.02700.x.


Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice.

Bietrix F, Lombardo E, van Roomen CP, Ottenhoff R, Vos M, Rensen PC, Verhoeven AJ, Aerts JM, Groen AK.

Arterioscler Thromb Vasc Biol. 2010 May;30(5):931-7. doi: 10.1161/ATVBAHA.109.201673. Epub 2010 Feb 18.


n-3 and n-6 Polyunsaturated fatty acids suppress sterol regulatory element binding protein activity and increase flow of non-esterified cholesterol in HepG2 cells.

Di Nunzio M, van Deursen D, Verhoeven AJ, Bordoni A.

Br J Nutr. 2010 Jan;103(2):161-7. doi: 10.1017/S000711450999167X. Epub 2009 Oct 14.


Complement receptor 3, not Dectin-1, is the major receptor on human neutrophils for beta-glucan-bearing particles.

van Bruggen R, Drewniak A, Jansen M, van Houdt M, Roos D, Chapel H, Verhoeven AJ, Kuijpers TW.

Mol Immunol. 2009 Dec;47(2-3):575-81. doi: 10.1016/j.molimm.2009.09.018. Epub 2009 Oct 7.


Hb Nile[A1] and Hb Nile[A2]: novel identical [alpha77(EF6)Pro-->Ser] variants found in either the alpha1- or alpha2-globin genes.

van Zwieten R, Kaufmann JO, Vuil H, Kouwenberg J, Verhoeven AJ, Fogelberg K, Harteveld CL, Giordano PC.

Hemoglobin. 2009;33(3):188-95. doi: 10.1080/03630260903091918.


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