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Items: 1 to 50 of 62


Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity.

Budaitis BG, Jariwala S, Reinemann DN, Schimert KI, Scarabelli G, Grant BJ, Sept D, Lang MJ, Verhey KJ.

Elife. 2019 May 14;8. pii: e44146. doi: 10.7554/eLife.44146.


Acute Inhibition of Heterotrimeric Kinesin-2 Function Reveals Mechanisms of Intraflagellar Transport in Mammalian Cilia.

Engelke MF, Waas B, Kearns SE, Suber A, Boss A, Allen BL, Verhey KJ.

Curr Biol. 2019 Apr 1;29(7):1137-1148.e4. doi: 10.1016/j.cub.2019.02.043. Epub 2019 Mar 21.


Intracellular cargo transport by single-headed kinesin motors.

Schimert KI, Budaitis BG, Reinemann DN, Lang MJ, Verhey KJ.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6152-6161. doi: 10.1073/pnas.1817924116. Epub 2019 Mar 8.


Motor Dynamics Underlying Cargo Transport by Pairs of Kinesin-1 and Kinesin-3 Motors.

Arpağ G, Norris SR, Mousavi SI, Soppina V, Verhey KJ, Hancock WO, Tüzel E.

Biophys J. 2019 Mar 19;116(6):1115-1126. doi: 10.1016/j.bpj.2019.01.036. Epub 2019 Feb 5.


Polyglutamylation of tubulin's C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A.

Lessard DV, Zinder OJ, Hotta T, Verhey KJ, Ohi R, Berger CL.

J Biol Chem. 2019 Apr 19;294(16):6353-6363. doi: 10.1074/jbc.RA118.005765. Epub 2019 Feb 15.


Promoting Diversity in the Cytoskeleton through STEM-Structural Transitions and Energetics of Microtubule Subunits.

Ohi R, Verhey KJ.

Dev Cell. 2018 Oct 22;47(2):137-139. doi: 10.1016/j.devcel.2018.10.008.


MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport.

Tymanskyj SR, Yang BH, Verhey KJ, Ma L.

Elife. 2018 Aug 22;7. pii: e36374. doi: 10.7554/eLife.36374.


Autoinhibition of kinesin-1 is essential to the dendrite-specific localization of Golgi outposts.

Kelliher MT, Yue Y, Ng A, Kamiyama D, Huang B, Verhey KJ, Wildonger J.

J Cell Biol. 2018 Jul 2;217(7):2531-2547. doi: 10.1083/jcb.201708096. Epub 2018 May 4.


Dynein Engages and Disassembles Cytosol-Localized Simian Virus 40 To Promote Infection.

Ravindran MS, Spriggs CC, Verhey KJ, Tsai B.

J Virol. 2018 May 29;92(12). pii: e00353-18. doi: 10.1128/JVI.00353-18. Print 2018 Jun 15.


Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7.

Yue Y, Blasius TL, Zhang S, Jariwala S, Walker B, Grant BJ, Cochran JC, Verhey KJ.

J Cell Biol. 2018 Apr 2;217(4):1319-1334. doi: 10.1083/jcb.201708179. Epub 2018 Jan 19.


Axonemal Lumen Dominates Cytosolic Protein Diffusion inside the Primary Cilium.

Luo W, Ruba A, Takao D, Zweifel LP, Lim RYH, Verhey KJ, Yang W.

Sci Rep. 2017 Nov 17;7(1):15793. doi: 10.1038/s41598-017-16103-z.


Protein Interaction Analysis Provides a Map of the Spatial and Temporal Organization of the Ciliary Gating Zone.

Takao D, Wang L, Boss A, Verhey KJ.

Curr Biol. 2017 Aug 7;27(15):2296-2306.e3. doi: 10.1016/j.cub.2017.06.044. Epub 2017 Jul 20.


Exploiting the kinesin-1 molecular motor to generate a virus membrane penetration site.

Ravindran MS, Engelke MF, Verhey KJ, Tsai B.

Nat Commun. 2017 May 24;8:15496. doi: 10.1038/ncomms15496.


The MgcRacGAP SxIP motif tethers Centralspindlin to microtubule plus ends in Xenopus laevis.

Breznau EB, Murt M, Blasius TL, Verhey KJ, Miller AL.

J Cell Sci. 2017 May 15;130(10):1809-1821. doi: 10.1242/jcs.195891. Epub 2017 Apr 7.


Dual Chromatin and Cytoskeletal Remodeling by SETD2.

Park IY, Powell RT, Tripathi DN, Dere R, Ho TH, Blasius TL, Chiang YC, Davis IJ, Fahey CC, Hacker KE, Verhey KJ, Bedford MT, Jonasch E, Rathmell WK, Walker CL.

Cell. 2016 Aug 11;166(4):950-962. doi: 10.1016/j.cell.2016.07.005.


Methods for Studying Ciliary Import Mechanisms.

Takao D, Verhey KJ.

Methods Mol Biol. 2016;1454:1-14. doi: 10.1007/978-1-4939-3789-9_1.


Permeability barriers for generating a unique ciliary protein and lipid composition.

Verhey KJ, Yang W.

Curr Opin Cell Biol. 2016 Aug;41:109-16. doi: 10.1016/ Epub 2016 May 25. Review.


Engineered kinesin motor proteins amenable to small-molecule inhibition.

Engelke MF, Winding M, Yue Y, Shastry S, Teloni F, Reddy S, Blasius TL, Soppina P, Hancock WO, Gelfand VI, Verhey KJ.

Nat Commun. 2016 Apr 5;7:11159. doi: 10.1038/ncomms11159.


KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons.

Padzik A, Deshpande P, Hollos P, Franker M, Rannikko EH, Cai D, Prus P, Mågård M, Westerlund N, Verhey KJ, James P, Hoogenraad CC, Coffey ET.

Front Cell Neurosci. 2016 Mar 15;10:57. doi: 10.3389/fncel.2016.00057. eCollection 2016.


Mapping the Processivity Determinants of the Kinesin-3 Motor Domain.

Scarabelli G, Soppina V, Yao XQ, Atherton J, Moores CA, Verhey KJ, Grant BJ.

Biophys J. 2015 Oct 20;109(8):1537-40. doi: 10.1016/j.bpj.2015.08.027.


Gated entry into the ciliary compartment.

Takao D, Verhey KJ.

Cell Mol Life Sci. 2016 Jan;73(1):119-27. Review.


Influence of fluorescent tag on the motility properties of kinesin-1 in single-molecule assays.

Norris SR, Núñez MF, Verhey KJ.

Biophys J. 2015 Mar 10;108(5):1133-43. doi: 10.1016/j.bpj.2015.01.031.


The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.

Carpenter BS, Barry RL, Verhey KJ, Allen BL.

J Cell Sci. 2015 Mar 1;128(5):1034-50. doi: 10.1242/jcs.162552. Epub 2015 Jan 14.


A method for multiprotein assembly in cells reveals independent action of kinesins in complex.

Norris SR, Soppina V, Dizaji AS, Schimert KI, Sept D, Cai D, Sivaramakrishnan S, Verhey KJ.

J Cell Biol. 2014 Nov 10;207(3):393-406. doi: 10.1083/jcb.201407086. Epub 2014 Nov 3.


An assay for clogging the ciliary pore complex distinguishes mechanisms of cytosolic and membrane protein entry.

Takao D, Dishinger JF, Kee HL, Pinskey JM, Allen BL, Verhey KJ.

Curr Biol. 2014 Oct 6;24(19):2288-94. doi: 10.1016/j.cub.2014.08.012. Epub 2014 Sep 25.


Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells.

Broekhuis JR, Verhey KJ, Jansen G.

PLoS One. 2014 Sep 22;9(9):e108470. doi: 10.1371/journal.pone.0108470. eCollection 2014.


Effects of α-tubulin K40 acetylation and detyrosination on kinesin-1 motility in a purified system.

Kaul N, Soppina V, Verhey KJ.

Biophys J. 2014 Jun 17;106(12):2636-43. doi: 10.1016/j.bpj.2014.05.008.


The family-specific K-loop influences the microtubule on-rate but not the superprocessivity of kinesin-3 motors.

Soppina V, Verhey KJ.

Mol Biol Cell. 2014 Jul 15;25(14):2161-70. doi: 10.1091/mbc.E14-01-0696. Epub 2014 May 21.


Dimerization of mammalian kinesin-3 motors results in superprocessive motion.

Soppina V, Norris SR, Dizaji AS, Kortus M, Veatch S, Peckham M, Verhey KJ.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5562-7. doi: 10.1073/pnas.1400759111. Epub 2014 Apr 2.


Recycling of kinesin-1 motors by diffusion after transport.

Blasius TL, Reed N, Slepchenko BM, Verhey KJ.

PLoS One. 2013 Sep 30;8(9):e76081. doi: 10.1371/journal.pone.0076081. eCollection 2013.


Molecular connections between nuclear and ciliary import processes.

Kee HL, Verhey KJ.

Cilia. 2013 Aug 28;2(1):11. doi: 10.1186/2046-2530-2-11.


Analysis of ciliary import.

Dishinger JF, Kee HL, Verhey KJ.

Methods Enzymol. 2013;524:75-89. doi: 10.1016/B978-0-12-397945-2.00005-6.


Luminal localization of α-tubulin K40 acetylation by cryo-EM analysis of fab-labeled microtubules.

Soppina V, Herbstman JF, Skiniotis G, Verhey KJ.

PLoS One. 2012;7(10):e48204. doi: 10.1371/journal.pone.0048204. Epub 2012 Oct 26.


A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia.

Kee HL, Dishinger JF, Blasius TL, Liu CJ, Margolis B, Verhey KJ.

Nat Cell Biol. 2012 Mar 4;14(4):431-7. doi: 10.1038/ncb2450.


Induction of Ran GTP drives ciliogenesis.

Fan S, Whiteman EL, Hurd TW, McIntyre JC, Dishinger JF, Liu CJ, Martens JR, Verhey KJ, Sajjan U, Margolis B.

Mol Biol Cell. 2011 Dec;22(23):4539-48. doi: 10.1091/mbc.E11-03-0267. Epub 2011 Oct 12.


Kinesin motors and primary cilia.

Verhey KJ, Dishinger J, Kee HL.

Biochem Soc Trans. 2011 Oct;39(5):1120-5. doi: 10.1042/BST0391120. Review.


Kinesin assembly and movement in cells.

Verhey KJ, Kaul N, Soppina V.

Annu Rev Biophys. 2011;40:267-88. doi: 10.1146/annurev-biophys-042910-155310. Review.


ER sliding dynamics and ER-mitochondrial contacts occur on acetylated microtubules.

Friedman JR, Webster BM, Mastronarde DN, Verhey KJ, Voeltz GK.

J Cell Biol. 2010 Aug 9;190(3):363-75. doi: 10.1083/jcb.200911024.


Recording single motor proteins in the cytoplasm of mammalian cells.

Cai D, Kaul N, Lionberger TA, Wiener DM, Verhey KJ, Meyhofer E.

Methods Enzymol. 2010;475:81-107. doi: 10.1016/S0076-6879(10)75004-7.


Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms.

Hammond JW, Blasius TL, Soppina V, Cai D, Verhey KJ.

J Cell Biol. 2010 Jun 14;189(6):1013-25. doi: 10.1083/jcb.201001057. Epub 2010 Jun 7.


Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP.

Dishinger JF, Kee HL, Jenkins PM, Fan S, Hurd TW, Hammond JW, Truong YN, Margolis B, Martens JR, Verhey KJ.

Nat Cell Biol. 2010 Jul;12(7):703-10. doi: 10.1038/ncb2073. Epub 2010 Jun 6.


Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons.

Hammond JW, Huang CF, Kaech S, Jacobson C, Banker G, Verhey KJ.

Mol Biol Cell. 2010 Feb 15;21(4):572-83. doi: 10.1091/mbc.E09-01-0044. Epub 2009 Dec 23.


Traffic control: regulation of kinesin motors.

Verhey KJ, Hammond JW.

Nat Rev Mol Cell Biol. 2009 Nov;10(11):765-77. doi: 10.1038/nrm2782. Review.


Single molecule imaging reveals differences in microtubule track selection between Kinesin motors.

Cai D, McEwen DP, Martens JR, Meyhofer E, Verhey KJ.

PLoS Biol. 2009 Oct;7(10):e1000216. doi: 10.1371/journal.pbio.1000216. Epub 2009 Oct 13.


A lipid receptor sorts polyomavirus from the endolysosome to the endoplasmic reticulum to cause infection.

Qian M, Cai D, Verhey KJ, Tsai B.

PLoS Pathog. 2009 Jun;5(6):e1000465. doi: 10.1371/journal.ppat.1000465. Epub 2009 Jun 5.


Mammalian Kinesin-3 motors are dimeric in vivo and move by processive motility upon release of autoinhibition.

Hammond JW, Cai D, Blasius TL, Li Z, Jiang Y, Jih GT, Meyhofer E, Verhey KJ.

PLoS Biol. 2009 Mar 31;7(3):e72. doi: 10.1371/journal.pbio.1000072.


Co-operative versus independent transport of different cargoes by Kinesin-1.

Hammond JW, Griffin K, Jih GT, Stuckey J, Verhey KJ.

Traffic. 2008 May;9(5):725-41. doi: 10.1111/j.1600-0854.2008.00722.x. Epub 2008 Feb 11.


Tubulin modifications and their cellular functions.

Hammond JW, Cai D, Verhey KJ.

Curr Opin Cell Biol. 2008 Feb;20(1):71-6. doi: 10.1016/ Epub 2008 Jan 15. Review.


Motor proteins: trafficking and signaling collide.

Verhey KJ.

Curr Biol. 2007 Sep 18;17(18):R804-6.


The tubulin code.

Verhey KJ, Gaertig J.

Cell Cycle. 2007 Sep 1;6(17):2152-60. Epub 2007 Jun 26. Review.


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