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The Effects of Sindbis Viral Vectors on Neuronal Function.

Uyaniker S, van der Spek SJF, Reinders NR, Xiong H, Li KW, Bossers K, Smit AB, Verhaagen J, Kessels HW.

Front Cell Neurosci. 2019 Aug 8;13:362. doi: 10.3389/fncel.2019.00362. eCollection 2019.


Enhanced regeneration and reinnervation following timed GDNF gene therapy in a cervical ventral root avulsion.

Eggers R, de Winter F, Arkenaar C, Tannemaat MR, Verhaagen J.

Exp Neurol. 2019 Nov;321:113037. doi: 10.1016/j.expneurol.2019.113037. Epub 2019 Aug 16.


Recent advances in the therapeutic uses of chondroitinase ABC.

Muir E, De Winter F, Verhaagen J, Fawcett J.

Exp Neurol. 2019 Nov;321:113032. doi: 10.1016/j.expneurol.2019.113032. Epub 2019 Aug 6. Review.


Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis.

Melief J, Orre M, Bossers K, van Eden CG, Schuurman KG, Mason MRJ, Verhaagen J, Hamann J, Huitinga I.

Acta Neuropathol Commun. 2019 Apr 25;7(1):60. doi: 10.1186/s40478-019-0705-7.


Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex.

Boggio EM, Ehlert EM, Lupori L, Moloney EB, De Winter F, Vander Kooi CW, Baroncelli L, Mecollari V, Blits B, Fawcett JW, Verhaagen J, Pizzorusso T.

Mol Neurobiol. 2019 Sep;56(9):5987-5997. doi: 10.1007/s12035-019-1499-0. Epub 2019 Jan 31.


Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration.

Eggers R, de Winter F, Hoyng SA, Hoeben RC, Malessy MJA, Tannemaat MR, Verhaagen J.

Brain. 2019 Feb 1;142(2):295-311. doi: 10.1093/brain/awy340.


Early growth response-1 regulates acetylcholinesterase and its relation with the course of Alzheimer's disease.

Hu YT, Chen XL, Huang SH, Zhu QB, Yu SY, Shen Y, Sluiter A, Verhaagen J, Zhao J, Swaab D, Bao AM.

Brain Pathol. 2019 Jul;29(4):502-512. doi: 10.1111/bpa.12688. Epub 2019 Mar 24.


Intrinsic Determinants of Axon Regeneration.

Fawcett JW, Verhaagen J.

Dev Neurobiol. 2018 Oct;78(10):890-897. doi: 10.1002/dneu.22637. Epub 2018 Oct 21.


Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury.

Burnside ER, De Winter F, Didangelos A, James ND, Andreica EC, Layard-Horsfall H, Muir EM, Verhaagen J, Bradbury EJ.

Brain. 2018 Aug 1;141(8):2362-2381. doi: 10.1093/brain/awy158.


Mesenchymal Stem Cell-Macrophage Choreography Supporting Spinal Cord Repair.

Maldonado-Lasunción I, Verhaagen J, Oudega M.

Neurotherapeutics. 2018 Jul;15(3):578-587. doi: 10.1007/s13311-018-0629-0. Review.


The Dorsal Column Lesion Model of Spinal Cord Injury and Its Use in Deciphering the Neuron-Intrinsic Injury Response.

Attwell CL, van Zwieten M, Verhaagen J, Mason MRJ.

Dev Neurobiol. 2018 Oct;78(10):926-951. doi: 10.1002/dneu.22601. Epub 2018 May 11. Review.


Integrins promote axonal regeneration after injury of the nervous system.

Nieuwenhuis B, Haenzi B, Andrews MR, Verhaagen J, Fawcett JW.

Biol Rev Camb Philos Soc. 2018 Aug;93(3):1339-1362. doi: 10.1111/brv.12398. Epub 2018 Feb 15. Review.


Small Scale Production of Recombinant Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System.

Verhaagen J, Hobo B, Ehlert EME, Eggers R, Korecka JA, Hoyng SA, Attwell CL, Harvey AR, Mason MRJ.

Methods Mol Biol. 2018;1715:3-17. doi: 10.1007/978-1-4939-7522-8_1.


Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease.

Korecka JA, Moloney EB, Eggers R, Hobo B, Scheffer S, Ras-Verloop N, Pasterkamp RJ, Swaab DF, Smit AB, van Kesteren RE, Bossers K, Verhaagen J.

J Neurosci. 2017 Sep 27;37(39):9361-9379. doi: 10.1523/JNEUROSCI.0084-17.2017. Epub 2017 Aug 21.


Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent.

Andrews MR, Soleman S, Cheah M, Tumbarello DA, Mason MR, Moloney E, Verhaagen J, Bensadoun JC, Schneider B, Aebischer P, Fawcett JW.

eNeuro. 2016 Jul 27;3(4). pii: ENEURO.0029-16.2016. doi: 10.1523/ENEURO.0029-16.2016. eCollection 2016 Jul-Aug.


Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface.

O'Neill P, Lindsay SL, Pantiru A, Guimond SE, Fagoe N, Verhaagen J, Turnbull JE, Riddell JS, Barnett SC.

Glia. 2017 Jan;65(1):19-33. doi: 10.1002/glia.23047. Epub 2016 Aug 18.


Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord.

Cheah M, Andrews MR, Chew DJ, Moloney EB, Verhaagen J, Fässler R, Fawcett JW.

J Neurosci. 2016 Jul 6;36(27):7283-97. doi: 10.1523/JNEUROSCI.0901-16.2016.


The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity.

de Winter F, Kwok JC, Fawcett JW, Vo TT, Carulli D, Verhaagen J.

Neural Plast. 2016;2016:3679545. doi: 10.1155/2016/3679545. Epub 2016 Jan 14. Review.


Evaluation of Five Tests for Sensitivity to Functional Deficits following Cervical or Thoracic Dorsal Column Transection in the Rat.

Fagoe ND, Attwell CL, Eggers R, Tuinenbreijer L, Kouwenhoven D, Verhaagen J, Mason MR.

PLoS One. 2016 Mar 2;11(3):e0150141. doi: 10.1371/journal.pone.0150141. eCollection 2016.


Differential myofiber-type transduction preference of adeno-associated virus serotypes 6 and 9.

Riaz M, Raz Y, Moloney EB, van Putten M, Krom YD, van der Maarel SM, Verhaagen J, Raz V.

Skelet Muscle. 2015 Nov 10;5:37. doi: 10.1186/s13395-015-0064-4. eCollection 2015.


Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models.

Huang Y, Skwarek-Maruszewska A, Horré K, Vandewyer E, Wolfs L, Snellinx A, Saito T, Radaelli E, Corthout N, Colombelli J, Lo AC, Van Aerschot L, Callaerts-Vegh Z, Trabzuni D, Bossers K, Verhaagen J, Ryten M, Munck S, D'Hooge R, Swaab DF, Hardy J, Saido TC, De Strooper B, Thathiah A.

Sci Transl Med. 2015 Oct 14;7(309):309ra164. doi: 10.1126/scitranslmed.aab3492.


Clinical and neurobiological advances in promoting regeneration of the ventral root avulsion lesion.

Eggers R, Tannemaat MR, De Winter F, Malessy MJ, Verhaagen J.

Eur J Neurosci. 2016 Feb;43(3):318-35. doi: 10.1111/ejn.13089. Epub 2015 Oct 29. Review.


Overexpression of ATF3 or the combination of ATF3, c-Jun, STAT3 and Smad1 promotes regeneration of the central axon branch of sensory neurons but without synergistic effects.

Fagoe ND, Attwell CL, Kouwenhoven D, Verhaagen J, Mason MR.

Hum Mol Genet. 2015 Dec 1;24(23):6788-800. doi: 10.1093/hmg/ddv383. Epub 2015 Sep 18.


Gene therapy and peripheral nerve repair: a perspective.

Hoyng SA, de Winter F, Tannemaat MR, Blits B, Malessy MJ, Verhaagen J.

Front Mol Neurosci. 2015 Jul 15;8:32. doi: 10.3389/fnmol.2015.00032. eCollection 2015.


Human Neuroma-in-Continuity Contains Focal Deficits in Myelination.

van Vliet AC, Tannemaat MR, van Duinen SG, Verhaagen J, Malessy MJ, De Winter F.

J Neuropathol Exp Neurol. 2015 Sep;74(9):901-11. doi: 10.1097/NEN.0000000000000229.


Chondroitinase gene therapy improves upper limb function following cervical contusion injury.

James ND, Shea J, Muir EM, Verhaagen J, Schneider BL, Bradbury EJ.

Exp Neurol. 2015 Sep;271:131-5. doi: 10.1016/j.expneurol.2015.05.022. Epub 2015 Jun 1.


Genetic Deletion of the Transcriptional Repressor NFIL3 Enhances Axon Growth In Vitro but Not Axonal Repair In Vivo.

van der Kallen LR, Eggers R, Ehlert EM, Verhaagen J, Smit AB, van Kesteren RE.

PLoS One. 2015 May 20;10(5):e0127163. doi: 10.1371/journal.pone.0127163. eCollection 2015.


Gene delivery to rat and human Schwann cells and nerve segments: a comparison of AAV 1-9 and lentiviral vectors.

Hoyng SA, De Winter F, Gnavi S, van Egmond L, Attwell CL, Tannemaat MR, Verhaagen J, Malessy MJ.

Gene Ther. 2015 Oct;22(10):767-80. doi: 10.1038/gt.2015.47. Epub 2015 May 4.


A perspective on the role of class III semaphorin signaling in central nervous system trauma.

Mecollari V, Nieuwenhuis B, Verhaagen J.

Front Cell Neurosci. 2014 Oct 27;8:328. doi: 10.3389/fncel.2014.00328. eCollection 2014. Review.


A role for neuropilins in the interaction between Schwann cells and meningeal cells.

Roet KC, Wirz KT, Franssen EH, Verhaagen J.

PLoS One. 2014 Oct 14;9(10):e109401. doi: 10.1371/journal.pone.0109401. eCollection 2014.


Spinal cord injury and the neuron-intrinsic regeneration-associated gene program.

Fagoe ND, van Heest J, Verhaagen J.

Neuromolecular Med. 2014 Dec;16(4):799-813. doi: 10.1007/s12017-014-8329-3. Epub 2014 Oct 1.


ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease.

Moloney EB, de Winter F, Verhaagen J.

Front Neurosci. 2014 Aug 14;8:252. doi: 10.3389/fnins.2014.00252. eCollection 2014. Review.


A comparative morphological, electrophysiological and functional analysis of axon regeneration through peripheral nerve autografts genetically modified to overexpress BDNF, CNTF, GDNF, NGF, NT3 or VEGF.

Hoyng SA, De Winter F, Gnavi S, de Boer R, Boon LI, Korvers LM, Tannemaat MR, Malessy MJ, Verhaagen J.

Exp Neurol. 2014 Nov;261:578-93. doi: 10.1016/j.expneurol.2014.08.002. Epub 2014 Aug 12.


Schwann cells transduced with a lentiviral vector encoding Fgf-2 promote motor neuron regeneration following sciatic nerve injury.

Allodi I, Mecollari V, González-Pérez F, Eggers R, Hoyng S, Verhaagen J, Navarro X, Udina E.

Glia. 2014 Oct;62(10):1736-46. doi: 10.1002/glia.22712. Epub 2014 Jul 2.


Understanding the neural repair-promoting properties of olfactory ensheathing cells.

Roet KC, Verhaagen J.

Exp Neurol. 2014 Nov;261:594-609. doi: 10.1016/j.expneurol.2014.05.007. Epub 2014 May 17. Review.


Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury.

Bartus K, James ND, Didangelos A, Bosch KD, Verhaagen J, Yáñez-Muñoz RJ, Rogers JH, Schneider BL, Muir EM, Bradbury EJ.

J Neurosci. 2014 Apr 2;34(14):4822-36. doi: 10.1523/JNEUROSCI.4369-13.2014.


Developing a potentially immunologically inert tetracycline-regulatable viral vector for gene therapy in the peripheral nerve.

Hoyng SA, Gnavi S, de Winter F, Eggers R, Ozawa T, Zaldumbide A, Hoeben RC, Malessy MJ, Verhaagen J.

Gene Ther. 2014 Jun;21(6):549-57. doi: 10.1038/gt.2014.22. Epub 2014 Apr 3.


Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A.

Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK, Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V.

PLoS Biol. 2014 Mar 11;12(3):e1001808. doi: 10.1371/journal.pbio.1001808. eCollection 2014 Mar.


AAV vector-mediated secretion of chondroitinase provides a sensitive tracer for axonal arborisations.

Alves JN, Muir EM, Andrews MR, Ward A, Michelmore N, Dasgupta D, Verhaagen J, Moloney EB, Keynes RJ, Fawcett JW, Rogers JH.

J Neurosci Methods. 2014 Apr 30;227:107-20. doi: 10.1016/j.jneumeth.2014.02.010. Epub 2014 Feb 28.


Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa.

Alves CH, Pellissier LP, Vos RM, Garcia Garrido M, Sothilingam V, Seide C, Beck SC, Klooster J, Furukawa T, Flannery JG, Verhaagen J, Seeliger MW, Wijnholds J.

Hum Mol Genet. 2014 Jul 1;23(13):3384-401. doi: 10.1093/hmg/ddu048. Epub 2014 Feb 2.


Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background.

Alves CH, Bossers K, Vos RM, Essing AH, Swagemakers S, van der Spek PJ, Verhaagen J, Wijnholds J.

PLoS One. 2013 Dec 6;8(12):e82532. doi: 10.1371/journal.pone.0082532. eCollection 2013.


A compact dual promoter adeno-associated viral vector for efficient delivery of two genes to dorsal root ganglion neurons.

Fagoe ND, Eggers R, Verhaagen J, Mason MR.

Gene Ther. 2014 Mar;21(3):242-52. doi: 10.1038/gt.2013.71. Epub 2013 Nov 28.


Misdirection and guidance of regenerating axons after experimental nerve injury and repair.

de Ruiter GC, Spinner RJ, Verhaagen J, Malessy MJ.

J Neurosurg. 2014 Feb;120(2):493-501. doi: 10.3171/2013.8.JNS122300. Epub 2013 Oct 11. Review.


Early molecular changes in Alzheimer disease: can we catch the disease in its presymptomatic phase?

Wirz KT, Keitel S, Swaab DF, Verhaagen J, Bossers K.

J Alzheimers Dis. 2014;38(4):719-40. doi: 10.3233/JAD-130920. Review.


Alteration of the microRNA network during the progression of Alzheimer's disease.

Lau P, Bossers K, Janky R, Salta E, Frigerio CS, Barbash S, Rothman R, Sierksma AS, Thathiah A, Greenberg D, Papadopoulou AS, Achsel T, Ayoubi T, Soreq H, Verhaagen J, Swaab DF, Aerts S, De Strooper B.

EMBO Mol Med. 2013 Oct;5(10):1613-34. doi: 10.1002/emmm.201201974. Epub 2013 Sep 9.


Wnt signaling through the Ror receptor in the nervous system.

Petrova IM, Malessy MJ, Verhaagen J, Fradkin LG, Noordermeer JN.

Mol Neurobiol. 2014 Feb;49(1):303-15. doi: 10.1007/s12035-013-8520-9. Epub 2013 Aug 30. Review.


Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B.

Petrova IM, Lahaye LL, Martiáñez T, de Jong AW, Malessy MJ, Verhaagen J, Noordermeer JN, Fradkin LG.

Mol Cell Biol. 2013 Oct;33(20):4116-27. doi: 10.1128/MCB.00169-13. Epub 2013 Aug 26.


Lentiviral vector-mediated gradients of GDNF in the injured peripheral nerve: effects on nerve coil formation, Schwann cell maturation and myelination.

Eggers R, de Winter F, Hoyng SA, Roet KC, Ehlert EM, Malessy MJ, Verhaagen J, Tannemaat MR.

PLoS One. 2013 Aug 12;8(8):e71076. doi: 10.1371/journal.pone.0071076. eCollection 2013.


Immunohistochemical, ultrastructural and functional analysis of axonal regeneration through peripheral nerve grafts containing Schwann cells expressing BDNF, CNTF or NT3.

Godinho MJ, Teh L, Pollett MA, Goodman D, Hodgetts SI, Sweetman I, Walters M, Verhaagen J, Plant GW, Harvey AR.

PLoS One. 2013 Aug 9;8(8):e69987. doi: 10.1371/journal.pone.0069987. eCollection 2013.

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