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Items: 1 to 50 of 173

1.

The interplay between genetic risk factors and proteolytic dysregulation in the pathophysiology of inflammatory bowel disease.

Solà Tapias N, Vergnolle N, Denadai-Souza A, Barreau F.

J Crohns Colitis. 2020 Feb 22. pii: jjaa033. doi: 10.1093/ecco-jcc/jjaa033. [Epub ahead of print]

PMID:
32090263
2.

Revisiting the Hallmarks of Aging to Identify Markers of Biological Age.

Guerville F, De Souto Barreto P, Ader I, Andrieu S, Casteilla L, Dray C, Fazilleau N, Guyonnet S, Langin D, Liblau R, Parini A, Valet P, Vergnolle N, Rolland Y, Vellas B.

J Prev Alzheimers Dis. 2020;7(1):56-64. doi: 10.14283/jpad.2019.50.

PMID:
32010927
3.

Sexual dimorphism in PAR2-dependent regulation of primitive colonic cells.

Noguerol J, Roustan PJ, N'Taye M, Delcombel L, Rolland C, Guiraud L, Sagnat D, Edir A, Bonnart C, Denadai-Souza A, Deraison C, Vergnolle N, Racaud-Sultan C.

Biol Sex Differ. 2019 Sep 6;10(1):47. doi: 10.1186/s13293-019-0262-6.

4.

Active thrombin produced by the intestinal epithelium controls mucosal biofilms.

Motta JP, Denadai-Souza A, Sagnat D, Guiraud L, Edir A, Bonnart C, Sebbag M, Rousset P, Lapeyre A, Seguy C, Mathurine-Thomas N, Galipeau HJ, Bonnet D, Alric L, Buret AG, Wallace JL, Dufour A, Verdu EF, Hollenberg MD, Oswald E, Serino M, Deraison C, Vergnolle N.

Nat Commun. 2019 Jul 19;10(1):3224. doi: 10.1038/s41467-019-11140-w.

5.

Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner.

Rincel M, Aubert P, Chevalier J, Grohard PA, Basso L, Monchaux de Oliveira C, Helbling JC, Lévy É, Chevalier G, Leboyer M, Eberl G, Layé S, Capuron L, Vergnolle N, Neunlist M, Boudin H, Lepage P, Darnaudéry M.

Brain Behav Immun. 2019 Aug;80:179-192. doi: 10.1016/j.bbi.2019.03.006. Epub 2019 Mar 11.

PMID:
30872090
6.

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2.

Caminero A, McCarville JL, Galipeau HJ, Deraison C, Bernier SP, Constante M, Rolland C, Meisel M, Murray JA, Yu XB, Alaedini A, Coombes BK, Bercik P, Southward CM, Ruf W, Jabri B, Chirdo FG, Casqueiro J, Surette MG, Vergnolle N, Verdu EF.

Nat Commun. 2019 Mar 13;10(1):1198. doi: 10.1038/s41467-019-09037-9.

7.

FAK alternative splice mRNA variants expression pattern in colorectal cancer.

Devaud C, Tilkin-Mariamé AF, Vignolle-Vidoni A, Souleres P, Denadai-Souza A, Rolland C, Duthoit C, Blanpied C, Chabot S, Bouillé P, Lluel P, Vergnolle N, Racaud-Sultan C, Ferrand A.

Int J Cancer. 2019 Jul 15;145(2):494-502. doi: 10.1002/ijc.32120. Epub 2019 Feb 14.

8.

5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D.

Bautzova T, Hockley JRF, Perez-Berezo T, Pujo J, Tranter MM, Desormeaux C, Barbaro MR, Basso L, Le Faouder P, Rolland C, Malapert P, Moqrich A, Eutamene H, Denadai-Souza A, Vergnolle N, Smith ESJ, Hughes DI, Barbara G, Dietrich G, Bulmer DC, Cenac N.

Sci Signal. 2018 Dec 18;11(561). pii: eaal2171. doi: 10.1126/scisignal.aal2171.

9.

Aluminum Ingestion Promotes Colorectal Hypersensitivity in Rodents.

Esquerre N, Basso L, Dubuquoy C, Djouina M, Chappard D, Blanpied C, Desreumaux P, Vergnolle N, Vignal C, Body-Malapel M.

Cell Mol Gastroenterol Hepatol. 2018 Sep 20;7(1):185-196. doi: 10.1016/j.jcmgh.2018.09.012. eCollection 2019.

10.

Sustainable Positive Response to Sirolimus in Juvenile Polyposis of Infancy.

Quaranta M, Laborde N, Ferrand A, Danjoux M, Vergnolle N, Barreau F, Racaud-Sultan C, Mas E.

J Pediatr Gastroenterol Nutr. 2019 Feb;68(2):e38-e40. doi: 10.1097/MPG.0000000000002179. No abstract available.

PMID:
30334931
11.

Young GI angle: My biggest (career) mistake.

Fichna J, Vergnolle N, Rooman I.

United European Gastroenterol J. 2018 Oct;6(8):1278-1279. doi: 10.1177/2050640618803045. Epub 2018 Sep 30. No abstract available.

12.

Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1- and protease-activated receptor 4-dependent mechanism.

Sébert M, Denadai-Souza A, Quaranta M, Racaud-Sultan C, Chabot S, Lluel P, Monjotin N, Alric L, Portier G, Kirzin S, Bonnet D, Ferrand A, Vergnolle N.

Br J Pharmacol. 2018 Sep;175(18):3656-3668. doi: 10.1111/bph.14430. Epub 2018 Aug 7.

13.

Neurons and Glia in the Enteric Nervous System and Epithelial Barrier Function.

Vergnolle N, Cirillo C.

Physiology (Bethesda). 2018 Jul 1;33(4):269-280. doi: 10.1152/physiol.00009.2018. Review.

14.

Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease.

Denadai-Souza A, Bonnart C, Tapias NS, Marcellin M, Gilmore B, Alric L, Bonnet D, Burlet-Schiltz O, Hollenberg MD, Vergnolle N, Deraison C.

Sci Rep. 2018 May 18;8(1):7834. doi: 10.1038/s41598-018-26282-y.

15.

Protease-activated receptor 1 is implicated in irritable bowel syndrome mediators-induced signaling to thoracic human sensory neurons.

Desormeaux C, Bautzova T, Garcia-Caraballo S, Rolland C, Barbaro MR, Brierley SM, Barbara G, Vergnolle N, Cenac N.

Pain. 2018 Jul;159(7):1257-1267. doi: 10.1097/j.pain.0000000000001208.

PMID:
29554016
16.

Mobilization of CD4+ T lymphocytes in inflamed mucosa reduces pain in colitis mice: toward a vaccinal strategy to alleviate inflammatory visceral pain.

Basso L, Boué J, Augé C, Deraison C, Blanpied C, Cenac N, Lluel P, Vergnolle N, Dietrich G.

Pain. 2018 Feb;159(2):331-341. doi: 10.1097/j.pain.0000000000001103.

PMID:
29140925
17.

Protease-activated receptor 2 contributes to Toxoplasma gondii-mediated gut inflammation.

Bonnart C, Feuillet G, Vasseur V, Cenac N, Vergnolle N, Blanchard N.

Parasite Immunol. 2017 Nov;39(11). doi: 10.1111/pim.12489. Epub 2017 Sep 27.

18.

Using murine colitis models to analyze probiotics-host interactions.

Martín R, Chain F, Miquel S, Motta JP, Vergnolle N, Sokol H, Langella P.

FEMS Microbiol Rev. 2017 Aug 1;41(Supp_1):S49-S70. doi: 10.1093/femsre/fux035. Review.

PMID:
28830096
19.

Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT).

Bashashati M, Fichna J, Piscitelli F, Capasso R, Izzo AA, Sibaev A, Timmermans JP, Cenac N, Vergnolle N, Di Marzo V, Storr M.

Neurogastroenterol Motil. 2017 Dec;29(12). doi: 10.1111/nmo.13148. Epub 2017 Jul 11.

PMID:
28695708
20.

Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study.

Denadai-Souza A, Ribeiro CM, Rolland C, Thouard A, Deraison C, Scavone C, Gonzalez-Dunia D, Vergnolle N, Avellar MCW.

Arthritis Res Ther. 2017 Jun 6;19(1):124. doi: 10.1186/s13075-017-1326-9.

21.

Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection.

Gobbetti T, Dalli J, Colas RA, Federici Canova D, Aursnes M, Bonnet D, Alric L, Vergnolle N, Deraison C, Hansen TV, Serhan CN, Perretti M.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3963-3968. doi: 10.1073/pnas.1617290114. Epub 2017 Mar 29.

22.

Epithelial expression and function of trypsin-3 in irritable bowel syndrome.

Rolland-Fourcade C, Denadai-Souza A, Cirillo C, Lopez C, Jaramillo JO, Desormeaux C, Cenac N, Motta JP, Larauche M, Taché Y, Vanden Berghe P, Neunlist M, Coron E, Kirzin S, Portier G, Bonnet D, Alric L, Vanner S, Deraison C, Vergnolle N.

Gut. 2017 Oct;66(10):1767-1778. doi: 10.1136/gutjnl-2016-312094. Epub 2017 Jan 17.

23.

Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis harra through GSK3β regulation in intestinal cells.

Nasri I, Chawech R, Girardi C, Mas E, Ferrand A, Vergnolle N, Fabre N, Mezghani-Jarraya R, Racaud-Sultan C.

Pharm Biol. 2017 Dec;55(1):124-131. Epub 2016 Sep 22.

24.

PAR2-dependent activation of GSK3β regulates the survival of colon stem/progenitor cells.

Nasri I, Bonnet D, Zwarycz B, d'Aldebert E, Khou S, Mezghani-Jarraya R, Quaranta M, Rolland C, Bonnart C, Mas E, Ferrand A, Cenac N, Magness S, Van Landeghem L, Vergnolle N, Racaud-Sultan C.

Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G221-36. doi: 10.1152/ajpgi.00328.2015. Epub 2016 Jun 16.

25.

Endogenous analgesia mediated by CD4(+) T lymphocytes is dependent on enkephalins in mice.

Basso L, Boué J, Mahiddine K, Blanpied C, Robiou-du-Pont S, Vergnolle N, Deraison C, Dietrich G.

J Neuroinflammation. 2016 Jun 1;13(1):132. doi: 10.1186/s12974-016-0591-x.

26.

Protease inhibition as new therapeutic strategy for GI diseases.

Vergnolle N.

Gut. 2016 Jul;65(7):1215-24. doi: 10.1136/gutjnl-2015-309147. Epub 2016 Apr 12. Review.

27.

The Intestinal Microenvironment and Functional Gastrointestinal Disorders.

Barbara G, Feinle-Bisset C, Ghoshal UC, Quigley EM, Santos J, Vanner S, Vergnolle N, Zoetendal EG.

Gastroenterology. 2016 Feb 18. pii: S0016-5085(16)00219-5. doi: 10.1053/j.gastro.2016.02.028. [Epub ahead of print]

PMID:
27144620
28.

The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn's disease.

Coquenlorge S, Van Landeghem L, Jaulin J, Cenac N, Vergnolle N, Duchalais E, Neunlist M, Rolli-Derkinderen M.

Sci Rep. 2016 May 3;6:25203. doi: 10.1038/srep25203.

29.

F16357, a novel protease-activated receptor 1 antagonist, improves urodynamic parameters in a rat model of interstitial cystitis.

Monjotin N, Gillespie J, Farrié M, Le Grand B, Junquero D, Vergnolle N.

Br J Pharmacol. 2016 Jul;173(14):2224-36. doi: 10.1111/bph.13501. Epub 2016 Jun 3.

30.

Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections.

Tcherniuk S, Cenac N, Comte M, Frouard J, Errazuriz-Cerda E, Galabov A, Morange PE, Vergnolle N, Si-Tahar M, Alessi MC, Riteau B.

J Infect Dis. 2016 Jul 15;214(2):237-47. doi: 10.1093/infdis/jiw127. Epub 2016 Mar 30.

PMID:
27034344
31.

Sacral nerve stimulation enhances early intestinal mucosal repair following mucosal injury in a pig model.

Brégeon J, Coron E, Da Silva AC, Jaulin J, Aubert P, Chevalier J, Vergnolle N, Meurette G, Neunlist M.

J Physiol. 2016 Aug 1;594(15):4309-23. doi: 10.1113/JP271783. Epub 2016 May 29.

32.

Bladder telemetry: A new approach to evaluate micturition behavior under physiological and inflammatory conditions.

Monjotin N, Farrié M, Vergnolle N, Le Grand B, Gillespie J, Junquero D.

Neurourol Urodyn. 2017 Feb;36(2):308-315. doi: 10.1002/nau.22970. Epub 2016 Feb 16.

PMID:
26879122
33.

Reply.

Vergnolle N.

Gastroenterology. 2016 Mar;150(3):777-8. doi: 10.1053/j.gastro.2016.01.026. Epub 2016 Jan 29. No abstract available.

PMID:
26827802
34.

Presence of commensal house dust mite allergen in human gastrointestinal tract: a potential contributor to intestinal barrier dysfunction.

Tulic MK, Vivinus-Nébot M, Rekima A, Rabelo Medeiros S, Bonnart C, Shi H, Walker A, Dainese R, Boyer J, Vergnolle N, Piche T, Verhasselt V.

Gut. 2016 May;65(5):757-66. doi: 10.1136/gutjnl-2015-310523. Epub 2015 Dec 8.

PMID:
26646935
35.

Apelin targets gut contraction to control glucose metabolism via the brain.

Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C.

Gut. 2017 Feb;66(2):258-269. doi: 10.1136/gutjnl-2015-310230. Epub 2015 Nov 12.

36.

A novel orally administered trimebutine compound (GIC-1001) is anti-nociceptive and features peripheral opioid agonistic activity and Hydrogen Sulphide-releasing capacity in mice.

Cenac N, Castro M, Desormeaux C, Colin P, Sie M, Ranger M, Vergnolle N.

Eur J Pain. 2016 May;20(5):723-30. doi: 10.1002/ejp.798. Epub 2015 Nov 6.

PMID:
26541237
37.

Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells From Patients With Crohn's Disease.

Pochard C, Coquenlorge S, Jaulin J, Cenac N, Vergnolle N, Meurette G, Freyssinet M, Neunlist M, Rolli-Derkinderen M.

Gastroenterology. 2016 Jan;150(1):168-80. doi: 10.1053/j.gastro.2015.09.038. Epub 2015 Nov 11.

PMID:
26433161
38.

TRPV1 sensitization mediates postinflammatory visceral pain following acute colitis.

Lapointe TK, Basso L, Iftinca MC, Flynn R, Chapman K, Dietrich G, Vergnolle N, Altier C.

Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G87-99. doi: 10.1152/ajpgi.00421.2014. Epub 2015 May 28.

39.

Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome.

Cenac N, Bautzova T, Le Faouder P, Veldhuis NA, Poole DP, Rolland C, Bertrand J, Liedtke W, Dubourdeau M, Bertrand-Michel J, Zecchi L, Stanghellini V, Bunnett NW, Barbara G, Vergnolle N.

Gastroenterology. 2015 Aug;149(2):433-44.e7. doi: 10.1053/j.gastro.2015.04.011. Epub 2015 Apr 22.

PMID:
25911511
40.

Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci.

Bermúdez-Humarán LG, Motta JP, Aubry C, Kharrat P, Rous-Martin L, Sallenave JM, Deraison C, Vergnolle N, Langella P.

Microb Cell Fact. 2015 Feb 26;14:26. doi: 10.1186/s12934-015-0198-4.

41.

Effects of 1-week sacral nerve stimulation on the rectal intestinal epithelial barrier and neuromuscular transmission in a porcine model.

Provost M, Brégeon J, Aubert P, Duchalais-Dassonneville E, D'Aldebert E, Vergnolle N, Neunlist M, Meurette G.

Neurogastroenterol Motil. 2015 Jan;27(1):40-50. doi: 10.1111/nmo.12465. Epub 2014 Nov 11.

PMID:
25388954
42.

Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor.

Gobbetti T, Ducheix S, le Faouder P, Perez T, Riols F, Boue J, Bertrand-Michel J, Dubourdeau M, Guillou H, Perretti M, Vergnolle N, Cenac N.

Br J Pharmacol. 2015 Feb;172(3):910-23. doi: 10.1111/bph.12957. Epub 2014 Dec 15.

43.

Activation of the endogenous nociceptin system by selective nociceptin receptor agonist SCH 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea-predominant IBS.

Fichna J, Sobczak M, Mokrowiecka A, Cygankiewicz AI, Zakrzewski PK, Cenac N, Sałaga M, Timmermans JP, Vergnolle N, Małecka-Panas E, Krajewska WM, Storr M.

Neurogastroenterol Motil. 2014 Nov;26(11):1539-50. doi: 10.1111/nmo.12390. Epub 2014 Jul 15.

PMID:
25041572
44.

Novel role of the serine protease inhibitor elafin in gluten-related disorders.

Galipeau HJ, Wiepjes M, Motta JP, Schulz JD, Jury J, Natividad JM, Pinto-Sanchez I, Sinclair D, Rousset P, Martin-Rosique R, Bermudez-Humaran L, Leroux JC, Murray JA, Smecuol E, Bai JC, Vergnolle N, Langella P, Verdu EF.

Am J Gastroenterol. 2014 May;109(5):748-56. doi: 10.1038/ajg.2014.48. Epub 2014 Apr 8.

45.

Activated protein C based therapeutic strategies in chronic diseases.

Bock F, Shahzad K, Vergnolle N, Isermann B.

Thromb Haemost. 2014 Apr 1;111(4):610-7. doi: 10.1160/TH13-11-0967. Epub 2014 Mar 20. Review.

PMID:
24652581
46.

TRPV4: new therapeutic target for inflammatory bowel diseases.

Vergnolle N.

Biochem Pharmacol. 2014 May 15;89(2):157-61. doi: 10.1016/j.bcp.2014.01.005. Epub 2014 Jan 16. Review.

47.

Chronic stress mediators act synergistically on colonic nociceptive mouse dorsal root ganglia neurons to increase excitability.

Ochoa-Cortes F, Guerrero-Alba R, Valdez-Morales EE, Spreadbury I, Barajas-Lopez C, Castro M, Bertrand J, Cenac N, Vergnolle N, Vanner SJ.

Neurogastroenterol Motil. 2014 Mar;26(3):334-45. doi: 10.1111/nmo.12268. Epub 2013 Nov 29.

PMID:
24286174
48.

Polyunsaturated fatty acid metabolism signature in ischemia differs from reperfusion in mouse intestine.

Gobbetti T, Le Faouder P, Bertrand J, Dubourdeau M, Barocelli E, Cenac N, Vergnolle N.

PLoS One. 2013 Sep 20;8(9):e75581. doi: 10.1371/journal.pone.0075581. eCollection 2013.

49.

Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice.

Boué J, Basso L, Cenac N, Blanpied C, Rolli-Derkinderen M, Neunlist M, Vergnolle N, Dietrich G.

Gastroenterology. 2014 Jan;146(1):166-75. doi: 10.1053/j.gastro.2013.09.020. Epub 2013 Sep 18.

PMID:
24055279
50.

Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model.

Aerts L, Hamelin MÈ, Rhéaume C, Lavigne S, Couture C, Kim W, Susan-Resiga D, Prat A, Seidah NG, Vergnolle N, Riteau B, Boivin G.

PLoS One. 2013 Aug 28;8(8):e72529. doi: 10.1371/journal.pone.0072529. eCollection 2013.

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