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Items: 1 to 50 of 87

1.

Trophic factors are essential for the survival of grafted oligodendrocyte progenitors and for neuroprotection after perinatal excitotoxicity.

Hirose-Ikeda M, Chu B, Zhao P, Akil O, Escalante E, Vergnes L, Cepeda C, Espinosa-Jeffrey A.

Neural Regen Res. 2020 Mar;15(3):557-568. doi: 10.4103/1673-5374.266066.

2.

Diesel Exhaust Induces Mitochondrial Dysfunction, Hyperlipidemia, and Liver Steatosis.

Yin F, Gupta R, Vergnes L, Driscoll WS, Ricks J, Ramanathan G, Stewart JA, Shih DM, Faull KF, Beaven SW, Lusis AJ, Reue K, Rosenfeld ME, Araujo JA.

Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):1776-1786. doi: 10.1161/ATVBAHA.119.312736. Epub 2019 Jul 25.

PMID:
31340670
3.

Stimulation of Hair Growth by Small Molecules that Activate Autophagy.

Chai M, Jiang M, Vergnes L, Fu X, de Barros SC, Doan NB, Huang W, Chu J, Jiao J, Herschman H, Crooks GM, Reue K, Huang J.

Cell Rep. 2019 Jun 18;27(12):3413-3421.e3. doi: 10.1016/j.celrep.2019.05.070.

4.

Noggin depletion in adipocytes promotes obesity in mice.

Blázquez-Medela AM, Jumabay M, Rajbhandari P, Sallam T, Guo Y, Yao J, Vergnes L, Reue K, Zhang L, Yao Y, Fogelman AM, Tontonoz P, Lusis AJ, Wu X, Boström KI.

Mol Metab. 2019 Jul;25:50-63. doi: 10.1016/j.molmet.2019.04.004. Epub 2019 Apr 10.

5.

PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity.

Shih DM, Meng Y, Sallam T, Vergnes L, Shu ML, Reue K, Tontonoz P, Fogelman AM, Lusis AJ, Reddy ST.

Antioxidants (Basel). 2019 Jan 11;8(1). pii: E19. doi: 10.3390/antiox8010019.

6.

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits.

Norheim F, Hasin-Brumshtein Y, Vergnes L, Chella Krishnan K, Pan C, Seldin MM, Hui ST, Mehrabian M, Zhou Z, Gupta S, Parks BW, Walch A, Reue K, Hofmann SM, Arnold AP, Lusis AJ.

Cell Metab. 2019 Apr 2;29(4):932-949.e4. doi: 10.1016/j.cmet.2018.12.013. Epub 2019 Jan 10.

PMID:
30639359
7.

KDM4B protects against obesity and metabolic dysfunction.

Cheng Y, Yuan Q, Vergnes L, Rong X, Youn JY, Li J, Yu Y, Liu W, Cai H, Lin JD, Tontonoz P, Hong C, Reue K, Wang CY.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5566-E5575. doi: 10.1073/pnas.1721814115. Epub 2018 May 29. Erratum in: Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2384-2385.

8.

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism.

Seldin MM, Koplev S, Rajbhandari P, Vergnes L, Rosenberg GM, Meng Y, Pan C, Phuong TMN, Gharakhanian R, Che N, Mäkinen S, Shih DM, Civelek M, Parks BW, Kim ED, Norheim F, Chella Krishnan K, Hasin-Brumshtein Y, Mehrabian M, Laakso M, Drevon CA, Koistinen HA, Tontonoz P, Reue K, Cantor RM, Björkegren JLM, Lusis AJ.

Cell Metab. 2018 May 1;27(5):1138-1155.e6. doi: 10.1016/j.cmet.2018.03.015.

9.

Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases.

Singh R, Pervin S, Lee SJ, Kuo A, Grijalva V, David J, Vergnes L, Reddy ST.

Diabetes Metab Syndr Obes. 2018 Mar 26;11:65-84. doi: 10.2147/DMSO.S159315. eCollection 2018.

10.

Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells.

Hodeib M, Ogrodzinski MP, Vergnes L, Reue K, Karlan BY, Lunt SY, Aspuria PP.

Oncotarget. 2017 Dec 23;9(3):4044-4060. doi: 10.18632/oncotarget.23661. eCollection 2018 Jan 9.

11.

Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress.

Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL.

J Biol Chem. 2018 Mar 30;293(13):4735-4751. doi: 10.1074/jbc.M117.805069. Epub 2018 Jan 29.

12.

Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease.

Chella Krishnan K, Kurt Z, Barrere-Cain R, Sabir S, Das A, Floyd R, Vergnes L, Zhao Y, Che N, Charugundla S, Qi H, Zhou Z, Meng Y, Pan C, Seldin MM, Norheim F, Hui S, Reue K, Lusis AJ, Yang X.

Cell Syst. 2018 Jan 24;6(1):103-115.e7. doi: 10.1016/j.cels.2017.12.006. Epub 2018 Jan 18.

13.

Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants.

Lee JM, Ong JR, Vergnes L, de Aguiar Vallim TQ, Nolan J, Cantor RM, Walters JRF, Reue K.

J Lipid Res. 2018 Mar;59(3):429-438. doi: 10.1194/jlr.M078279. Epub 2018 Jan 2.

14.

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure.

Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P.

Cell. 2018 Jan 11;172(1-2):218-233.e17. doi: 10.1016/j.cell.2017.11.019. Epub 2017 Dec 14.

15.

Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis.

Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, Vergnes L, Fu K, Morselli M, Dunham C, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis AJ, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A.

Elife. 2017 Dec 12;6. pii: e29330. doi: 10.7554/eLife.29330.

16.

Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues.

Singh R, Braga M, Reddy ST, Lee SJ, Parveen M, Grijalva V, Vergnes L, Pervin S.

Endocrinology. 2017 May 1;158(5):1217-1230. doi: 10.1210/en.2016-1607.

17.

Adipocyte Browning and Higher Mitochondrial Function in Periadrenal But Not SC Fat in Pheochromocytoma.

Vergnes L, Davies GR, Lin JY, Yeh MW, Livhits MJ, Harari A, Symonds ME, Sacks HS, Reue K.

J Clin Endocrinol Metab. 2016 Nov;101(11):4440-4448. Epub 2016 Aug 30.

18.

Simulated microgravity enhances oligodendrocyte mitochondrial function and lipid metabolism.

Espinosa-Jeffrey A, Nguyen K, Kumar S, Toshimasa O, Hirose R, Reue K, Vergnes L, Kinchen J, Vellis J.

J Neurosci Res. 2016 Dec;94(12):1434-1450. doi: 10.1002/jnr.23958. Epub 2016 Sep 28.

PMID:
27680492
19.

StarD7 Protein Deficiency Adversely Affects the Phosphatidylcholine Composition, Respiratory Activity, and Cristae Structure of Mitochondria.

Horibata Y, Ando H, Zhang P, Vergnes L, Aoyama C, Itoh M, Reue K, Sugimoto H.

J Biol Chem. 2016 Nov 25;291(48):24880-24891. Epub 2016 Sep 30.

20.

Prdm4 induction by the small molecule butein promotes white adipose tissue browning.

Song NJ, Choi S, Rajbhandari P, Chang SH, Kim S, Vergnes L, Kwon SM, Yoon JH, Lee S, Ku JM, Lee JS, Reue K, Koo SH, Tontonoz P, Park KW.

Nat Chem Biol. 2016 Jul;12(7):479-81. doi: 10.1038/nchembio.2081. Epub 2016 May 9.

21.

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells.

Zhang J, Khvorostov I, Hong JS, Oktay Y, Vergnes L, Nuebel E, Wahjudi PN, Setoguchi K, Wang G, Do A, Jung HJ, McCaffery JM, Kurland IJ, Reue K, Lee WN, Koehler CM, Teitell MA.

EMBO J. 2016 Apr 15;35(8):899. doi: 10.15252/embj.201694054. No abstract available.

22.

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females.

Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL.

Sci Transl Med. 2016 Apr 13;8(334):334ra54. doi: 10.1126/scitranslmed.aad3815.

23.

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.

York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ.

Cell. 2015 Dec 17;163(7):1716-29. doi: 10.1016/j.cell.2015.11.045. Epub 2015 Dec 10.

24.

SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.

Vergnes L, Chin RG, de Aguiar Vallim T, Fong LG, Osborne TF, Young SG, Reue K.

J Lipid Res. 2016 Mar;57(3):410-21. doi: 10.1194/jlr.M064022. Epub 2015 Dec 18.

25.

Dietary fructose aggravates the pathobiology of traumatic brain injury by influencing energy homeostasis and plasticity.

Agrawal R, Noble E, Vergnes L, Ying Z, Reue K, Gomez-Pinilla F.

J Cereb Blood Flow Metab. 2016 May;36(5):941-53. doi: 10.1177/0271678X15606719. Epub 2015 Oct 1.

26.

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure.

Dijk W, Heine M, Vergnes L, Boon MR, Schaart G, Hesselink MK, Reue K, van Marken Lichtenbelt WD, Olivecrona G, Rensen PC, Heeren J, Kersten S.

Elife. 2015 Oct 17;4. pii: e08428. doi: 10.7554/eLife.08428.

27.

Increased Expression of Beige/Brown Adipose Markers from Host and Breast Cancer Cells Influence Xenograft Formation in Mice.

Singh R, Parveen M, Basgen JM, Fazel S, Meshesha MF, Thames EC, Moore B, Martinez L, Howard CB, Vergnes L, Reue K, Pervin S.

Mol Cancer Res. 2016 Jan;14(1):78-92. doi: 10.1158/1541-7786.MCR-15-0151. Epub 2015 Oct 13.

28.

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

Fu X, Chin RM, Vergnes L, Hwang H, Deng G, Xing Y, Pai MY, Li S, Ta L, Fazlollahi F, Chen C, Prins RM, Teitell MA, Nathanson DA, Lai A, Faull KF, Jiang M, Clarke SG, Cloughesy TF, Graeber TG, Braas D, Christofk HR, Jung ME, Reue K, Huang J.

Cell Metab. 2015 Sep 1;22(3):508-15. doi: 10.1016/j.cmet.2015.06.009. Epub 2015 Jul 16.

29.

Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis.

Li R, Jen N, Wu L, Lee J, Fang K, Quigley K, Lee K, Wang S, Zhou B, Vergnes L, Chen YR, Li Z, Reue K, Ann DK, Hsiai TK.

Antioxid Redox Signal. 2015 Nov 20;23(15):1207-19. doi: 10.1089/ars.2014.5896. Epub 2015 Jun 29.

30.

Diet1 is a regulator of fibroblast growth factor 15/19-dependent bile acid synthesis.

Reue K, Lee JM, Vergnes L.

Dig Dis. 2015;33(3):307-13. doi: 10.1159/000371649. Epub 2015 May 27.

31.

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism.

Aspuria PP, Lunt SY, Väremo L, Vergnes L, Gozo M, Beach JA, Salumbides B, Reue K, Wiedemeyer WR, Nielsen J, Karlan BY, Orsulic S.

Cancer Metab. 2014 Dec 15;2:21. doi: 10.1186/2049-3002-2-21. eCollection 2014.

32.

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis.

Shih DM, Yu JM, Vergnes L, Dali-Youcef N, Champion MD, Devarajan A, Zhang P, Castellani LW, Brindley DN, Jamey C, Auwerx J, Reddy ST, Ford DA, Reue K, Lusis AJ.

FASEB J. 2015 Apr;29(4):1185-97. doi: 10.1096/fj.14-260570. Epub 2014 Dec 4.

33.

Adaptive thermogenesis in white adipose tissue: is lactate the new brown(ing)?

Vergnes L, Reue K.

Diabetes. 2014 Oct;63(10):3175-6. doi: 10.2337/db14-0815. No abstract available.

34.

Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein.

Subramaniam SR, Vergnes L, Franich NR, Reue K, Chesselet MF.

Neurobiol Dis. 2014 Oct;70:204-13. doi: 10.1016/j.nbd.2014.06.017. Epub 2014 Jul 10.

35.

Metabolic differences in breast cancer stem cells and differentiated progeny.

Vlashi E, Lagadec C, Vergnes L, Reue K, Frohnen P, Chan M, Alhiyari Y, Dratver MB, Pajonk F.

Breast Cancer Res Treat. 2014 Aug;146(3):525-34. doi: 10.1007/s10549-014-3051-2. Epub 2014 Jul 10.

36.

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.

Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J.

Nature. 2014 Jun 19;510(7505):397-401. doi: 10.1038/nature13264. Epub 2014 May 14.

37.

Regulation of bile acid homeostasis by the intestinal Diet1-FGF15/19 axis.

Reue K, Lee JM, Vergnes L.

Curr Opin Lipidol. 2014 Apr;25(2):140-7. doi: 10.1097/MOL.0000000000000060. Review.

38.

Follistatin promotes adipocyte differentiation, browning, and energy metabolism.

Braga M, Reddy ST, Vergnes L, Pervin S, Grijalva V, Stout D, David J, Li X, Tomasian V, Reid CB, Norris KC, Devaskar SU, Reue K, Singh R.

J Lipid Res. 2014 Mar;55(3):375-84. doi: 10.1194/jlr.M039719. Epub 2014 Jan 17.

39.

HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle.

Drew BG, Ribas V, Le JA, Henstridge DC, Phun J, Zhou Z, Soleymani T, Daraei P, Sitz D, Vergnes L, Wanagat J, Reue K, Febbraio MA, Hevener AL.

Diabetes. 2014 May;63(5):1488-505. doi: 10.2337/db13-0665. Epub 2013 Dec 30.

40.

Coupling energy homeostasis with a mechanism to support plasticity in brain trauma.

Agrawal R, Tyagi E, Vergnes L, Reue K, Gomez-Pinilla F.

Biochim Biophys Acta. 2014 Apr;1842(4):535-46. doi: 10.1016/j.bbadis.2013.12.004. Epub 2013 Dec 15.

41.

Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.

Vergnes L, Lee JM, Chin RG, Auwerx J, Reue K.

Cell Metab. 2013 Jun 4;17(6):916-28. doi: 10.1016/j.cmet.2013.04.007.

42.

Response to Pomozi et al's research commentary.

Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ.

Circ Res. 2013 May 24;112(11):e152-3. doi: 10.1161/CIRCRESAHA.113.301666. Epub 2013 Apr 26. No abstract available.

43.

Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.

Kidani Y, Elsaesser H, Hock MB, Vergnes L, Williams KJ, Argus JP, Marbois BN, Komisopoulou E, Wilson EB, Osborne TF, Graeber TG, Reue K, Brooks DG, Bensinger SJ.

Nat Immunol. 2013 May;14(5):489-99. doi: 10.1038/ni.2570. Epub 2013 Apr 7.

44.

Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs.

Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P.

Cell Metab. 2013 Mar 5;17(3):423-35. doi: 10.1016/j.cmet.2013.01.016.

45.

Zbtb16 has a role in brown adipocyte bioenergetics.

Plaisier CL, Bennett BJ, He A, Guan B, Lusis AJ, Reue K, Vergnes L.

Nutr Diabetes. 2012 Sep 17;2:e46. doi: 10.1038/nutd.2012.21.

46.

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.

Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ.

Cancer Res. 2013 May 1;73(9):2850-62. doi: 10.1158/0008-5472.CAN-13-0382-T. Epub 2013 Feb 25.

47.

Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization.

Chao LC, Wroblewski K, Ilkayeva OR, Stevens RD, Bain J, Meyer GA, Schenk S, Martinez L, Vergnes L, Narkar VA, Drew BG, Hong C, Boyadjian R, Hevener AL, Evans RM, Reue K, Spencer MJ, Newgard CB, Tontonoz P.

J Lipid Res. 2012 Dec;53(12):2610-9. doi: 10.1194/jlr.M029355. Epub 2012 Oct 1.

48.

Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.

Dwyer JR, Donkor J, Zhang P, Csaki LS, Vergnes L, Lee JM, Dewald J, Brindley DN, Atti E, Tetradis S, Yoshinaga Y, De Jong PJ, Fong LG, Young SG, Reue K.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2486-95. doi: 10.1073/pnas.1205221109. Epub 2012 Aug 20.

49.

ABCC6 localizes to the mitochondria-associated membrane.

Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ.

Circ Res. 2012 Aug 17;111(5):516-20. doi: 10.1161/CIRCRESAHA.112.276667. Epub 2012 Jul 17.

50.

Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells.

Zhang J, Nuebel E, Wisidagama DR, Setoguchi K, Hong JS, Van Horn CM, Imam SS, Vergnes L, Malone CS, Koehler CM, Teitell MA.

Nat Protoc. 2012 May 10;7(6):1068-85. doi: 10.1038/nprot.2012.048.

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