Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 61

1.

An efficient synthesis of a 6″-BODIPY-α-Galactosylceramide probe for monitoring α-Galactosylceramide uptake by cells.

Cheng JMH, Chee SH, Dölen Y, Verdoes M, Timmer MSM, Stocker BL.

Carbohydr Res. 2019 Dec 1;486:107840. doi: 10.1016/j.carres.2019.107840. Epub 2019 Oct 18.

PMID:
31689579
2.

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering.

van der Schoot JMS, Fennemann FL, Valente M, Dolen Y, Hagemans IM, Becker AMD, Le Gall CM, van Dalen D, Cevirgel A, van Bruggen JAC, Engelfriet M, Caval T, Bentlage AEH, Fransen MF, Nederend M, Leusen JHW, Heck AJR, Vidarsson G, Figdor CG, Verdoes M, Scheeren FA.

Sci Adv. 2019 Aug 28;5(8):eaaw1822. doi: 10.1126/sciadv.aaw1822. eCollection 2019 Aug.

3.

Synthetic Semiflexible and Bioactive Brushes.

Voerman D, Schluck M, Weiden J, Joosten B, Eggermont LJ, van den Eijnde T, Ignacio B, Cambi A, Figdor CG, Kouwer PHJ, Verdoes M, Hammink R, Rowan AE.

Biomacromolecules. 2019 Jul 8;20(7):2587-2597. doi: 10.1021/acs.biomac.9b00385. Epub 2019 Jun 13.

4.

Biomaterial-Based Activation and Expansion of Tumor-Specific T Cells.

Schluck M, Hammink R, Figdor CG, Verdoes M, Weiden J.

Front Immunol. 2019 May 3;10:931. doi: 10.3389/fimmu.2019.00931. eCollection 2019.

5.

Attacking Tumors From All Sides: Personalized Multiplex Vaccines to Tackle Intratumor Heterogeneity.

Fennemann FL, de Vries IJM, Figdor CG, Verdoes M.

Front Immunol. 2019 Apr 16;10:824. doi: 10.3389/fimmu.2019.00824. eCollection 2019.

6.

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.

Logtenberg MEW, Jansen JHM, Raaben M, Toebes M, Franke K, Brandsma AM, Matlung HL, Fauster A, Gomez-Eerland R, Bakker NAM, van der Schot S, Marijt KA, Verdoes M, Haanen JBAG, van den Berg JH, Neefjes J, van den Berg TK, Brummelkamp TR, Leusen JHW, Scheeren FA, Schumacher TN.

Nat Med. 2019 Apr;25(4):612-619. doi: 10.1038/s41591-019-0356-z. Epub 2019 Mar 4.

PMID:
30833751
7.

The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K.

Mons E, Jansen IDC, Loboda J, van Doodewaerd BR, Hermans J, Verdoes M, van Boeckel CAA, van Veelen PA, Turk B, Turk D, Ovaa H.

J Am Chem Soc. 2019 Feb 27;141(8):3507-3514. doi: 10.1021/jacs.8b11027. Epub 2019 Feb 14.

8.

The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation.

Baranov MV, Bianchi F, Schirmacher A, van Aart MAC, Maassen S, Muntjewerff EM, Dingjan I, Ter Beest M, Verdoes M, Keyser SGL, Bertozzi CR, Diederichsen U, van den Bogaart G.

iScience. 2019 Jan 25;11:160-177. doi: 10.1016/j.isci.2018.12.015. Epub 2018 Dec 20.

9.

Molecular Repolarisation of Tumour-Associated Macrophages.

van Dalen FJ, van Stevendaal MHME, Fennemann FL, Verdoes M, Ilina O.

Molecules. 2018 Dec 20;24(1). pii: E9. doi: 10.3390/molecules24010009. Review.

10.

Endolysosomal-Escape Nanovaccines through Adjuvant-Induced Tumor Antigen Assembly for Enhanced Effector CD8+ T Cell Activation.

Qiu L, Valente M, Dolen Y, Jäger E, Beest MT, Zheng L, Figdor CG, Verdoes M.

Small. 2018 Apr;14(15):e1703539. doi: 10.1002/smll.201703539. Epub 2018 Mar 1.

PMID:
29493121
11.

Toll-like Receptor Agonist Conjugation: A Chemical Perspective.

Ignacio BJ, Albin TJ, Esser-Kahn AP, Verdoes M.

Bioconjug Chem. 2018 Mar 21;29(3):587-603. doi: 10.1021/acs.bioconjchem.7b00808. Epub 2018 Feb 16. Review.

PMID:
29378134
12.

Cathepsin B as a potential cystatin M/E target in the mouse hair follicle.

Oortveld MAW, van Vlijmen-Willems IMJJ, Kersten FFJ, Cheng T, Verdoes M, van Erp PEJ, Verbeek S, Reinheckel T, Hendriks WJAJ, Schalkwijk J, Zeeuwen PLJM.

FASEB J. 2017 Oct;31(10):4286-4294. doi: 10.1096/fj.201700267R. Epub 2017 Jun 8.

13.

A Rab20-Dependent Membrane Trafficking Pathway Controls M. tuberculosis Replication by Regulating Phagosome Spaciousness and Integrity.

Schnettger L, Rodgers A, Repnik U, Lai RP, Pei G, Verdoes M, Wilkinson RJ, Young DB, Gutierrez MG.

Cell Host Microbe. 2017 May 10;21(5):619-628.e5. doi: 10.1016/j.chom.2017.04.004.

14.

Live Cell Imaging and Profiling of Cysteine Cathepsin Activity Using a Quenched Activity-Based Probe.

Edgington-Mitchell LE, Bogyo M, Verdoes M.

Methods Mol Biol. 2017;1491:145-159.

PMID:
27778287
15.

Legumain is activated in macrophages during pancreatitis.

Edgington-Mitchell LE, Wartmann T, Fleming AK, Gocheva V, van der Linden WA, Withana NP, Verdoes M, Aurelio L, Edgington-Mitchell D, Lieu T, Parker BS, Graham B, Reinheckel T, Furness JB, Joyce JA, Storz P, Halangk W, Bogyo M, Bunnett NW.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G548-60. doi: 10.1152/ajpgi.00047.2016. Epub 2016 Aug 11.

16.

Bifunctional Probes of Cathepsin Protease Activity and pH Reveal Alterations in Endolysosomal pH during Bacterial Infection.

Sanman LE, van der Linden WA, Verdoes M, Bogyo M.

Cell Chem Biol. 2016 Jul 21;23(7):793-804. doi: 10.1016/j.chembiol.2016.05.019. Epub 2016 Jul 14.

17.

Dual-Modality Activity-Based Probes as Molecular Imaging Agents for Vascular Inflammation.

Withana NP, Saito T, Ma X, Garland M, Liu C, Kosuge H, Amsallem M, Verdoes M, Ofori LO, Fischbein M, Arakawa M, Cheng Z, McConnell MV, Bogyo M.

J Nucl Med. 2016 Oct;57(10):1583-1590. Epub 2016 May 19.

18.

Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes.

Withana NP, Ma X, McGuire HM, Verdoes M, van der Linden WA, Ofori LO, Zhang R, Li H, Sanman LE, Wei K, Yao S, Wu P, Li F, Huang H, Xu Z, Wolters PJ, Rosen GD, Collard HR, Zhu Z, Cheng Z, Bogyo M.

Sci Rep. 2016 Jan 22;6:19755. doi: 10.1038/srep19755.

19.

Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes.

Withana NP, Garland M, Verdoes M, Ofori LO, Segal E, Bogyo M.

Nat Protoc. 2016 Jan;11(1):184-91. doi: 10.1038/nprot.2016.004. Epub 2015 Dec 30.

PMID:
26716706
20.

Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer.

Edgington-Mitchell LE, Rautela J, Duivenvoorden HM, Jayatilleke KM, van der Linden WA, Verdoes M, Bogyo M, Parker BS.

Oncotarget. 2015 Sep 29;6(29):27008-22. doi: 10.18632/oncotarget.4714.

21.

Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery.

Ofori LO, Withana NP, Prestwood TR, Verdoes M, Brady JJ, Winslow MM, Sorger J, Bogyo M.

ACS Chem Biol. 2015 Sep 18;10(9):1977-88. doi: 10.1021/acschembio.5b00205. Epub 2015 Jun 24.

22.

Regulation of immunoproteasome function in the lung.

Keller IE, Vosyka O, Takenaka S, Kloß A, Dahlmann B, Willems LI, Verdoes M, Overkleeft HS, Marcos E, Adnot S, Hauck SM, Ruppert C, Günther A, Herold S, Ohno S, Adler H, Eickelberg O, Meiners S.

Sci Rep. 2015 May 19;5:10230. doi: 10.1038/srep10230.

23.

Detection of protease activity in cells and animals.

Verdoes M, Verhelst SH.

Biochim Biophys Acta. 2016 Jan;1864(1):130-42. doi: 10.1016/j.bbapap.2015.04.029. Epub 2015 May 7. Review.

PMID:
25960278
24.

Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization.

Oresic Bender K, Ofori L, van der Linden WA, Mock ED, Datta GK, Chowdhury S, Li H, Segal E, Sanchez Lopez M, Ellman JA, Figdor CG, Bogyo M, Verdoes M.

J Am Chem Soc. 2015 Apr 15;137(14):4771-7. doi: 10.1021/jacs.5b00315. Epub 2015 Apr 1.

25.

Detection of intestinal cancer by local, topical application of a quenched fluorescence probe for cysteine cathepsins.

Segal E, Prestwood TR, van der Linden WA, Carmi Y, Bhattacharya N, Withana N, Verdoes M, Habtezion A, Engleman EG, Bogyo M.

Chem Biol. 2015 Jan 22;22(1):148-58. doi: 10.1016/j.chembiol.2014.11.008. Epub 2015 Jan 8.

26.

Restoring immunosurveillance by dendritic cell vaccines and manipulation of the tumor microenvironment.

Vasaturo A, Verdoes M, de Vries J, Torensma R, Figdor CG.

Immunobiology. 2015 Feb;220(2):243-8. doi: 10.1016/j.imbio.2014.11.007. Epub 2014 Nov 15. Review.

PMID:
25466585
27.

Exploring dual electrophiles in peptide-based proteasome inhibitors: carbonyls and epoxides.

Xin BT, de Bruin G, Verdoes M, Filippov DV, van der Marel GA, Overkleeft HS.

Org Biomol Chem. 2014 Aug 14;12(30):5710-8. doi: 10.1039/c4ob00893f. Epub 2014 Jun 26.

PMID:
24968066
28.

Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probes.

Li H, van der Linden WA, Verdoes M, Florea BI, McAllister FE, Govindaswamy K, Elias JE, Bhanot P, Overkleeft HS, Bogyo M.

ACS Chem Biol. 2014 Aug 15;9(8):1869-76. doi: 10.1021/cb5001263. Epub 2014 Jun 19.

29.

Improved quenched fluorescent probe for imaging of cysteine cathepsin activity.

Verdoes M, Oresic Bender K, Segal E, van der Linden WA, Syed S, Withana NP, Sanman LE, Bogyo M.

J Am Chem Soc. 2013 Oct 2;135(39):14726-30. doi: 10.1021/ja4056068. Epub 2013 Sep 19.

30.

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.

Gloeckl S, Ong VA, Patel P, Tyndall JD, Timms P, Beagley KW, Allan JA, Armitage CW, Turnbull L, Whitchurch CB, Merdanovic M, Ehrmann M, Powers JC, Oleksyszyn J, Verdoes M, Bogyo M, Huston WM.

Mol Microbiol. 2013 Aug;89(4):676-89. doi: 10.1111/mmi.12306. Epub 2013 Jul 12.

31.

Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS.

Li N, Kuo CL, Paniagua G, van den Elst H, Verdoes M, Willems LI, van der Linden WA, Ruben M, van Genderen E, Gubbens J, van Wezel GP, Overkleeft HS, Florea BI.

Nat Protoc. 2013 Jun;8(6):1155-68. doi: 10.1038/nprot.2013.065. Epub 2013 May 23.

PMID:
23702832
32.

Functional imaging of legumain in cancer using a new quenched activity-based probe.

Edgington LE, Verdoes M, Ortega A, Withana NP, Lee J, Syed S, Bachmann MH, Blum G, Bogyo M.

J Am Chem Soc. 2013 Jan 9;135(1):174-82. doi: 10.1021/ja307083b. Epub 2012 Dec 18.

33.

Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity.

Li H, Ponder EL, Verdoes M, Asbjornsdottir KH, Deu E, Edgington LE, Lee JT, Kirk CJ, Demo SD, Williamson KC, Bogyo M.

Chem Biol. 2012 Dec 21;19(12):1535-45. doi: 10.1016/j.chembiol.2012.09.019. Epub 2012 Nov 8.

34.

A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages.

Verdoes M, Edgington LE, Scheeren FA, Leyva M, Blum G, Weiskopf K, Bachmann MH, Ellman JA, Bogyo M.

Chem Biol. 2012 May 25;19(5):619-28. doi: 10.1016/j.chembiol.2012.03.012.

35.

An optimized activity-based probe for the study of caspase-6 activation.

Edgington LE, van Raam BJ, Verdoes M, Wierschem C, Salvesen GS, Bogyo M.

Chem Biol. 2012 Mar 23;19(3):340-52. doi: 10.1016/j.chembiol.2011.12.021.

36.

Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics.

Richau KH, Kaschani F, Verdoes M, Pansuriya TC, Niessen S, Stüber K, Colby T, Overkleeft HS, Bogyo M, Van der Hoorn RA.

Plant Physiol. 2012 Apr;158(4):1583-99. doi: 10.1104/pp.112.194001. Epub 2012 Feb 27.

37.

New approaches for dissecting protease functions to improve probe development and drug discovery.

Deu E, Verdoes M, Bogyo M.

Nat Struct Mol Biol. 2012 Jan 5;19(1):9-16. doi: 10.1038/nsmb.2203. Review.

38.

Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe.

Ren G, Blum G, Verdoes M, Liu H, Syed S, Edgington LE, Gheysens O, Miao Z, Jiang H, Gambhir SS, Bogyo M, Cheng Z.

PLoS One. 2011;6(11):e28029. doi: 10.1371/journal.pone.0028029. Epub 2011 Nov 21.

39.

Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes.

Edgington LE, Verdoes M, Bogyo M.

Curr Opin Chem Biol. 2011 Dec;15(6):798-805. doi: 10.1016/j.cbpa.2011.10.012. Epub 2011 Nov 16. Review.

40.

Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: a comparative study.

van der Linden WA, Li N, Hoogendoorn S, Ruben M, Verdoes M, Guo J, Boons GJ, van der Marel GA, Florea BI, Overkleeft HS.

Bioorg Med Chem. 2012 Jan 15;20(2):662-6. doi: 10.1016/j.bmc.2011.06.037. Epub 2011 Jun 23.

PMID:
21757357
41.

Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib.

Mirabella AC, Pletnev AA, Downey SL, Florea BI, Shabaneh TB, Britton M, Verdoes M, Filippov DV, Overkleeft HS, Kisselev AF.

Chem Biol. 2011 May 27;18(5):608-18. doi: 10.1016/j.chembiol.2011.02.015.

42.

Proteasome activity imaging and profiling characterizes bacterial effector syringolin A.

Kolodziejek I, Misas-Villamil JC, Kaschani F, Clerc J, Gu C, Krahn D, Niessen S, Verdoes M, Willems LI, Overkleeft HS, Kaiser M, van der Hoorn RA.

Plant Physiol. 2011 Jan;155(1):477-89. doi: 10.1104/pp.110.163733. Epub 2010 Nov 2.

43.

Nature of pharmacophore influences active site specificity of proteasome inhibitors.

Screen M, Britton M, Downey SL, Verdoes M, Voges MJ, Blom AE, Geurink PP, Risseeuw MD, Florea BI, van der Linden WA, Pletnev AA, Overkleeft HS, Kisselev AF.

J Biol Chem. 2010 Dec 17;285(51):40125-34. doi: 10.1074/jbc.M110.160606. Epub 2010 Oct 11.

44.

Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t.

Florea BI, Verdoes M, Li N, van der Linden WA, Geurink PP, van den Elst H, Hofmann T, de Ru A, van Veelen PA, Tanaka K, Sasaki K, Murata S, den Dulk H, Brouwer J, Ossendorp FA, Kisselev AF, Overkleeft HS.

Chem Biol. 2010 Aug 27;17(8):795-801. doi: 10.1016/j.chembiol.2010.05.027.

45.

Two-step labeling of endogenous enzymatic activities by Diels-Alder ligation.

Willems LI, Verdoes M, Florea BI, van der Marel GA, Overkleeft HS.

Chembiochem. 2010 Aug 16;11(12):1769-81. doi: 10.1002/cbic.201000280.

PMID:
20623570
46.

A panel of subunit-selective activity-based proteasome probes.

Verdoes M, Willems LI, van der Linden WA, Duivenvoorden BA, van der Marel GA, Florea BI, Kisselev AF, Overkleeft HS.

Org Biomol Chem. 2010 Jun 21;8(12):2719-27. doi: 10.1039/c001036g. Epub 2010 May 6.

47.

Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites.

Britton M, Lucas MM, Downey SL, Screen M, Pletnev AA, Verdoes M, Tokhunts RA, Amir O, Goddard AL, Pelphrey PM, Wright DL, Overkleeft HS, Kisselev AF.

Chem Biol. 2009 Dec 24;16(12):1278-89. doi: 10.1016/j.chembiol.2009.11.015.

48.

Proteasome activity profiling: a simple, robust and versatile method revealing subunit-selective inhibitors and cytoplasmic, defense-induced proteasome activities.

Gu C, Kolodziejek I, Misas-Villamil J, Shindo T, Colby T, Verdoes M, Richau KH, Schmidt J, Overkleeft HS, van der Hoorn RA.

Plant J. 2010 Apr 1;62(1):160-70. doi: 10.1111/j.1365-313X.2009.04122.x. Epub 2009 Dec 23.

49.

O-GlcNAc peptide epoxyketones are recognized by mammalian proteasomes.

Witte MD, Florea BI, Verdoes M, Adeyanju O, Van der Marel GA, Overkleeft HS.

J Am Chem Soc. 2009 Sep 2;131(34):12064-5. doi: 10.1021/ja901231w.

PMID:
19658393
50.

Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells.

Rückrich T, Kraus M, Gogel J, Beck A, Ovaa H, Verdoes M, Overkleeft HS, Kalbacher H, Driessen C.

Leukemia. 2009 Jun;23(6):1098-105. doi: 10.1038/leu.2009.8. Epub 2009 Feb 19.

PMID:
19225532

Supplemental Content

Loading ...
Support Center