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Items: 1 to 50 of 164

1.

Identification of cyclosporin C from Amphichorda felina using a Cryptococcus neoformans differential temperature sensitivity assay.

Xu L, Li Y, Biggins JB, Bowman BR, Verdine GL, Gloer JB, Alspaugh JA, Bills GF.

Appl Microbiol Biotechnol. 2018 Mar;102(5):2337-2350. doi: 10.1007/s00253-018-8792-0. Epub 2018 Feb 2.

2.

Exceptionally high-affinity Ras binders that remodel its effector domain.

McGee JH, Shim SY, Lee SJ, Swanson PK, Jiang SY, Durney MA, Verdine GL.

J Biol Chem. 2018 Mar 2;293(9):3265-3280. doi: 10.1074/jbc.M117.816348. Epub 2017 Dec 27.

3.

Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer.

Mitra S, Montgomery JE, Kolar MJ, Li G, Jeong KJ, Peng B, Verdine GL, Mills GB, Moellering RE.

Nat Commun. 2017 Sep 22;8(1):660. doi: 10.1038/s41467-017-00888-8.

4.

Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides.

Iwamoto N, Butler DCD, Svrzikapa N, Mohapatra S, Zlatev I, Sah DWY, Meena, Standley SM, Lu G, Apponi LH, Frank-Kamenetsky M, Zhang JJ, Vargeese C, Verdine GL.

Nat Biotechnol. 2017 Sep;35(9):845-851. doi: 10.1038/nbt.3948. Epub 2017 Aug 21.

PMID:
28829437
5.

Total Chemical Synthesis and Folding of All-l and All-d Variants of Oncogenic KRas(G12V).

Levinson AM, McGee JH, Roberts AG, Creech GS, Wang T, Peterson MT, Hendrickson RC, Verdine GL, Danishefsky SJ.

J Am Chem Soc. 2017 Jun 7;139(22):7632-7639. doi: 10.1021/jacs.7b02988. Epub 2017 May 22.

6.

Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase.

Wang L, Chakravarthy S, Verdine GL.

J Biol Chem. 2017 Mar 24;292(12):5007-5017. doi: 10.1074/jbc.M116.757039. Epub 2017 Jan 27.

7.

IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex.

Pua KH, Stiles DT, Sowa ME, Verdine GL.

Cell Rep. 2017 Jan 10;18(2):432-442. doi: 10.1016/j.celrep.2016.12.030.

8.

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin.

Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT.

Nat Biotechnol. 2016 Jul;34(7):738-45. doi: 10.1038/nbt.3584. Epub 2016 Jun 6.

9.

Correction to "Stitched α-Helical Peptides via Bis Ring-Closing Metathesis".

Hilinski GJ, Kim YW, Hong J, Kutchukian PS, Crenshaw CM, Berkovitch SS, Chang A, Ham S, Verdine GL.

J Am Chem Soc. 2015 Jul 15;137(27):8858. doi: 10.1021/jacs.5b04245. Epub 2015 Jul 2. No abstract available.

PMID:
26134449
10.

Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase.

Wang L, Lee SJ, Verdine GL.

J Biol Chem. 2015 Jul 10;290(28):17096-105. doi: 10.1074/jbc.M115.657866. Epub 2015 May 20.

11.

Stitched α-helical peptides via bis ring-closing metathesis.

Hilinski GJ, Kim YW, Hong J, Kutchukian PS, Crenshaw CM, Berkovitch SS, Chang A, Ham S, Verdine GL.

J Am Chem Soc. 2014 Sep 3;136(35):12314-22. doi: 10.1021/ja505141j. Epub 2014 Aug 21. Erratum in: J Am Chem Soc. 2015 Jul 15;137(27):8858.

PMID:
25105213
12.

A new i, i + 3 peptide stapling system for α-helix stabilization.

Shim SY, Kim YW, Verdine GL.

Chem Biol Drug Des. 2013 Dec;82(6):635-42. doi: 10.1111/cbdd.12231. Epub 2013 Oct 30.

PMID:
24267668
13.

Structural and biochemical analysis of DNA helix invasion by the bacterial 8-oxoguanine DNA glycosylase MutM.

Sung RJ, Zhang M, Qi Y, Verdine GL.

J Biol Chem. 2013 Apr 5;288(14):10012-23. doi: 10.1074/jbc.M112.415612. Epub 2013 Feb 12.

14.

Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin.

Grossmann TN, Yeh JT, Bowman BR, Chu Q, Moellering RE, Verdine GL.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):17942-7. doi: 10.1073/pnas.1208396109. Epub 2012 Oct 15.

15.

Structural origins of DNA target selection and nucleobase extrusion by a DNA cytosine methyltransferase.

Didovyk A, Verdine GL.

J Biol Chem. 2012 Nov 23;287(48):40099-105. doi: 10.1074/jbc.M112.413054. Epub 2012 Sep 25.

16.

Enforced presentation of an extrahelical guanine to the lesion recognition pocket of human 8-oxoguanine glycosylase, hOGG1.

Crenshaw CM, Nam K, Oo K, Kutchukian PS, Bowman BR, Karplus M, Verdine GL.

J Biol Chem. 2012 Jul 20;287(30):24916-28. doi: 10.1074/jbc.M111.316497. Epub 2012 Apr 16.

17.

Sequence-dependent structural variation in DNA undergoing intrahelical inspection by the DNA glycosylase MutM.

Sung RJ, Zhang M, Qi Y, Verdine GL.

J Biol Chem. 2012 May 25;287(22):18044-54. doi: 10.1074/jbc.M111.313635. Epub 2012 Mar 30.

18.

Mapping targetable sites on human telomerase RNA pseudoknot/template domain using 2'-OMe RNA-interacting polynucleotide (RIPtide) microarrays.

Gude L, Berkovitch SS, Santos WL, Kutchukian PS, Pawloski AR, Kuimelis R, McGall G, Verdine GL.

J Biol Chem. 2012 May 25;287(22):18843-53. doi: 10.1074/jbc.M111.316596. Epub 2012 Mar 26.

19.

Protein engineering for therapeutics, part B. Preface.

Wittrup KD, Verdine GL.

Methods Enzymol. 2012;503:xiii-xiv. doi: 10.1016/B978-0-12-396962-0.00013-6. No abstract available.

PMID:
22230575
20.

Stapled peptides for intracellular drug targets.

Verdine GL, Hilinski GJ.

Methods Enzymol. 2012;503:3-33. doi: 10.1016/B978-0-12-396962-0.00001-X.

PMID:
22230563
21.

Strandwise translocation of a DNA glycosylase on undamaged DNA.

Qi Y, Nam K, Spong MC, Banerjee A, Sung RJ, Zhang M, Karplus M, Verdine GL.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1086-91. doi: 10.1073/pnas.1111237108. Epub 2012 Jan 4.

22.

Protein engineering for therapeutics, Part A. Preface.

Wittrup KD, Verdine GL.

Methods Enzymol. 2012;502:xiii-xiv. doi: 10.1016/B978-0-12-416039-2.00031-8. No abstract available.

PMID:
22208991
23.

Structure of the stapled p53 peptide bound to Mdm2.

Baek S, Kutchukian PS, Verdine GL, Huber R, Holak TA, Lee KW, Popowicz GM.

J Am Chem Soc. 2012 Jan 11;134(1):103-6. doi: 10.1021/ja2090367. Epub 2011 Dec 14.

PMID:
22148351
24.

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis.

Kim YW, Grossmann TN, Verdine GL.

Nat Protoc. 2011 Jun;6(6):761-71. doi: 10.1038/nprot.2011.324. Epub 2011 May 12.

PMID:
21637196
25.

Structure of Escherichia coli AlkA in complex with undamaged DNA.

Bowman BR, Lee S, Wang S, Verdine GL.

J Biol Chem. 2010 Nov 12;285(46):35783-91. doi: 10.1074/jbc.M110.155663. Epub 2010 Sep 15.

26.

Introduction of all-hydrocarbon i,i+3 staples into alpha-helices via ring-closing olefin metathesis.

Kim YW, Kutchukian PS, Verdine GL.

Org Lett. 2010 Jul 2;12(13):3046-9. doi: 10.1021/ol1010449.

PMID:
20527740
27.

Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme.

Qi Y, Spong MC, Nam K, Banerjee A, Jiralerspong S, Karplus M, Verdine GL.

Nature. 2009 Dec 10;462(7274):762-6. doi: 10.1038/nature08561.

28.

Analysis of an anomalous mutant of MutM DNA glycosylase leads to new insights into the catalytic mechanism.

Nam K, Verdine GL, Karplus M.

J Am Chem Soc. 2009 Dec 30;131(51):18208-9. doi: 10.1021/ja907544b.

29.

Direct inhibition of the NOTCH transcription factor complex.

Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner JE.

Nature. 2009 Nov 12;462(7270):182-8. doi: 10.1038/nature08543. Erratum in: Nature. 2010 Jan 21;463(7279):384.

30.

Nonspecifically bound proteins spin while diffusing along DNA.

Blainey PC, Luo G, Kou SC, Mangel WF, Verdine GL, Bagchi B, Xie XS.

Nat Struct Mol Biol. 2009 Dec;16(12):1224-9. doi: 10.1038/nsmb.1716. Epub 2009 Nov 8.

31.

Entrapment and structure of an extrahelical guanine attempting to enter the active site of a bacterial DNA glycosylase, MutM.

Qi Y, Spong MC, Nam K, Karplus M, Verdine GL.

J Biol Chem. 2010 Jan 8;285(2):1468-78. doi: 10.1074/jbc.M109.069799. Epub 2009 Nov 4.

32.

Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase.

Lee S, Verdine GL.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18497-502. doi: 10.1073/pnas.0902908106. Epub 2009 Oct 19.

33.

All-atom model for stabilization of alpha-helical structure in peptides by hydrocarbon staples.

Kutchukian PS, Yang JS, Verdine GL, Shakhnovich EI.

J Am Chem Soc. 2009 Apr 8;131(13):4622-7. doi: 10.1021/ja805037p.

34.

Stereochemical effects of all-hydrocarbon tethers in i,i+4 stapled peptides.

Kim YW, Verdine GL.

Bioorg Med Chem Lett. 2009 May 1;19(9):2533-6. doi: 10.1016/j.bmcl.2009.03.022. Epub 2009 Mar 13.

PMID:
19332370
35.

A structural model for the damage-sensing complex in bacterial nucleotide excision repair.

Pakotiprapha D, Liu Y, Verdine GL, Jeruzalmi D.

J Biol Chem. 2009 May 8;284(19):12837-44. doi: 10.1074/jbc.M900571200. Epub 2009 Mar 13.

36.

Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine.

Lee S, Bowman BR, Ueno Y, Wang S, Verdine GL.

J Am Chem Soc. 2008 Sep 3;130(35):11570-1. doi: 10.1021/ja8025328. Epub 2008 Aug 8.

37.

The human cytomegalovirus UL44 C clamp wraps around DNA.

Komazin-Meredith G, Petrella RJ, Santos WL, Filman DJ, Hogle JM, Verdine GL, Karplus M, Coen DM.

Structure. 2008 Aug 6;16(8):1214-25. doi: 10.1016/j.str.2008.05.008.

38.

Structure of the E. coli DNA glycosylase AlkA bound to the ends of duplex DNA: a system for the structure determination of lesion-containing DNA.

Bowman BR, Lee S, Wang S, Verdine GL.

Structure. 2008 Aug 6;16(8):1166-74. doi: 10.1016/j.str.2008.04.012.

39.

Trapping and structural elucidation of a very advanced intermediate in the lesion-extrusion pathway of hOGG1.

Lee S, Radom CT, Verdine GL.

J Am Chem Soc. 2008 Jun 25;130(25):7784-5. doi: 10.1021/ja800821t. Epub 2008 May 29.

40.

The positively charged surface of herpes simplex virus UL42 mediates DNA binding.

Komazin-Meredith G, Santos WL, Filman DJ, Hogle JM, Verdine GL, Coen DM.

J Biol Chem. 2008 Mar 7;283(10):6154-61. doi: 10.1074/jbc.M708691200. Epub 2008 Jan 4.

41.

Crystal structure of Bacillus stearothermophilus UvrA provides insight into ATP-modulated dimerization, UvrB interaction, and DNA binding.

Pakotiprapha D, Inuzuka Y, Bowman BR, Moolenaar GF, Goosen N, Jeruzalmi D, Verdine GL.

Mol Cell. 2008 Jan 18;29(1):122-33. Epub 2007 Dec 27.

42.

The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members.

Verdine GL, Walensky LD.

Clin Cancer Res. 2007 Dec 15;13(24):7264-70. Review.

43.

A concise synthesis of 4'-fluoro nucleosides.

Lee S, Uttamapinant C, Verdine GL.

Org Lett. 2007 Nov 22;9(24):5007-9. Epub 2007 Nov 2.

PMID:
17975917
44.

Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide.

Bernal F, Tyler AF, Korsmeyer SJ, Walensky LD, Verdine GL.

J Am Chem Soc. 2007 Mar 7;129(9):2456-7. Epub 2007 Feb 7. No abstract available. Erratum in: J Am Chem Soc. 2007 Apr 25;129(16):5298.

45.

Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations.

Radom CT, Banerjee A, Verdine GL.

J Biol Chem. 2007 Mar 23;282(12):9182-94. Epub 2006 Nov 16.

46.

A stapled BID BH3 helix directly binds and activates BAX.

Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J, Smith E, Verdine GL, Korsmeyer SJ.

Mol Cell. 2006 Oct 20;24(2):199-210.

47.

A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex.

Banerjee A, Verdine GL.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15020-5. Epub 2006 Oct 2.

48.

Regulation of MLL1 H3K4 methyltransferase activity by its core components.

Dou Y, Milne TA, Ruthenburg AJ, Lee S, Lee JW, Verdine GL, Allis CD, Roeder RG.

Nat Struct Mol Biol. 2006 Aug;13(8):713-9. Epub 2006 Jul 30.

PMID:
16878130
49.

Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.

Ruthenburg AJ, Wang W, Graybosch DM, Li H, Allis CD, Patel DJ, Verdine GL.

Nat Struct Mol Biol. 2006 Aug;13(8):704-12. Epub 2006 Jul 9.

50.

A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA.

Blainey PC, van Oijen AM, Banerjee A, Verdine GL, Xie XS.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5752-7. Epub 2006 Apr 3.

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