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Items: 1 to 50 of 92

1.

Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site.

Wald J, Pasin M, Richter M, Walther C, Mathai N, Kirchmair J, Makarov VA, Goessweiner-Mohr N, Marlovits TC, Zanella I, Real-Hohn A, Verdaguer N, Blaas D, Schmidtke M.

Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19109-19115. doi: 10.1073/pnas.1904732116. Epub 2019 Aug 28.

PMID:
31462495
2.

(F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase.

de Castro S, Ferrer-Orta C, Mills A, Fernández-Cureses G, Gago F, Verdaguer N, Camarasa MJ.

Molecules. 2019 Jun 26;24(13). pii: E2360. doi: 10.3390/molecules24132360.

3.

Supramolecular arrangement of the full-length Zika virus NS5.

Ferrero DS, Ruiz-Arroyo VM, Soler N, Usón I, Guarné A, Verdaguer N.

PLoS Pathog. 2019 Apr 5;15(4):e1007656. doi: 10.1371/journal.ppat.1007656. eCollection 2019 Apr.

4.

Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis.

de la Higuera I, Ferrer-Orta C, Moreno E, de Ávila AI, Soria ME, Singh K, Caridi F, Sobrino F, Sarafianos SG, Perales C, Verdaguer N, Domingo E.

J Virol. 2018 Sep 26;92(20). pii: e01119-18. doi: 10.1128/JVI.01119-18. Print 2018 Oct 15.

5.

Viral RNA-Dependent RNA Polymerases: A Structural Overview.

Ferrero D, Ferrer-Orta C, Verdaguer N.

Subcell Biochem. 2018;88:39-71. doi: 10.1007/978-981-10-8456-0_3. Review.

PMID:
29900492
6.

Structural basis for biologically relevant mechanical stiffening of a virus capsid by cavity-creating or spacefilling mutations.

Guerra P, Valbuena A, Querol-Audí J, Silva C, Castellanos M, Rodríguez-Huete A, Garriga D, Mateu MG, Verdaguer N.

Sci Rep. 2017 Jun 22;7(1):4101. doi: 10.1038/s41598-017-04345-w.

7.

Structural characterization of the Rabphilin-3A-SNAP25 interaction.

Ferrer-Orta C, Pérez-Sánchez MD, Coronado-Parra T, Silva C, López-Martínez D, Baltanás-Copado J, Gómez-Fernández JC, Corbalán-García S, Verdaguer N.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5343-E5351. doi: 10.1073/pnas.1702542114. Epub 2017 Jun 20.

8.

Structure of eIF4E in Complex with an eIF4G Peptide Supports a Universal Bipartite Binding Mode for Protein Translation.

Miras M, Truniger V, Silva C, Verdaguer N, Aranda MA, Querol-Audí J.

Plant Physiol. 2017 Jul;174(3):1476-1491. doi: 10.1104/pp.17.00193. Epub 2017 May 18.

9.

Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.

de la Higuera I, Ferrer-Orta C, de Ávila AI, Perales C, Sierra M, Singh K, Sarafianos SG, Dehouck Y, Bastolla U, Verdaguer N, Domingo E.

Genome Biol Evol. 2017 May 1;9(5):1212-1228. doi: 10.1093/gbe/evx075.

10.

Decrease in pH destabilizes individual vault nanocages by weakening the inter-protein lateral interaction.

Llauró A, Guerra P, Kant R, Bothner B, Verdaguer N, de Pablo PJ.

Sci Rep. 2016 Oct 14;6:34143. doi: 10.1038/srep34143.

11.

Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.

Herod MR, Ferrer-Orta C, Loundras EA, Ward JC, Verdaguer N, Rowlands DJ, Stonehouse NJ.

J Virol. 2016 Jul 11;90(15):6864-6883. doi: 10.1128/JVI.00469-16. Print 2016 Aug 1.

12.

The Structure of the RNA-Dependent RNA Polymerase of a Permutotetravirus Suggests a Link between Primer-Dependent and Primer-Independent Polymerases.

Ferrero DS, Buxaderas M, Rodríguez JF, Verdaguer N.

PLoS Pathog. 2015 Dec 1;11(12):e1005265. doi: 10.1371/journal.ppat.1005265. eCollection 2015 Dec.

13.

Infectious Bursal Disease Virus VP3 Upregulates VP1-Mediated RNA-Dependent RNA Replication.

Ferrero D, Garriga D, Navarro A, Rodríguez JF, Verdaguer N.

J Virol. 2015 Nov;89(21):11165-8. doi: 10.1128/JVI.00218-15. Epub 2015 Aug 26.

14.

RNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to Regulatory Mechanisms.

Ferrer-Orta C, Ferrero D, Verdaguer N.

Viruses. 2015 Aug 6;7(8):4438-60. doi: 10.3390/v7082829. Review.

15.

Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.

Ferrer-Orta C, de la Higuera I, Caridi F, Sánchez-Aparicio MT, Moreno E, Perales C, Singh K, Sarafianos SG, Sobrino F, Domingo E, Verdaguer N.

J Virol. 2015 Jul;89(13):6848-59. doi: 10.1128/JVI.03283-14. Epub 2015 Apr 22.

16.

The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.

van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ.

PLoS Pathog. 2015 Mar 23;11(3):e1004733. doi: 10.1371/journal.ppat.1004733. eCollection 2015 Mar.

17.

Structural basis for host membrane remodeling induced by protein 2B of hepatitis A virus.

Vives-Adrián L, Garriga D, Buxaderas M, Fraga J, Pereira PJ, Macedo-Ribeiro S, Verdaguer N.

J Virol. 2015 Apr;89(7):3648-58. doi: 10.1128/JVI.02881-14. Epub 2015 Jan 14.

18.

Viruses and viral proteins.

Verdaguer N, Ferrero D, Murthy MR.

IUCrJ. 2014 Oct 14;1(Pt 6):492-504. doi: 10.1107/S205225251402003X. eCollection 2014 Nov 1. Review.

19.

A novel benzonitrile analogue inhibits rhinovirus replication.

Lacroix C, Querol-Audí J, Roche M, Franco D, Froeyen M, Guerra P, Terme T, Vanelle P, Verdaguer N, Neyts J, Leyssen P.

J Antimicrob Chemother. 2014 Oct;69(10):2723-32. doi: 10.1093/jac/dku200. Epub 2014 Jun 19.

PMID:
24948704
20.

Cryo-EM near-atomic structure of a dsRNA fungal virus shows ancient structural motifs preserved in the dsRNA viral lineage.

Luque D, Gómez-Blanco J, Garriga D, Brilot AF, González JM, Havens WM, Carrascosa JL, Trus BL, Verdaguer N, Ghabrial SA, Castón JR.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7641-6. doi: 10.1073/pnas.1404330111. Epub 2014 May 12.

21.

The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site.

Vives-Adrian L, Lujan C, Oliva B, van der Linden L, Selisko B, Coutard B, Canard B, van Kuppeveld FJ, Ferrer-Orta C, Verdaguer N.

J Virol. 2014 May;88(10):5595-607. doi: 10.1128/JVI.03502-13. Epub 2014 Mar 5.

22.

Mechanical stability and reversible fracture of vault particles.

Llauró A, Guerra P, Irigoyen N, Rodríguez JF, Verdaguer N, de Pablo PJ.

Biophys J. 2014 Feb 4;106(3):687-95. doi: 10.1016/j.bpj.2013.12.035.

23.

Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1.

Guillén J, Ferrer-Orta C, Buxaderas M, Pérez-Sánchez D, Guerrero-Valero M, Luengo-Gil G, Pous J, Guerra P, Gómez-Fernández JC, Verdaguer N, Corbalán-García S.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20503-8. doi: 10.1073/pnas.1316179110. Epub 2013 Dec 3.

24.

Uncoating of common cold virus is preceded by RNA switching as determined by X-ray and cryo-EM analyses of the subviral A-particle.

Pickl-Herk A, Luque D, Vives-Adrián L, Querol-Audí J, Garriga D, Trus BL, Verdaguer N, Blaas D, Castón JR.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20063-8. doi: 10.1073/pnas.1312128110. Epub 2013 Nov 25.

25.

X-ray crystallography of viruses.

Verdaguer N, Garriga D, Fita I.

Subcell Biochem. 2013;68:117-44. doi: 10.1007/978-94-007-6552-8_4. Review.

PMID:
23737050
26.

New features of vault architecture and dynamics revealed by novel refinement using the deformable elastic network approach.

Casañas A, Querol-Audí J, Guerra P, Pous J, Tanaka H, Tsukihara T, Verdaguer N, Fita I.

Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1054-61. doi: 10.1107/S0907444913004472. Epub 2013 May 14.

27.

Role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity.

Garriga D, Ferrer-Orta C, Querol-Audí J, Oliva B, Verdaguer N.

J Mol Biol. 2013 Jul 10;425(13):2279-87. doi: 10.1016/j.jmb.2013.03.034. Epub 2013 Mar 28. Review.

PMID:
23542342
28.

Purification, crystallization and preliminary X-ray diffraction analysis of the RNA-dependent RNA polymerase from Thosea asigna virus.

Ferrero D, Buxaderas M, Rodriguez JF, Verdaguer N.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1263-6. doi: 10.1107/S1744309112037529. Epub 2012 Sep 29.

29.

Conformational changes in motif D of RdRPs as fidelity determinant.

Verdaguer N, Ferrer-Orta C.

Structure. 2012 Sep 5;20(9):1448-50. doi: 10.1016/j.str.2012.08.014.

30.

Vault particles: a new generation of delivery nanodevices.

Casañas A, Guerra P, Fita I, Verdaguer N.

Curr Opin Biotechnol. 2012 Dec;23(6):972-7. doi: 10.1016/j.copbio.2012.05.004. Epub 2012 Jun 6. Review.

PMID:
22677067
31.

Epitope insertion at the N-terminal molecular switch of the rabbit hemorrhagic disease virus T = 3 capsid protein leads to larger T = 4 capsids.

Luque D, González JM, Gómez-Blanco J, Marabini R, Chichón J, Mena I, Angulo I, Carrascosa JL, Verdaguer N, Trus BL, Bárcena J, Castón JR.

J Virol. 2012 Jun;86(12):6470-80. doi: 10.1128/JVI.07050-11. Epub 2012 Apr 4.

32.

Insights into minor group rhinovirus uncoating: the X-ray structure of the HRV2 empty capsid.

Garriga D, Pickl-Herk A, Luque D, Wruss J, Castón JR, Blaas D, Verdaguer N.

PLoS Pathog. 2012 Jan;8(1):e1002473. doi: 10.1371/journal.ppat.1002473. Epub 2012 Jan 5.

33.

Cloning, purification and preliminary crystallographic studies of the 2AB protein from hepatitis A virus.

Garriga D, Vives-Adrián L, Buxaderas M, Ferreira-da-Silva F, Almeida B, Macedo-Ribeiro S, Pereira PJ, Verdaguer N.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1224-7. doi: 10.1107/S1744309111026261. Epub 2011 Sep 29.

34.

A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.

Agudo R, Ferrer-Orta C, Arias A, de la Higuera I, Perales C, Pérez-Luque R, Verdaguer N, Domingo E.

PLoS Pathog. 2010 Aug 26;6(8):e1001072. doi: 10.1371/journal.ppat.1001072.

35.

The T=1 capsid protein of Penicillium chrysogenum virus is formed by a repeated helix-rich core indicative of gene duplication.

Luque D, González JM, Garriga D, Ghabrial SA, Havens WM, Trus B, Verdaguer N, Carrascosa JL, Castón JR.

J Virol. 2010 Jul;84(14):7256-66. doi: 10.1128/JVI.00432-10. Epub 2010 May 12.

36.

Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin.

Ferrer-Orta C, Sierra M, Agudo R, de la Higuera I, Arias A, Pérez-Luque R, Escarmís C, Domingo E, Verdaguer N.

J Virol. 2010 Jun;84(12):6188-99. doi: 10.1128/JVI.02420-09. Epub 2010 Apr 14.

37.

Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase.

Ferrer-Orta C, Agudo R, Domingo E, Verdaguer N.

Curr Opin Struct Biol. 2009 Dec;19(6):752-8. doi: 10.1016/j.sbi.2009.10.016. Epub 2009 Nov 13. Review.

PMID:
19914060
38.

The mechanism of vault opening from the high resolution structure of the N-terminal repeats of MVP.

Querol-Audí J, Casañas A, Usón I, Luque D, Castón JR, Fita I, Verdaguer N.

EMBO J. 2009 Nov 4;28(21):3450-7. doi: 10.1038/emboj.2009.274. Epub 2009 Sep 24.

39.

Structural and mechanistic insights into the association of PKCalpha-C2 domain to PtdIns(4,5)P2.

Guerrero-Valero M, Ferrer-Orta C, Querol-Audí J, Marin-Vicente C, Fita I, Gómez-Fernández JC, Verdaguer N, Corbalán-García S.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6603-7. doi: 10.1073/pnas.0813099106. Epub 2009 Apr 3.

40.

Autoproteolytic activity derived from the infectious bursal disease virus capsid protein.

Irigoyen N, Garriga D, Navarro A, Verdaguer N, Rodríguez JF, Castón JR.

J Biol Chem. 2009 Mar 20;284(12):8064-72. doi: 10.1074/jbc.M808942200. Epub 2009 Jan 14.

41.

Minor group human rhinovirus-receptor interactions: geometry of multimodular attachment and basis of recognition.

Querol-Audí J, Konecsni T, Pous J, Carugo O, Fita I, Verdaguer N, Blaas D.

FEBS Lett. 2009 Jan 5;583(1):235-40. doi: 10.1016/j.febslet.2008.12.014. Epub 2008 Dec 13.

42.

Structural insights into the multifunctional protein VP3 of birnaviruses.

Casañas A, Navarro A, Ferrer-Orta C, González D, Rodríguez JF, Verdaguer N.

Structure. 2008 Jan;16(1):29-37. doi: 10.1016/j.str.2007.10.023.

43.

Activation mechanism of a noncanonical RNA-dependent RNA polymerase.

Garriga D, Navarro A, Querol-Audí J, Abaitua F, Rodríguez JF, Verdaguer N.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20540-5. Epub 2007 Dec 11.

44.

Sequential structures provide insights into the fidelity of RNA replication.

Ferrer-Orta C, Arias A, Pérez-Luque R, Escarmís C, Domingo E, Verdaguer N.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9463-8. Epub 2007 May 21.

45.

Infectious bursal disease virus capsid assembly and maturation by structural rearrangements of a transient molecular switch.

Luque D, Saugar I, Rodríguez JF, Verdaguer N, Garriga D, Martín CS, Velázquez-Muriel JA, Trus BL, Carrascosa JL, Castón JR.

J Virol. 2007 Jul;81(13):6869-78. Epub 2007 Apr 18.

46.

The 2.6-Angstrom structure of infectious bursal disease virus-derived T=1 particles reveals new stabilizing elements of the virus capsid.

Garriga D, Querol-Audí J, Abaitua F, Saugar I, Pous J, Verdaguer N, Castón JR, Rodriguez JF.

J Virol. 2006 Jul;80(14):6895-905.

47.

The structure of a protein primer-polymerase complex in the initiation of genome replication.

Ferrer-Orta C, Arias A, Agudo R, Pérez-Luque R, Escarmís C, Domingo E, Verdaguer N.

EMBO J. 2006 Feb 22;25(4):880-8. Epub 2006 Feb 2.

48.

A comparison of viral RNA-dependent RNA polymerases.

Ferrer-Orta C, Arias A, Escarmís C, Verdaguer N.

Curr Opin Struct Biol. 2006 Feb;16(1):27-34. Epub 2005 Dec 20. Review.

PMID:
16364629
49.

Mutant viral polymerase in the transition of virus to error catastrophe identifies a critical site for RNA binding.

Arias A, Agudo R, Ferrer-Orta C, Pérez-Luque R, Airaksinen A, Brocchi E, Domingo E, Verdaguer N, Escarmís C.

J Mol Biol. 2005 Nov 11;353(5):1021-32. Epub 2005 Sep 26.

PMID:
16216271
50.

Preliminary analysis of two and three dimensional crystals of vault ribonucleoprotein particles.

Querol-Audí J, Perez-Luque R, Fita I, Lopéz-Iglesias C, Castón JR, Carrascosa JL, Verdaguer N.

J Struct Biol. 2005 Jul;151(1):111-5.

PMID:
15964767

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