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Items: 1 to 50 of 90

1.

A CD133-AKT-Wnt signaling axis drives glioblastoma brain tumor-initiating cells.

Manoranjan B, Chokshi C, Venugopal C, Subapanditha M, Savage N, Tatari N, Provias JP, Murty NK, Moffat J, Doble BW, Singh SK.

Oncogene. 2019 Nov 6. doi: 10.1038/s41388-019-1086-x. [Epub ahead of print]

PMID:
31695152
2.

Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells.

Vora P, Seyfrid M, Venugopal C, Qazi MA, Salim S, Isserlin R, Subapanditha M, O'Farrell E, Mahendram S, Singh M, Bakhshinyan D, Chokshi C, McFarlane N, Dvorkin-Gheva A, Brown KR, Murty N, Moffat J, Bader GD, Singh SK.

J Neurooncol. 2019 Jul;143(3):417-428. doi: 10.1007/s11060-019-03192-1. Epub 2019 May 21.

PMID:
31115870
3.

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer.

Shouksmith AE, Shah F, Grimard ML, Gawel JM, Raouf YS, Geletu M, Berger-Becvar A, de Araujo ED, Luchman HA, Heaton WL, Bakhshinyan D, Adile AA, Venugopal C, O'Hare T, Deininger MW, Singh SK, Konieczny SF, Weiss S, Fishel ML, Gunning PT.

J Med Chem. 2019 Mar 14;62(5):2651-2665. doi: 10.1021/acs.jmedchem.8b01957. Epub 2019 Mar 6.

PMID:
30776234
4.

TAp73 Modifies Metabolism and Positively Regulates Growth of Cancer Stem-Like Cells in a Redox-Sensitive Manner.

Sharif T, Dai C, Martell E, Ghassemi-Rad MS, Hanes MR, Murphy PJ, Kennedy BE, Venugopal C, Subapanditha M, Giacomantonio CA, Marcato P, Singh SK, Gujar S.

Clin Cancer Res. 2019 Mar 15;25(6):2001-2017. doi: 10.1158/1078-0432.CCR-17-3177. Epub 2018 Dec 28.

PMID:
30593514
5.

BMI1 is a therapeutic target in recurrent medulloblastoma.

Bakhshinyan D, Venugopal C, Adile AA, Garg N, Manoranjan B, Hallett R, Wang X, Mahendram S, Vora P, Vijayakumar T, Subapanditha M, Singh M, Kameda-Smith MM, Qazi M, McFarlane N, Mann A, Ajani OA, Yarascavitch B, Ramaswamy V, Farooq H, Morrissy S, Cao L, Sydorenko N, Baiazitov R, Du W, Sheedy J, Weetall M, Moon YC, Lee CS, Kwiecien JM, Delaney KH, Doble B, Cho YJ, Mitra S, Kaplan D, Taylor MD, Davis TW, Singh SK.

Oncogene. 2019 Mar;38(10):1702-1716. doi: 10.1038/s41388-018-0549-9. Epub 2018 Oct 22.

PMID:
30348991
6.

In Vitro Assays for Screening Small Molecules.

Adile AA, Bakhshinyan D, Venugopal C, Singh SK.

Methods Mol Biol. 2019;1869:189-196. doi: 10.1007/978-1-4939-8805-1_16.

PMID:
30324524
7.

Differentiation of Brain Tumor Initiating Cells.

Kameda-Smith MM, Subapanditha MK, Salim SK, Venugopal C, Singh SK.

Methods Mol Biol. 2019;1869:85-91. doi: 10.1007/978-1-4939-8805-1_8.

PMID:
30324516
8.

In Vitro Self-Renewal Assays for Brain Tumor Stem Cells.

Seyfrid M, Bobrowski D, Bakhshinyan D, Tatari N, Venugopal C, Singh SK.

Methods Mol Biol. 2019;1869:79-84. doi: 10.1007/978-1-4939-8805-1_7.

PMID:
30324515
9.

Flow Cytometric Analysis of Brain Tumor Stem Cells.

Subapanditha MK, Adile AA, Venugopal C, Singh SK.

Methods Mol Biol. 2019;1869:69-77. doi: 10.1007/978-1-4939-8805-1_6.

PMID:
30324514
10.

Introduction to Brain Tumor Stem Cells.

Yelle N, Bakhshinyan D, Venugopal C, Singh SK.

Methods Mol Biol. 2019;1869:1-9. doi: 10.1007/978-1-4939-8805-1_1. Review.

PMID:
30324509
11.

Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano.

Venugopal C, K S, Rai KS, Pinnelli VB, Kutty BM, Dhanushkodi A.

Curr Gene Ther. 2018;18(5):307-323. doi: 10.2174/1566523218666180913152615.

PMID:
30209999
12.

Therapeutic Targeting of the Premetastatic Stage in Human Lung-to-Brain Metastasis.

Singh M, Venugopal C, Tokar T, McFarlane N, Subapanditha MK, Qazi M, Bakhshinyan D, Vora P, Murty NK, Jurisica I, Singh SK.

Cancer Res. 2018 Sep 1;78(17):5124-5134. doi: 10.1158/0008-5472.CAN-18-1022. Epub 2018 Jul 9.

13.

Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma.

Qazi MA, Vora P, Venugopal C, Adams J, Singh M, Hu A, Gorelik M, Subapanditha MK, Savage N, Yang J, Chokshi C, London M, Gont A, Bobrowski D, Grinshtein N, Brown KR, Murty NK, Nilvebrant J, Kaplan D, Moffat J, Sidhu S, Singh SK.

Cancer Res. 2018 Sep 1;78(17):5023-5037. doi: 10.1158/0008-5472.CAN-18-0267. Epub 2018 Jun 26.

14.

Association of Glioblastoma Multiforme Stem Cell Characteristics, Differentiation, and Microglia Marker Genes with Patient Survival.

Bien-Möller S, Balz E, Herzog S, Plantera L, Vogelgesang S, Weitmann K, Seifert C, Fink MA, Marx S, Bialke A, Venugopal C, Singh SK, Hoffmann W, Rauch BH, Schroeder HWS.

Stem Cells Int. 2018 Jan 17;2018:9628289. doi: 10.1155/2018/9628289. eCollection 2018.

15.

Dosage and Passage Dependent Neuroprotective Effects of Exosomes Derived from Rat Bone Marrow Mesenchymal Stem Cells: An In Vitro Analysis.

Venugopal C, Shamir C, Senthilkumar S, Babu JV, Sonu PK, Nishtha KJ, Rai KS, K S, Dhanushkodi A.

Curr Gene Ther. 2017;17(5):379-390. doi: 10.2174/1566523218666180125091952.

PMID:
29366415
16.

HEK-293 secretome attenuates kainic acid neurotoxicity through insulin like growth factor-phosphatidylinositol-3-kinases pathway and by temporal regulation of antioxidant defense machineries.

Venugopal C, Prasad YSHC, Shobha K, Pinnelli VB, Dhanushkodi A.

Neurotoxicology. 2018 Dec;69:189-200. doi: 10.1016/j.neuro.2017.11.010. Epub 2017 Dec 6.

PMID:
29208536
17.

Erratum to: Introduction to Cancer Stem Cells: Past, Present, and Future.

Bakhshinyan D, Adile AA, Qazi MA, Singh M, Kameda-Smith MM, Yelle N, Chokshi C, Venugopal C, Singh SK.

Methods Mol Biol. 2018;1692:E1. doi: 10.1007/978-1-4939-7401-6_19. No abstract available.

PMID:
29185235
18.

Introduction to Cancer Stem Cells: Past, Present, and Future.

Bakhshinyan D, Adile AA, Qazi MA, Singh M, Kameda-Smith MM, Yelle N, Chokshi C, Venugopal C, Singh SK.

Methods Mol Biol. 2018;1692:1-16. doi: 10.1007/978-1-4939-7401-6_1. Review. Erratum in: Methods Mol Biol. 2018;1692:E1.

PMID:
28986882
19.

Preclinical Modeling and Therapeutic Avenues for Cancer Metastasis to the Central Nervous System.

Singh M, Bakhshinyan D, Venugopal C, Singh SK.

Front Oncol. 2017 Sep 19;7:220. doi: 10.3389/fonc.2017.00220. eCollection 2017. Review.

20.

EMT: Mechanisms and therapeutic implications.

Singh M, Yelle N, Venugopal C, Singh SK.

Pharmacol Ther. 2018 Feb;182:80-94. doi: 10.1016/j.pharmthera.2017.08.009. Epub 2017 Aug 20. Review.

PMID:
28834698
21.

RNAi screen identifies essential regulators of human brain metastasis-initiating cells.

Singh M, Venugopal C, Tokar T, Brown KR, McFarlane N, Bakhshinyan D, Vijayakumar T, Manoranjan B, Mahendram S, Vora P, Qazi M, Dhillon M, Tong A, Durrer K, Murty N, Hallet R, Hassell JA, Kaplan DR, Cutz JC, Jurisica I, Moffat J, Singh SK.

Acta Neuropathol. 2017 Dec;134(6):923-940. doi: 10.1007/s00401-017-1757-z. Epub 2017 Aug 1.

PMID:
28766011
22.

Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastoma.

Qazi MA, Vora P, Venugopal C, Sidhu SS, Moffat J, Swanton C, Singh SK.

Ann Oncol. 2017 Jul 1;28(7):1448-1456. doi: 10.1093/annonc/mdx169. Review.

PMID:
28407030
23.

The identification of human pituitary adenoma-initiating cells.

Manoranjan B, Mahendram S, Almenawer SA, Venugopal C, McFarlane N, Hallett R, Vijayakumar T, Algird A, Murty NK, Sommer DD, Provias JP, Reddy K, Singh SK.

Acta Neuropathol Commun. 2016 Nov 28;4(1):125.

24.

CD133+ brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence.

Garg N, Bakhshinyan D, Venugopal C, Mahendram S, Rosa DA, Vijayakumar T, Manoranjan B, Hallett R, McFarlane N, Delaney KH, Kwiecien JM, Arpin CC, Lai PS, Gómez-Biagi RF, Ali AM, de Araujo ED, Ajani OA, Hassell JA, Gunning PT, Singh SK.

Oncogene. 2017 Feb 2;36(5):606-617. doi: 10.1038/onc.2016.235. Epub 2016 Oct 24.

25.

Development of a Patient-Derived Xenograft Model Using Brain Tumor Stem Cell Systems to Study Cancer.

Chokshi C, Dhillon M, McFarlane N, Venugopal C, Singh SK.

Methods Mol Biol. 2016;1458:231-45. doi: 10.1007/978-1-4939-3801-8_17.

PMID:
27581026
26.

Dental pulp stem cells for treating neurodegenerative diseases.

Shamir C, Venugopal C, Dhanushkodi A.

Neural Regen Res. 2015 Dec;10(12):1910-1. doi: 10.4103/1673-5374.169629. No abstract available.

27.

A novel stem cell culture model of recurrent glioblastoma.

Qazi MA, Vora P, Venugopal C, McFarlane N, Subapanditha MK, Murty NK, Hassell JA, Hallett RM, Singh SK.

J Neurooncol. 2016 Jan;126(1):57-67. doi: 10.1007/s11060-015-1951-6.

PMID:
26498281
28.

STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation.

Singh M, Garg N, Venugopal C, Hallett R, Tokar T, McFarlane N, Mahendram S, Bakhshinyan D, Manoranjan B, Vora P, Qazi M, Arpin CC, Page B, Haftchenary S, Rosa DA, Lai PS, Gómez-Biagi RF, Ali AM, Lewis A, Geletu M, Murty NK, Hassell JA, Jurisica I, Gunning PT, Singh SK.

Oncotarget. 2015 Sep 29;6(29):27461-77. doi: 10.18632/oncotarget.4742.

29.

Culture and Isolation of Brain Tumor Initiating Cells.

Vora P, Venugopal C, McFarlane N, Singh SK.

Curr Protoc Stem Cell Biol. 2015 Aug 3;34:3.3.1-3.3.13. doi: 10.1002/9780470151808.sc0303s34.

PMID:
26237571
30.

Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor-Initiating Cells.

Venugopal C, Hallett R, Vora P, Manoranjan B, Mahendram S, Qazi MA, McFarlane N, Subapanditha M, Nolte SM, Singh M, Bakhshinyan D, Garg N, Vijayakumar T, Lach B, Provias JP, Reddy K, Murty NK, Doble BW, Bhatia M, Hassell JA, Singh SK.

Clin Cancer Res. 2015 Dec 1;21(23):5324-37. doi: 10.1158/1078-0432.CCR-14-3147. Epub 2015 Jul 7.

31.

Regenerative therapy for hippocampal degenerative diseases: lessons from preclinical studies.

Venugopal C, Chandanala S, Prasad HC, Nayeem D, Bhonde RR, Dhanushkodi A.

J Tissue Eng Regen Med. 2017 Feb;11(2):321-333. doi: 10.1002/term.2052. Epub 2015 Jun 29. Review.

PMID:
26118731
32.

MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours.

Garg N, Vijayakumar T, Bakhshinyan D, Venugopal C, Singh SK.

Stem Cells Int. 2015;2015:141793. doi: 10.1155/2015/141793. Epub 2015 May 3. Review.

33.

Conditioned Medium Reconditions Hippocampal Neurons against Kainic Acid Induced Excitotoxicity: An In Vitro Study.

Bevinahal PK, Venugopal C, Yencharla HC, Chandanala S, Trichur RR, Talakad SN, Bhonde RR, Dhanushkodi A.

J Toxicol. 2014;2014:194967. doi: 10.1155/2014/194967. Epub 2014 Nov 23.

34.

Revealed: The spy who regulates neuroblastoma stem cells.

Vora P, Venugopal C, Singh SK.

Oncotarget. 2014 Nov 30;5(22):11014-6.

35.

Infusion of human embryonic kidney cell line conditioned medium reverses kainic acid induced hippocampal damage in mice.

Dhanushkodi A, Venugopal C, Bevinahal PK, Rai KS, Trichur RR, Talakad SN, Bhonde RR.

Cytotherapy. 2014 Dec;16(12):1760-70. doi: 10.1016/j.jcyt.2014.07.001. Epub 2014 Oct 22.

PMID:
25442789
36.

Generation of murine xenograft models of brain tumors from primary human tissue for in vivo analysis of the brain tumor-initiating cell.

Qazi M, Mann A, van Ommeren R, Venugopal C, McFarlane N, Vora P, Singh SK.

Methods Mol Biol. 2014;1210:37-49. doi: 10.1007/978-1-4939-1435-7_4.

PMID:
25173159
37.

Vasorelaxation responses to insulin in laminar vessel rings from healthy, lean horses.

Wooldridge AA, Waguespack RW, Schwartz DD, Venugopal CS, Eades SC, Beadle RE.

Vet J. 2014 Oct;202(1):83-8. doi: 10.1016/j.tvjl.2014.07.021. Epub 2014 Jul 29.

PMID:
25155219
38.

Isolated free fluid on abdominal computed tomography in blunt trauma: watch and wait or operate?

Gonser-Hafertepen LN, Davis JW, Bilello JF, Ballow SL, Sue LP, Cagle KM, Venugopal C, Hafertepen SC, Kaups KL.

J Am Coll Surg. 2014 Oct;219(4):599-605. doi: 10.1016/j.jamcollsurg.2014.04.020. Epub 2014 Jun 6.

PMID:
25127510
39.

Noninvasive assessment of the risk of tobacco abuse in oral mucosa using fluorescence spectroscopy: a clinical approach.

Nazeer SS, Asish R, Venugopal C, Anita B, Gupta AK, Jayasree RS.

J Biomed Opt. 2014 May;19(5):057013. doi: 10.1117/1.JBO.19.5.057013.

40.

Brain metastasis-initiating cells: survival of the fittest.

Singh M, Manoranjan B, Mahendram S, McFarlane N, Venugopal C, Singh SK.

Int J Mol Sci. 2014 May 22;15(5):9117-33. doi: 10.3390/ijms15059117. Review.

41.

Autofluorescence spectroscopy augmented by multivariate analysis as a potential noninvasive tool for early diagnosis of oral cavity disorders.

Venugopal C, Nazeer SS, Balan A, Jayasree RS.

Photomed Laser Surg. 2013 Dec;31(12):605-12. doi: 10.1089/pho.2013.3547. Epub 2013 Nov 19.

PMID:
24251928
42.

Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children.

Triscott J, Lee C, Foster C, Manoranjan B, Pambid MR, Berns R, Fotovati A, Venugopal C, O'Halloran K, Narendran A, Hawkins C, Ramaswamy V, Bouffet E, Taylor MD, Singhal A, Hukin J, Rassekh R, Yip S, Northcott P, Singh SK, Dunham C, Dunn SE.

Cancer Res. 2013 Nov 15;73(22):6734-44. doi: 10.1158/0008-5472.CAN-12-4331. Epub 2013 Sep 9.

43.

FoxG1 interacts with Bmi1 to regulate self-renewal and tumorigenicity of medulloblastoma stem cells.

Manoranjan B, Wang X, Hallett RM, Venugopal C, Mack SC, McFarlane N, Nolte SM, Scheinemann K, Gunnarsson T, Hassell JA, Taylor MD, Lee C, Triscott J, Foster CM, Dunham C, Hawkins C, Dunn SE, Singh SK.

Stem Cells. 2013 Jul;31(7):1266-77. doi: 10.1002/stem.1401.

44.

A cancer stem cell model for studying brain metastases from primary lung cancer.

Nolte SM, Venugopal C, McFarlane N, Morozova O, Hallett RM, O'Farrell E, Manoranjan B, Murty NK, Klurfan P, Kachur E, Provias JP, Farrokhyar F, Hassell JA, Marra M, Singh SK.

J Natl Cancer Inst. 2013 Apr 17;105(8):551-62. doi: 10.1093/jnci/djt022. Epub 2013 Feb 15.

PMID:
23418195
45.

Processing of primary brain tumor tissue for stem cell assays and flow sorting.

Venugopal C, McFarlane NM, Nolte S, Manoranjan B, Singh SK.

J Vis Exp. 2012 Sep 25;(67). pii: 4111. doi: 10.3791/4111.

46.

Medulloblastoma stem cells: modeling tumor heterogeneity.

Manoranjan B, Venugopal C, McFarlane N, Doble BW, Dunn SE, Scheinemann K, Singh SK.

Cancer Lett. 2013 Sep 10;338(1):23-31. doi: 10.1016/j.canlet.2012.07.010. Epub 2012 Jul 14. Review.

PMID:
22796365
47.

GBM secretome induces transient transformation of human neural precursor cells.

Venugopal C, Wang XS, Manoranjan B, McFarlane N, Nolte S, Li M, Murty N, Siu KW, Singh SK.

J Neurooncol. 2012 Sep;109(3):457-66. doi: 10.1007/s11060-012-0917-1. Epub 2012 Jul 1.

PMID:
22752853
48.

Effect of potential therapeutic agents in reducing oxidative stress in pulmonary tissues of recurrent airway obstruction-affected and clinically healthy horses.

Venugopal C, Mariappan N, Holmes E, Kearney M, Beadle R.

Equine Vet J. 2013 Jan;45(1):80-4. doi: 10.1111/j.2042-3306.2012.00566.x. Epub 2012 Apr 17.

PMID:
22506732
49.

Medulloblastoma stem cells: where development and cancer cross pathways.

Manoranjan B, Venugopal C, McFarlane N, Doble BW, Dunn SE, Scheinemann K, Singh SK.

Pediatr Res. 2012 Apr;71(4 Pt 2):516-22. doi: 10.1038/pr.2011.62. Epub 2012 Feb 8. Review.

PMID:
22430388
50.

Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice.

Lee C, Fotovati A, Triscott J, Chen J, Venugopal C, Singhal A, Dunham C, Kerr JM, Verreault M, Yip S, Wakimoto H, Jones C, Jayanthan A, Narendran A, Singh SK, Dunn SE.

Stem Cells. 2012 Jun;30(6):1064-75. doi: 10.1002/stem.1081.

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