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Items: 1 to 50 of 280

1.

Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk.

Cirulli ET, Guo L, Leon Swisher C, Shah N, Huang L, Napier LA, Kirkness EF, Spector TD, Caskey CT, Thorens B, Venter JC, Telenti A.

Cell Metab. 2018 Oct 8. pii: S1550-4131(18)30630-2. doi: 10.1016/j.cmet.2018.09.022. [Epub ahead of print]

2.

Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders.

Iranmehr A, Stobdan T, Zhou D, Poulsen O, Strohl KP, Aldashev A, Telenti A, Wong EHM, Kirkness EF, Venter JC, Bafna V, Haddad GG.

Eur J Hum Genet. 2018 Sep 25. doi: 10.1038/s41431-018-0270-8. [Epub ahead of print]

PMID:
30254217
3.

Tuning Gene Activity by Inducible and Targeted Regulation of Gene Expression in Minimal Bacterial Cells.

Mariscal AM, Kakizawa S, Hsu JY, Tanaka K, González-González L, Broto A, Querol E, Lluch-Senar M, Piñero-Lambea C, Sun L, Weyman PD, Wise KS, Merryman C, Tse G, Moore AJ, Hutchison CA 3rd, Smith HO, Tomita M, Venter JC, Glass JI, Piñol J, Suzuki Y.

ACS Synth Biol. 2018 Jun 15;7(6):1538-1552. doi: 10.1021/acssynbio.8b00028. Epub 2018 May 22.

4.

Paternally inherited cis-regulatory structural variants are associated with autism.

Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J.

Science. 2018 Apr 20;360(6386):327-331. doi: 10.1126/science.aan2261.

5.

Identification of Misclassified ClinVar Variants via Disease Population Prevalence.

Shah N, Hou YC, Yu HC, Sainger R, Caskey CT, Venter JC, Telenti A.

Am J Hum Genet. 2018 Apr 5;102(4):609-619. doi: 10.1016/j.ajhg.2018.02.019.

6.

Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults.

Perkins BA, Caskey CT, Brar P, Dec E, Karow DS, Kahn AM, Hou YC, Shah N, Boeldt D, Coughlin E, Hands G, Lavrenko V, Yu J, Procko A, Appis J, Dale AM, Guo L, Jönsson TJ, Wittmann BM, Bartha I, Ramakrishnan S, Bernal A, Brewer JB, Brewerton S, Biggs WH, Turpaz Y, Venter JC.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3686-3691. doi: 10.1073/pnas.1706096114. Epub 2018 Mar 19.

7.

Microbial metagenome of urinary tract infection.

Moustafa A, Li W, Singh H, Moncera KJ, Torralba MG, Yu Y, Manuel O, Biggs W, Venter JC, Nelson KE, Pieper R, Telenti A.

Sci Rep. 2018 Mar 12;8(1):4333. doi: 10.1038/s41598-018-22660-8.

8.

The human noncoding genome defined by genetic diversity.

di Iulio J, Bartha I, Wong EHM, Yu HC, Lavrenko V, Yang D, Jung I, Hicks MA, Shah N, Kirkness EF, Fabani MM, Biggs WH, Ren B, Venter JC, Telenti A.

Nat Genet. 2018 Mar;50(3):333-337. doi: 10.1038/s41588-018-0062-7. Epub 2018 Feb 26.

PMID:
29483654
9.

Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones.

Cohen IV, Cirulli ET, Mitchell MW, Jonsson TJ, Yu J, Shah N, Spector TD, Guo L, Venter JC, Telenti A.

EBioMedicine. 2018 Feb;28:316-323. doi: 10.1016/j.ebiom.2018.01.033. Epub 2018 Feb 15.

10.

Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease.

Moustafa A, Li W, Anderson EL, Wong EHM, Dulai PS, Sandborn WJ, Biggs W, Yooseph S, Jones MB, Venter JC, Nelson KE, Chang JT, Telenti A, Boland BS.

Clin Transl Gastroenterol. 2018 Jan 18;9(1):e132. doi: 10.1038/ctg.2017.58.

11.

Building Bridges through Science.

Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA, Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT.

Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028.

PMID:
29144972
12.

Profiling of Short-Tandem-Repeat Disease Alleles in 12,632 Human Whole Genomes.

Tang H, Kirkness EF, Lippert C, Biggs WH, Fabani M, Guzman E, Ramakrishnan S, Lavrenko V, Kakaradov B, Hou C, Hicks B, Heckerman D, Och FJ, Caskey CT, Venter JC, Telenti A.

Am J Hum Genet. 2017 Nov 2;101(5):700-715. doi: 10.1016/j.ajhg.2017.09.013.

13.

Human gene essentiality.

Bartha I, di Iulio J, Venter JC, Telenti A.

Nat Rev Genet. 2018 Jan;19(1):51-62. doi: 10.1038/nrg.2017.75. Epub 2017 Oct 30. Review.

PMID:
29082913
14.

New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude.

Stobdan T, Akbari A, Azad P, Zhou D, Poulsen O, Appenzeller O, Gonzales GF, Telenti A, Wong EHM, Saini S, Kirkness EF, Venter JC, Bafna V, Haddad GG.

Mol Biol Evol. 2017 Dec 1;34(12):3154-3168. doi: 10.1093/molbev/msx239.

PMID:
29029226
15.

Fine population structure analysis method for genomes of many.

Pan X, Wang Y, Wong EHM, Telenti A, Venter JC, Jin L.

Sci Rep. 2017 Oct 3;7(1):12608. doi: 10.1038/s41598-017-12319-1.

16.

Identification of individuals by trait prediction using whole-genome sequencing data.

Lippert C, Sabatini R, Maher MC, Kang EY, Lee S, Arikan O, Harley A, Bernal A, Garst P, Lavrenko V, Yocum K, Wong T, Zhu M, Yang WY, Chang C, Lu T, Lee CWH, Hicks B, Ramakrishnan S, Tang H, Xie C, Piper J, Brewerton S, Turpaz Y, Telenti A, Roby RK, Och FJ, Venter JC.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10166-10171. doi: 10.1073/pnas.1711125114. Epub 2017 Sep 5. Erratum in: Proc Natl Acad Sci U S A. 2017 Oct 2;:.

17.

Fast and accurate HLA typing from short-read next-generation sequence data with xHLA.

Xie C, Yeo ZX, Wong M, Piper J, Long T, Kirkness EF, Biggs WH, Bloom K, Spellman S, Vierra-Green C, Brady C, Scheuermann RH, Telenti A, Howard S, Brewerton S, Turpaz Y, Venter JC.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8059-8064. doi: 10.1073/pnas.1707945114. Epub 2017 Jul 3.

18.

Digital-to-biological converter for on-demand production of biologics.

Boles KS, Kannan K, Gill J, Felderman M, Gouvis H, Hubby B, Kamrud KI, Venter JC, Gibson DG.

Nat Biotechnol. 2017 Jul;35(7):672-675. doi: 10.1038/nbt.3859. Epub 2017 May 29.

PMID:
28553942
19.

Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease.

Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE.

Cell Metab. 2017 May 2;25(5):1054-1062.e5. doi: 10.1016/j.cmet.2017.04.001.

20.

Utilization of defined microbial communities enables effective evaluation of meta-genomic assemblies.

Greenwald WW, Klitgord N, Seguritan V, Yooseph S, Venter JC, Garner C, Nelson KE, Li W.

BMC Genomics. 2017 Apr 13;18(1):296. doi: 10.1186/s12864-017-3679-5.

21.

The blood DNA virome in 8,000 humans.

Moustafa A, Xie C, Kirkness E, Biggs W, Wong E, Turpaz Y, Bloom K, Delwart E, Nelson KE, Venter JC, Telenti A.

PLoS Pathog. 2017 Mar 22;13(3):e1006292. doi: 10.1371/journal.ppat.1006292. eCollection 2017 Mar.

22.

Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites.

Long T, Hicks M, Yu HC, Biggs WH, Kirkness EF, Menni C, Zierer J, Small KS, Mangino M, Messier H, Brewerton S, Turpaz Y, Perkins BA, Evans AM, Miller LA, Guo L, Caskey CT, Schork NJ, Garner C, Spector TD, Venter JC, Telenti A.

Nat Genet. 2017 Apr;49(4):568-578. doi: 10.1038/ng.3809. Epub 2017 Mar 6.

PMID:
28263315
23.

The Baltic Sea Virome: Diversity and Transcriptional Activity of DNA and RNA Viruses.

Zeigler Allen L, McCrow JP, Ininbergs K, Dupont CL, Badger JH, Hoffman JM, Ekman M, Allen AE, Bergman B, Venter JC.

mSystems. 2017 Feb 14;2(1). pii: e00125-16. doi: 10.1128/mSystems.00125-16. eCollection 2017 Jan-Feb.

24.

The Human Microbiome and Cancer.

Rajagopala SV, Vashee S, Oldfield LM, Suzuki Y, Venter JC, Telenti A, Nelson KE.

Cancer Prev Res (Phila). 2017 Apr;10(4):226-234. doi: 10.1158/1940-6207.CAPR-16-0249. Epub 2017 Jan 17. Review.

25.

Deep sequencing of 10,000 human genomes.

Telenti A, Pierce LC, Biggs WH, di Iulio J, Wong EH, Fabani MM, Kirkness EF, Moustafa A, Shah N, Xie C, Brewerton SC, Bulsara N, Garner C, Metzker G, Sandoval E, Perkins BA, Och FJ, Turpaz Y, Venter JC.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11901-11906. Epub 2016 Oct 4.

26.

A robust ambient temperature collection and stabilization strategy: Enabling worldwide functional studies of the human microbiome.

Anderson EL, Li W, Klitgord N, Highlander SK, Dayrit M, Seguritan V, Yooseph S, Biggs W, Venter JC, Nelson KE, Jones MB.

Sci Rep. 2016 Aug 25;6:31731. doi: 10.1038/srep31731.

27.

One step engineering of the small-subunit ribosomal RNA using CRISPR/Cas9.

Kannan K, Tsvetanova B, Chuang RY, Noskov VN, Assad-Garcia N, Ma L, Hutchison Iii CA, Smith HO, Glass JI, Merryman C, Venter JC, Gibson DG.

Sci Rep. 2016 Aug 4;6:30714. doi: 10.1038/srep30714.

28.

Dynamics of an Aging Genome.

Telenti A, Perkins BA, Venter JC.

Cell Metab. 2016 Jun 14;23(6):949-950. doi: 10.1016/j.cmet.2016.06.002.

29.

Design and synthesis of a minimal bacterial genome.

Hutchison CA 3rd, Chuang RY, Noskov VN, Assad-Garcia N, Deerinck TJ, Ellisman MH, Gill J, Kannan K, Karas BJ, Ma L, Pelletier JF, Qi ZQ, Richter RA, Strychalski EA, Sun L, Suzuki Y, Tsvetanova B, Wise KS, Smith HO, Glass JI, Merryman C, Gibson DG, Venter JC.

Science. 2016 Mar 25;351(6280):aad6253. doi: 10.1126/science.aad6253. Erratum in: ACS Chem Biol. 2016 May 20;11(5):1463.

PMID:
27013737
30.

Library preparation methodology can influence genomic and functional predictions in human microbiome research.

Jones MB, Highlander SK, Anderson EL, Li W, Dayrit M, Klitgord N, Fabani MM, Seguritan V, Green J, Pride DT, Yooseph S, Biggs W, Nelson KE, Venter JC.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14024-9. doi: 10.1073/pnas.1519288112. Epub 2015 Oct 28.

31.

The Sequence of the Human Genome.

Venter JC, Smith HO, Adams MD.

Clin Chem. 2015 Sep;61(9):1207-8. doi: 10.1373/clinchem.2014.237016. Epub 2015 Jul 16. No abstract available.

32.

CRISPR germline engineering--the community speaks.

Bosley KS, Botchan M, Bredenoord AL, Carroll D, Charo RA, Charpentier E, Cohen R, Corn J, Doudna J, Feng G, Greely HT, Isasi R, Ji W, Kim JS, Knoppers B, Lanphier E, Li J, Lovell-Badge R, Martin GS, Moreno J, Naldini L, Pera M, Perry AC, Venter JC, Zhang F, Zhou Q.

Nat Biotechnol. 2015 May;33(5):478-86. doi: 10.1038/nbt.3227. No abstract available.

PMID:
25965754
33.

Designer diatom episomes delivered by bacterial conjugation.

Karas BJ, Diner RE, Lefebvre SC, McQuaid J, Phillips AP, Noddings CM, Brunson JK, Valas RE, Deerinck TJ, Jablanovic J, Gillard JT, Beeri K, Ellisman MH, Glass JI, Hutchison CA 3rd, Smith HO, Venter JC, Allen AE, Dupont CL, Weyman PD.

Nat Commun. 2015 Apr 21;6:6925. doi: 10.1038/ncomms7925.

34.

Green research labs: Zero net emissions from Venter facility.

Venter JC, Friedman RM.

Nature. 2015 Apr 16;520(7547):295. doi: 10.1038/520295d. No abstract available.

PMID:
25877193
35.

Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling.

Suzuki Y, Assad-Garcia N, Kostylev M, Noskov VN, Wise KS, Karas BJ, Stam J, Montague MG, Hanly TJ, Enriquez NJ, Ramon A, Goldgof GM, Richter RA, Vashee S, Chuang RY, Winzeler EA, Hutchison CA 3rd, Gibson DG, Smith HO, Glass JI, Venter JC.

Genome Res. 2015 Mar;25(3):435-44. doi: 10.1101/gr.182477.114. Epub 2015 Feb 5.

36.

Genomes and gene expression across light and productivity gradients in eastern subtropical Pacific microbial communities.

Dupont CL, McCrow JP, Valas R, Moustafa A, Walworth N, Goodenough U, Roth R, Hogle SL, Bai J, Johnson ZI, Mann E, Palenik B, Barbeau KA, Venter JC, Allen AE.

ISME J. 2015 May;9(5):1076-92. doi: 10.1038/ismej.2014.198. Epub 2014 Oct 21.

37.
38.

Rescue of mutant fitness defects using in vitro reconstituted designer transposons in Mycoplasma mycoides.

Karas BJ, Wise KS, Sun L, Venter JC, Glass JI, Hutchison CA 3rd, Smith HO, Suzuki Y.

Front Microbiol. 2014 Jul 23;5:369. doi: 10.3389/fmicb.2014.00369. eCollection 2014.

39.

Synthetic biology: Construction of a yeast chromosome.

Gibson DG, Venter JC.

Nature. 2014 May 8;509(7499):168-9. doi: 10.1038/509168a. No abstract available.

PMID:
24805340
40.

Transferring whole genomes from bacteria to yeast spheroplasts using entire bacterial cells to reduce DNA shearing.

Karas BJ, Jablanovic J, Irvine E, Sun L, Ma L, Weyman PD, Gibson DG, Glass JI, Venter JC, Hutchison CA 3rd, Smith HO, Suzuki Y.

Nat Protoc. 2014 Apr;9(4):743-50. doi: 10.1038/nprot.2014.045. Epub 2014 Mar 6.

PMID:
24603933
41.

Functional tradeoffs underpin salinity-driven divergence in microbial community composition.

Dupont CL, Larsson J, Yooseph S, Ininbergs K, Goll J, Asplund-Samuelsson J, McCrow JP, Celepli N, Allen LZ, Ekman M, Lucas AJ, Hagström Å, Thiagarajan M, Brindefalk B, Richter AR, Andersson AF, Tenney A, Lundin D, Tovchigrechko A, Nylander JA, Brami D, Badger JH, Allen AE, Rusch DB, Hoffman J, Norrby E, Friedman R, Pinhassi J, Venter JC, Bergman B.

PLoS One. 2014 Feb 27;9(2):e89549. doi: 10.1371/journal.pone.0089549. eCollection 2014.

42.

A metagenomic framework for the study of airborne microbial communities.

Yooseph S, Andrews-Pfannkoch C, Tenney A, McQuaid J, Williamson S, Thiagarajan M, Brami D, Zeigler-Allen L, Hoffman J, Goll JB, Fadrosh D, Glass J, Adams MD, Friedman R, Venter JC.

PLoS One. 2013 Dec 11;8(12):e81862. doi: 10.1371/journal.pone.0081862. eCollection 2013.

43.

Assembly of eukaryotic algal chromosomes in yeast.

Karas BJ, Molparia B, Jablanovic J, Hermann WJ, Lin YC, Dupont CL, Tagwerker C, Yonemoto IT, Noskov VN, Chuang RY, Allen AE, Glass JI, Hutchison CA 3rd, Smith HO, Venter JC, Weyman PD.

J Biol Eng. 2013 Dec 10;7(1):30. doi: 10.1186/1754-1611-7-30.

44.

Candidate phylum TM6 genome recovered from a hospital sink biofilm provides genomic insights into this uncultivated phylum.

McLean JS, Lombardo MJ, Badger JH, Edlund A, Novotny M, Yee-Greenbaum J, Vyahhi N, Hall AP, Yang Y, Dupont CL, Ziegler MG, Chitsaz H, Allen AE, Yooseph S, Tesler G, Pevzner PA, Friedman RM, Nealson KH, Venter JC, Lasken RS.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):E2390-9. doi: 10.1073/pnas.1219809110. Epub 2013 Jun 10.

45.

Synthetic generation of influenza vaccine viruses for rapid response to pandemics.

Dormitzer PR, Suphaphiphat P, Gibson DG, Wentworth DE, Stockwell TB, Algire MA, Alperovich N, Barro M, Brown DM, Craig S, Dattilo BM, Denisova EA, De Souza I, Eickmann M, Dugan VG, Ferrari A, Gomila RC, Han L, Judge C, Mane S, Matrosovich M, Merryman C, Palladino G, Palmer GA, Spencer T, Strecker T, Trusheim H, Uhlendorff J, Wen Y, Yee AC, Zaveri J, Zhou B, Becker S, Donabedian A, Mason PW, Glass JI, Rappuoli R, Venter JC.

Sci Transl Med. 2013 May 15;5(185):185ra68. doi: 10.1126/scitranslmed.3006368.

46.

Assembly of large, high G+C bacterial DNA fragments in yeast.

Noskov VN, Karas BJ, Young L, Chuang RY, Gibson DG, Lin YC, Stam J, Yonemoto IT, Suzuki Y, Andrews-Pfannkoch C, Glass JI, Smith HO, Hutchison CA 3rd, Venter JC, Weyman PD.

ACS Synth Biol. 2012 Jul 20;1(7):267-73. doi: 10.1021/sb3000194. Epub 2012 May 21.

PMID:
23651249
47.

Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform.

McLean JS, Lombardo MJ, Ziegler MG, Novotny M, Yee-Greenbaum J, Badger JH, Tesler G, Nurk S, Lesin V, Brami D, Hall AP, Edlund A, Allen LZ, Durkin S, Reed S, Torriani F, Nealson KH, Pevzner PA, Friedman R, Venter JC, Lasken RS.

Genome Res. 2013 May;23(5):867-77. doi: 10.1101/gr.150433.112. Epub 2013 Apr 5.

48.

Direct transfer of whole genomes from bacteria to yeast.

Karas BJ, Jablanovic J, Sun L, Ma L, Goldgof GM, Stam J, Ramon A, Manary MJ, Winzeler EA, Venter JC, Weyman PD, Gibson DG, Glass JI, Hutchison CA 3rd, Smith HO, Suzuki Y.

Nat Methods. 2013 May;10(5):410-2. doi: 10.1038/nmeth.2433. Epub 2013 Mar 31.

49.

Sequencing of isolated sperm cells for direct haplotyping of a human genome.

Kirkness EF, Grindberg RV, Yee-Greenbaum J, Marshall CR, Scherer SW, Lasken RS, Venter JC.

Genome Res. 2013 May;23(5):826-32. doi: 10.1101/gr.144600.112. Epub 2013 Jan 2.

50.

Metagenomic exploration of viruses throughout the Indian Ocean.

Williamson SJ, Allen LZ, Lorenzi HA, Fadrosh DW, Brami D, Thiagarajan M, McCrow JP, Tovchigrechko A, Yooseph S, Venter JC.

PLoS One. 2012;7(10):e42047. doi: 10.1371/journal.pone.0042047. Epub 2012 Oct 17.

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