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Dextrin Nanocomposites as Matrices for Solid Dosage Forms.

Phillips J, Venter JL, Atanasova M, Wesley-Smith J, Oosthuizen H, Emmambux MN, Du Toit EL, Focke WW.

ACS Appl Mater Interfaces. 2020 Mar 27. doi: 10.1021/acsami.0c02061. [Epub ahead of print]


Predictors of Patient Satisfaction After Refractive Lens Exchange With an Extended Depth of Focus IOL.

Schallhorn SC, Hettinger KA, Teenan D, Venter JA, Hannan SJ, Schallhorn JM.

J Refract Surg. 2020 Mar 1;36(3):175-184. doi: 10.3928/1081597X-20200211-01.


Outcomes and Adverse Events of Sub-Tenon's Anesthesia with the Use of a Flexible Cannula in 35,850 Refractive Lens Exchange/Cataract Procedures.

Lerch D, Venter JA, James AM, Pelouskova M, Collins BM, Schallhorn SC.

Clin Ophthalmol. 2020 Jan 31;14:307-315. doi: 10.2147/OPTH.S234807. eCollection 2020.


Investigating the effects of management practice on mammalian co-occurrence along the West Coast of South Africa.

Winterton DJ, van Wilgen NJ, Venter JA.

PeerJ. 2020 Jan 27;8:e8184. doi: 10.7717/peerj.8184. eCollection 2020.


Precision medicine integrating whole-genome sequencing, comprehensive metabolomics, and advanced imaging.

Hou YC, Yu HC, Martin R, Cirulli ET, Schenker-Ahmed NM, Hicks M, Cohen IV, Jönsson TJ, Heister R, Napier L, Swisher CL, Dominguez S, Tang H, Li W, Perkins BA, Barea J, Rybak C, Smith E, Duchicela K, Doney M, Brar P, Hernandez N, Kirkness EF, Kahn AM, Venter JC, Karow DS, Caskey CT.

Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):3053-3062. doi: 10.1073/pnas.1909378117. Epub 2020 Jan 24.


Correction to: Knockout of α-calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes.

Wan Y, Ceci L, Wu N, Zhou T, Chen L, Venter J, Francis H, Bernuzzi F, Invernizzi P, Kyritsi K, Baker P, Huang Q, Wu C, Sybenga A, Alpini G, Meng F, Glaser S.

Lab Invest. 2020 Jan 14. doi: 10.1038/s41374-020-0376-9. [Epub ahead of print]


An unsupervised learning approach to identify novel signatures of health and disease from multimodal data.

Shomorony I, Cirulli ET, Huang L, Napier LA, Heister RR, Hicks M, Cohen IV, Yu HC, Swisher CL, Schenker-Ahmed NM, Li W, Nelson KE, Brar P, Kahn AM, Spector TD, Caskey CT, Venter JC, Karow DS, Kirkness EF, Shah N.

Genome Med. 2020 Jan 10;12(1):7. doi: 10.1186/s13073-019-0705-z.


Ultrasound-guided L5 dorsal ramus block: validation of a novel technique.

Etheridge JB, De Villiers F, Venter J, Squire P, Farnquist B, Finlayson RJ.

Reg Anesth Pain Med. 2020 Mar;45(3):176-179. doi: 10.1136/rapm-2019-100783. Epub 2019 Oct 25.


Incidence of Intraoperative and Early Postoperative Adverse Events in a Large Cohort of Consecutive Laser Vision Correction Treatments.

Schallhorn JM, Schallhorn SC, Teenan D, Hannan SJ, Pelouskova M, Venter JA.

Am J Ophthalmol. 2020 Feb;210:97-106. doi: 10.1016/j.ajo.2019.10.011. Epub 2019 Oct 18.


Interplay between the human gut microbiome and host metabolism.

Visconti A, Le Roy CI, Rosa F, Rossi N, Martin TC, Mohney RP, Li W, de Rinaldis E, Bell JT, Venter JC, Nelson KE, Spector TD, Falchi M.

Nat Commun. 2019 Oct 3;10(1):4505. doi: 10.1038/s41467-019-12476-z.


Incidence of Intraoperative and Early Postoperative Adverse Events in a Large Cohort of Consecutive Refractive Lens Exchange Procedures.

Schallhorn JM, Schallhorn SC, Teenan D, Hannan SJ, Pelouskova M, Venter JA.

Am J Ophthalmol. 2019 Dec;208:406-414. doi: 10.1016/j.ajo.2019.08.025. Epub 2019 Sep 4.


Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease.

Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE.

Cell Metab. 2019 Sep 3;30(3):607. doi: 10.1016/j.cmet.2019.08.002. No abstract available.


Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis.

Kyritsi K, Chen L, O'Brien A, Francis H, Hein TW, Venter J, Wu N, Ceci L, Zhou T, Zawieja D, Gashev AA, Meng F, Invernizzi P, Fabris L, Wu C, Skill NJ, Saxena R, Liangpunsakul S, Alpini G, Glaser SS.

Hepatology. 2020 Mar;71(3):990-1008. doi: 10.1002/hep.30880. Epub 2019 Oct 18.


Initial Clinical Outcomes of a New Extended Depth of Focus Intraocular Lens.

Schallhorn SC, Teenan D, Venter JA, Hannan SJ, Schallhorn JM.

J Refract Surg. 2019 Jul 1;35(7):426-433. doi: 10.3928/1081597X-20190530-01.


Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.

Kennedy L, Francis H, Invernizzi P, Venter J, Wu N, Carbone M, Gershwin ME, Bernuzzi F, Franchitto A, Alvaro D, Marzioni M, Onori P, Gaudio E, Sybenga A, Fabris L, Meng F, Glaser S, Alpini G.

FASEB J. 2019 Sep;33(9):10269-10279. doi: 10.1096/fj.201802606R. Epub 2019 Jun 28.


The Prevalence of Mycoplasma genitalium and Association With Human Immunodeficiency Virus Infection in Symptomatic Patients, Johannesburg, South Africa, 2007-2014.

Mahlangu MP, Müller EE, Venter JME, Maseko DV, Kularatne RS.

Sex Transm Dis. 2019 Jun;46(6):395-399. doi: 10.1097/OLQ.0000000000000984.


1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation.

Venter J, Perez C, van Otterlo WAL, Martínez A, Blackie MAL.

Bioorg Med Chem Lett. 2019 Jul 1;29(13):1597-1600. doi: 10.1016/j.bmcl.2019.04.049. Epub 2019 Apr 29.


Functional characterization of 3D protein structures informed by human genetic diversity.

Hicks M, Bartha I, di Iulio J, Venter JC, Telenti A.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8960-8965. doi: 10.1073/pnas.1820813116. Epub 2019 Apr 15.


Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis.

Chen L, Zhou T, Wu N, O'Brien A, Venter J, Ceci L, Kyritsi K, Onori P, Gaudio E, Sybenga A, Xie L, Wu C, Fabris L, Invernizzi P, Zawieja D, Liangpunsakul S, Meng F, Francis H, Alpini G, Huang Q, Glaser S.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1525-1539. doi: 10.1016/j.bbadis.2019.03.002. Epub 2019 Mar 16.


The prevalence of Mycoplasma genitalium and association with HIV infection in symptomatic patients, Johannesburg, South Africa, 2007-2014.

Mahlangu MP, Müller EE, Venter JM, Maseko DV, Kularatne RS.

Sex Transm Dis. 2019 Feb 11. doi: 10.1097/OLQ.0000000000000984. [Epub ahead of print]


Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 Knockout Mice via Lethal-7 microRNA.

McDaniel K, Wu N, Zhou T, Huang L, Sato K, Venter J, Ceci L, Chen D, Ramos-Lorenzo S, Invernizzi P, Bernuzzi F, Wu C, Francis H, Glaser S, Alpini G, Meng F.

Hepatology. 2019 Jun;69(6):2562-2578. doi: 10.1002/hep.30542. Epub 2019 Apr 12.


Knockout of α-calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes.

Wan Y, Ceci L, Wu N, Zhou T, Chen L, Venter J, Francis H, Bernuzzi F, Invernizzi P, Kyritsi K, Baker P, Huang Q, Wu C, Sybenga A, Alpini G, Meng F, Glaser S.

Lab Invest. 2019 Jun;99(6):764-776. doi: 10.1038/s41374-018-0178-5. Epub 2019 Jan 30. Erratum in: Lab Invest. 2020 Jan 14;:.


Direct Transfer of a Mycoplasma mycoides Genome to Yeast Is Enhanced by Removal of the Mycoides Glycerol Uptake Factor Gene glpF.

Karas BJ, Moreau NG, Deerinck TJ, Gibson DG, Venter JC, Smith HO, Glass JI.

ACS Synth Biol. 2019 Feb 15;8(2):239-244. doi: 10.1021/acssynbio.8b00449. Epub 2019 Jan 24.


Response to Whiffin et al.

Shah N, Claire Hou YC, Yu HC, Sainger R, Caskey CT, Venter JC, Telenti A.

Am J Hum Genet. 2019 Jan 3;104(1):186. doi: 10.1016/j.ajhg.2018.11.011. No abstract available.


Comparison of an in-house real-time duplex PCR assay with commercial HOLOGIC® APTIMA assays for the detection of Neisseria gonorrhoeae and Chlamydia trachomatis in urine and extra-genital specimens.

Venter JME, Mahlangu PM, Müller EE, Lewis DA, Rebe K, Struthers H, McIntyre J, Kularatne RS.

BMC Infect Dis. 2019 Jan 3;19(1):6. doi: 10.1186/s12879-018-3629-0.


Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk.

Cirulli ET, Guo L, Leon Swisher C, Shah N, Huang L, Napier LA, Kirkness EF, Spector TD, Caskey CT, Thorens B, Venter JC, Telenti A.

Cell Metab. 2019 Feb 5;29(2):488-500.e2. doi: 10.1016/j.cmet.2018.09.022. Epub 2018 Oct 11.


Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders.

Iranmehr A, Stobdan T, Zhou D, Poulsen O, Strohl KP, Aldashev A, Telenti A, Wong EHM, Kirkness EF, Venter JC, Bafna V, Haddad GG.

Eur J Hum Genet. 2019 Jan;27(1):150-159. doi: 10.1038/s41431-018-0270-8. Epub 2018 Sep 25.


The Secretin/Secretin Receptor Axis Modulates Ductular Reaction and Liver Fibrosis through Changes in Transforming Growth Factor-β1-Mediated Biliary Senescence.

Wu N, Meng F, Zhou T, Venter J, Giang TK, Kyritsi K, Wu C, Alvaro D, Onori P, Mancinelli R, Gaudio E, Francis H, Alpini G, Glaser S, Franchitto A.

Am J Pathol. 2018 Oct;188(10):2264-2280. doi: 10.1016/j.ajpath.2018.06.015. Epub 2018 Jul 21.


Author Correction: The role of the secretin/secretin receptor axis in inflammatory cholangiocyte communication via extracellular vesicles.

Sato K, Meng F, Venter J, Giang T, Glaser S, Alpini G.

Sci Rep. 2018 Jul 20;8(1):11238. doi: 10.1038/s41598-018-29609-x.


Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2-/- mice by diminishing senescence of cholangiocytes.

Zhou T, Wu N, Meng F, Venter J, Giang TK, Francis H, Kyritsi K, Wu C, Franchitto A, Alvaro D, Marzioni M, Onori P, Mancinelli R, Gaudio E, Glaser S, Alpini G.

Lab Invest. 2018 Nov;98(11):1449-1464. doi: 10.1038/s41374-018-0093-9. Epub 2018 Jul 5.


Tuning Gene Activity by Inducible and Targeted Regulation of Gene Expression in Minimal Bacterial Cells.

Mariscal AM, Kakizawa S, Hsu JY, Tanaka K, González-González L, Broto A, Querol E, Lluch-Senar M, Piñero-Lambea C, Sun L, Weyman PD, Wise KS, Merryman C, Tse G, Moore AJ, Hutchison CA 3rd, Smith HO, Tomita M, Venter JC, Glass JI, Piñol J, Suzuki Y.

ACS Synth Biol. 2018 Jun 15;7(6):1538-1552. doi: 10.1021/acssynbio.8b00028. Epub 2018 May 22.


Paternally inherited cis-regulatory structural variants are associated with autism.

Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J.

Science. 2018 Apr 20;360(6386):327-331. doi: 10.1126/science.aan2261.


Identification of Misclassified ClinVar Variants via Disease Population Prevalence.

Shah N, Hou YC, Yu HC, Sainger R, Caskey CT, Venter JC, Telenti A.

Am J Hum Genet. 2018 Apr 5;102(4):609-619. doi: 10.1016/j.ajhg.2018.02.019.


Sodium–glucose co-transporter 2 inhibitors: Think twice about diabetic ketoacidosis

Markey AG, Scott TA, Killen JC, Venter JA.

Aust J Gen Pract. 2018 Apr;47(4):223-225. doi: 10.31128/AFP-09-17-4348. No abstract available.


α7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice.

Ehrlich L, O'Brien A, Hall C, White T, Chen L, Wu N, Venter J, Scrushy M, Mubarak M, Meng F, Dostal D, Wu C, Lairmore TC, Alpini G, Glaser S.

Gene Expr. 2018 Aug 22;18(3):197-207. doi: 10.3727/105221618X15216453076707. Epub 2018 Mar 26.


Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults.

Perkins BA, Caskey CT, Brar P, Dec E, Karow DS, Kahn AM, Hou YC, Shah N, Boeldt D, Coughlin E, Hands G, Lavrenko V, Yu J, Procko A, Appis J, Dale AM, Guo L, Jönsson TJ, Wittmann BM, Bartha I, Ramakrishnan S, Bernal A, Brewer JB, Brewerton S, Biggs WH, Turpaz Y, Venter JC.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3686-3691. doi: 10.1073/pnas.1706096114. Epub 2018 Mar 19.


Microbial metagenome of urinary tract infection.

Moustafa A, Li W, Singh H, Moncera KJ, Torralba MG, Yu Y, Manuel O, Biggs W, Venter JC, Nelson KE, Pieper R, Telenti A.

Sci Rep. 2018 Mar 12;8(1):4333. doi: 10.1038/s41598-018-22660-8.


The human noncoding genome defined by genetic diversity.

di Iulio J, Bartha I, Wong EHM, Yu HC, Lavrenko V, Yang D, Jung I, Hicks MA, Shah N, Kirkness EF, Fabani MM, Biggs WH, Ren B, Venter JC, Telenti A.

Nat Genet. 2018 Mar;50(3):333-337. doi: 10.1038/s41588-018-0062-7. Epub 2018 Feb 26.


Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones.

Cohen IV, Cirulli ET, Mitchell MW, Jonsson TJ, Yu J, Shah N, Spector TD, Guo L, Venter JC, Telenti A.

EBioMedicine. 2018 Feb;28:316-323. doi: 10.1016/j.ebiom.2018.01.033. Epub 2018 Feb 15.


Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease.

Moustafa A, Li W, Anderson EL, Wong EHM, Dulai PS, Sandborn WJ, Biggs W, Yooseph S, Jones MB, Venter JC, Nelson KE, Chang JT, Telenti A, Boland BS.

Clin Transl Gastroenterol. 2018 Jan 18;9(1):e132. doi: 10.1038/ctg.2017.58.


Assessment of inpatient psychiatric readmission risk among patients discharged on an antipsychotic polypharmacy regimen: A retrospective cohort study.

Boskailo E, Malkoc A, McCurry DB, Venter J, Drachman D, Ramos GM.

Acta Med Acad. 2017 Nov;46(2):133-144. doi: 10.5644/ama2006-124.198.


Provision of acute and elective general surgical care at a tertiary facility in the era of subspecialisation.

Klopper JH, Rayamajhi S, Venter JJ, De Villiers DJ, Almgla N, Kloppers JC.

S Afr Med J. 2017 Oct 31;107(11):948-951. doi: 10.7196/SAMJ.2017.v107i11.12335.


Building Bridges through Science.

Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA, Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT.

Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028.


Regulation of Cellular Senescence by miR-34a in Alcoholic Liver Injury.

Wan Y, McDaniel K, Wu N, Ramos-Lorenzo S, Glaser T, Venter J, Francis H, Kennedy L, Sato K, Zhou T, Kyritsi K, Huang Q, Annable T, Wu C, Glaser S, Alpini G, Meng F.

Am J Pathol. 2017 Dec;187(12):2788-2798. doi: 10.1016/j.ajpath.2017.08.027. Epub 2017 Nov 8.


Monovision LASIK Versus Presbyopia-Correcting IOLs: Comparison of Clinical and Patient-Reported Outcomes.

Schallhorn SC, Teenan D, Venter JA, Schallhorn JM, Hettinger KA, Hannan SJ, Pelouskova M.

J Refract Surg. 2017 Nov 1;33(11):749-758. doi: 10.3928/1081597X-20170721-03.


Profiling of Short-Tandem-Repeat Disease Alleles in 12,632 Human Whole Genomes.

Tang H, Kirkness EF, Lippert C, Biggs WH, Fabani M, Guzman E, Ramakrishnan S, Lavrenko V, Kakaradov B, Hou C, Hicks B, Heckerman D, Och FJ, Caskey CT, Venter JC, Telenti A.

Am J Hum Genet. 2017 Nov 2;101(5):700-715. doi: 10.1016/j.ajhg.2017.09.013.


Human gene essentiality.

Bartha I, di Iulio J, Venter JC, Telenti A.

Nat Rev Genet. 2018 Jan;19(1):51-62. doi: 10.1038/nrg.2017.75. Epub 2017 Oct 30. Review.


New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude.

Stobdan T, Akbari A, Azad P, Zhou D, Poulsen O, Appenzeller O, Gonzales GF, Telenti A, Wong EHM, Saini S, Kirkness EF, Venter JC, Bafna V, Haddad GG.

Mol Biol Evol. 2017 Dec 1;34(12):3154-3168. doi: 10.1093/molbev/msx239.


Fine population structure analysis method for genomes of many.

Pan X, Wang Y, Wong EHM, Telenti A, Venter JC, Jin L.

Sci Rep. 2017 Oct 3;7(1):12608. doi: 10.1038/s41598-017-12319-1.


Refractive lens exchange in younger and older presbyopes: comparison of complication rates, 3 months clinical and patient-reported outcomes.

Schallhorn SC, Schallhorn JM, Pelouskova M, Venter JA, Hettinger KA, Hannan SJ, Teenan D.

Clin Ophthalmol. 2017 Aug 28;11:1569-1581. doi: 10.2147/OPTH.S143201. eCollection 2017.

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