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A systems view of spliceosomal assembly and branchpoints with iCLIP.

Briese M, Haberman N, Sibley CR, Faraway R, Elser AS, Chakrabarti AM, Wang Z, König J, Perera D, Wickramasinghe VO, Venkitaraman AR, Luscombe NM, Saieva L, Pellizzoni L, Smith CWJ, Curk T, Ule J.

Nat Struct Mol Biol. 2019 Sep 30. doi: 10.1038/s41594-019-0300-4. [Epub ahead of print]


ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining.

Nicolai S, Mahen R, Raschellà G, Marini A, Pieraccioli M, Malewicz M, Venkitaraman AR, Melino G.

Oncogene. 2019 Sep 30. doi: 10.1038/s41388-019-1028-7. [Epub ahead of print]


Fast single-cell biochemistry: theory, open source microscopy and applications.

Trinh AL, Ber S, Howitt A, Valls PO, Fries MW, Venkitaraman AR, Esposito A.

Methods Appl Fluoresc. 2019 Aug 29;7(4):044001. doi: 10.1088/2050-6120/ab3bd2.


How do mutations affecting the breast cancer genes BRCA1 and BRCA2 cause cancer susceptibility?

Venkitaraman AR.

DNA Repair (Amst). 2019 Sep;81:102668. doi: 10.1016/j.dnarep.2019.102668. Epub 2019 Jul 8. Review.


Structure-Guided Synthesis and Evaluation of Small-Molecule Inhibitors Targeting Protein-Protein Interactions of BRCA1 tBRCT Domain.

Kurdekar V, Giridharan S, Subbarao J, Nijaguna MB, Periasamy J, Boggaram S, Shivange AV, Sadasivam G, Padigaru M, Potluri V, Venkitaraman AR, Bharatham K.

ChemMedChem. 2019 Sep 18;14(18):1620-1632. doi: 10.1002/cmdc.201900300. Epub 2019 Sep 9.


Enhancing Biochemical Resolution by Hyperdimensional Imaging Microscopy.

Esposito A, Venkitaraman AR.

Biophys J. 2019 May 21;116(10):1815-1822. doi: 10.1016/j.bpj.2019.04.015. Epub 2019 Apr 22.


BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment.

D'Alessandro G, Whelan DR, Howard SM, Vitelli V, Renaudin X, Adamowicz M, Iannelli F, Jones-Weinert CW, Lee M, Matti V, Lee WTC, Morten MJ, Venkitaraman AR, Cejka P, Rothenberg E, d'Adda di Fagagna F.

Nat Commun. 2018 Dec 18;9(1):5376. doi: 10.1038/s41467-018-07799-2.


Science in Focus: Genomic Instability and its Implications for Clinical Cancer Care.

Ahmad SS, Ahmed K, Venkitaraman AR.

Clin Oncol (R Coll Radiol). 2018 Dec;30(12):751-755. doi: 10.1016/j.clon.2018.09.001. Epub 2018 Sep 27. No abstract available.


Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling.

Periasamy J, Kurdekar V, Jasti S, Nijaguna MB, Boggaram S, Hurakadli MA, Raina D, Kurup LM, Chintha C, Manjunath K, Goyal A, Sadasivam G, Bharatham K, Padigaru M, Potluri V, Venkitaraman AR.

Cell Chem Biol. 2018 Jun 21;25(6):677-690.e12. doi: 10.1016/j.chembiol.2018.02.012. Epub 2018 Mar 29.


BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation.

Shivji MKK, Renaudin X, Williams ÇH, Venkitaraman AR.

Cell Rep. 2018 Jan 23;22(4):1031-1039. doi: 10.1016/j.celrep.2017.12.086. Epub 2018 Jan 28.


Single-molecule localization microscopy reveals molecular transactions during RAD51 filament assembly at cellular DNA damage sites.

Haas KT, Lee M, Esposito A, Venkitaraman AR.

Nucleic Acids Res. 2018 Mar 16;46(5):2398-2416. doi: 10.1093/nar/gkx1303.


Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS.

Narvaez AJ, Ber S, Crooks A, Emery A, Hardwick B, Guarino Almeida E, Huggins DJ, Perera D, Roberts-Thomson M, Azzarelli R, Hood FE, Prior IA, Walker DW, Boyce R, Boyle RG, Barker SP, Torrance CJ, McKenzie GJ, Venkitaraman AR.

Cell Chem Biol. 2017 Aug 17;24(8):1017-1028.e7. doi: 10.1016/j.chembiol.2017.07.009. Epub 2017 Aug 10.


Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.

Cole DJ, Janecek M, Stokes JE, Rossmann M, Faver JC, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR, Huggins DJ, Jorgensen WL.

Chem Commun (Camb). 2017 Aug 17;53(67):9372-9375. doi: 10.1039/c7cc05379g.


Impact of Alternative Splicing on the Human Proteome.

Liu Y, Gonzàlez-Porta M, Santos S, Brazma A, Marioni JC, Aebersold R, Venkitaraman AR, Wickramasinghe VO.

Cell Rep. 2017 Aug 1;20(5):1229-1241. doi: 10.1016/j.celrep.2017.07.025.


A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.

Tan SLW, Chadha S, Liu Y, Gabasova E, Perera D, Ahmed K, Constantinou S, Renaudin X, Lee M, Aebersold R, Venkitaraman AR.

Cell. 2017 Jun 1;169(6):1105-1118.e15. doi: 10.1016/j.cell.2017.05.010.


Specific inhibition of CK2α from an anchor outside the active site.

Brear P, De Fusco C, Hadje Georgiou K, Francis-Newton NJ, Stubbs CJ, Sore HF, Venkitaraman AR, Abell C, Spring DR, Hyvönen M.

Chem Sci. 2016 Nov 1;7(11):6839-6845. doi: 10.1039/c6sc02335e. Epub 2016 Jul 12.


High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy.

Short JM, Liu Y, Chen S, Soni N, Madhusudhan MS, Shivji MK, Venkitaraman AR.

Nucleic Acids Res. 2016 Nov 2;44(19):9017-9030. Epub 2016 Sep 5.


Oncogenic KRAS triggers MAPK-dependent errors in mitosis and MYC-dependent sensitivity to anti-mitotic agents.

Perera D, Venkitaraman AR.

Sci Rep. 2016 Jul 14;6:29741. doi: 10.1038/srep29741.


Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.

Janeček M, Rossmann M, Sharma P, Emery A, Huggins DJ, Stockwell SR, Stokes JE, Tan YS, Almeida EG, Hardwick B, Narvaez AJ, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR.

Sci Rep. 2016 Jun 24;6:28528. doi: 10.1038/srep28528.


RNA Processing and Genome Stability: Cause and Consequence.

Wickramasinghe VO, Venkitaraman AR.

Mol Cell. 2016 Feb 18;61(4):496-505. doi: 10.1016/j.molcel.2016.02.001. Review.


Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.

Lau YH, Wu Y, Rossmann M, Tan BX, de Andrade P, Tan YS, Verma C, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR.

Angew Chem Int Ed Engl. 2015 Dec 14;54(51):15410-3. doi: 10.1002/anie.201508416. Epub 2015 Nov 2.


Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength.

Wickramasinghe VO, Gonzàlez-Porta M, Perera D, Bartolozzi AR, Sibley CR, Hallegger M, Ule J, Marioni JC, Venkitaraman AR.

Genome Biol. 2015 Sep 21;16:201. doi: 10.1186/s13059-015-0749-3.


Fast and simple spectral FLIM for biochemical and medical imaging.

Popleteeva M, Haas KT, Stoppa D, Pancheri L, Gasparini L, Kaminski CF, Cassidy LD, Venkitaraman AR, Esposito A.

Opt Express. 2015 Sep 7;23(18):23511-25. doi: 10.1364/OE.23.023511.


Micro(mi) RNA-34a targets protein phosphatase (PP)1γ to regulate DNA damage tolerance.

Takeda Y, Venkitaraman AR.

Cell Cycle. 2015;14(24):3830-41. doi: 10.1080/15384101.2015.1064202.


Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.

Laraia L, McKenzie G, Spring DR, Venkitaraman AR, Huggins DJ.

Chem Biol. 2015 Jun 18;22(6):689-703. doi: 10.1016/j.chembiol.2015.04.019. Review.


Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reaction.

Alza E, Laraia L, Ibbeson BM, Collins S, Galloway WRJD, Stokes JE, Venkitaraman AR, Spring DR.

Chem Sci. 2015 Jan 1;6(1):390-396. doi: 10.1039/c4sc02547d. Epub 2014 Sep 9.


p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response.

Hattori H, Janky R, Nietfeld W, Aerts S, Madan Babu M, Venkitaraman AR.

Cell Cycle. 2014;13(16):2572-86. doi: 10.4161/15384101.2015.942209.


A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis.

Lee M, Venkitaraman AR.

Cell Cycle. 2014;13(16):2554-63. doi: 10.4161/15384101.2014.942204.


Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone.

Piccirillo SG, Spiteri I, Sottoriva A, Touloumis A, Ber S, Price SJ, Heywood R, Francis NJ, Howarth KD, Collins VP, Venkitaraman AR, Curtis C, Marioni JC, Tavaré S, Watts C.

Cancer Res. 2015 Jan 1;75(1):194-202. doi: 10.1158/0008-5472.CAN-13-3131. Epub 2014 Nov 18.


Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides.

Lau YH, de Andrade P, McKenzie GJ, Venkitaraman AR, Spring DR.

Chembiochem. 2014 Dec 15;15(18):2680-3. doi: 10.1002/cbic.201402374. Epub 2014 Oct 29.


High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics.

Laraia L, Stokes J, Emery A, McKenzie GJ, Venkitaraman AR, Spring DR.

ACS Med Chem Lett. 2014 Feb 24;5(5):598-603. doi: 10.1021/ml5000564. eCollection 2014 May 8.


Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing.

Liang H, Esposito A, De S, Ber S, Collin P, Surana U, Venkitaraman AR.

Nat Commun. 2014 Jun 4;5:4048. doi: 10.1038/ncomms5048.


Investigating peptide sequence variations for 'double-click' stapled p53 peptides.

Lau YH, de Andrade P, Sköld N, McKenzie GJ, Venkitaraman AR, Verma C, Lane DP, Spring DR.

Org Biomol Chem. 2014 Jun 28;12(24):4074-7. doi: 10.1039/c4ob00742e.


Cancer suppression by the chromosome custodians, BRCA1 and BRCA2.

Venkitaraman AR.

Science. 2014 Mar 28;343(6178):1470-5. doi: 10.1126/science.1252230.


Tumour suppressor mechanisms in the control of chromosome stability: insights from BRCA2.

Venkitaraman AR.

Mol Cells. 2014 Feb;37(2):95-9. doi: 10.14348/molcells.2014.2346. Epub 2014 Feb 19. Review.


Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP.

Wickramasinghe VO, Andrews R, Ellis P, Langford C, Gurdon JB, Stewart M, Venkitaraman AR, Laskey RA.

Nucleic Acids Res. 2014 Apr;42(8):5059-71. doi: 10.1093/nar/gku095. Epub 2014 Feb 7.


Diversity-oriented synthesis as a tool for identifying new modulators of mitosis.

Ibbeson BM, Laraia L, Alza E, O' Connor CJ, Tan YS, Davies HM, McKenzie G, Venkitaraman AR, Spring DR.

Nat Commun. 2014;5:3155. doi: 10.1038/ncomms4155.


Chromosome instability and carcinogenesis: insights from murine models of human pancreatic cancer associated with BRCA2 inactivation.

Cassidy LD, Liau SS, Venkitaraman AR.

Mol Oncol. 2014 Mar;8(2):161-8. doi: 10.1016/j.molonc.2013.10.005. Epub 2013 Nov 6. Review.


Maximizing the biochemical resolving power of fluorescence microscopy.

Esposito A, Popleteeva M, Venkitaraman AR.

PLoS One. 2013 Oct 28;8(10):e77392. doi: 10.1371/journal.pone.0077392. eCollection 2013.


Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity.

Wickramasinghe VO, Savill JM, Chavali S, Jonsdottir AB, Rajendra E, Grüner T, Laskey RA, Babu MM, Venkitaraman AR.

Mol Cell. 2013 Sep 26;51(6):737-50. doi: 10.1016/j.molcel.2013.08.031.


A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.

Jeyasekharan AD, Liu Y, Hattori H, Pisupati V, Jonsdottir AB, Rajendra E, Lee M, Sundaramoorthy E, Schlachter S, Kaminski CF, Ofir-Rosenfeld Y, Sato K, Savill J, Ayoub N, Venkitaraman AR.

Nat Struct Mol Biol. 2013 Oct;20(10):1191-8. doi: 10.1038/nsmb.2666. Epub 2013 Sep 8.


A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei.

Mahen R, Hattori H, Lee M, Sharma P, Jeyasekharan AD, Venkitaraman AR.

PLoS One. 2013 May 2;8(5):e61893. doi: 10.1371/journal.pone.0061893. Print 2013.


Using a fragment-based approach to target protein-protein interactions.

Scott DE, Ehebauer MT, Pukala T, Marsh M, Blundell TL, Venkitaraman AR, Abell C, Hyvönen M.

Chembiochem. 2013 Feb 11;14(3):332-42. doi: 10.1002/cbic.201200521. Epub 2013 Jan 23.


Expression of LY6D is induced at the surface of MCF10A cells by X-ray irradiation.

Kurosawa M, Jeyasekharan AD, Surmann EM, Hashimoto N, Venkatraman V, Kurosawa G, Furukawa K, Venkitaraman AR, Kurosawa Y.

FEBS J. 2012 Dec;279(24):4479-91. doi: 10.1111/febs.12034. Epub 2012 Nov 22.


A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.

O'Connell KM, Beckmann HS, Laraia L, Horsley HT, Bender A, Venkitaraman AR, Spring DR.

Org Biomol Chem. 2012 Oct 7;10(37):7545-51. doi: 10.1039/c2ob26272j.


A DNA-damage selective role for BRCA1 E3 ligase in claspin ubiquitylation, CHK1 activation, and DNA repair.

Sato K, Sundaramoorthy E, Rajendra E, Hattori H, Jeyasekharan AD, Ayoub N, Schiess R, Aebersold R, Nishikawa H, Sedukhina AS, Wada H, Ohta T, Venkitaraman AR.

Curr Biol. 2012 Sep 25;22(18):1659-66. doi: 10.1016/j.cub.2012.07.034. Epub 2012 Aug 2.


Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin.

Bolderson E, Savage KI, Mahen R, Pisupati V, Graham ME, Richard DJ, Robinson PJ, Venkitaraman AR, Khanna KK.

J Biol Chem. 2012 Aug 10;287(33):28122-31. doi: 10.1074/jbc.M112.368381. Epub 2012 Jun 18.


Palladium-catalysed cross-coupling of vinyldisiloxanes with benzylic and allylic halides and sulfonates.

Frye EC, O'Connor CJ, Twigg DG, Elbert B, Laraia L, Hulcoop DG, Venkitaraman AR, Spring DR.

Chemistry. 2012 Jul 9;18(28):8774-9. doi: 10.1002/chem.201200431. Epub 2012 Jun 8.


Beyond cancer genomics: after the end of the beginning.

Venkitaraman AR.

Curr Opin Genet Dev. 2012 Feb;22(1):1-2. doi: 10.1016/j.gde.2012.02.010. Epub 2012 Mar 6. No abstract available.


Genome instability mechanisms and the structure of cancer genomes.

Cassidy LD, Venkitaraman AR.

Curr Opin Genet Dev. 2012 Feb;22(1):10-3. doi: 10.1016/j.gde.2012.02.003. Epub 2012 Feb 25. Review.


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